Patents by Inventor Homme W. Hellinga

Homme W. Hellinga has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • RATIONALLY-DESIGNED MEGANUCLEASES WITH ALTERED SEQUENCE SPECIFICITY AND DNA-BINDING AFFINITY
    Publication number: 20170335299
    Abstract: Rationally-designed LAGLIDADG meganucleases and methods of making such meganucleases are provided. In addition, methods are provided for using the meganucleases to generate recombinant cells and organisms having a desired DNA sequence inserted into a limited number of loci within the genome, as well as methods of gene therapy, for treatment of pathogenic infections, and for in vitro applications in diagnostics and research.
    Type: Application
    Filed: March 11, 2017
    Publication date: November 23, 2017
    Applicant: Duke University
    Inventors: James Jefferson SMITH, Derek JANTZ, Homme W. HELLINGA
  • BIOSENSOR
    Publication number: 20170322209
    Abstract: Biosensors are made by attaching covalently or non-covalently at least one reporter group to one or more specific positions of a bacterial periplasmic binding protein (bPBP). Upon binding of ligand to the biosensor, there is a change in the signal transduced by the reporter group.
    Type: Application
    Filed: April 14, 2017
    Publication date: November 9, 2017
    Inventors: Homme W. Hellinga, Loren L. Looger
  • Biosensor
    Patent number: 9625458
    Abstract: Biosensors are made by attaching covalently or non-covalently at least one reporter group to one or more specific positions of a bacterial periplasmic binding protein (bPBP). Upon binding of ligand to the biosensor, there is a change in the signal transduced by the reporter group.
    Type: Grant
    Filed: October 16, 2003
    Date of Patent: April 18, 2017
    Assignee: Duke University
    Inventors: Homme W. Hellinga, Loren L. Looger
  • Rationally Designed Meganucleases With Altered Sequence Specificity and DNA-Binding Affinity
    Publication number: 20150135345
    Abstract: Rationally-designed LAGLIDADG meganucleases and methods of making such meganucleases are provided. In addition, methods are provided for using the meganucleases to generate recombinant cells and organisms having a desired DNA sequence inserted into a limited number of loci within the genome, as well as methods of gene therapy, for treatment of pathogenic infections, and for in vitro applications in diagnostics and research.
    Type: Application
    Filed: August 19, 2014
    Publication date: May 14, 2015
    Inventors: James Jefferson SMITH, Derek JANTZ, Homme W. HELLINGA
  • Method for producing genetically-modified cells with rationally-designed meganucleases with altered sequence specificity
    Patent number: 8377674
    Abstract: Rationally-designed LAGLIDADG meganucleases and methods of making such meganucleases are provided. In addition, methods are provided for using the meganucleases to generate recombinant cells and organisms having a desired DNA sequence inserted into a limited number of loci within the genome, as well as methods of gene therapy, for treatment of pathogenic infections, and for in vitro applications in diagnostics and research.
    Type: Grant
    Filed: June 25, 2012
    Date of Patent: February 19, 2013
    Assignee: Duke University
    Inventors: James Jefferson Smith, Derek Jantz, Homme W. Hellinga
  • Rationally-designed meganucleases with altered sequence specificity and heterodimer formation
    Patent number: 8304222
    Abstract: Rationally-designed LAGLIDADG meganucleases and methods of making such meganucleases are provided. In addition, methods are provided for using the meganucleases to generate recombinant cells and organisms having a desired DNA sequence inserted into a limited number of loci within the genome, as well as methods of gene therapy, for treatment of pathogenic infections, and for in vitro applications in diagnostics and research.
    Type: Grant
    Filed: April 26, 2012
    Date of Patent: November 6, 2012
    Assignee: Duke University
    Inventors: James Jefferson Smith, Derek Jantz, Homme W. Hellinga
  • METHODS OF PRODUCING GENETICALLY-MODIFIED EUKARYOTIC CELLS WITH RATIONALLY-DESIGNED MEGANUCLEASES
    Publication number: 20120266266
    Abstract: Rationally-designed LAGLIDADG meganucleases and methods of making such meganucleases are provided. In addition, methods are provided for using the meganucleases to generate recombinant cells and organisms having a desired DNA sequence inserted into a limited number of loci within the genome, as well as methods of gene therapy, for treatment of pathogenic infections, and for in vitro applications in diagnostics and research.
