Abstract: The present invention provides a novel class of macrocyclic compounds, which are useful as cysteine protease inhibitors. Also provided are novel intermediates and methods of preparing the compounds. The invention also provides pharmaceutical compositions comprising the compounds. The compounds and compositions are useful in methods of treating or preventing one or more diseases associated with cysteine protease activity, particularly those associated with calpain activity.

Abstract: The present invention relates to particles and to methods of making particles. In particular, the invention relates to methods of making composite active particles comprising a pharmaceutically active material for pulmonary inhalation, the method comprising a jet milling process.

Abstract: An improved user interface is provided for displaying selectable software functionality controls and for presenting logical groupings of particular functionality controls associated with a selected top-level functionality. Underneath a row of top-level functionality tabs, functionalities controls associated with a given top-level functionality tab are presented in logical groupings. Selection of a particular tab switches modes of the user interface to present controls for functionalities associated with the selected tab.

Abstract: The present invention is concerned with a refinement of the processing of particles that are to form a dry powder formulation which is to be administered to the lung using a dry powder inhaler (DPI) device. In particular, the present invention provides the processing of particles of active material and particles of carrier material in the presence of additive material to provide a powder composition which exhibits excellent powder properties and which is economical to produce.

Abstract: An improved user interface is provided for displaying selectable software functionality controls and for presenting logical groupings of particular functionality controls associated with a selected top-level functionality. Underneath a row of top-level functionality tabs, functionalities controls associated with a given top-level functionality tab are presented in logical groupings. Selection of a particular tab switches modes of the user interface to present controls for functionalities associated with the selected tab.

Abstract: An infill balise is arranged upstream of a route component in the direction of travel. The infill balise receives information relating to a state of the route component, and the control of a rail vehicle is carried out by taking into account the state of the route component. Since the infill balise is positioned ahead of the route component, the rail vehicle can still react in good time to the state of the route component and, initiate a braking or an acceleration process. This reduces the delay and increases the safety as well as the efficiency in the railway mode, in particular if the route component lying ahead is located at the start of an area which is controlled by another interlock box. The infill balise is used instead of a block interface. This is advantageous because the implementation of block interfaces is challenging, complicated and costly.

Abstract: An infill balise is provided for making available a state of a route component (for example of a signal) which lies ahead in the direction of travel of a rail line. Depending on a state of the route component, the infill balise brings about a change of the European train control system (ETCS) mode of a rail vehicle if the rail vehicle is in a manual travel mode or is not in a monitored travel mode. The presented solution has the advantage that the infill balise can ensure safety even in a manual ETCS mode (for example a staff responsible mode or an on-site mode). The solution can preferably be used in conjunction with ETCS level 1 applications.

Abstract: Some embodiments can include a method of manufacturing first electronic device(s) and second electronic device(s), the method including: providing a carrier substrate having a first side and a second side, a first substrate bonded to the first side of the carrier substrate, and a second substrate bonded to the second side of the carrier substrate; depositing at least one layer of a first material over the first substrate while the first substrate is bonded to the first side of the carrier substrate to create a portion of the first electronic device(s); and depositing at least one layer of a second material over the second substrate while the second substrate is bonded to the second side of the carrier substrate to create a portion of the second electronic device(s). In many embodiments, the first substrate and/or the second substrate includes a flexible substrate. Other related systems and methods are also disclosed.

Abstract: An oven rack system has a two piece oven rack (100) with a cooking rack (102) and a base rack (104). The base rack (104) is adapted to remain stationary and may be positioned on ledges or other protrusions associated with inner liners of oven cavities. In one embodiment, a pair of angled pieces (118) extend between outer lateral braces (114) and a rear brace (106). The cooking rack (102) is adapted to slide on and be extendable relative to the base rack (104). A user can exert manual forces on the cooking rack (102) so as to move the cooking rack (102) relative to the base rack (104). The movement occurs in the absence of the requirement of any type of rotatable or rolling elements.

Abstract: An apparatus (1) for the atomisation of a liquid including: a piezoelectric substrate (5) having at least one working surface (7), at least one electrode (9) supported on the piezoelectric substrate (5), a signal generating means (21) for applying an ultrasonic signal to said electrode (9) for generating a surface acoustic wave (SAW) in the working surface (7) of the piezoelectric substrate (5); a liquid delivery arrangement (11) including a wick (17) in contact with the working surface (7) for delivering liquid thereof, wherein liquid delivered to the working surface (7) is atomised by SAW irradiation.

Abstract: A tipping method for a tipping arrangement which includes a first element (1) and a second element (2), arranged between a moveable base unit (4) and a rotatable container (3). The container (3) is rotated by moving the second element (2) along a first track (7) on the first element (1). The second element (2) is moved along the track (7) by rotating the second element (2) relative to the first element (1). A number of engaging parts (9, 10) may be arranged on the tracks (7, 8) of the elements (1, 2), respectively. An interlocking arrangement may be arranged between the first element (1) and the second element (2) to secure the second element (2) in a starting position. A movable unit includes the tipping arrangement and a section unit, with the container (3) locked in a vertical position by a locking arrangement.

Abstract: This invention relates to drug delivery and in particular to the delivery of biologically active agents in the form of dry powders for inhalation. The invention also relates to methods for preparing such dry powder formulations and methods for their use.

Abstract: The present invention provides a novel class of macrocyclic compounds, which are useful as cysteine protease inhibitors. Also provided are novel intermediates and methods of preparing the compounds. The invention also provides pharmaceutical compositions comprising the compounds. The compounds and compositions are useful in methods of treating or preventing one or more diseases associated with cysteine protease activity, particularly those associated with calpain activity.

Abstract: A protective garment including a waist portion adapted to be donned proximate the waist of a wearer and first and second leg portions extending from a waist portion to at least proximate a knee portion of the wearer and a tourniquet member attached to an inner surface of at least one of said first and second leg portions.

Abstract: The present invention provides a novel class of macrocyclic compounds, which are useful as cysteine protease inhibitors. Also provided are novel intermediates and methods of preparing the compounds. The invention also provides pharmaceutical compositions comprising the compounds. The compounds and compositions are useful in methods of treating or preventing one or more diseases associated with cysteine protease activity, particularly those associated with calpain activity.

Abstract: The invention provides a switching device for an irrigation system. The switching device provides selective communication between a supply port to which a supply of fluid under pressure can be attached and a balloon port to which a fixing balloon of a catheter can be attached, and between the supply port and a port to which a liquid reservoir can be attached. By use of a selection handle, the user can deform conduits in a pre-determined sequence and thus control an irrigation procedure by opening and closing fluid flow in various conduits. The invention further provides an irrigation device incorporating the switching device and a method of controlling a fluid flow e.g. in an irrigation system.

Abstract: The present disclosure relates generally to binder powders for use in powder material processing and processes for their preparation. The disclosure further relates to binder powders for use in making solid powder compact forms, solid powder compact forms containing said binder powders and methods for making solid powder compact forms.

Abstract: An improved user interface is provided for displaying selectable software functionality controls that are relevant to a selected object and that remain visibly available for use while the selected object is being edited. Upon selection of a particular object for editing, functionality available for editing the object is presented in a ribbon-shaped user interface above the software application workspace to allow the user ready and efficient access to functionality needed for editing the selected object. The display of relevant functionality controls is persisted until the user dismisses the display, selects another top-level functionality control or selects another object for editing.

Abstract: A protective garment including a waist portion adapted to be donned proximate the waist of a wearer and first and second leg portions extending from a waist portion to at least proximate a knee portion of the wearer and a tourniquet member attached to an inner surface of at least one of said first and second leg portions.