Patents by Inventor Garry P. Nolan

Garry P. Nolan has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • METHODS OF DETERMINING THE HEALTH STATUS OF AN INDIVIDUAL
    Publication number: 20140134648
    Abstract: Methods of determining health status based on analysis of single cells in a sample or set of samples from an individual are described.
    Type: Application
    Filed: October 3, 2013
    Publication date: May 15, 2014
    Applicant: NODALITY, INC.
    Inventors: Wendy J. Fantl, Helen L. Francis-Lang, Aileen C. Cohen, Garry P. Nolan
  • BENCHMARKS FOR NORMAL CELL IDENTIFICATION
    Publication number: 20140127716
    Abstract: Provided herein are methods, compositions, and kits for determining cell signaling profiles in normal cells and comparing the cell signaling profiles of normal cells to cell signaling profiles from a test sample.
    Type: Application
    Filed: November 5, 2013
    Publication date: May 8, 2014
    Applicant: Nodality, Inc
    Inventors: Diane Longo, Alessandra Cesano, Garry P. Nolan
  • Compressed Sensing for Simultaneous Measurement of Multiple Different Biological Molecule Types in a Sample
    Publication number: 20140106976
    Abstract: A method and apparatus for simultaneously determining multiple different biological molecule types in a sample include labeling each different biological molecule type in a biological sample with a unique combination of a plurality of labels. Each different biological molecule type is selected from a population of M different biological molecules types. The plurality of labels is selected from a population of L different labels; and, M is greater than L. Measurements are obtained of relative abundances of the L different labels in the sample. Relative abundance of up to M different biological molecule types in the sample are determined based on the measurements and a method of compressed sensing.
    Type: Application
    Filed: March 15, 2013
    Publication date: April 17, 2014
    Applicant: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Karen Sachs, Mohammed N. AlQuraishi, Solomon Itani, Garry P. Nolan, Sean C. Bendall, Tyler J. Burns
  • DETECTION OF TARGET NUCLEIC ACIDS IN A CELLULAR SAMPLE
    Publication number: 20140099637
    Abstract: Methods of assaying cells of a cellular sample for the presence of a target nucleic acid are provided. Aspects of the methods include evaluating a cellular sample that has been contacted with a nuclease inhibitor for the presence of a target nucleic acid. Also provided are devices and kits that find use in practicing the methods described herein.
    Type: Application
    Filed: October 3, 2013
    Publication date: April 10, 2014
    Inventors: Garry P. Nolan, Yury Goltsev
  • Lanthanide mass dots: nanoparticle isotope tags
    Patent number: 8679858
    Abstract: Compositions and methods are provided for the use of nanoparticles, which may be referred to herein as mass dots, as mass tags for probes such as antibodies, aptamers, nucleic acids, etc. in multiplexed bioassays with ICP-MS detection.
    Type: Grant
    Filed: January 11, 2012
    Date of Patent: March 25, 2014
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Garry P. Nolan, Erin F. Simonds, Sean C. Bendall
  • BENCHMARKS FOR NORMAL CELL IDENTIFICATION
    Publication number: 20140031308
    Abstract: Provided herein are methods, compositions, and kits for determining cell signaling profiles in normal cells and comparing the cell signaling profiles of normal cells to cell signaling profiles from a test sample.
    Type: Application
    Filed: September 8, 2011
    Publication date: January 30, 2014
    Inventors: Longo Diane, Todd M. Covey, David M. Soper, Garry P. Nolan, Alessandra Cesano
  • METHODS AND COMPOSITIONS FOR DETECTING THE ACTIVATION STATE OF MULTIPLE PROTEINS IN SINGLE CELLS
    Publication number: 20130177970
    Abstract: The invention provides methods and compositions for simultaneously detecting the activation state of a plurality of proteins in single cells using flow cytometry. The invention further provides methods and compositions of screening for bioactive agents capable of coordinately modulating the activity of a plurality of proteins in single cells. The methods and compositions can be used to determine the protein activation profile of a cell for predicting or diagnosing a disease state, and for monitoring treatment of a disease state.
    Type: Application
    Filed: April 26, 2011
    Publication date: July 11, 2013
    Inventors: Omar D. Perez, Garry P. Nolan
  • METHODS FOR AUTOIMMUNE DISEASE DIAGNOSIS, PROGNOSIS, AND TREATMENT`
    Publication number: 20130071860
    Abstract: In one aspect, the present invention provides methods for the classification, diagnosis, prognosis, theranosis, and/or prediction of an outcome of an autoimmune disease in a subject.
