Patents by Inventor Geoffrey von Maltzahn

Geoffrey von Maltzahn has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods and products for in vivo enzyme profiling
    Patent number: 11703510
    Abstract: The present invention relates to methods and products associated with in vivo enzyme profiling. In particular, the invention relates to methods of in vivo processing of exogenous molecules followed by detection of signature molecules as representative of the presence of active enzymes associated with diseases or conditions. The invention also relates to products, kits, and databases for use in the methods of the invention.
    Type: Grant
    Filed: November 6, 2020
    Date of Patent: July 18, 2023
    Assignee: Massachusetts Institute of Technology
    Inventors: Sangeeta N. Bhatia, Geoffrey A. von Maltzahn, Gabriel A. Kwong
  • METHODS AND PRODUCTS FOR IN VIVO ENZYME PROFILING
    Publication number: 20230194544
    Abstract: The present invention relates to methods and products associated with in vivo enzyme profiling. In particular, the invention relates to methods of in vivo processing of exogenous molecules followed by detection of signature molecules as representative of the presence of active enzymes associated with diseases or conditions. The invention also relates to products, kits, and databases for use in the methods of the invention.
    Type: Application
    Filed: November 18, 2022
    Publication date: June 22, 2023
    Applicant: Massachusetts Institute of Technology
    Inventors: Sangeeta N. Bhatia, Geoffrey A. von Maltzahn, Gabriel A. Kwong
  • OLIGOSACCHARIDE COMPOSITIONS AND METHODS OF USE THEREOF FOR TREATING VIRAL INFECTIONS
    Publication number: 20230165881
    Abstract: Aspects of the disclosure relate to oligosaccharide compositions and methods of making the same. Also provided are methods of using oligosaccharide compositions as microbiome metabolic therapies for treating respiratory viral illnesses, such as COVID-19.
    Type: Application
    Filed: April 29, 2021
    Publication date: June 1, 2023
    Inventors: Jonathan Lawrence, Jeffrey Meisner, Christopher Matthew Liu, Madeline Rosini, Max Hecht, Mark Wingertzahn, Geoffrey A. von Maltzahn
  • GLYCAN COMPOSITIONS AND METHODS OF USE
    Publication number: 20230123695
    Abstract: Compositions, e.g., pharmaceutical compositions, nutritional compositions, medical foods, and food ingredients, as well as their methods of use, are provided, for modulating exogenous substances, enzyme activities, and drug activities.
    Type: Application
    Filed: October 20, 2022
    Publication date: April 20, 2023
    Inventors: Geoffrey A. von Maltzahn, Jacob Rosenblum Rubens
  • COMPOSITIONS AND METHODS FOR COMPARTMENT-SPECIFIC CARGO DELIVERY
    Publication number: 20230068547
    Abstract: Fusosome compositions and methods are described herein.
    Type: Application
    Filed: November 14, 2019
    Publication date: March 2, 2023
    Inventors: Geoffrey A. von Maltzahn, John Miles Milwid, Jacob Rosenblum Rubens, Michael Travis Mee, Neal Francis Gordon, Jagesh Vijaykumar Shah, Kyle Marvin Trudeau, Brigham Jay Hartley
  • FUSOSOME COMPOSITIONS FOR HEMATOPOIETIC STEM CELL DELIVERY
    Publication number: 20230048166
    Abstract: The present disclosure provides, at least in part, methods and compositions for in vivo fusosome delivery. In some embodiments, the fusosome comprises a combination of elements that promote specificity for target cells, e.g., one or more of a fusogen, a positive target cell-specific regulatory element, and a non-target cell-specific regulatory element. In some embodiments, the fusosome comprises one or more modifications that decrease an immune response against the fusosome.
    Type: Application
    Filed: November 14, 2019
    Publication date: February 16, 2023
    Inventors: Geoffrey A. von Maltzahn, Jacob Rosenblum Rubens, Jagesh Vijaykumar Shah, Albert Ruzo Matias, Ferdinando Pucci, John Miles Milwid, Michael Travis Mee, Neal Francis Gordon
  • Compositions for facilitating membrane fusion and uses thereof
    Patent number: 11576872
    Abstract: In some aspects, fusosome compositions and methods are described herein that comprise membrane enclosed preparations, comprising a fusogen. In some embodiments, the fusosome can the target cell, thereby delivering complex biologic agents to the target cell cytoplasm.
    Type: Grant
    Filed: May 8, 2018
    Date of Patent: February 14, 2023
    Assignee: FLAGSHIP PIONEERING INNOVATIONS V, INC.
