Patents by Inventor Francisco Romero

Francisco Romero has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Macrolides with antitumor activity
    Patent number: 6395711
    Abstract: The compound referred to herein as IB-962 12, having structure (I) can be obtained by cultivating the strain of Micromonospora sp. ES25-008, available under the accession number CECT-3333, and can be hydrolyzed to give IB-96212B having structure (II). The sugar substituent which is L-rhodinose, can its elf be derivatized or the sugar can be replaced, in either case, giving further derivatives of IB-96212 having a group other than L-rhodinose at the position of the sugar.
    Type: Grant
    Filed: April 17, 2000
    Date of Patent: May 28, 2002
    Assignee: Instituto Biomar S.A.
    Inventors: Rosa Isabel Fernandez-Chimeno, Francisco Romero, Jose Luis Fernandez-Puentes, Julia Perez-Baz, Librada Maria Canedo, Fernando Espliego
  • Immunosuppressive sesbanimide compositions and methods of treatment using same
    Publication number: 20010039041
    Abstract: The active component of the pharmaceutical composition of the present invention is a compound which has been isolated from the controlled aerobic fermentation of a marine microorganism, Agrobacterium sp. PH-103.
    Type: Application
    Filed: January 8, 2001
    Publication date: November 8, 2001
    Applicant: Pharma Mar, S.a.
    Inventors: Glynn T. Faircloth, Francisco Romero Millan, Librada Maria Canedo Fernandez, Cristina Accbal Sarabia
  • Method of treating tumors with thiodepsipeptide isolated from a marine actinomycete
    Patent number: 6214793
    Abstract: The present invention is directed to a novel depsipeptide has been isolated from a new marine strain L-13-ACM2-092 belonging to the family Micromonosporaceae. Its production by aerobic fermentation under controlled conditions of the strain, and the isolation and purification of PM-93135 are described herein. The compound and the fermentation broth demonstrate significant activity against several cancer cell lines. The compound also shows activity against several gram positive bacteria.
    Type: Grant
    Filed: September 24, 1997
    Date of Patent: April 10, 2001
    Assignee: Pharma Mar, s.a.
    Inventors: Julia Perez Baz, Francisco Romero Millan, Teresa Garcia De Quesada, Dolores Garcia Gravalos
  • Thiodepsipeptide isolated from a marine actinomycete
    Patent number: 5849540
    Abstract: The present invention is directed to a novel depsipeptide has been isolated from a new marine strain L-13-ACM2-092 belonging to the family Micromonosporaceae. Its production by aerobic fermentation under controlled conditions of the strain, and the isolation and purification of PM-93135 are described herein. The compound and the fermentation broth demonstrate significant activity against several cancer cell lines. The compound also shows activity against several gram positive bacteria.
    Type: Grant
    Filed: September 24, 1997
    Date of Patent: December 15, 1998
    Assignee: Pharma Mar, S.A.
    Inventors: Julia Perez Baz, Francisco Romero Millan, Teresa Garcia De Quesada, Dolores Garcia Gravalos
  • Thiodepsipeptide isolated from a marine actinomycete
    Patent number: 5681813
    Abstract: The present invention is directed to a novel depsipeptide has been isolated from a new marine strain L-13-ACM2-092 belonging to the family Micromonosporaceae. Its production by aerobic fermentation under controlled conditions of the strain, and the isolation and purification of PM-93135 are described herein. The compound and the fermentation broth demonstrate significant activity against several cancer cell lines. The compound also shows activity against several gram positive bacteria.
    Type: Grant
    Filed: April 6, 1994
    Date of Patent: October 28, 1997
    Assignee: Pharma Mar, s.a.
    Inventors: Julia Perez Baz, Francisco Romero Millan, Teresa Garcia De Quesada, Dolores Garcia Gravalos