Patents by Inventor Garry P. Nolan

Garry P. Nolan has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • METHODS AND COMPOSITIONS FOR DETECTING THE ACTIVATION STATE OF MULTIPLE PROTEINS IN SINGLE CELLS
    Publication number: 20110250614
    Abstract: The invention provides methods and compositions for simultaneously detecting the activation state of a plurality of proteins in single cells using flow cytometry. The invention further provides methods and compositions of screening for bioactive agents capable of coordinately modulating the activity of a plurality of proteins in single cells. The methods and compositions can be used to determine the protein activation profile of a cell for predicting or diagnosing a disease state, and for monitoring treatment of a disease state.
    Type: Application
    Filed: May 2, 2011
    Publication date: October 13, 2011
    Inventors: Omar D. Perez, Garry P. Nolan
  • METHODS AND COMPOSITIONS FOR RISK STRATIFICATION
    Publication number: 20110207149
    Abstract: The present invention provides an approach for the simultaneous determination of the activation states of a plurality of proteins in single cells. This approach permits the rapid detection of heterogeneity in a complex cell population based on activation states, and the identification of cellular subsets that exhibit correlated changes in activation within the cell population. Moreover, this approach allows the correlation of cellular activities or properties. In addition, the use of potentiators of cellular activation allows for characterization of such pathways and cell populations.
    Type: Application
    Filed: May 2, 2011
    Publication date: August 25, 2011
    Inventors: Omar D. Perez, Garry P. Nolan, Jonathan M. Irish
  • METHODS AND COMPOSITIONS FOR DETECTING RECEPTOR-LIGAND INTERACTIONS IN SINGLE CELLS
    Publication number: 20110207146
    Abstract: The invention provides methods and compositions for simultaneously detecting the activation state of a plurality of proteins in single cells using flow cytometry. The invention further provides methods and compositions of screening for bioactive agents capable of coordinately modulating the activity of a plurality of proteins in single cells. The methods and compositions can be used to determine the protein activation profile of a cell for predicting or diagnosing a disease state, and for monitoring treatment of a disease state.
    Type: Application
    Filed: May 2, 2011
    Publication date: August 25, 2011
    Inventors: Omar D. Perez, Garry P. Nolan
  • METHODS AND COMPOSITIONS FOR RISK STRATIFICATION
    Publication number: 20110201018
    Abstract: The present invention provides an approach for the simultaneous determination of the activation states of a plurality of proteins in single cells. This approach permits the rapid detection of heterogeneity in a complex cell population based on activation states, and the identification of cellular subsets that exhibit correlated changes in activation within the cell population. Moreover, this approach allows the correlation of cellular activities or properties. In addition, the use of potentiators of cellular activation allows for characterization of such pathways and cell populations.
    Type: Application
    Filed: April 26, 2011
    Publication date: August 18, 2011
    Inventors: Omar D. Perez, Garry P. Nolan, Jonathan M. Irish
  • Methods and Compositions for Detecting Receptor-Ligand Interactions in Single Cells
    Publication number: 20110201019
    Abstract: The invention provides methods and compositions for simultaneously detecting the activation state of a plurality of proteins in single cells using flow cytometry. The invention further provides methods and compositions of screening for bioactive agents capable of coordinately modulating the activity of a plurality of proteins in single cells. The methods and compositions can be used to determine the protein activation profile of a cell for predicting or diagnosing a disease state, and for monitoring treatment of a disease state.
    Type: Application
    Filed: April 26, 2011
    Publication date: August 18, 2011
    Inventors: Omar D. Perez, Garry P. Nolan
  • Methods and compositions for risk stratification
    Patent number: 7939278
    Abstract: The present invention provides an approach for the simultaneous determination of the activation states of a plurality of proteins in single cells. This approach permits the rapid detection of heterogeneity in a complex cell population based on activation states, and the identification of cellular subsets that exhibit correlated changes in activation within the cell population. Moreover, this approach allows the correlation of cellular activities or properties. In addition, the use of potentiators of cellular activation allows for characterization of such pathways and cell populations.
    Type: Grant
    Filed: January 17, 2008
    Date of Patent: May 10, 2011
    Assignee: The Board of Trustees of Leland Stanford Junior University
    Inventors: Omar D. Perez, Garry P. Nolan, Jonathan M. Irish
  • ANALYSIS OF CELL NETWORKS
    Publication number: 20110059861
    Abstract: The present invention provides an approach for the determination of activation state of a plurality of discrete cell populations and/or the state of one or more cellular networks in an individual.
