Abstract: A method and apparatus are disclosed for supporting a flexible pipe. The method includes the steps of responsive to a change in at least one condition experienced by a flexible pipe, varying an amount of support provided at least one location on the flexible pipe.

Abstract: Monoclonal antibodies that specifically bind to ANGPTL3 are provided. Monoclonal antibodies that neutralize at least one activity of ANGPTL3 are provided. Methods of treating a disorder of lipid metabolism using neutralizing monoclonal antibodies are provided.

Abstract: Substituted heteroaromatic compounds of structural formula I are inhibitors of stearoyl-coenzyme A delta-9 desaturase. The compounds of the present invention are useful for the prevention and treatment of conditions related to abnormal lipid synthesis and metabolism, including cardiovascular disease, such as atherosclerosis; obesity; Type 2 diabetes; insulin resistance; hyperglycemia; Metabolic Syndrome; neurological disease; cancer; and liver steatosis. Formula (I).

Abstract: The present invention provides an EC mirror assembly including an EC mirror cell and a control for controlling the reflectivity of the mirror cell, the assembly also including a pair of contact elements independently displaceable relative to the mirror cell while maintaining an electrical connection with the control, the contact elements also being engageable with opposite edges of the mirror cell in order to provide an electrical connection between the control and the mirror cell.

Abstract: Bicyclic heteroaromatic compounds of structural formula I are inhibitors of stearoyl-coenzyme A delta-9 desaturase (SCD). The compounds of the present invention are useful for the prevention and treatment of conditions related to abnormal lipid synthesis and metabolism, including cardiovascular disease, such as atherosclerosis; obesity; Type 2 diabetes; insulin resistance; hyperglycemia; Metabolic Syndrome; neurological disease; cancer; and liver steatosis. Formula (I).

Abstract: The present invention relates to a mesalamine rectal suppository designed to provide improved comfort of use. One embodiment of the invention is a mesalamine rectal suppository comprising mesalamine and one or more pharmaceutically acceptable excipients, wherein the drug load of the suppository ranges from 35% to 50%. Yet another embodiment of the invention is a mesalamine rectal suppository comprising mesalamine having a tap density ranging from about 600 to about 800 g/L (as measured by USP <616>) and a hard fat having an ascending melting point of 32 to 35.5° C. Yet another embodiment is a mesalamine rectal suppository comprising mesalamine particles and one or more pharmaceutically acceptable excipients, where the mesalamine particles have a surface area of from about 0.1 m2/g to about 2.8 m2/g (e.g., from about 0.1 m2/g to about 1.3 m2/g). Methods of preparing and methods of treatment with mesalamine suppositories are also provided.

Abstract: An optical transmission system comprises two optical fibers carrying optical signal traffic between two terminals, and a plurality of optical repeaters coupled to the two fibers each repeater having a permanently connected passive high loss loop back circuit between the two fibers. One terminal includes a transmitter, which launches a pulsed supervisory signal on a dedicated supervisory wavelength into one optical fiber, and a receiver, which detects a portion of the supervisory signal looped back from each repeater in order to identify the existence and location of faults in the transmission system. The pulsed supervisory signal is of sufficiently short duration such that portions of the signal returned from each repeater do not overlap with one another and interference with the counter-propagating traffic is avoided by utilizing a dedicated supervisory wavelength. Each return pulse is integrated sequentially by a single detector and processed by heterodyne reception and synchronous demodulation.

Abstract: A haptic seat and system for use in imparting sensations to an occupant thereof. The haptic seat may be used to alert passengers of various operating conditions with some sort of tactile sensation, such as a vibration, pulse, shake, or other inducement that involves the occupant's sense of touch.

Abstract: Methods, systems, and computer readable media for tracking subject matter of an e-mail discussion are described. A query e-mail is received, wherein the query e-mail includes an initial request and wherein the query e-mail commences the e-mail discussion. At least one marked response e-mail is received, wherein the at least one marked response e-mail includes information responsive to the query e-mail and is marked with an indication that the initial request has been resolved, and wherein the at least one marked response e-mail is appended to the e-mail discussion. At least one visual indicator in the e-mail discussion is provided that distinguishes at least one of the query e-mail and the at least one marked response e-mail when the e-mail discussion is opened at a later time.

Abstract: Azacycloalkane derivatives of structural formula (I) are selective inhibitors of stearoyl-coenzyme A delta-9 desaturase (SCD1) relative to other known stearoyl-coenzyme A desaturases. The compounds of the present invention are useful for the prevention and treatment of conditions related to abnormal lipid synthesis and metabolism, including cardiovascular disease, such as atherosclerosis; obesity; diabetes; neurological disease; metabolic syndrome; insulin resistance; and liver steatosis.

Abstract: The present invention relates to novel renin inhibitors of the general Formula (I), and their use as active ingredients in the preparation of pharmaceutical compositions. The invention also concerns related aspects including processes for the preparation of the compounds. These novel renin inhibitors are used in treating cardiovascular events and renal insufficiency.

