Abstract: A valve train assembly (16) includes a fuel injector (1), an intake rocker lever assembly (10), and an exhaust rocker lever assembly (14). The intake and exhaust rocker lever assemblies (10) can include an eccentric hydraulic lash adjuster (11) that is located in the nose (31) of the respective rocker lever assemblies (10). The rocker lever assemblies (10) are configured to allow a clearance area between a nose (31) of the intake rocker lever assembly (10) and the nose (31) of the exhaust rocker lever assembly (14). As such, the fuel injector (1) can be positioned in the clearance area, while still allowing the eccentric hydraulic lash adjusters to apply a load onto a corresponding valve bridge (2). For example, the eccentric hydraulic lash adjuster (11) can include an outer housing (20) and a pivot ball (21), wherein the pivot ball (21) is positioned at an offset (23) from a lateral centerline of the outer housing (20).

Abstract: The present disclosure provides a lubrication system comprising: a pump having an inlet in fluid communication with a lubricant source and an outlet; a cooler having an inlet in fluid communication with the outlet of the pump and an outlet; a lubrication filter having an inlet in fluid communication with the outlet of the cooler and an outlet; a first delivery path in fluid communication with the outlet of the lubrication filter, the first delivery path being configured to deliver cooled, filtered lubricant to a bearing system of an engine; and a second delivery path in fluid communication with the outlet of the pump, the second delivery path being configured to deliver uncooled, unfiltered lubricant to piston cooling nozzles of the engine.

Abstract: A crystalline form of a drug, ways to make it, compositions containing it and methods of treatment of diseases and inhibition of adverse physiological events using it are disclosed.

Abstract: A valve train assembly is provided, comprising an exhaust camshaft having an exhaust lobe and a brake lobe, an exhaust lever mounted adjacent the exhaust lobe, a brake lever mounted adjacent the brake lobe, wherein the exhaust lever is coupled to the brake lever to provide simultaneous movement of the exhaust lever and the brake lever in response to the exhaust lobe and independent movement of the brake lever in response to the brake lobe.

Abstract: An eccentric hydraulic lash adjuster, a combustion engine comprising the eccentric hydraulic lash adjuster, and a method of assembling the combustion engine, the combustion engine including a rocker lever having a nose at a distal end thereof, and a bridge bar extending between two valves, the rocker lever configured to apply pressure on the bridge bar to actuate the two valves, and an eccentric hydraulic lash adjuster positioned in the nose of the rocker lever; and a fuel injector adjacent to the nose of the rocker lever and the bridge bar, wherein the eccentric hydraulic lash adjuster includes a housing having a pivot point and a longitudinal axis offset from the pivot point and is configured to pivot about the pivot point when the rocker lever pivots about the rocket lever shaft, wherein the offset is dimensioned to prevent interference between the nose and the fuel injector.

Abstract: Variable counterweight apparatuses, systems and methods. The variable counterweight system includes at least one rotatable actuator, a first variable counterweight assembly, and a second variable counterweight assembly. The first variable counterweight assembly is rotatably coupled to the rotatable actuator to rotate about a first axis. The first variable counterweight assembly is configured to geometrically reconfigure so as to change a first variable counterweight assembly center of gravity position with respect to the first variable counterweight assembly. The second variable counterweight assembly is rotatably coupled to the rotatable actuator to rotate about a second axis. The second variable counterweight assembly is configured to geometrically reconfigure so as to change a second variable counterweight assembly center of gravity position with respect to the second variable counterweight assembly.

Abstract: An eccentric hydraulic lash adjuster, a combustion engine comprising the eccentric hydraulic lash adjuster, and a method of assembling the combustion engine, the combustion engine including a rocker lever having a nose at a distal end thereof, and a bridge bar extending between two valves, the rocker lever configured to apply pressure on the bridge bar to actuate the two valves, and an eccentric hydraulic lash adjuster positioned in the nose of the rocker lever; and a fuel injector adjacent to the nose of the rocker lever and the bridge bar, wherein the eccentric hydraulic lash adjuster includes a housing having a pivot point and a longitudinal axis offset from the pivot point and is configured to pivot about the pivot point when the rocker lever pivots about the rocket lever shaft, wherein the offset is dimensioned to prevent interference between the nose and the fuel injector.