    Type: Application
    Filed: June 25, 2012
    Publication date: October 18, 2012
    Applicant: DUKE UNIVERSITY
    Inventors: James J. SMITH, Derek JANTZ, Homme W. HELLINGA
  • Rationally-Designed Meganucleases With Altered Sequence Specificity and DNA-Binding Affinity
    Publication number: 20120264189
    Abstract: Rationally-designed LAGLIDADG meganucleases and methods of making such meganucleases are provided. In addition, methods are provided for using the meganucleases to generate recombinant cells and organisms having a desired DNA sequence inserted into a limited number of loci within the genome, as well as methods of gene therapy, for treatment of pathogenic infections, and for in vitro applications in diagnostics and research.
    Type: Application
    Filed: April 26, 2012
    Publication date: October 18, 2012
    Inventors: James J. Smith, Derek Jantz, Homme W. Hellinga
  • Methods of cleaving DNA with rationally-designed meganucleases
    Patent number: 8163514
    Abstract: Rationally-designed LAGLIDADG meganucleases and methods of making such meganucleases are provided. In addition, methods are provided for using the meganucleases to generate recombinant cells and organisms having a desired DNA sequence inserted into a limited number of loci within the genome, as well as methods of gene therapy, for treatment of pathogenic infections, and for in vitro applications in diagnostics and research.
    Type: Grant
    Filed: September 27, 2011
    Date of Patent: April 24, 2012
    Assignee: Duke University
    Inventors: James Jefferson Smith, Derek Jantz, Homme W. Hellinga
  • Biological systems input-output response system and plant sentinels
    Patent number: 8148605
    Abstract: A eukaryotic input circuit: computationally designed receptors, synthetic eukaryotic signal transduction pathways, and a synthetic signal sensitive promoter that allow highly specific transcriptional induction in response to an externally provided ligand is disclosed. The input circuit is able to specifically bind a targeted substance and transmit a signal to the nucleus where transcription of a gene is activated. An output circuit serves as a simple readout system of the substance detected by the input circuit. The readout circuit exemplified here is a degreening circuit which causes plants to turn white. Activation of the degreening circuit can be detected by eye, or remotely with a variety of machines (hand-held, aircraft or satellite based) and is also resettable. When linked the input circuit if operably linked to the output circuit, produces a functional plant detector.
    Type: Grant
    Filed: April 25, 2007
    Date of Patent: April 3, 2012
    Assignees: Colorado State University Research Foundation, Duke University
    Inventors: June Medford, Mauricio S. Antunes, Kevin J. Morey, Homme W. Hellinga, James Jefferson Smith
  • Methods of cleaving DNA with rationally-designed meganucleases
    Patent number: 8148098
    Abstract: Rationally-designed LAGLIDADG meganucleases and methods of making such meganucleases are provided. In addition, methods are provided for using the meganucleases to generate recombinant cells and organisms having a desired DNA sequence inserted into a limited number of loci within the genome, as well as methods of gene therapy, for treatment of pathogenic infections, and for in vitro applications in diagnostics and research.
    Type: Grant
    Filed: September 27, 2011
    Date of Patent: April 3, 2012
    Assignee: Duke University
    Inventors: James Jefferson Smith, Derek Jantz, Homme W. Hellinga
  • Methods of cleaving DNA with rationally-designed meganucleases
    Patent number: 8143015
    Abstract: Rationally-designed LAGLIDADG meganucleases and methods of making such meganucleases are provided. In addition, methods are provided for using the meganucleases to generate recombinant cells and organisms having a desired DNA sequence inserted into a limited number of loci within the genome, as well as methods of gene therapy, for treatment of pathogenic infections, and for in vitro applications in diagnostics and research.
    Type: Grant
    Filed: September 26, 2011
    Date of Patent: March 27, 2012
    Assignee: Duke University
    Inventors: James Jefferson Smith, Derek Jantz, Homme W. Hellinga
  • Methods of cleaving DNA with rationally-designed meganucleases
    Patent number: 8143016
    Abstract: Rationally-designed LAGLIDADG meganucleases and methods of making such meganucleases are provided. In addition, methods are provided for using the meganucleases to generate recombinant cells and organisms having a desired DNA sequence inserted into a limited number of loci within the genome, as well as methods of gene therapy, for treatment of pathogenic infections, and for in vitro applications in diagnostics and research.
    Type: Grant
    Filed: September 27, 2011
    Date of Patent: March 27, 2012
    Assignee: Duke University
    Inventors: James Jefferson Smith, Derek Jantz, Homme W. Hellinga
  • RATIONALLY DESIGNED MEGANUCLEASES WITH ALTERED SEQUENCE SPECIFICITY AND DNA-BINDING AFFINITY
    Publication number: 20120070877
    Abstract: Rationally-designed LAGLIDADG meganucleases and methods of making such meganucleases are provided. In addition, methods are provided for using the meganucleases to generate recombinant cells and organisms having a desired DNA sequence inserted into a limited number of loci within the genome, as well as methods of gene therapy, for treatment of pathogenic infections, and for in vitro applications in diagnostics and research.