Abstract: Azacycloalkane derivatives of structural formula I are selective inhibitors of stearoyl-coenzyme A delta-9 desaturase (SCD1) relative to other known stearoyl-coenzyme A desaturases. The compounds of the present invention are useful for the prevention and treatment of conditions related to abnormal lipid synthesis and metabolism, including cardiovascular disease, such as atherosclerosis; obesity; diabetes; neurological disease; metabolic syndrome; insulin resistance; and liver steatosis.

Abstract: The present invention relates to a mesalamine rectal suppository designed to provide improved comfort of use. One embodiment of the invention is a mesalamine rectal suppository comprising mesalamine and one or more pharmaceutically acceptable excipients, wherein the drug load of the suppository ranges from 35% to 50%. Another embodiment of the invention is a mesalamine rectal suppository comprising from about 850 to about 1150 mg mesalamine and one or more pharmaceutically acceptable excipients, wherein the total weight of the suppository ranges from about 2250 to about 2700 mg. Another embodiment of the invention is a mesalamine rectal suppository comprising from about 400 to about 600 mg mesalamine and one or more pharmaceutically acceptable excipients, wherein the total weight of the suppository ranges from about 870 to about 1715 mg.

Abstract: Azacycloalkane derivatives of structural formula I are selective inhibitors of stearoyl-coenzyme A delta-9 desaturase (SCD1) relative to other known stearoyl-coenzyme A desaturases. The compounds of the present invention are useful for the prevention and treatment of conditions related to abnormal lipid synthesis and metabolism, including cardiovascular disease, such as atherosclerosis; obesity; diabetes; neurological disease; metabolic syndrome; insulin resistance; and liver steatosis.

Abstract: A system for facilitating transfer of an intellectual asset includes a data interface receiving electronic patent application data respecting a primary patent application. A processor creates a plurality of option records, each option record respectively including data relating to an option to file a patent application in a respective secondary jurisdiction based on the primary patent application. A storage device stores the plurality of option records and a first input device interface receives authorization to make at least one option individually available for transfer. The processor modifies at least one option record in accordance with the authorization, and a second input device permits third parties to view data relating to which options are individually available for transfer.

Abstract: The invention relates to novel secondary amine derivatives of formula (I) and the use thereof as active ingredients in the preparation of pharmaceutical compositions. The invention also concerns related aspects including processes for the preparation of the compounds, pharmaceutical compositions containing one or more of those compounds and especially their use as inhibitors of renin.

Abstract: Azetidine derivatives of structural formula I are selective inhibitors of stearoyl-coenzyme A delta-9 desaturase (SCD1) relative to other known stearoyl-coenzyme A desaturases. The compounds of the present invention are useful for the prevention and treatment of conditions related to abnormal lipid synthesis and metabolism, including cardiovascular disease; atherosclerosis; obesity; diabetes; neurological disease; metabolic syndrome; insulin resistance; liver steatosis; and non-alcoholic steatohepatitis.

Abstract: An alerting element for use with occupant seating to alert a seat occupant with a haptic and/or audible sensation. The alerting element being suitable for use with any type of seat, including vehicle seats. The alerting element optionally including a striking element for striking a structural component of the seat, and thereby, generating an alerting sensation.

Abstract: An optical transmission system comprises two optical fibbers carrying optical signal traffic between two terminals, and a plurality of optical repeaters coupled to the two fibers each repeater having a permanently connected passive high loss loop back circuit between the two fibers. One terminal includes a transmitter, which launches a pulsed supervisory signal on a dedicated supervisory wavelength into one optical fiber, and a receiver, which detects a portion of the supervisory signal looped back from each repeater in order to identify the existence and location of faults in the transmission system. The pulsed supervisory signal is of sufficiently short duration such that portions of the signal returned from each repeater do not overlap with one another and interference with the counter-propagating traffic is avoided by utilising a dedicated supervisory wavelength. Each return pulse is integrated sequentially by a single detector and processed by heterodyne reception and synchronous demodulation.

Abstract: The present invention relates to a mesalamine rectal suppository designed to provide improved comfort of use. One embodiment of the invention is a mesalamine rectal suppository containing mesalamine and one or more pharmaceutically acceptable excipients, wherein the drug load of the suppository ranges from 35% to 50%. Another embodiment of the invention is a mesalamine rectal suppository containing from about 850 to about 1150 mg mesalamine and one or more pharmaceutically acceptable excipients, wherein the total weight of the suppository ranges from about 2250 to about 2700 mg. Yet another embodiment of the invention is a mesalamine rectal suppository comprising mesalamine having a tap density ranging from about 600 to about 800 g/L (as measured by USP <616>) and a hard fat having an ascending melting point of 32 to 35.5° C. Methods of preparing and methods of treatment with mesalamine suppositories are also provided.