    Type: Application
    Filed: September 8, 2010
    Publication date: March 10, 2011
    Applicant: Nodality, Inc.
    Inventors: Garry P. Nolan, Alessandra Cesano
  • METHODS AND COMPOSITIONS FOR DETECTING THE ACTIVATION STATE OF MULTIPLE PROTEINS IN SINGLE CELLS
    Publication number: 20110020839
    Abstract: The invention provides methods and compositions for simultaneously detecting the activation state of a plurality of proteins in single cells using flow cytometry. The invention further provides methods and compositions of screening for bioactive agents capable of coordinately modulating the activity of a plurality of proteins in single cells. The methods and compositions can be used to determine the protein activation profile of a cell for predicting or diagnosing a disease state, and for monitoring treatment of a disease state.
    Type: Application
    Filed: February 17, 2009
    Publication date: January 27, 2011
    Inventors: Omar D. Perez, Garry P. Nolan
  • Methods and Compositions for Risk Stratification
    Publication number: 20100221750
    Abstract: The present invention provides an approach for the simultaneous determination of the activation states of a plurality of proteins in single cells. This approach permits the rapid detection of heterogeneity in a complex cell population based on activation states, and the identification of cellular subsets that exhibit correlated changes in activation within the cell population. Moreover, this approach allows the correlation of cellular activities or properties. In addition, the use of potentiators of cellular activation allows for characterization of such pathways and cell populations.
    Type: Application
    Filed: May 12, 2010
    Publication date: September 2, 2010
    Inventors: Omar D. PEREZ, Garry P. NOLAN, Jonathan M. IRISH
  • Methods and Compositions for Detecting Receptor-Ligand Interactions in Single Cells
    Publication number: 20100184092
    Abstract: The invention provides methods and compositions for simultaneously detecting the activation state of a plurality of proteins in single cells using flow cytometry. The invention further provides methods and compositions of screening for bioactive agents capable of coordinately modulating the activity of a plurality of proteins in single cells. The methods and compositions can be used to determine the protein activation profile of a cell for predicting or diagnosing a disease state, and for monitoring treatment of a disease state.
    Type: Application
    Filed: August 31, 2009
    Publication date: July 22, 2010
    Inventors: Omar D. Perez, Garry P. Nolan
  • Methods and compositions for detecting receptor-ligand interactions in single cells
    Patent number: 7695924
    Abstract: The invention provides methods and compositions for simultaneously detecting the activation state of a plurality of proteins in single cells using flow cytometry. The invention further provides methods and compositions of screening for bioactive agents capable of coordinately modulating the activity of a plurality of proteins in single cells. The methods and compositions can be used to determine the protein activation profile of a cell for predicting or diagnosing a disease state, and for monitoring treatment of a disease state.
    Type: Grant
    Filed: January 18, 2007
    Date of Patent: April 13, 2010
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Omar D. Perez, Garry P. Nolan
  • Methods and compositions for detecting receptor-ligand interactions in single cells
    Patent number: 7695926
    Abstract: The invention provides methods and compositions for simultaneously detecting the activation state of a plurality of proteins in single cells using flow cytometry. The invention further provides methods and compositions of screening for bioactive agents capable of coordinately modulating the activity of a plurality of proteins in single cells. The methods and compositions can be used to determine the protein activation profile of a cell for predicting or diagnosing a disease state, and for monitoring treatment of a disease state.
    Type: Grant
    Filed: January 18, 2007
    Date of Patent: April 13, 2010
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Omar D. Perez, Garry P. Nolan
  • DEVICE AND METHOD FOR PROCESSING CELL SAMPLES
    Publication number: 20090269800
    Abstract: A cell analysis device and method is described which enables the user to efficiently treat cells in a sample. The cells can be treated with reagents at a time and place proximate to collection and may be handled in a automated or semi automated fashion.
    Type: Application
    Filed: April 29, 2009
    Publication date: October 29, 2009
    Inventors: Todd COVEY, Garry P. Nolan
  • METHODS OF DETERMINING THE HEALTH STATUS OF AN INDIVIDUAL
    Publication number: 20090269773
    Abstract: Methods of determining health status based on analysis of single cells in a sample or set of samples from an individual are described.
