Patents by Inventor Garry P. Nolan

Garry P. Nolan has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods and compositions for detecting receptor-ligand interactions in single cells
    Patent number: 7381535
    Abstract: The invention provides methods and compositions for simultaneously detecting the activation state of a plurality of proteins in single cells using flow cytometry. The invention further provides methods and compositions of screening for bioactive agents capable of coordinately modulating the activity of a plurality of proteins in single cells. The methods and compositions can be used to determine the protein activation profile of a cell for predicting or diagnosing a disease state, and for monitoring treatment of a disease state.
    Type: Grant
    Filed: January 16, 2003
    Date of Patent: June 3, 2008
    Assignee: The Board of Trustees of the Leland Stanford Junior
    Inventors: Omar D. Perez, Garry P. Nolan
  • Fluorescent dye binding peptides
    Patent number: 7332356
    Abstract: The present invention is directed to novel polypeptides, termed fluorettes, that bind with high avidity to fluorophore dyes. The peptides find use in a variety of methods and approaches involving fluorophore dyes.
    Type: Grant
    Filed: October 14, 2003
    Date of Patent: February 19, 2008
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Garry P. Nolan, Michael N. Rozinov
  • Combinatorial enzymatic complexes
    Patent number: 6969584
    Abstract: The invention relates to the formation of novel in vivo combinatorial enzyme complexes for use in screening candidate drug agents for bioactivity.
    Type: Grant
    Filed: June 12, 1997
    Date of Patent: November 29, 2005
    Assignee: Rigel Pharmaceuticals, Inc.
    Inventors: Garry P. Nolan, Donald Payan
  • Methods for screening for transdominant effector peptides and RNA molecules
    Patent number: 6833245
    Abstract: Methods and compositions for screening for transdominant effector peptides and RNA molecules selected inside living cells from randomized pools are provided.
    Type: Grant
    Filed: March 12, 2002
    Date of Patent: December 21, 2004
    Assignees: Rigel Pharmaceuticals, Inc., The Board of Trustees of the Leland Stanford Junior University
    Inventors: Garry P. Nolan, S. Michael Rothenberg
  • Fluorescent dye binding peptides
    Publication number: 20040176578
    Abstract: The present invention is directed to novel polypeptides, termed fluorettes, that bind with high avidity to fluorophore dyes. The peptides find use in a variety of methods and approaches involving fluorophore dyes.
    Type: Application
    Filed: October 14, 2003
    Publication date: September 9, 2004
    Inventors: Garry P. Nolan, Michael N. Rozinov
  • Fluorescent dye binding peptides
    Patent number: 6747135
    Abstract: The present invention is directed to novel polypeptides, termed fluorettes, that bind with high avidity to fluorophore dyes. The peptides find use in a variety of methods and approaches involving fluorophore dyes.
    Type: Grant
    Filed: October 15, 1999
    Date of Patent: June 8, 2004
    Assignee: The Board of Trustees for the Leland Stanford Junior University
    Inventors: Garry P. Nolan, Michael N. Rozinov
  • Methods and compositions for detecting receptor-ligand interactions in single cells
    Publication number: 20040106156
    Abstract: The invention provides methods and compositions for simultaneously detecting the activation state of a plurality of proteins in single cells using flow cytometry. The invention further provides methods and compositions of screening for bioactive agents capable of coordinately modulating the activity of a plurality of proteins in single cells. The methods and compositions can be used to determine the protein activation profile of a cell for predicting or diagnosing a disease state, and for monitoring treatment of a disease state.
    Type: Application
    Filed: January 16, 2003
    Publication date: June 3, 2004
    Inventors: Omar D. Perez, Garry P. Nolan
  • Methods for screening for transdominant intracellular effector peptides and RNA molecules
    Patent number: 6737241
    Abstract: Methods and compositions for screening for intracellular transdominant effector peptides and RNA molecules selected inside living cells from randomized pools are provided.
    Type: Grant
    Filed: July 27, 2001
    Date of Patent: May 18, 2004
    Assignee: Rigel Pharmaceuticals, Inc.
    Inventor: Garry P. Nolan
  • Toso
    Patent number: 6727350
    Abstract: The present invention is directed to novel polypeptides such as the the Toso protein and related molecuels which have an inhibitory effect on TNF mediated apoptosis and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.
    Type: Grant
    Filed: August 17, 1998
    Date of Patent: April 27, 2004
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Garry P. Nolan, Yasumichi Hitoshi
  • Single cell assessement of viral infection/replication
    Publication number: 20040033488
    Abstract: This invention relates to methods of separating virally infected viable cells from dead cells using antibodies specific for intracellular proteins and a covalent nucleic acid binding agent.
