Patents by Inventor Gabor Szabo
Gabor Szabo has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 6413967Abstract: The present invention provides methods for screening for voltage gated (VG)-selective inhibitors, novel VG-selective inhibitors, compositions containing the same, methods for inhibiting calcium entry into electrically non-excitable cells with said VG-selective inhibitors, methods for preventing proliferation of electrically non-excitable cells with said VG-selective inhibitors as well as methods of treating autoimmune diseases, preventing graft rejections, preventing apoptosis and treating cancer with the same.Type: GrantFiled: March 30, 1995Date of Patent: July 2, 2002Assignee: The University of Virginia Patents FoundationInventors: Lloyd S. Gray, Doris M. Haverstick, John J. Densmore, Gabor Szabo
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Patent number: 5458999Abstract: A phase shifting method uses a special interferometer in which the illuminating beam is divided into two or more components and the mask is irradiated from both sides. The pattern to be transferred onto the wafer (the mask) is generated on an optically transmissive substrate by appropriately combining reflective, transparent and absorptive areas. The optical paths of the beams illuminating the back side and the front side of the mask (that will be called transmitted and reflected beams respectively) are chosen so that the phase of the two beams is different by approximately an odd multiple of .pi. radians at the surface of the mask. The combined beams are projected onto the target wafer by suitable optics. The phase difference between the illuminating beams reduces the edge blurring that results from diffraction effects.Type: GrantFiled: June 24, 1993Date of Patent: October 17, 1995Inventors: Gabor Szabo, Frank K. Tittel, Joseph R. Cavallaro, Motoi Kido
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Patent number: 5233182Abstract: For the acquisition of data for determining the duration and chirp (frequency modulation) of a single ultrashort laser radiation pulse said pulse is split into two partial pulses which are each conducted through one of two TREACY compressors having different group delay dispersions and then recorded in succession on the same time basis with a streak camera.Type: GrantFiled: July 12, 1991Date of Patent: August 3, 1993Assignee: Max-Planck-Gesellschaft zur Foerderung der Wissenschaften e.V.Inventors: Gabor Szabo, Alexander Mueller, Zsolt Bor
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Patent number: 4902884Abstract: In a circuit arrangement for carrying out light intensity measurements, comprising an input terminal (5), an output terminal (6), a first and a second photodiodes (D.sub.1, D.sub.2) for receiving light emitted by an optical light source (S) and a first and a second operational amplifiers (1, 2) for receiving output current signals of the first and second photodiodes (D.sub.1, D.sub.2) generated under influence of the emitted light, the novelty lies in further comprising a four branch bridge circuit including in two adjacent branches the first and second photodiodes (D.sub.1, D.sub.2) coupled to a common point by their respective poles of the same sign and oppositely to them in the further two adjacent branches two bridge resistors (R.sub.1, R.sub.Type: GrantFiled: April 5, 1988Date of Patent: February 20, 1990Assignee: Dunacoop Kereskedelmi es Idegenforgalmi Vallalkozasokat Szervezo Szolgaltato Lebonyolitacu/o/ GTInventors: Gabor Szabo, Marta S. Burgert
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Patent number: 4764613Abstract: The invention relates to the novel 2,6-bis(chloromethyloxy-carbonyloxymethyl)pyridine of the formula (I) ##STR1## as well as a process for the preparation of this compound, which is a useful intermediate in the preparation of the anti-atherosclerotic 2,6-bis(hydroxymethyl)pyridine bis(N-methylcarbamate) (pyridinolcarbamate) and other drugs.According to the invention, the compound of the formula (I) is prepared by reacting 2,6-bis(hydroxymethyl)pyridine of the formula (II) ##STR2## with chloromethyl chloroformate of the formula (III) ##STR3## in a polar-aprotic, water-immiscible organic solvent, in the presence of a basic substance between about -30.degree. C. and +10.degree. C.Type: GrantFiled: August 24, 1987Date of Patent: August 16, 1988Assignee: Richter Gedeon Vegyeszeti Gyar Rt.Inventors: Jozsef Toth, Mate Kovatsits, Laszlo Csutoras, Gabor Szabo, Sandor Gorog, Ferenc Trischler, Sandor Holly, Erzsebet Francsics, Bela Losonczi, Gabor Havasi