    Type: Application
    Filed: February 24, 2011
    Publication date: March 21, 2013
    Inventors: Matthew B. Hale, Jason Ptacek, Garry P. Nolan
  • Methods and compositions for risk stratification
    Patent number: 8394599
    Abstract: The present invention provides an approach for the simultaneous determination of the activation states of a plurality of proteins in single cells. This approach permits the rapid detection of heterogeneity in a complex cell population based on activation states, and the identification of cellular subsets that exhibit correlated changes in activation within the cell population. Moreover, this approach allows the correlation of cellular activities or properties. In addition, the use of potentiators of cellular activation allows for characterization of such pathways and cell populations.
    Type: Grant
    Filed: May 12, 2010
    Date of Patent: March 12, 2013
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Omar D. Perez, Garry P. Nolan, Jonathan M. Irish
  • METHODS AND COMPOSITIONS FOR DETECTING THE ACTIVATION STATE OF MULTIPLE PROTEINS IN SINGLE CELLS
    Publication number: 20120309026
    Abstract: The invention provides methods and compositions for simultaneously detecting the activation state of a plurality of proteins in single cells using flow cytometry. The invention further provides methods and compositions of screening for bioactive agents capable of coordinately modulating the activity of a plurality of proteins in single cells. The methods and compositions can be used to determine the protein activation profile of a cell for predicting or diagnosing a disease state, and for monitoring treatment of a disease state.
    Type: Application
    Filed: April 26, 2011
    Publication date: December 6, 2012
    Inventors: Omar D. Perez, Garry P. Nolan
  • Methods and compositions for risk stratification
    Patent number: 8309316
    Abstract: The present invention provides an approach for the simultaneous determination of the activation states of a plurality of proteins in single cells. This approach permits the rapid detection of heterogeneity in a complex cell population based on activation states, and the identification of cellular subsets that exhibit correlated changes in activation within the cell population. Moreover, this approach allows the correlation of cellular activities or properties. In addition, the use of potentiators of cellular activation allows for characterization of such pathways and cell populations.
    Type: Grant
    Filed: April 26, 2011
    Date of Patent: November 13, 2012
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Omar D. Perez, Garry P. Nolan, Jonathan M. Irish
  • Mass Dots: Nanoparticle Isotope Tags
    Publication number: 20120178183
    Abstract: Compositions and methods are provided for the use of nanoparticles, which may be referred to herein as mass dots, as mass tags for probes such as antibodies, aptamers, nucleic acids, etc. in multiplexed bioassays with ICP-MS detection.
    Type: Application
    Filed: January 11, 2012
    Publication date: July 12, 2012
    Inventors: Garry P. Nolan, Erin F. Simonds, Sean C. Bendall
  • Methods and compositions for risk stratification
    Patent number: 8206939
    Abstract: The present invention provides an approach for the simultaneous determination of the activation states of a plurality of proteins in single cells. This approach permits the rapid detection of heterogeneity in a complex cell population based on activation states, and the identification of cellular subsets that exhibit correlated changes in activation within the cell population. Moreover, this approach allows the correlation of cellular activities or properties. In addition, the use of potentiators of cellular activation allows for characterization of such pathways and cell populations.
    Type: Grant
    Filed: May 2, 2011
    Date of Patent: June 26, 2012
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Omar D. Perez, Garry P. Nolan, Jonathan M. Irish
  • Methods and compositions for detecting receptor-ligand interactions in single cells
    Patent number: 8198037
    Abstract: The invention provides methods and compositions for simultaneously detecting the activation state of a plurality of proteins in single cells using flow cytometry. The invention further provides methods and compositions of screening for bioactive agents capable of coordinately modulating the activity of a plurality of proteins in single cells. The methods and compositions can be used to determine the protein activation profile of a cell for predicting or diagnosing a disease state, and for monitoring treatment of a disease state.