    Type: Application
    Filed: February 19, 2003
    Publication date: February 19, 2004
    Inventors: Omar Perez, Garry P. Nolan
  • Methods for screening for transdominant effector peptides and RNA molecules
    Publication number: 20030170641
    Abstract: Methods and compositions for screening for transdominant effector peptides and RNA molecules selected inside living cells from randomized pools are provided.
    Type: Application
    Filed: March 12, 2002
    Publication date: September 11, 2003
    Applicant: Board of Trustees of the Leland Stanford Junior University
    Inventors: Garry P. Nolan, S. Michael Rothenberg
  • Methods for screening for transdominant intracellular effector peptides and RNA molecules
    Publication number: 20030104384
    Abstract: Methods and compositions for screening for intracellular transdominant effector peptides and RNA molecules selected inside living cells from randomized pools are provided.
    Type: Application
    Filed: July 31, 2001
    Publication date: June 5, 2003
    Inventors: Garry P. Nolan, S. Michael Rothenberg
  • Methods for screening for transdominant effector peptides and RNA molecules
    Publication number: 20030044767
    Abstract: Biochemical libraries are screened for transdominant intracellularly bioactive agents by expressing a molecular library of randomized nucleic acids as a plurality of corresponding expression products in a plurality of cells, each of the nucleic acids comprising a different nucleotide sequence, detecting a cell of the plurality of cells exhibiting a changed physiology in response to the presence in the cell of a transdominant expression product of the corresponding expressio products; and isolating the cell and/or transdominant expression product.
    Type: Application
    Filed: January 22, 2002
    Publication date: March 6, 2003
    Applicant: Board of Trustees of the Leland Stanford Junior University
    Inventor: Garry P. Nolan
  • TOSO
    Publication number: 20020177565
    Abstract: The present invention is directed to novel polypeptides such as the the Toso protein and related molecuels which have an inhibitory effect on TNF mediated apoptosis and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologouspolypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.
    Type: Application
    Filed: August 17, 1998
    Publication date: November 28, 2002
    Inventors: GARRY P. NOLAN, YASUMICHI HITOSHI
  • Methods for screening for transdominant intracellular effector peptides and RNA molecules
    Publication number: 20020146710
    Abstract: Methods and compositions for screening for intracellular transdominant effector peptides and RNA molecules selected inside living cells from randomized pools are provided.
    Type: Application
    Filed: July 30, 2001
    Publication date: October 10, 2002
    Inventor: Garry P. Nolan
  • Methods for screening for transdominant effector peptides and RNA molecules
    Patent number: 6455247
    Abstract: Methods and compositons for screening for transdominant effector peptides and RNA molecules selected inside living cells from randomized pools are provided.
    Type: Grant
    Filed: January 23, 1997
    Date of Patent: September 24, 2002
    Assignees: Board of Trustees of the Leland Stanford Junior University, Rigel Pharmaceuticals, Inc.
    Inventors: Garry P. Nolan, S. Michael Rothenberg
  • Methods for screening for transdominant intracellular effector peptides and RNA molecules
    Publication number: 20020127564
    Abstract: Methods and compositions for screening for intracellular transdominant effector peptides and RNA molecules selected inside living cells from randomized pools are provided.
    Type: Application
    Filed: July 27, 2001
    Publication date: September 12, 2002
    Inventor: Garry P. Nolan
  • COMBINATORIAL ENZYMATIC COMPLEXES
    Publication number: 20020064798
    Abstract: The invention relates to the formation of novel in vivo combinatorial enzyme complexes for use in screening candidate drug agents for bioactivity.
    Type: Application
    Filed: June 12, 1997
    Publication date: May 30, 2002
    Inventors: GARRY P. NOLAN, DONALD PAYAN
  • Methods for screening for transdominant effector peptides and RNA molecules
    Patent number: 6365344
    Abstract: Biochemical libraries are screened for transdominant intracellularly bioactive agents by expressing a molecular library of randomized nucleic acids as a plurality of corresponding expression products in a plurality of cells, each of the nucleic acids comprising a different nucleotide sequence, detecting a cell of the plurality of cells exhibiting a changed physiology in response to the presence in the cell of a transdominant expression product of the corresponding expressio products; and isolating the cell and/or transdominant expression product.
    Type: Grant
    Filed: January 23, 1996
    Date of Patent: April 2, 2002
    Assignees: The Board of Trustees of the Leland Stanford Junior University, Rigel Pharmaceuticals, Inc.
    Inventors: Garry P. Nolan, S. Michael Rothenberg
  • Combinatorial enzymatic complexes
    Publication number: 20010036638
    Abstract: The invention relates to the formation of novel in vivo combinatorial enzyme complexes for use in screening candidate drug agents for bioactivity.
    Type: Application
    Filed: February 20, 2001
    Publication date: November 1, 2001
    Applicant: Rigel Pharmaceuticals, Inc.
    Inventors: Garry P. Nolan, Donald Payan