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Patent number: 4709081Abstract: The invention relates to a process for the preparation of compounds of formula (I) ##STR1## wherein R.sup.1 stands for hydrogen or the group COR.sup.2, whereinR.sup.2 stands for a straight or branched chained alkyl having 1 to 8 carbon atoms optionally substituted with phenyl, naphthyl, tetrahydronaphthyl or m-phenoxy-benzyl, cycloalkyl having 3 to 6 carbon atoms optionally substituted with one or more straight or branched chained alkyl or alkenyl having 1 to 6 carbon atoms, phenyl or naphthyl.The compounds of formula (I) are prepared according to the invention by(a) reacting esters of formula (II) ##STR2## wherein X stands for chlorine or bromine andR.sup.2 has the same meanings as defined above with a phenol alkali metal salt and(b) if desired converting the diphenyl ethers so obtained to a specific compound of formula (I), m-phenoxybenzyl alcohol by the hydrolysis of the ester group.Type: GrantFiled: September 26, 1985Date of Patent: November 24, 1987Assignee: Chinoin Gyogyszer es Vegyeszeti Termekek Gyara R.T.Inventors: Gergely Heja, Dezso Korbonits, Endre Palosi, Pal Kiss, Csaba Gonczi, Ida Szvoboda nee Kanzel, Ede Marvanyos, Judit Kun, Maria Szomor nee Wundele, Gabor Szabo, Tamas Kallay, Laszlo Ledniczky
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Patent number: 4564706Abstract: The invention relates to a new process for the preparation of propargyl ammonium chlorides of the Formula I ##STR1## by alkaline decomposition of the d-tartarate of the 1-isomer of an amine of the Formula II ##STR2## and subsequent reaction of the amine of the Formula II with a halide of the Formula IIIX--CH.sub.2 --C.tbd.Type: GrantFiled: July 14, 1983Date of Patent: January 14, 1986Assignee: Chinoin Gyogyszer es Vegyeszeti Termekek Gyara R.T.Inventors: Zoltan Ecsery, Eva Somfai, Judit Hermann nee Voros, Lajos Nagy, Gabor Szabo, Otto Orban, Laslzo Arvai
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Patent number: 4508658Abstract: Compounds of the formula ##STR1## wherein R.sup.1 is hydrogen or C.sub.1 to C.sub.6 alkyl;R.sup.2 is hydrogen, phenyl, thienyl, furyl, pyridyl, C.sub.1 to C.sub.6 alkyl, furylalkyl where the alkyl is C.sub.1 to C.sub.6, or phenylalkyl where the alkyl is C.sub.1 to C.sub.6 ; orR.sup.1 and R.sup.2 together form C.sub.1 to C.sub.4 alkylene, furyl-C.sub.1 to C.sub.4 alkylene or phenyl-C.sub.1 to C.sub.4 alkylene; and X is halo; ora pharmaceutically acceptable salt thereof, are disclosed as well as a process for the preparation thereof. The new compounds are intermediates useful in the production of penicillins and cephalosporins with antibiotic activity.Type: GrantFiled: January 18, 1980Date of Patent: April 2, 1985Assignee: Chinoin Gyogyszer es Vegyeszeti Termekek Gyara Rt.Inventors: Magda Huhn, Gabor Szabo, Peter Dvortsak, Marianna Karpati, Eva Somfai
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Patent number: 4393008Abstract: 2-(3-phenoxy-phenyl)-propionic acid or its pharmaceutical treatments, are prepared by hydrolyzing and partially decarboxylating ##STR1## wherein R=C.sub.1 -C.sub.6 alkyl or amino, the latter compounds being themselves new and, where R=C.sub.1 -C.sub.6 alkyl, have antiinflammatory pharmaceutical properties.Type: GrantFiled: August 12, 1981Date of Patent: July 12, 1983Assignee: Chinoin Gyogyszer Es Vegyeszeti Termekek Gyara RtInventors: Endre Palosi, Gergely Heja, Dezso Korbonits, Pal Kiss, Csaba Gunczi, Judit Cser, Ida Szvoboda, Gabor Szabo, Tamas Kallay, Laszlo Ledniczky, Maria Szomor
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Patent number: 4347377Abstract: The invention concerns a new process for the preparation of polyhalogenphenyl carbamates of the formula (I)R.sup.2 -OCONHR.sup.1 (I)whereinR.sup.1 is alkyl, aralkyl or aryl, where the aromatic rings may optionally be substituted; andR.sup.2 is phenyl substituted with three, four or five halogens, through intermediates of the formula (IV)(R.sup.2 --O).sub.2 C.dbd.NR.sup.1 (IV)wherein R.sup.1 and R.sup.2 are as defined above.The compounds of the formula (I) are valuable acylating agents. The intermediates of the formula (IV) are new compounds, which are also encompassed by the invention.Type: GrantFiled: September 19, 1980Date of Patent: August 31, 1982Assignee: Chinoin Gyogyszer es Vegyeszeti Termekek Gyara R.T.Inventors: Istvan Bitter, Rudolf Soos, Geza Toth, Laszlo Toke, Gabor Szabo
