Abstract: Adapting a machine learning model to process data that differs from training data used to configure the model for a specified objective is described. A domain adaptation system trains the model to process new domain data that differs from a training data domain by using the model to generate a feature representation for the new domain data, which describes different content types included in the new domain data. The domain adaptation system then generates a probability distribution for each discrete region of the new domain data, which describes a likelihood of the region including different content described by the feature representation. The probability distribution is compared to ground truth information for the new domain data to determine a loss function, which is used to refine model parameters. After determining that model outputs achieve a threshold similarity to the ground truth information, the model is output as a domain-agnostic model.

Abstract: The present invention discloses a method for onset time detection of a time-domain acoustic emission signal based on histogram distance. The method comprises the following steps: acquiring an acoustic emission signal; dividing the signal into two intervals with a sliding point k as the demarcation point; obtaining the relative frequency histograms of two adjacent intervals; obtaining histogram distance of the relative frequency histograms of two adjacent intervals; moving the sliding point k to the next element to obtain two new intervals and generating new histograms of the two new intervals and calculating the histogram distance of two new intervals; searching for the point which gives the maximum value of the histogram distances, and the corresponding time to this point is regarded as the onset time.

Abstract: The invention provides compositions and methods for sequencing nucleic acids and other applications. In sequencing by synthesis, unlabeled reversible terminators are incorporated by a polymerase in each cycle, then labeled after incorporation by binding to the reversible terminator a directly or indirectly labeled antibody or other affinity reagent.

Abstract: A modified nucleoside or nucleotide, the 3?-OH of the modified nucleoside or nucleotide being reversibly blocked; meanwhile, the present invention also relates to a kit comprising the nucleoside or nucleotide, and a sequencing method based on the nucleoside or nucleotide.

Abstract: Disclosed herein are methods and compositions for corresponding positions on an array with differently labeled affinity reagents immobilized at the positions. A first and a second affinity reagents are immobilized on at least some of the first and second positions, respectively. The first affinity reagent and the second affinity reagent are associated with a first luciferase polypeptide and a second luciferase polypeptide, respectively. The first luciferase polypeptide does not cross react with the second substrate and the second luciferase polypeptide does not cross react with the first substrate. The method further comprises contacting the array with the first substrate, which reacts with the first luciferase polypeptide and detecting the first luminescent signal and detecting the second luminescent signal at positions, thereby corresponding positions on an array with the first affinity reagent or the second affinity reagent immobilized at the positions.

Abstract: The invention provides compositions and methods for sequencing nucleic acids and other applications. In sequencing by synthesis, unlabeled reversible terminators are incorporated by a polymerase in each cycle, then labeled after incorporation by binding to the reversible terminator a directly or indirectly labeled antibody or other affinity reagent.

Abstract: A processor includes a block relevance determination hardware unit configured to determine a corresponding degree of relevance metric for each block of pixels included in blocks of pixels of a reference frame of a video being encoded. The processor also includes a hardware circular cache configured to store groups of cache entries. Each cache entry of each group of the groups of cache entries is configured to cache at least one corresponding one of the accumulated relevance amounts for the blocks of pixels of the reference frame. The processor further includes an encoder hardware unit configured to encode the reference frame using different quantization factors determined for a different block of pixels of the reference frame based on the corresponding degree of relevance metric.

Abstract: Provided are a tumour antigen polypeptide having the amino acid sequence as shown in SEQ ID NO: 2 or a variant thereof; a nucleic acid encoding same; a nucleic acid construct, an expression vector, and a host cell comprising the encoding nucleic acid; and an antigen presenting cell presenting the tumour antigen polypeptide on the cell surface and an immune effector cell thereof. Also provided is the use of the polypeptide, nucleic acid, antigen presenting cell or immune effector cell in the diagnosis, prevention and treatment of cancers.

Abstract: Provided is a sequencing chip. The sequencing chip includes: a chip main body, nucleic acids, and a phosphonic acid polymer film. The chip main body includes a plurality of chip particles arranged in a same layer, the chip particles are obtained by cutting a chip matrix along cutting lines of a wafer layer, and the chip matrix includes: the wafer layer having the cutting lines uniformly distributed thereon; a first silicon oxide layer made of silicon oxide and formed on an upper surface of the wafer layer; and a transition metal oxide layer made of a transition metal oxide and formed on an upper surface of the first silicon oxide layer. The nucleic acids are fixed on the transition metal oxide layer; and the phosphonic acid polymer film is made of a polyphosphonic acid polymer and formed on an upper surface of the transition metal oxide layer.