Abstract: A crystalline form of a drug, ways to make it, compositions containing it and methods of treatment of diseases and inhibition of adverse physiological events using it are disclosed.

Abstract: A diesel engine includes a cylinder block having a cylinder cavity defined therein. A cylinder head is coupled to the cylinder block and includes a lower semi-hemispherical surface defined thereon that defines an upper boundary of a combustion chamber. The engine includes a piston slideably disposed within the cylinder cavity that includes a piston crown having an upper surface configured to define a first portion of a lower boundary of the combustion chamber. The upper surface of the piston crown includes an axi-symmetric semi-hemispherical shape configured to correspond to the lower semi-hemispherical surface of the cylinder head.

Abstract: A crystalline form of a drug, ways to make it, compositions containing it and methods of treatment of diseases and inhibition of adverse physiological events using it are disclosed.

Abstract: An internal combustion engine and related components and methods of manufacturing and implementing an internal combustion engine and related components. The internal combustion engine includes a base, a cylinder block mounted onto the base, a cylinder head mounted onto the block, and a structural overhead member mounted onto the cylinder head, such that the cylinder head is positioned between the cylinder block and the structural overhead member. At least one through-bolt positioned in a through-bolt opening, the through-bolt opening extending from the base to the structural overhead member through the cylinder block and the cylinder head to couple the base, the cylinder block, the cylinder head and the structural overhead member together.

Abstract: Engine lubrication systems and methods of manufacturing and implementing engine lubrication systems and methods. In particular embodiments, an engine system includes an internal combustion engine lubrication system that utilizes a stacked configuration of a through-bolted engine to pattern around through-bolts and utilizes substantially hollow bulkheads to define a central high-pressure lubrication reservoir that minimizes lube system pressure while maintaining pressure at the extremities of the lubrication circuit. Available space is utilized within the bulkheads to provide a lubrication drainage restriction for reducing lubrication losses at engine shut-down.

Abstract: This disclosure is directed to: (a) processes for preparing compounds and salts thereof that, inter alia, are useful for inhibiting hepatitis C virus (HCV); (b) intermediates useful for the preparation of the compounds and salts; (c) pharmaceutical compositions comprising the compounds or salts; and (d) methods of use of such compositions.

Abstract: The disclosure is directed to: (a) phosphacycle ligands; (b) catalyst compositions comprising phosphacycle ligands; and (c) methods of using such phosphacycle ligands and catalyst compositions in bond forming reactions.

Abstract: An apparatus includes an internal combustion engine having a plurality of cylinders allocated between a first bank having a first cylinder head and a second bank having a second cylinder head. A medial space is defined between the first bank and the second bank. An exhaust system is in fluid receiving communication with the internal combustion engine and in fluid providing communication with the atmosphere. The exhaust system includes an aftertreatment system that is disposed at least in part at the medial space between the first bank and the second bank of the internal combustion engine.

Abstract: A crystalline form of a drug, ways to make it, compositions containing it and methods of treatment of diseases and inhibition of adverse physiological events using it are disclosed.

Abstract: A crystalline form of a drug, ways to make it, compositions containing it and methods of treatment of diseases and inhibition of adverse physiological events using it are disclosed.

Abstract: This disclosure is directed to: (a) processes for preparing compounds and salts thereof that, inter alia, are useful for inhibiting hepatitis C virus (HCV); (b) intermediates useful for the preparation of the compounds and salts; (c) pharmaceutical compositions comprising the compounds or salts; and (d) methods of use of such compositions.

Abstract: Rib configurations for increasing the structural efficiency of a cylinder head, which relates to a peak combustion pressure capability of the cylinder head. In addition to increasing peak combustion pressure, the rib configurations may also improve sealing of the cylinder head and may improve the durability of an associated cylinder head gasket.

Abstract: A valve train assembly is provided, comprising an exhaust camshaft having an exhaust lobe and a brake lobe, an exhaust lever mounted adjacent the exhaust lobe, a brake lever mounted adjacent the brake lobe, wherein the exhaust lever is coupled to the brake lever to provide simultaneous movement of the exhaust lever and the brake lever in response to the exhaust lobe and independent movement of the brake lever in response to the brake lobe.