    Type: Application
    Filed: December 1, 2011
    Publication date: March 22, 2012
    Applicant: Duke University
    Inventors: James J. Smith, Derek Jantz, Homme W. Hellinga
  • Methods of cleaving DNA with rationally-designed meganucleases
    Patent number: 8133697
    Abstract: Rationally-designed LAGLIDADG meganucleases and methods of making such meganucleases are provided. In addition, methods are provided for using the meganucleases to generate recombinant cells and organisms having a desired DNA sequence inserted into a limited number of loci within the genome, as well as methods of gene therapy, for treatment of pathogenic infections, and for in vitro applications in diagnostics and research.
    Type: Grant
    Filed: September 27, 2011
    Date of Patent: March 13, 2012
    Assignee: Duke University
    Inventors: James Jefferson Smith, Derek Jantz, Homme W. Hellinga
  • Methods of cleaving DNA with rationally-designed meganucleases
    Patent number: 8129134
    Abstract: Rationally-designed LAGLIDADG meganucleases and methods of making such meganucleases are provided. In addition, methods are provided for using the meganucleases to generate recombinant cells and organisms having a desired DNA sequence inserted into a limited number of loci within the genome, as well as methods of gene therapy, for treatment of pathogenic infections, and for in vitro applications in diagnostics and research.
    Type: Grant
    Filed: September 27, 2011
    Date of Patent: March 6, 2012
    Assignee: Duke University
    Inventors: James Jefferson Smith, Derek Jantz, Homme W. Hellinga
  • Method of cleaving DNA with rationally-designed meganucleases
    Patent number: 8124369
    Abstract: Rationally-designed LAGLIDADG meganucleases and methods of making such meganucleases are provided. In addition, methods are provided for using the meganucleases to generate recombinant cells and organisms having a desired DNA sequence inserted into a limited number of loci within the genome, as well as methods of gene therapy, for treatment of pathogenic infections, and for in vitro applications in diagnostics and research.
    Type: Grant
    Filed: September 27, 2011
    Date of Patent: February 28, 2012
    Assignee: Duke University
    Inventors: James Jefferson Smith, Derek Jantz, Homme W. Hellinga
  • Methods of cleaving DNA with rationally-designed meganucleases
    Patent number: 8119361
    Abstract: Rationally-designed LAGLIDADG meganucleases and methods of making such meganucleases are provided. In addition, methods are provided for using the meganucleases to generate recombinant cells and organisms having a desired DNA sequence inserted into a limited number of loci within the genome, as well as methods of gene therapy, for treatment of pathogenic infections, and for in vitro applications in diagnostics and research.
    Type: Grant
    Filed: September 26, 2011
    Date of Patent: February 21, 2012
    Assignee: Duke University
    Inventors: James Jefferson Smith, Derek Jantz, Homme W. Hellinga
  • Rationally-designed meganucleases with altered sequence specificity and DNA-binding affinity
    Patent number: 8119381
    Abstract: Rationally-designed LAGLIDADG meganucleases and methods of making such meganucleases are provided. In addition, methods are provided for using the meganucleases to generate recombinant cells and organisms having a desired DNA sequence inserted into a limited number of loci within the genome, as well as methods of gene therapy, for treatment of pathogenic infections, and for in vitro applications in diagnostics and research.
    Type: Grant
    Filed: September 26, 2011
    Date of Patent: February 21, 2012
    Assignee: Duke University
    Inventors: James Jefferson Smith, Derek Jantz, Homme W. Hellinga
  • RATIONALLY-DESIGNED MEGANUCLEASES WITH ALTERED SEQUENCE SPECIFICITY AND DNA-BINDING AFFINITY
    Publication number: 20120040405
    Abstract: Rationally-designed LAGLIDADG meganucleases and methods of making such meganucleases are provided. In addition, methods are provided for using the meganucleases to generate recombinant cells and organisms having a desired DNA sequence inserted into a limited number of loci within the genome, as well as methods of gene therapy, for treatment of pathogenic infections, and for in vitro applications in diagnostics and research.
    Type: Application
    Filed: September 26, 2011
    Publication date: February 16, 2012
    Inventors: James J. Smith, Derek Jantz, Homme W. Hellinga