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Patent number: 4334103Abstract: The invention relates to a process for nucleophilic substitution reactions. According to the invention the reaction is carried out in a hetergeneous system, consisting of a solid and a dissolved reactant, one or several organic solvents, one or several linear polyether derivatives, and/or amino compounds and water. The volume of the water is preferably at the most 100% of the volume of the organic solvent and more preferably 5%.Type: GrantFiled: June 27, 1980Date of Patent: June 8, 1982Assignee: Chinoin Gyogyszer es Vegyeszeti Termekek Gyara Rt.Inventors: Laszlo Toke, Gabor T. Szabo, Gabor Szabo, Lajos Nagy, Istvan Rusznak
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Patent number: 4324903Abstract: A process for the preparation of new malonic esters of the formula: ##STR1## wherein R is a substituted or unsubstituted C.sub.1 to C.sub.6 alkyl, a substituted or unsubstituted aromatic ring, a heterocyclic ring, a cycloalkyl group, or a fused ring system; R.sup.1 is hydrogen, lower alkyl, aralkyl, aralkyl substituted by halogen or alkyl or a substituted aromatic, cycloaliphatic or heterocyclic ring; and X is halogen.Type: GrantFiled: June 21, 1976Date of Patent: April 13, 1982Assignee: Chinoin Gyogyszer es Vegyeszeti Termekek Gyara RT.Inventors: Magda Huhn, Eva Somfai, Gabor Szabo, Gabor Resovszki, Livia Gneth nee Zalantai
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Patent number: 4304930Abstract: 2-(3-Phenoxy-phenyl)-propionic acid or its pharmaceutical treatments, are prepared by hydrolyzing and partially decarboxylating ##STR1## wherein R=C.sub.1 -C.sub.6 alkyl or amino, the latter compounds being themselves new and, where R=C.sub.1 -C.sub.6 alkyl, have antiinflammatory pharmaceutical properties.Type: GrantFiled: December 21, 1979Date of Patent: December 8, 1981Assignee: Chinoin Gyogyszer- es Vegyeszeti Termekek Gyara RtInventors: Endre Palosi, Gergely Heja, Dezso Korbonits, Pal Kiss, Csaba Gonczi, Judit Cser nee Kun, Ida Szvoboda nee Kanzel, Gabor Szabo, Tamas Kallay, Laszlo Ledniczky, Maria Szomor nee Wundele
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Patent number: 4304717Abstract: This invention relates to a process for the preparation of acid amides having the formula (I) or their salts ##STR1## wherein R.sup.1 is hydrogen or an easily removable ester-forming or salt-forming group, preferably a trialkylamine, trialkylsilyl, trichloroethyl, acetoxymethyl, phenacyl, substituted phenacyl, substituted phenyl or benzyl group,R.sup.2 is hydrogen, alkyl group, alkenyl group, alkyl group having an aryl or heterocyclic (preferably furyl or thienyl) - substituent, an aryl group having an alkyl substituent (preferably xylyl), or an aryl, aralkyl or heterocyclic group (preferably a phenyl, thienyl, or furyl group) which can have one or more substituents,R.sup.3 is hydrogen, or substituted or unsubstituted aryl, alkyl, cycloalkyl or aralkyl group, andX is a group of one of the formulae ##STR2## according to the invention an amine of the formula (II), ##STR3## wherein R.sup.Type: GrantFiled: May 7, 1979Date of Patent: December 8, 1981Assignee: Chinoin Gyogyszer es Vegyeszeti Termekek Gyara RtInventors: Magda Huhn, Gabor Szabo, Gabor Resofszki, Eva Somfai
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Patent number: 4304938Abstract: 3-Phenoxybenzene derivatives are prepared by a method which comprises the steps of(a) chlorinating benzaldehyde with chlorine gas in the presence of a hydrocarbon and a Lewis acid catalyst to obtain 3-chlorobenzaldehyde; (b) reacting the 3-chlorobenzaldehyde with ethylene glycol to obtain 2-(3-chlorophenyl)-1,3-dioxolane; (c) etherifying said dioxolane with an alkali phenolate to yield the intermediate 2-(3-phenoxyphenyl)-1,3-dioxolane and converting this intermediate to the corresponding aldehyde, cyanohydrin, sulfonic acid salt or oxime derivative.Type: GrantFiled: December 21, 1979Date of Patent: December 8, 1981Assignee: Chinoin Gyogyszer es Vegyeszeti Termekek Gyara RTInventors: Endre Palosi, Gergely Heja, Dezso Korbonits, Pal Kiss, Csaba Gonczi, Judit Cser nee Kun, Ida Szvoboda nee Kauzel, Gabor Kovacs, Gabor Szabo, Tamas Kallay, Laszlo Ledniczky
