Abstract: The present invention provides an EC mirror assembly that include s an EC mirror cell and control means for controlling the reflectivity of the mirror cell, the assembly also including a pair of contact elements independently displaceable relative to the mirror cell while maintaining an electrical connection with the control means, the contact elements also being engageable with opposite edges of the mirror cell in order to provide an electrical connection between the control means and the mirror cell.

Abstract: A fire detection system for monitoring a volume containing fluid, typically air, for the presence of smoke particles is disclosed. A conduit for receiving the fluid, and any smoke particles therein, and directing the fluid to a smoke detector has a plurality of inlets formed therein. A respective temperature sensor is associated with each of the inlets which generate a signal indicative of a change in temperature in the region of the inlet. In the embodiments, the temperature sensor comprises one or more fibre Bragg gratings. The fibre Bragg gratings preferably have different grating periods. The reflected light from each fibre Bragg grating is returned back down the fibre optic cable and redirected via a 2×1 coupler to a wavelength detection system and a personal computer.

Abstract: A rail fence retractor allowing removal of a fence rail engaged with a fence post comprising a blade having a first and second end. The first end of the blade has a thickness and width allowing insertion into a fence post slot having a rail inserted therein. The rail has self-locking tabs which must be depressed for removal of the rail from the fence post slot. The fence rail retractor also has a handle which is attached to the second end of the blade. The handle allows the application of force against handle to fix the position of the handle against the fence post during removal of said rail from said fence post slot. The handle is also useful in carrying the rail fence retractor when not in use. The handles of the rail fence retractor may be configured to allow integration with the blade. The handles may be also be configured to allow a pair of rail fence retractors to fit or snap together when not in use.

Abstract: The present invention relates to a mesalamine rectal suppository designed to provide improved comfort of use. One embodiment of the invention is a mesalamine rectal suppository comprising mesalamine and one or more pharmaceutically acceptable excipients, wherein the drug load of the suppository ranges from 35% to 50%. Another embodiment of the invention is a mesalamine rectal suppository comprising from about 850 to about 1150 mg mesalamine and one or more pharmaceutically acceptable excipients, wherein the total weight of the suppository ranges from about 2250 to about 2700 mg. Yet another embodiment of the invention is a mesalamine rectal suppository comprising mesalamine having a tap density ranging from about 600 to about 800 g/L (as measured by USP <616>) and a hard fat having an ascending melting point of 32 to 35.5° C. Methods of preparing and methods of treatment with mesalamine suppositories are also provided.

Abstract: Systems are provided to increase the robustness of a low-cost GPS system by coupling it with an INS system, and by using one-satellite attitude determination in conjunction with the traditional multiple-satellite method. The system has demonstrated accuracy and robustness approaching needed standards for automobile control systems. The applications of this system are abundant, including real-time vehicle system ID, slip angle estimation, position estimation by GPS and dead reckoning, as well as sophisticated control systems.

Abstract: Azacycloalkane derivatives of structural formula I are selective inhibitors of stearoyl-coenzyme A delta-9 desaturase (SCD1) relative to other known stearoyl-coenzyme A desaturases. The compounds of the present invention are useful for the prevention and treatment of conditions related to abnormal lipid synthesis and metabolism, including cardiovascular disease, such as atherosclerosis; obesity; diabetes; neurological disease; metabolic syndrome; insulin resistance; and liver steatosis.

Abstract: Monoclonal antibodies that specifically bind to ANGPTL3 are provided. Monoclonal antibodies that neutralize at least one activity of ANGPTL3 are provided. Methods of treating a disorder of lipid metabolism using neutralizing monoclonal antibodies are provided.

Abstract: A rail fence retractor allowing removal of a fence rail engaged with a fence post comprising a blade having a first and second end. The first end of the blade has a thickness and width allowing insertion into a fence post slot having a rail inserted therein. The rail has self-locking tabs which must be depressed for removal of the rail from the fence post slot. The fence rail retractor also has a handle which is attached to the second end of the blade. The handle allows the application of force against handle to fix the position of the handle against the fence post during removal of said rail from said fence post slot. The handle is also useful in carrying the rail fence retractor when not in use. The handles of the rail fence retractor may be configured to allow integration with the blade. The handles may be also be configured to allow a pair of rail fence retractors to fit or snap together when not in use.

Abstract: A bumper system includes a bumper beam having a face and ends, and an energy absorber mounted on the face. The energy absorber has a one-piece injection-molded non-foam piece with box sections and interconnecting straps, and a one-piece or multi-piece foam component securely insert-molded onto the injection-molded non-foam piece. Different foam molds can be used to form differently shaped front surfaces on the foam component. By this arrangement, different energy absorbing systems are provided for vehicles, such as to satisfy the need for different styling and shapes, while still using the same non-foam piece. By this arrangement, the energy absorber is a single unit that can be handled and attached to the bumper beam. At the same time, capital investment in molding dies and tooling is reduced.

Abstract: An alerting element for use with occupant seating to alert a seat occupant with a haptic and/or audible sensation. The alerting element being suitable for use with any type of seat, including vehicle seats. The alerting element optionally including a striking element for striking a structural component of the seat, and thereby, generating an alerting sensation.