    Inventors: Geoffrey A. von Maltzahn, John Miles Milwid, Michael Travis Mee, Jacob Rosenblum Rubens, Nathan Wilson Stebbins, Molly Krisann Gibson, Neal Francis Gordon, Bo Zhang, Kyle Marvin Trudeau, Brigham Jay Hartley, Tamar Rose Putiri, Kiana Mahdaviani, Matthew Milnes Dobbin
  • FUSOSOME COMPOSITIONS FOR T CELL DELIVERY
    Publication number: 20230043255
    Abstract: The present disclosure provides, at least in part, methods and compositions for in vivo fusosome delivery. In some embodiments, the fusosome comprises a combination of elements that promote specificity for target cells, e.g., one or more of a fusogen, a positive target cell-specific regulatory element, and a non-target cell-specific regulatory element. In some embodiments, the fusosome comprises one or more modifications that decrease an immune response against the fusosome.
    Type: Application
    Filed: November 14, 2019
    Publication date: February 9, 2023
    Inventors: Geoffrey A. von Maltzahn, Jacob Rosenblum Rubens, Jagesh Vijaykumar Shah, Albert Ruzo Matias, Ferdinando Pucci, John Miles Milwid, Michael Travis Mee, Neal Francis Gordon
  • Endophytes, associated compositions, and methods of use
    Patent number: 11570993
    Abstract: Materials and methods for improving plant traits and for providing plant benefits are provided. In some embodiments, the materials, and methods employing the same, can comprise endophytes.
    Type: Grant
    Filed: December 20, 2018
    Date of Patent: February 7, 2023
    Assignee: Indigo Ag, Inc.
    Inventors: Geoffrey von Maltzahn, Richard Bailey Flavell, Gerardo V. Toledo, Jonathan W. Leff, Phillip Samayoa, Luis Miguel Marquez, David Morris Johnston, Slavica Djonovic, Yves Alain Millet, Craig Sadowski, Jeffrey Lyford, Karen V. Ambrose, Xuecheng Zhang
  • Methods and products for in vivo enzyme profiling
    Patent number: 11549951
    Abstract: The present invention relates to methods and products associated with in vivo enzyme profiling. In particular, the invention relates to methods of in vivo processing of exogenous molecules followed by detection of signature molecules as representative of the presence of active enzymes associated with diseases or conditions. The invention also relates to products, kits, and databases for use in the methods of the invention.
    Type: Grant
    Filed: January 7, 2022
    Date of Patent: January 10, 2023
    Assignee: Massachusetts Institute of Technology
    Inventors: Sangeeta N. Bhatia, Geoffrey A. von Maltzahn, Gabriel A. Kwong
  • MICROBIOME REGULATORS AND RELATED USES THEREOF
    Publication number: 20220395521
    Abstract: Compositions comprising microbiome regulators are provided, as well as methods of using the same for the modulation of the human microbiota and to treat or prevent related diseases, disorders, or conditions.
    Type: Application
    Filed: January 19, 2022
    Publication date: December 15, 2022
    Applicant: Kaleido Biosciences, Inc.
    Inventors: Geoffrey A. von Maltzahn, John M. Geremia
  • Synergistic bacterial compositions and methods of production and use thereof
    Patent number: 11464812
    Abstract: Provided are therapeutic compositions containing Ecobiotic™ populations for prevention, treatment and reduction of symptoms associated with a dysbiosis of a mammalian subject such as a human.
    Type: Grant
    Filed: December 14, 2020
    Date of Patent: October 11, 2022
    Assignee: Seres Therapeutics, Inc.
    Inventors: Matthew R. Henn, Geoffrey von Maltzahn, Anthony Mario D'Onofrio, Kevin Daniel Litcofsky, David Arthur Berry, David N. Cook, Noubar B. Afeyan, John Grant Aunins
  • Synergistic bacterial compositions and methods of production and use thereof
    Patent number: 11458174
    Abstract: Provided are therapeutic compositions containing Ecobiotic™ populations for prevention, treatment and reduction of symptoms associated with a dysbiosis of a mammalian subject such as a human.
    Type: Grant
    Filed: December 14, 2020
    Date of Patent: October 4, 2022
    Assignee: Seres Therapeutics, Inc.
    Inventors: Matthew R. Henn, Geoffrey von Maltzahn, Anthony Mario D'Onofrio, Kevin Daniel Litcofsky, David Arthur Berry, David N. Cook, Noubar B. Afeyan, John Grant Aunins
  • Synergistic bacterial compositions and methods of production and use thereof
    Patent number: 11458173
    Abstract: Provided are therapeutic compositions containing Ecobiotic™ populations for prevention, treatment and reduction of symptoms associated with a dysbiosis of a mammalian subject such as a human.
    Type: Grant
    Filed: December 14, 2020
    Date of Patent: October 4, 2022
    Assignee: Seres Therapeutics, Inc.