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Patent number: 4289894Abstract: Compounds of the formula: ##STR1## are disclosed wherein R is C.sub.1 to C.sub.6 alkyl, C.sub.1 to C.sub.6 haloalkyl, C.sub.3 to C.sub.8 cycloalkyl, phenyl, halophenyl, naphthyl, benzyl, indanyl, phenacyl, p-nitrophenacyl, xylyl or acetoxymethyl; R.sup.1 is phenyl, benzyl or phenyl or benzyl substituted by halo, nitro, dialkylamino, alkoxy or trifluoromethyl, lower alkyl or allyl; and X is halo. The compounds are intermediates in the manufacture of penicillins.Type: GrantFiled: March 6, 1979Date of Patent: September 15, 1981Assignee: Chinoin Gyogyszer es Vegylszeti Termekek Gyara R.T.Inventors: Magda Huhn, Eva Somfai, Gabor Szabo, Gabor Resovszki, Zoltan Gneth
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Patent number: 4229366Abstract: The invention relates to a process for nucleophilic substitution reactions. According to the invention the reaction is carried out in a heterogeneous system, consisting of a solid and a dissolved reactant, one or several organic solvents, one or several linear polyether derivatives, and/or amino compounds and water.The volume of the water is preferably at the most 100% of the volume of the organic solvent and more preferably 5%.According to the invention the anhydrous reaction medium which is difficult to ensure, is not necessary and the use of the expensive and in industrial scales unavailable crown ethers is eliminated.Type: GrantFiled: October 20, 1978Date of Patent: October 21, 1980Assignee: Chinoin Gyogyszer es Vegyeszeti Termeker Gyara Rt.Inventors: Laszlo Toke, Gabor T. Szabo, Gabor Szabo, Lajos Nagy, Istvan Rusznak
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Patent number: 4182892Abstract: A compound of the formula I: ##STR1## wherein: R is substituted or unsubstituted C.sub.1-6 alkyl, a substituted or unsubstituted aromatic ring, a heterocyclic ring, a cycloalkyl group or a fused ring system,R.sup.1 is hydrogen, lower alkyl, cycloaliphatic or heterocyclic ring, andX is a halogen atom.Type: GrantFiled: February 24, 1978Date of Patent: January 8, 1980Assignee: Chinoin Gyogyszer es Vegyeszeti Termekek Gyara RtInventors: Magda Huhn, Eva Somfai, Gabor Szabo, Gabor Resofszki, Livia Gneth nee Zalantai
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Patent number: 4171303Abstract: This invention relates to a process for the preparation of acid amides having the formula (I) or their salts ##STR1## wherein R.sup.1 is hydrogen or an easily removable ester-forming or salt-forming group, preferably a trialkylamino, trialkylsilyl, trichloroethyl, acetoxymethyl, phenacyl, substituted phenacyl, substituted phenyl or benzyl group,R.sup.2 is hydrogen, alkyl group, alkenyl group, alkyl group having an aryl or heterocyclic (preferably furyl or thienyl)-substituent, an aryl group having an alkyl substituent (preferably xylyl), or an aryl, aralkyl or heterocyclic group, (preferably a phenyl, thienyl, or furyl group) which can have one or more substituents,R.sup.3 is hydrogen, or substituted or unsubstituted aryl, alkyl, cycloalkyl or aralkyl group, andX is a group of one of the formulae ##STR2## according to the invention an amine of the formula (II), ##STR3## wherein R.sup.Type: GrantFiled: July 5, 1977Date of Patent: October 16, 1979Assignee: Chinoin Gyogyszer es Vegyeszeti Termekek Gyara Rt.Inventors: Magda Huhn, Gabor Szabo, Gabor Resofszki, Eva Somfai
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Patent number: 4150034Abstract: A process for the preparation of a substituted-phenyl-N-alkyl-carbamate of the formula ##STR1## wherein R.sup.1 and R.sup.2 form part of a carbamoyloxy group and are identical or different and each is hydrogen or lower alkyl,R is halogen, formyl group or a group of the formula ##STR2## in ortho or meta-position to the carbamoyloxy group, wherein X.sup.1 and X.sup.2 are identical or different and each is oxygen or sulphur andR.sup.3 and R.sup.4 are identical or different and each is alkyl, alkenyl or alkynyl or together form a 5-membered saturated or unsaturated heterocycle in which X.sup.1 and X.sup.2 are heteroatoms, said process comprising reacting a compound of the formula ##STR3## in the presence of a base with a compound of the formula ##STR4## wherein A is phenyl substituted with two or more electron withdragroups.Type: GrantFiled: August 10, 1977Date of Patent: April 17, 1979Assignee: Chinoin Gyogyszer es Vegyeszeti Termekek Gyara Rt.Inventors: Tamas U. Kallay, Gabor Szabo, Geza Toth, Kalman Harsanyi