Abstract: A haptic seat and system for use in imparting sensations to an occupant thereof. The haptic seat may be used to alert passengers of various operating conditions with some sort of tactile sensation, such as a vibration, pulse, shake, or other inducement that involves the occupant's sense of touch.

Abstract: Methods for site-specific modification of protein are provided. These methods modify proteins which have been labeled at a particular site by the reaction of a transglutaminase with a glutamine peptide sequence which has been engineered into the protein. The site-specific modification methods of the invention are useful for producing reagents useful in high throughput screening methods and in producing protein delivery vehicles for specifically targeting cellular and non-cellular targets. Also described are improved biotinylation reagents.

Abstract: Apparatus and method for degassing liquids particularly cationic monomers. Fluid comprising liquid to be degassed together with sweep gas is admitted tangentially into a column (10) and forced down the column by a tubular baffle (16) which defines, with the inner wall of the column, an annulus (18) that is closed at its top (20). After passing to the bottom of the annulus the fluid forms an even film over the inner surface of the column and gas disengaging from the liquid can rise up the column while liquid accumulates at the bottom of the column. To assist the disengagement of the gas from the liquid the column is preferably of increasing cross section towards the bottom so that the thickness of the film is also reduced.

Abstract: Apparatus and method for supplying AC power (e.g. from an inverter) to a discharge light via a ballast circuit formed by a resonant circuit, and controlling the frequency of the AC power signal so as to operate below the natural resonance frequency of the ballast circuit in use after the discharge light has “struck.

Abstract: A heat resistant positive-working photosensitive PBO precursor composition comprising: (a) at least one polybenzoxazole precursor polymer; (a) at least one plasticizer compound; (b) at least one solvent; wherein the amount of the plasticizer present in the composition is an amount effective to reduce the sidewall angle of imaged and cured features in the coated film on the substrate to prevent stress failures in subsequent metallization of the substrate due to steep angles of the imaged features, and with the proviso that if the polybenzoxazole precursor polymer solely consists of polybenzoxazole precursor polymers that do not contain a photoactive moiety on the polymer, then (c) at least one photoactive compound is also present in the composition.

Abstract: A bumper system includes a bumper beam having a face and ends, and an energy absorber mounted on the face. The energy absorber has a one-piece injection-molded non-foam piece with box sections and interconnecting straps, and a one-piece or multi-piece foam component securely insert-molded onto the injection-molded non-foam piece. Different foam molds can be used to form differently shaped front surfaces on the foam component. By this arrangement, different energy absorbing systems are provided for vehicles, such as to satisfy the need for different styling and shapes, while still using the same non-foam piece. By this arrangement, the energy absorber is a single unit that can be handled and attached to the bumper beam. At the same time, capital investment in molding dies and tooling is reduced.

Abstract: A method of screening compounds to identify those compounds which inhibit the Asp 1 mediated cleavage of a polypeptide or protein substrate, the method comprising: providing a reaction system comprising Asp 1 and substrate; and measuring the extent of cleavage of the substrate in the presence of test compound as compared with the extent of cleavage in the absence of test compound, and compounds identified thereby as well as compounds which are inhibitors of Asp 1 modulated APP cleavage and their use in therapy including the treatment or prophylaxis of ? amyloid protein-related disease including AD.

Abstract: An optical sheet that accepts light transmitted at or within a specific entrance cone angle that then redirects and transmits the light within an exit cone that is substantially normal to the sheet's plane. The intensity of the light within the exit cone is substantially uniform for any light source entering the sheet within the sheet's acceptance angle. The optical sheet is made of transparent material with microlens arrays formed on its opposite front and back surfaces. The thickness of the optical sheet is sufficient so that the microlens on the opposite surfaces are separated a distance equal to the microlens focal length, with each microlens on the front and back surfaces having substantially similar size and shape, with centers transversely aligned. When used with one or more light sources located on one surface, the transmitted light through the optical sheet is uniform in intensity across a second surface.

Abstract: A bumper system includes a bumper beam having a face and ends, and an energy absorber mounted on the face. The energy absorber has a one-piece injection-molded non-foam piece with box sections and interconnecting straps, and a one-piece or multi-piece foam component securely insert-molded onto the injection-molded non-foam piece. Different foam molds can be used to form differently shaped front surfaces on the foam component. By this arrangement, different energy absorbing systems are provided for vehicles, such as to satisfy the need for different styling and shapes, while still using the same non-foam piece. By this arrangement, the energy absorber is a single unit that can be handled and attached to the bumper beam. At the same time, capital investment in molding dies and tooling is reduced.

Abstract: A method of screening compounds to identify those compounds which inhibit the Asp 2 mediated cleavage of a polypeptide or protein substrate, the method comprising: providing a reaction system comprising Asp 2 and substrate; and measuring the extent of cleavage of the substrate in the presence of test compound as compared with the extent of cleavage in the absence of test compound, and compounds identified thereby as well as compounds which are inhibitors of Asp 2 modulated APP cleavage and their use in therapy including the treatment or prophylaxis of ? amyloid protein-related disease including AD.