    Type: Application
    Filed: April 29, 2009
    Publication date: October 29, 2009
    Inventors: Wendy J. Fantl, Helen Francis-Lang, Alleen C. Cohen, Garry P. Nolan, Malcol Frncis-Lang
  • Methods and compositions for detecting the activation state of multiple proteins in single cells
    Patent number: 7563584
    Abstract: The invention provides methods and compositions for simultaneously detecting the activation state of a plurality of proteins in single cells using flow cytometry. The invention further provides methods and compositions of screening for bioactive agents capable of coordinately modulating the activity of a plurality of proteins in single cells. The methods and compositions can be used to determine the protein activation profile of a cell for predicting or diagnosing a disease state, and for monitoring treatment of a disease state.
    Type: Grant
    Filed: July 10, 2002
    Date of Patent: July 21, 2009
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Omar D. Perez, Garry P. Nolan
  • METHODS AND COMPOSITIONS FOR RISK STRATIFICATION
    Publication number: 20090081699
    Abstract: The present invention provides an approach for the simultaneous determination of the activation states of a plurality of proteins in single cells. This approach permits the rapid detection of heterogeneity in a complex cell population based on activation states, and the identification of cellular subsets that exhibit correlated changes in activation within the cell population. Moreover, this approach allows the correlation of cellular activities or properties. In addition, the use of potentiators of cellular activation allows for characterization of such pathways and cell populations.
    Type: Application
    Filed: May 22, 2008
    Publication date: March 26, 2009
    Inventors: Omar D. Perez, Garry P. Nolan, Jonathan M. Irish
  • METHODS AND COMPOSITIONS FOR RISK STRATIFICATION
    Publication number: 20090068681
    Abstract: The present invention provides an approach for the simultaneous determination of the activation states of a plurality of proteins in single cells. This approach permits the rapid detection of heterogeneity in a complex cell population based on activation states, and the identification of cellular subsets that exhibit correlated changes in activation within the cell population. Moreover, this approach allows the correlation of cellular activities or properties. In addition, the use of potentiators of cellular activation allows for characterization of such pathways and cell populations.
    Type: Application
    Filed: May 22, 2008
    Publication date: March 12, 2009
    Inventors: Omar D. Perez, Garry P. Nolan, Jonathan M. Irish
  • METHODS AND COMPOSITIONS FOR RISK STRATIFICATION
    Publication number: 20080254489
    Abstract: The present invention provides an approach for the simultaneous determination of the activation states of a plurality of proteins in single cells. This approach permits the rapid detection of heterogeneity in a complex cell population based on activation states, and the identification of cellular subsets that exhibit correlated changes in activation within the cell population. Moreover, this approach allows the correlation of cellular activities or properties. In addition, the use of potentiators of cellular activation allows for characterization of such pathways and cell populations.
    Type: Application
    Filed: April 2, 2008
    Publication date: October 16, 2008
    Inventors: Omar D. Perez, Garry P. Nolan, Jonathan M. Irish
  • METHODS AND COMPOSITIONS FOR RISK STRATIFICATION
    Publication number: 20080182262
    Abstract: The present invention provides an approach for the simultaneous determination of the activation states of a plurality of proteins in single cells. This approach permits the rapid detection of heterogeneity in a complex cell population based on activation states, and the identification of cellular subsets that exhibit correlated changes in activation within the cell population. Moreover, this approach allows the correlation of cellular activities or properties. In addition, the use of potentiators of cellular activation allows for characterization of such pathways and cell populations.
    Type: Application
    Filed: January 17, 2008
    Publication date: July 31, 2008
    Inventors: Omar D. Perez, Garry P. Nolan, Jonathan M. Irish
  • Methods and compositions for risk stratification
    Patent number: 7393656
    Abstract: The present invention provides an approach for the simultaneous determination of the activation states of a plurality of proteins in single cells. This approach permits the rapid detection of heterogeneity in a complex cell population based on activation states, and the identification of cellular subsets that exhibit correlated changes in activation within the cell population. Moreover, this approach allows the correlation of cellular activities or properties. In addition, the use of potentiators of cellular activation allows for characterization of such pathways and cell populations.
    Type: Grant
    Filed: July 21, 2004
    Date of Patent: July 1, 2008
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Omar D. Perez, Garry P. Nolan, Jonathan M. Irish