Patents by Inventor Homme W. Hellinga

Homme W. Hellinga has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • RATIONALLY-DESIGNED MEGANUCLEASES WITH ALTERED SEQUENCE SPECIFICITY AND DNA-BINDING AFFINITY
    Publication number: 20240132862
    Abstract: Rationally-designed LAGLIDADG meganucleases and methods of making such meganucleases are provided. In addition, methods are provided for using the meganucleases to generate recombinant cells and organisms having a desired DNA sequence inserted into a limited number of loci within the genome, as well as methods of gene therapy, for treatment of pathogenic infections, and for in vitro applications in diagnostics and research.
    Type: Application
    Filed: September 21, 2023
    Publication date: April 25, 2024
    Applicant: Duke University
    Inventors: James Jefferson Smith, Derek Jantz, Homme W. Hellinga
  • Urea biosensors and uses thereof
    Patent number: 11906524
    Abstract: The present subject matter provides urea biosensors as well as compositions, devices, and methods comprising such biosensors.
    Type: Grant
    Filed: November 19, 2016
    Date of Patent: February 20, 2024
    Assignee: Duke University
    Inventors: Homme W. Hellinga, Malin J. Allert
  • Bicarbonate biosensors, calcium biosensors, and uses thereof
    Patent number: 11852637
    Abstract: The present subject matter provides biosensors for bicarbonate and calcium as well as compositions, devices, and methods comprising such biosensors.
    Type: Grant
    Filed: November 19, 2016
    Date of Patent: December 26, 2023
    Assignee: Duke University
    Inventors: Homme W. Hellinga, Malin J. Allert
  • THERMOSTABLE GLUCOSE BIOSENSORS AND USES THEREOF
    Publication number: 20230194538
    Abstract: The present subject matter provides glucose biosensors as well as compositions, devices, and methods comprising such biosensors.
    Type: Application
    Filed: July 28, 2022
    Publication date: June 22, 2023
    Inventors: Homme W. Hellinga, Malin J. Allert
  • GLUCOSE/GALACTOSE BIOSENSORS AND METHODS OF USING SAME
    Publication number: 20220411847
    Abstract: Provided herein are glucose and galactose biosensors and methods of making and using the same.
    Type: Application
    Filed: June 6, 2022
    Publication date: December 29, 2022
    Inventors: Homme W. Hellinga, Malin Allert
  • GLUCOSE BIOSENSORS AND USES THEREOF
    Publication number: 20220244266
    Abstract: The present subject matter provides glucose biosensors as well as compositions, devices, and methods comprising such biosensors.
    Type: Application
    Filed: September 14, 2021
    Publication date: August 4, 2022
    Inventors: Homme W. Hellinga, Malin J. Allert
  • Thermostable glucose biosensors and uses thereof
    Patent number: 11402384
    Abstract: The present subject matter provides glucose biosensors as well as compositions, devices, and methods comprising such biosensors.
    Type: Grant
    Filed: November 19, 2016
    Date of Patent: August 2, 2022
    Assignee: Duke University
    Inventors: Homme W. Hellinga, Malin J. Allert
  • Glucose/galactose biosensors and methods of using same
    Patent number: 11352657
    Abstract: Provided herein are glucose and galactose biosensors and methods of making and using the same.
    Type: Grant
    Filed: March 4, 2016
    Date of Patent: June 7, 2022
    Assignee: Duke University
    Inventors: Homme W. Hellinga, Malin Allert
  • Glucose biosensors and uses thereof
    Patent number: 11156615
    Abstract: The present subject matter provides glucose biosensors as well as compositions, devices, and methods comprising such biosensors.
    Type: Grant
    Filed: September 2, 2016
    Date of Patent: October 26, 2021
    Assignee: Duke University
    Inventors: Homme W. Hellinga, Malin J. Allert
  • RATIONALLY-DESIGNED MEGANUCLEASES WITH ALTERED SEQUENCE SPECIFICITY AND DNA-BINDING AFFINITY
    Publication number: 20210284980
    Abstract: Rationally-designed LAGLIDADG meganucleases and methods of making such meganucleases are provided. In addition, methods are provided for using the meganucleases to generate recombinant cells and organisms having a desired DNA sequence inserted into a limited number of loci within the genome, as well as methods of gene therapy, for treatment of pathogenic infections, and for in vitro applications in diagnostics and research.