    Inventors: Matthew R. Henn, Geoffrey von Maltzahn, Anthony Mario D'Onofrio, Kevin Daniel Litcofsky, David Arthur Berry, David N. Cook, Noubar B. Afeyan, John Grant Aunins
  • SYNERGISTIC BACTERIAL COMPOSITIONS AND METHODS OF PRODUCTION AND USE THEREOF
    Publication number: 20220257674
    Abstract: Provided are therapeutic compositions containing microbial populations for prevention, treatment and reduction of symptoms associated with a dysbiosis of a mammalian subject such as a human.
    Type: Application
    Filed: January 28, 2022
    Publication date: August 18, 2022
    Applicant: Seres Therapeutics, Inc.
    Inventors: Matthew R. HENN, Kevin Daniel LITCOFSKY, Anthony Mario D'ONOFRIO, Toshiro K. OHSUMI, Mary-Jane Lombardo MCKENZIE, Geoffrey VON MALTZAHN, David N. COOK, David Arthur BERRY, Noubar B. AFEYAN, John Grant AUNINS
  • METHODS OF USE OF SEED-ORIGIN ENDOPHYTE POPULATIONS
    Publication number: 20220232833
    Abstract: This application relates to methods and materials for providing a benefit to a seed or seedling of an agricultural plant (e.g., an agricultural grass plant), or the agricultural plant derived from the seed or seedling. For example, this application provides purified bacterial populations that include novel seed-origin bacterial endophytes, and synthetic combinations of seeds and/or seedlings (e.g., cereal seeds and/or seedlings) with heterologous seed-derived bacterial endophytes.
    Type: Application
    Filed: October 4, 2021
    Publication date: July 28, 2022
    Inventors: Geoffrey von Maltzahn, Richard Bailey Flavell, Gerardo V. Toledo, Slavica Djonovic, Luis Miguel Marquez, David Morris Johnston, Yves Alain Millet, Jeffrey Lyford, Alexander Naydich, Craig Sadowski
  • GLYCAN PREPARATIONS AND METHODS OF USE FOR HYPERAMMONEMIA
    Publication number: 20220233577
    Abstract: Compositions, e.g., pharmaceutical compositions, nutritional compositions, medical foods, and food ingredients, as well as their methods of use, are provided, for treating diseases associated with hyperammonemia, e.g., urea cycle disorders (UCD) and hepatic encephalopathy (HE), e.g., minimal HE (MHE) and overt HE (OHE), and modulating enzyme activities and levels of microbes and taxa, and metabolites (e.g., ammonia) in the microbiome of a subject.
    Type: Application
    Filed: November 3, 2018
    Publication date: July 28, 2022
    Inventors: Molly Krisann Gibson, Nathan Wilson Stebbins, Ruth Thieroff-Ekerdt, Geoffrey A. von Maltzahn
  • Synergistic bacterial compositions and methods of production and use thereof
    Patent number: 11389490
    Abstract: Provided are therapeutic compositions containing Ecobiotic™ populations for prevention, treatment and reduction of symptoms associated with a dysbiosis of a mammalian subject such as a human.
    Type: Grant
    Filed: December 14, 2020
    Date of Patent: July 19, 2022
    Assignee: Seres Therapeutics, Inc.
    Inventors: Matthew R. Henn, Geoffrey von MALTZAHN, Anthony Mario D'Onofrio, Kevin Daniel Litcofsky, David Arthur Berry, David N. Cook, Noubar B. Afeyan, John Grant Aunins
  • Nutritive polypeptides and formulations thereof, and methods of production and use thereof
    Patent number: 11357824
    Abstract: Nutritive polypeptides are provided herein. Also provided are various other embodiments including nucleic acids encoding the polypeptides, recombinant microorganisms that make the polypeptides, vectors for expressing the polypeptides, methods of making the polypeptides using recombinant microorganisms, compositions and formulations that comprise the polypeptides, and methods of using the polypeptides, compositions and formulations.
    Type: Grant
    Filed: March 16, 2020
    Date of Patent: June 14, 2022
    Assignee: Axcella Health Inc.
    Inventors: Michael Hamill, Brett Boghigian, Caitlyn Harvey, David Berry, David Young, Geoffrey Von Maltzahn, John Kramarczyk, Jameson Rogers, Kathryn Heard, Michael Doherty, Nathaniel Silver, Phillip Samayoa, Subhayu Basu, Shaila Rahman, Vimal Vaidya, Ying-Ja Chen
  • METHODS AND COMPOSITIONS OF CHONDRISOMES
    Publication number: 20220160784
    Abstract: Therapeutic chondrisome compositions and related methods are described.
    Type: Application
    Filed: February 14, 2022
    Publication date: May 26, 2022
    Inventors: Geoffrey A. von Maltzahn, John Miles Milwid, Michael Travis Mee, Jacob Rosenblum Rubens, David Chess, Kyle Marvin Trudeau, Kiana Mahdaviani, Jacob Feala, James D. McCully, Douglas B. Cowan