Abstract: Rib configurations for increasing the structural efficiency of a cylinder head, which relates to a peak combustion pressure capability of the cylinder head. In addition to increasing peak combustion pressure, the rib configurations may also improve sealing of the cylinder head and may improve the durability of an associated cylinder head gasket.

Abstract: This disclosure is directed to: (a) processes for preparing compounds and salts thereof that, inter alia, are useful for inhibiting hepatitis C virus (HCV); (b) intermediates useful for the preparation of the compounds and salts; (c) pharmaceutical compositions comprising the compounds or salts; and (d) methods of use of such compositions.

Abstract: The disclosure is directed to: (a) phosphacycle ligands; (b) catalyst compositions comprising phosphacycle ligands; and (c) methods of using such phosphacycle ligands and catalyst compositions in bond forming reactions.

Abstract: Octahydro-pyrrolo[3,4-b]pyrrole derivatives are useful in treating conditions or disorders prevented by or ameliorated by histamine-3 receptor ligands. Octahydro-pyrrolo[3,4-b]pyrrole compounds, methods for using such compounds, compositions for making them, and processes for preparing such compounds are disclosed herein.

Abstract: A crystalline form of a drug, ways to make it, compositions containing it and methods of treatment of diseases and inhibition of adverse physiological events using it are disclosed.

Abstract: The invention relates to compounds that are vitamin D receptor activators, compositions comprising such compounds, methods of using such compounds and compositions, processes for preparing such compounds, and intermediates obtained during such processes.

Abstract: A variable valve actuation system is disclosed. In one form a rocker is disclosed coupled with a valve stem at one end and a cam follower at the other end. The rocker is operable to pivot about a fixed axis. The cam follower is operable to be pivotally coupled with the rocker at one end of the cam follower. The cam follower includes a lower roller and an upper roller at its other end, each operable to engage cam lobes on separate cam shafts. In one form the cam follower includes a lower roller operable to follow a cam lobe on a lower cam shaft and an upper roller operable to follow a cam lobe on an upper cam shaft. The upper cam shaft and the lower cam shaft can have variable lobes. A spring can be used to bias the cam follower on the rocker.

Abstract: In one form a rocker is disclosed coupled with a valve stem at one end and a cam follower at the other end. The rocker is operable to rotate about a fixed axis. In one form the cam follower includes a set of lower rollers operable to follow one cam lobe and an upper roller operable to follow another cam lobe. A leaf spring can be used to couple the cam follower with the rocker. A cam shaft can have a nested configuration including an inner shaft, an intermediate tube, and an outer tube. Cam lobes can be fastened to the cam shaft in one form by fastening through each of the inner shaft, intermediate tube, and outer tube, and in another form by attaching at least two devices inserted from either side of the cam shaft and that are not inserted at least through the inner shaft.

Abstract: A process for making 1-(6-amino-3,5-difluoropyridin-2-yl)-8-chloro-6-fluoro-7-(3-hydroxyazetidin-1-yl)-4-oxo-1,4-dihydro-3-quinolinecarboxylic acid, and therapeutically acceptable salts thereof, and intermediates used in the process are disclosed.

Abstract: A crystalline form of a drug, ways to make it, compositions containing it and methods of treatment of diseases and inhibition of adverse physiological events using it are disclosed.

Abstract: An accessory drive motor configuration is disclosed. One embodiment of the accessory drive motor configuration is an apparatus including an internal combustion engine having a crankshaft, wherein the crankshaft is structured to provide traction power. The apparatus further includes an accessory drive system operably coupled to a shaft. The shaft is selectively coupled to an electro-mechanical device and selectively coupled to the internal combustion engine. The shaft extends through at least a portion of the electro-mechanical device.

Abstract: A waste heat recovery system connects a working fluid into passages formed within an internal combustion engine. The fluid passages transport the working fluid to high temperature areas of the engine, raising the temperature of the working fluid near the phase change point or above the phase change point. The heated working fluid drives an energy conversion portion located downstream from the engine. The heat absorbed by the working fluid decreases the load on an engine cooling system as well as driving an energy conversion portion, improving fuel efficiency.

Abstract: A crystalline form of a drug, ways to make it, compositions containing it and methods of treatment of diseases and inhibition of adverse physiological events using it are disclosed.

Abstract: A high-efficiency mechanism for variable valve actuation with increased engine architecture applicability is described. The high efficiency mechanism introduces an intermediate lever having a secondary cam profile forming a variable oscillating cam between a rotating camshaft and a rocker arm.

Abstract: An apparatus for an accessory drive configuration includes an internal combustion engine having a crankshaft which is structured to provide traction power. A torque-transmitting shaft extends through a portion of an internal combustion engine assembly, and the torque-transmitting shaft provides mechanical power to an accessory drive system. The internal combustion engine and an electric motor are operably coupled to the torque-transmitting shaft to selectively provide torque to the torque-transmitting shaft.

Abstract: An inertia assisted engine starting apparatus and method are disclosed. The apparatus includes an internal combustion engine and an accessory drive system including an accessory. The accessory includes a rotatable member. An electric motor is selectively rotationally coupled to the accessory drive system. A mechanical coupling device selectively transfers rotational kinetic energy from the accessory drive system to start the internal combustion engine.

Abstract: The disclosure is directed to: (a) phosphacycle ligands; (b) methods of using such phosphacycle ligands in bond forming reactions; and (c) methods of preparing phosphacycle ligands.

Abstract: This disclosure is directed to: (a) processes for preparing a compound and salts thereof that, inter alia, are useful for inhibiting hepatitis C virus (HCV); (b) intermediates useful for the preparation of the compound and salts; (c) pharmaceutical compositions comprising the compound or salts; and (d) methods of use of such compositions.

Abstract: A method for reducing gastrointestinal inflammation, enhancing growth, or improving feed efficiency in a human or non-human animal is disclosed. The method involves administering to the animal an agent that can reduce the formation of the signal transduction complex of endotoxin, TLR4 and CD14 on the cellular surface of a cell in the gastrointestinal tract of the animal. In a preferred embodiment, an antibody against the extracellular domain of TLR4 or CD14 is used to reduce the formation of the complex. A composition that contains the antibody and an ingestible carrier is also disclosed. Further disclosed is a method for producing a peptide for enhancing growth, improving feed efficiency, or both in a human or non-human animal.

Abstract: A method for reducing gastrointestinal inflammation, enhancing growth, or improving feed efficiency in a human or non-human animal is disclosed. The method involves administering to the animal an agent that can reduce the formation of the signal transduction complex of endotoxin, TLR4 and CD14 on the cellular surface of a cell in the gastrointestinal tract of the animal. In a preferred embodiment, an antibody against the extracellular domain of TLR4 or CD14 is used to reduce the formation of the complex. A composition that contains the antibody and an ingestible carrier is also disclosed. Further disclosed is a method for producing a peptide for enhancing growth, improving feed efficiency, or both in a human or non-human animal.