Abstract: One embodiment provides a method for predicting the performance of a device based upon parameters of an underlying material, comprising: measuring a predetermined parameter of a material to be used in manufacturing the device; identifying, from a value generated from the measuring, a value of a property of the material; and determining a predicted performance of the device by correlating the value of the property to a performance value. Other aspects are described and claimed.

Abstract: Various features of a high performance hardware scaler are disclosed herein. In some embodiments, a hardware scaler comprises a first processing unit configured to perform preparation and scaling operations and a second processing unit configured to perform preparation and scaling operations. The first processing unit and the second processing unit alternatively switch between performing preparation and scaling operations when processing a current input pixel block such that the first processing unit performs scaling operations while the second processing unit performs preparation operations and the second processing unit performs scaling operations while the first processing unit performs preparation operations.

Abstract: Provided are a tumor antigen polypeptide having the amino acid sequence as shown in SEQ ID NO: 2 or a variant thereof; a nucleic acid encoding the same; a nucleic acid construct, an expression vector, and a host cell containing the encoding nucleic acid; and an antigen presenting cell presenting the tumor antigen polypeptide on the cell surface and an immune effector cell thereof. Also provided is the use of the polypeptide, nucleic acid, antigen presenting cell or immune effector cell in the diagnosis, prevention and treatment of cancers.

Abstract: The disclosed method may include (1) receiving an input datum to be processed using a non-linear function to produce an output datum, (2) comparing the input datum to a plurality of indexes of a lookup table, where the indexes designate input endpoints of a plurality of piecewise-linear sections approximating the non-linear functions, and where the lookup table further includes, for each of the indexes (a) a slope of the piecewise-linear section corresponding to the index, and (b) an axis intercept of the piecewise-linear section corresponding to the index (2) selecting, based on comparing the input datum to the plurality of indexes, an index that designates the piecewise-linear section associated with the input datum, and (4) calculating, using the slope and the axis intercept corresponding to the selected index, the output data corresponding to the input datum. Video processing systems employing such a method are also disclosed.

Abstract: The invention provides compositions and methods for sequencing nucleic acids and other applications. In sequencing by synthesis, unlabeled reversible terminators are incorporated by a polymerase in each cycle, then labeled after incorporation by binding to the reversible terminator a directly or indirectly labeled antibody or other affinity reagent.

Abstract: Provided are a chip matrix, a sequencing chip, and a manufacturing method thereof. The chip matrix includes: a wafer layer (111), the wafer layer (111) having cutting lines that are evenly distributed thereon; a first silicon oxide layer (112), the first silicon oxide layer (112) being made of silicon oxide and formed on an upper surface of the wafer layer (111); a transition metal oxide layer (113), the transition metal oxide layer (113) being made of transition metal oxide and formed on an upper surface of the first silicon oxide layer (112). The chip matrix has characteristics such as resistances against high temperature, high humidity and other harsh environments. Meanwhile, by changing pH, surfactant and other components of a solution containing sequences to be sequenced, a surface functional region of the chip matrix can specifically adsorb a sequence to be sequenced.

Abstract: The disclosed may include various systems and methods for improving the efficiency and scalability of large-scale systems. For example, the disclosed may include systems and methods for automatic privacy enforcement using privacy-aware infrastructure, scalable general-purpose low cost integer motion search, efficient scaler filter coefficients layout for flexible scaling quality control with limited hardware resources, hardware optimization for power saving with both different codecs enabled, optimizing storage overhead and performance for large distributed data warehouse, mass and volume efficient integration of intersatellite link terminals to a satellite bus, and overcoming retention limit for memory-based distributed database systems.

Abstract: The invention provides compositions and methods for sequencing nucleic acids and other applications. In sequencing by synthesis, unlabeled reversible terminators are incorporated by a polymerase in each cycle, then labeled after incorporation by binding to the reversible terminator a directly or indirectly labeled antibody or other affinity reagent.

Abstract: Reversibly blocked nucleoside analogues and methods of using such nucleoside analogues for sequencing of nucleic acids are provided.

Abstract: Reversibly blocked nucleoside analogues and methods of using such nucleoside analogues for sequencing of nucleic acids are provided.

Abstract: Acridinium ester-containing compounds are provided herein. Also provided herein are chemiluminescence-based one-color sequencing methods and methods of using the acridinium ester-containing compounds in chemiluminescence-based one-color sequencing.