    Type: Grant
    Filed: April 26, 2011
    Date of Patent: June 12, 2012
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Omar D. Perez, Garry P. Nolan
  • Methods and compositions for detecting the activation state of multiple proteins in single cells
    Patent number: 8148094
    Abstract: The invention provides methods and compositions for simultaneously detecting the activation state of a plurality of proteins in single cells using flow cytometry. The invention further provides methods and compositions of screening for bioactive agents capable of coordinately modulating the activity of a plurality of proteins in single cells. The methods and compositions can be used to determine the protein activation profile of a cell for predicting or diagnosing a disease state, and for monitoring treatment of a disease state.
    Type: Grant
    Filed: February 17, 2009
    Date of Patent: April 3, 2012
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Garry P. Nolan, Omar D. Perez
  • Mass Spectrometry Based Particle Separation
    Publication number: 20120077714
    Abstract: Certain embodiments provide a method of sample analysis that comprises: a) labeling a particle using a specific binding reagent that is cleavably linked to an elemental tag; b) flowing the labeled particle through a flow cell of a mass cytometer; c) cleaving the elemental tag from the labeled particle; d) performing elemental analysis of the cleaved elemental tag without destroying the particle, to produce data; e) matching data for the particle with the particle; and f) collecting the particle. Also provided is a specific binding reagent that is cleavably linked to an elemental tag, and a mass cytometer adapted to perform the method.
    Type: Application
    Filed: September 19, 2011
    Publication date: March 29, 2012
    Inventors: Garry P. Nolan, Sean C. Bendall, Peter O. Krutzik
  • METHODS AND COMPOSITIONS FOR RISK STRATIFICATION
    Publication number: 20120070849
    Abstract: The present invention provides an approach for the simultaneous determination of the activation states of a plurality of proteins in single cells. This approach permits the rapid detection of heterogeneity in a complex cell population based on activation states, and the identification of cellular subsets that exhibit correlated changes in activation within the cell population. Moreover, this approach allows the correlation of cellular activities or properties. In addition, the use of potentiators of cellular activation allows for characterization of such pathways and cell populations.
    Type: Application
    Filed: May 2, 2011
    Publication date: March 22, 2012
    Inventors: Omar D. Perez, Garry P. Nolan, Jonathan M. Irish
  • MUTATIONS IN THE LNK GENE IN PATIENTS WITH MYELOPROLIFERATIVE NEOPLASMS AND OTHER HEMATOLYMPHOID MALIGNANCIES
    Publication number: 20120046233
    Abstract: Aspects of the present invention include methods, compositions and kits for classifying a subject as having or being predisposed to a hematolymphoid neoplasm or malignancy if they harbor a mutation in the LNK gene. Aspects of the present invention also include screening for candidate agents for treating LNK mutation-based hematolymphoid neoplasms or malignancies in cell-based and cell free assays as well as therapeutic compositions for treating a LNK-mutant based hematolymphoid disorder. Also provided are compositions, systems, kits and computer program products that find use in practicing the subject methods.
    Type: Application
    Filed: January 12, 2011
    Publication date: February 23, 2012
    Inventors: Jason Robert Gotlib, Garry P. Nolan, James L. Zehnder, Stephen Tracy Oh
  • COMPOSITIONS AND METHODS FOR INTRACELLULAR ANALYTE ANALYSIS
    Publication number: 20110311970
    Abstract: Compositions and methods for multiplex immunodetection of analytes in single cells or cell populations are described. The invention utilizes analytical nanotags (ANTs) each specific for a different target analyte (TA) species. Analytical nanotags typically comprise biocompatible composite organic-inorganic nanoparticles (bCOINs) that include probe molecules specific for a particular TA species. A plurality of ANTs each specific for a different TA species can be used in a single multiplex assay, including assays for analyzing intracellular analytes in living cells.
    Type: Application
    Filed: April 14, 2011
    Publication date: December 22, 2011
    Inventors: Catherine M. SHACHAF, Garry P. NOLAN
  • Methods and Compositions for Risk Stratification
    Publication number: 20110269634
    Abstract: The present invention provides an approach for the simultaneous determination of the activation states of a plurality of proteins in single cells. This approach permits the rapid detection of heterogeneity in a complex cell population based on activation states, and the identification of cellular subsets that exhibit correlated changes in activation within the cell population. Moreover, this approach allows the correlation of cellular activities or properties. In addition, the use of potentiators of cellular activation allows for characterization of such pathways and cell populations.
    Type: Application
    Filed: April 7, 2011
    Publication date: November 3, 2011
    Inventors: Omar D. Perez, Garry P. Nolan, Jonathan M. Irish