Abstract: Early detection of lysosomal storage diseases (LSDs) including Mucopolysaccharidosis Type I (MPS I) and Pompe Disease can greatly improve patient outcome as each disease can be fatal once symptoms emerge. Screening for MPS I and Pompe Disease using biological samples including dried blood spots (DBS), buccal swab, peripheral blood mononuclear cells (PBMCs), or white blood cells (WBCs) is described. The disclosed methods and assays provide a robust way to screen newborns for LSDs. The disclosed methods and assays can also allow rapid prediction of whether a patient with LSD will develop an immune response to enzyme replacement therapy (ERT), thus improving treatment for patients with LSDs. The disclosed methods and assays can also further reduce the number of false positives caused by pseudo deficiency cases of LSD, such as MPS I and Pompe Disease.

Abstract: The present disclosure provides a semiconductor structure, including a substrate, a gate structure over the substrate, including a work function layer over the substrate, a dielectric layer at least partially surrounding the gate structure, and a capping layer over the gate structure, wherein a bottom of the capping layer includes at least one protrusion protruding toward the substrate.

Abstract: Improved control of via anchor profiles in metals at a contact layer can be achieved by slowing down an anchor etching process and by introducing a passivation operation. By first passivating a metallic surface, etchants can be prevented from dispersing along grain boundaries, thereby distorting the shape of the via anchor. An iterative scheme that involves multiple cycles of alternating passivation and etching operations can control the formation of optimal via anchor profiles. When a desirable anchor shape is achieved, the anchor maintains structural integrity of the vias, thereby improving reliability of the interconnect structure.

Abstract: A virtual metrology method using a convolutional neural network (CNN) is provided. In this method, a dynamic time warping (DTW) algorithm is used to delete unsimilar sets of process data, and adjust the sets of process data to be of the same length, thereby enabling the CNN to be used for virtual metrology. A virtual metrology model of the embodiments of the present invention includes several CNN models and a conjecture model, in which plural inputs of the CNN model are sets of time sequence data of respective parameters, and plural outputs of the CNN models are inputs to the conjecture model.

Abstract: A voltage conversion circuit and a non-isolated power supply system are provided. The voltage conversion circuit includes: a switching power supply chip which includes a power MOS transistor and a driving circuit, where the driving circuit is adapted to drive the power MOS transistor; and a driving circuit power supply unit which includes a boost unit, wherein when an output voltage of the boost unit is less than a working voltage of the driving circuit, an internal power supply of the switching power supply chip provides the working voltage for the driving circuit; and when the output voltage of the boost unit reaches the working voltage of the driving circuit, the output voltage of the boost unit provides the working voltage for the driving circuit.

Abstract: The present disclosure relates to ophthalmic devices such as ophthalmic lenses. An ophthalmic device may comprise an ophthalmic lens for at least one of slowing, retarding or preventing myopia progression. The ophthalmic lens may comprise a center zone with a negative power for myopic vision correction; and at least one treatment zone surrounding the center zone, the at least one treatment zone having a power profile comprising an ADD power, the at least one treatment zone having a surface shape comprising a portion of a generally toroidal shape, wherein the at least one treatment zone is arranged as to form a continuous surface with the center zone.

Abstract: Certain aspects provide a method of wireless communications by a user equipment, such as a low-power user equipment. The method includes receiving, from one grouped user equipment of a first group of user equipments, an indication that the user equipment is a current group leader of the first group of user equipments; receiving, from one or more grouped user equipments of the first group of user equipments via a first wireless transceiver system, one or more data requests; and sending, to a network entity via a second wireless transceiver system, one or more data payloads associated with the one or more data requests.

Abstract: A write control method based on write behavior prediction, a memory storage device, and a memory control circuit unit are provided. The method includes: monitoring a first data write behavior of a host system during a first time range; according to the first data write behavior, predicting a second data write behavior of the host system during a second time range; obtaining a first measurement parameter and a first target parameter corresponding to the first data write behavior; according to the first measurement parameter, the first target parameter, and the second data write behavior, determining a write control parameter; and sending a write command sequence according to the write control parameter to instruct a rewritable non-volatile memory module to perform a data write based on multiple write modes during the second time range.

Abstract: The present disclosure discloses a phase-change flame-retardant fiber material for thermal management of a lithium ion battery in a closed space and a preparation method. The phase-change flame-retardant fiber material is prepared in a coaxial electrostatic spinning manner and includes a composite phase-change fiber material PASA-TPU at a core part and a flame-retardant fiber material TB-PAN wrapping a surface of the core part. The composite phase-change fiber material is well wrapped with the flame-retardant fiber material, and the lithium ion battery wrapping the whole phase-change flame-retardant fiber material in the closed space is subjected to charge-discharge cycle; the result shows that the surface temperature of the battery can be effectively reduced by about 20° C.

Abstract: The present disclosure relates to ophthalmic devices such as ophthalmic lenses. An ophthalmic device may comprise an ophthalmic lens for at least one of slowing, retarding or preventing myopia progression. The ophthalmic lens may comprise a center zone with a negative power for myopic vision correction; and at least one treatment zone surrounding the center zone, the at least one treatment zone having a power profile comprising an ADD power, the at least one treatment zone having a surface shape comprising a portion of a generally toroidal shape, wherein the at least one treatment zone is arranged as to form a continuous surface with the center zone.