    Type: Application
    Filed: March 23, 2021
    Publication date: September 16, 2021
    Applicant: Duke University
    Inventors: James Jefferson Smith, Derek Jantz, Homme W. Hellinga
  • Lactate biosensors and uses thereof
    Patent number: 11099176
    Abstract: The present subject matter provides lactate biosensors as well as compositions, devices, and methods comprising such biosensors.
    Type: Grant
    Filed: November 19, 2016
    Date of Patent: August 24, 2021
    Assignee: Duke University
    Inventors: Homme W. Hellinga, Malin J. Allert
  • UREA BIOSENSORS AND USES THEREOF
    Publication number: 20200319194
    Abstract: The present subject matter provides urea biosensors as well as compositions, devices, and methods comprising such biosensors.
    Type: Application
    Filed: November 19, 2016
    Publication date: October 8, 2020
    Inventors: Homme W. Hellinga, Malin J. Allert
  • BICARBONATE BIOSENSORS, CALCIUM BIOSENSORS, AND USES THEREOF
    Publication number: 20200284811
    Abstract: The present subject matter provides biosensors for bicarbonate and calcium as well as compositions, devices, and methods comprising such biosensors.
    Type: Application
    Filed: November 19, 2016
    Publication date: September 10, 2020
    Inventors: Homme W. Hellinga, Malin J. Allert
  • THERMOSTABLE GLUCOSE BIOSENSORS AND USES THEREOF
    Publication number: 20200271659
    Abstract: The present subject matter provides glucose biosensors as well as compositions, devices, and methods comprising such biosensors.
    Type: Application
    Filed: November 19, 2016
    Publication date: August 27, 2020
    Inventors: Homme W. Hellinga, Malin J. Allert
  • Biosensor
    Patent number: 10712341
    Abstract: Biosensors are made by attaching covalently or non-covalently at least one reporter group to one or more specific positions of a bacterial periplasmic binding protein (bPBP). Upon binding of ligand to the biosensor, there is a change in the signal transduced by the reporter group.
    Type: Grant
    Filed: April 14, 2017
    Date of Patent: July 14, 2020
    Assignee: Duke University
    Inventors: Homme W. Hellinga, Loren L. Looger
  • RATIONALLY-DESIGNED MEGANUCLEASES WITH ALTERED SEQUENCE SPECIFICITY AND DNA-BINDING AFFINITY
    Publication number: 20200109383
    Abstract: Rationally-designed LAGLIDADG meganucleases and methods of making such meganucleases are provided. In addition, methods are provided for using the meganucleases to generate recombinant cells and organisms having a desired DNA sequence inserted into a limited number of loci within the genome, as well as methods of gene therapy, for treatment of pathogenic infections, and for in vitro applications in diagnostics and research.
    Type: Application
    Filed: September 13, 2019
    Publication date: April 9, 2020
    Applicant: Duke University
    Inventors: James Jefferson Smith, Derek Jantz, Homme W. Hellinga
  • LACTATE BIOSENSORS AND USES THEREOF
    Publication number: 20180364217
    Abstract: The present subject matter provides lactate biosensors as well as compositions, devices, and methods comprising such biosensors.
    Type: Application
    Filed: November 19, 2016
    Publication date: December 20, 2018
    Inventors: Homme W. Hellinga, Malin J. Allert
  • GLUCOSE BISENSORS AND USES THEREOF
    Publication number: 20180328935
    Abstract: The present subject matter provides glucose biosensors as well as compositions, devices, and methods comprising such biosensors.
    Type: Application
    Filed: September 2, 2016
    Publication date: November 15, 2018
    Inventors: Homme W. Hellinga, Malin J. Allert
  • Protein engineering
    Patent number: 9927440
    Abstract: Methods of optimizing mRNA sequences for expression in host cells are provided. Methods of determining the stability of a protein are also provided. Methods of determining the affinity of a ligand for a protein are also provided.
    Type: Grant
    Filed: November 24, 2010
    Date of Patent: March 27, 2018
    Assignee: Duke University
    Inventors: Homme W. Hellinga, Malin J. Allert
  • GLUCOSE/GALACTOSE BIOSENSORS AND METHODS OF USING SAME
    Publication number: 20180037928
    Abstract: Provided herein are glucose and galactose biosensors and methods of making and using the same.
    Type: Application
    Filed: March 4, 2016
    Publication date: February 8, 2018
    Inventors: Homme W. Hellinga, Malin J. Allert