Abstract: The present disclosure relates to ophthalmic devices such as ophthalmic lenses. An ophthalmic device may comprise an ophthalmic lens for at least one of slowing, retarding or preventing myopia progression. The ophthalmic lens may comprise a center zone with a negative power for myopic vision correction; and at least one treatment zone surrounding the center zone, the at least one treatment zone having a power profile comprising an ADD power, the at least one treatment zone having a surface shape comprising a portion of a generally toroidal shape, wherein the at least one treatment zone is arranged as to form a continuous surface with the center zone.

Abstract: The present disclosure relates to ophthalmic devices such as ophthalmic lenses. An ophthalmic device may comprise an ophthalmic lens for at least one of slowing, retarding or preventing myopia progression. The ophthalmic lens may comprise a center zone with a negative power for myopic vision correction; and at least one treatment zone surrounding the center zone, the at least one treatment zone having a power profile comprising an ADD power, the at least one treatment zone having a surface shape comprising a portion of a generally toroidal shape, wherein the at least one treatment zone is arranged as to form a continuous surface with the center zone.

Abstract: A ranging system includes: a source generating a wideband incident wave that is transmitted toward a target and that is reflected by the target to form a reflected wave; a feedback detector to detect the reflected wave to generate a detected signal; an operator configured to perform low-pass filtering on the detected signal at an adjustable filtering bandwidth to generate a filtered signal, and calculate cross-correlation of a feedback signal that originates from the filtered signal and a reference signal that corresponds to the incident wave to generate a cross-correlation result; and a controller calculating a distance to the target based on an operation output that originates from the cross-correlation result.

Abstract: The current disclosure provides antibodies that bind to peptides associated with the primary immunodeficiency disorders (PIDD) Wiskott-Aldrich Syndrome (WAS) and X-linked agammaglobulinemia (XLA). The antibodies can be used in peptide immunoaffinity enrichment coupled to selected reaction monitoring mass spectrometry (immuno-SRM) assays for clinical diagnosis and newborn screening of WAS and XLA, among other uses.

Abstract: The present application discloses a high-precision mapping method and device, which relates to the field of autonomous driving. A specific implementation includes: acquiring global initial poses of multiple point clouds, where the point clouds are point clouds of a location for which a map is to be built and are collected by a lidar using a multi-circle collection mode; dividing the multiple point clouds into multiple spatial submap graphs according to a spatial distribution relationship of the multiple point clouds; optimizing, for each spatial submap graph, global initial poses of point clouds belonging to the spatial submap graph to acquire global poses of the point clouds in each spatial submap graph; and stitching the multiple spatial submap graphs together according to global poses of the point clouds in the multiple spatial submap graphs to acquire a base graph of the map to be built.

Abstract: The present disclosure relates to ophthalmic devices such as ophthalmic lenses. An ophthalmic device may comprise an ophthalmic lens for at least one of slowing, retarding or preventing myopia progression. The ophthalmic lens may comprise a center zone with a negative power for myopic vision correction; and at least one treatment zone surrounding the center zone, the at least one treatment zone having a power profile comprising an ADD power, the at least one treatment zone having a surface shape comprising a portion of a generally toroidal shape, wherein the at least one treatment zone is arranged as to form a continuous surface with the center zone.

Abstract: A tape-free packing box, which can be in an open state or a closed state, the tape-free packing box comprises a box body; two tongue plates, respectively arranged on the opposite sides of the open ends of the box body; a connecting element, one end of the connecting element is integrally formed or slidably installed on one of the two tongue plates, when the tape-free packing box is in a closed state, the other end of the connecting element is connected to the other of the two tongue plates.

Abstract: The invention provides a dynamic positioning and thrust distribution method based on an artificial neural network, is a quadratic programming problem in the optimization problem, and can compute the thrust coefficient of a rear thruster in a constraint condition of a thrust distribution problem by taking into account of the corner of a front thruster and through the artificial neural network. Then the optimization problem enabling the power of the thruster to be minimized is solved according to a sequential quadratic programming algorithm, so that a thrust distribution scheme on the azimuth thrusters is obtained. Meanwhile the invention further provides a dynamic positioning and thrust distribution device based on an artificial neural network.

Abstract: A ranging system includes: a source generating a wideband incident wave that is transmitted toward a target and that is reflected by the target to form a reflected wave; a feedback detector to detect the reflected wave to generate a detected signal; an operator configured to perform low-pass filtering on the detected signal at an adjustable filtering bandwidth to generate a filtered signal, and calculate cross-correlation of a feedback signal that originates from the filtered signal and a reference signal that corresponds to the incident wave to generate a cross-correlation result; and a controller calculating a distance to the target based on an operation output that originates from the cross-correlation result.

Abstract: A multi-channel transmitter includes a light source, a pulse generator and a mode splitter. The light source generates a continuous source light wave with multiple modes that are different from each other in terms of wavelength and waveform. The pulse generator generates, based on the continuous source light wave, an intermediate light pulse with multiple modes that are different from each other in terms of wavelength and waveform. The mode splitter has a plurality of output terminals, and generates, based on the intermediate light pulse and respectively at the output terminals thereof, a plurality of output light pulses that respectively correspond to the modes of the intermediate light pulse.