Abstract: Bispecific aptamers having a first end that specifically binds to a first tumor specific marker, tumor antigen, or viral protein and a second end that specifically binds to a second tumor specific marker, tumor antigen, or viral protein are provide. The bispecific aptamers can be used to treat cancer or virally infected cells. Generally, the bispecific aptamers bind to two surface proteins, preferably different proteins, on the same cell. In a preferred embodiment the bispecific aptamers bind to two different tumor markers, tumor antigens, tumor specific proteins and combinations thereof.

Abstract: Techniques for reducing read disturb of memory cells in a two-tier stack having a lower tier and an upper tier separated by an interface. In a read operation, the channels of NAND strings are discharged before reading the selected memory cells. The discharge involves ramping up the word line voltages and grounding the ends of the NAND strings. To increase the discharge, a ramp up rate may be greater for the selected word line and for dummy memory cells adjacent to the interface, compared to the ramp up rate for the unselected word lines. In an option, the greater ramp up rate is also used for the word lines between the selected word line and the interface. In another option, the greater ramp up rate is used for the word lines in the same tier as the selected word line.

Abstract: Techniques for reducing read disturb of memory cells. A discharge process reduces a channel gradient in a NAND string by using a two-step ramp up of adjacent word lines of the selected word line. The voltages of the adjacent word lines can be provided at an intermediate level while the selected word line voltage is spiked up to a read pass voltage and then decreased. The voltages of the adjacent word lines can then be increased from the intermediate level to a read pass voltage and maintained at that level during the sensing of the memory cells. The voltage of the selected word line is decreased from a read pass voltage to a positive control gate read voltage at the end of the discharge process.

Abstract: In one embodiment, a method includes a computer server machine receiving information about a first media player event with the information about the first media player event including a viewing session identifier. Using a state machine, the computer server machine identifies a current state of the viewing session using the information about the first media player event. The computer server machine receives information about a second media player event. Using a state machine, the computer server machine identifies a subsequent state of the viewing session using the information about the second media player event. The computer server machine calculates metrics for the viewing session based on the current state and subsequent state, and stores the metrics. The computer server machine generates a session summary with the session summary including information about the metrics for the viewing session.

Abstract: Techniques are described for reducing an injection type of program disturb in a memory device. A charge isolation region is created in a channel of a NAND string on the source side of the selected word line, WLn, and spaced apart from WLn by one or more other word lines, when the program voltage is increased to a program voltage (Vpgm). The isolation region is created by applying 0 V or other low voltage to an isolation word line. The isolation region is maintained for a first portion of a time period in which Vpgm is applied. The charge isolation region can be modified based on factors associated with a risk of program disturb including the magnitude of Vpgm, the position of WLn in a set of word lines and an ambient temperature.

Abstract: The present invention provides devices and methods for treating depression in a patient, comprising administering to the patient in need of the treatment a therapeutically effective amount of esketamine. In some embodiments, the depression is major depressive disorder or treatment resistant depression. In other embodiments, the therapeutically effective amount is clinically proven safe and/or effective. Also provided are methods to mitigate the risk or misuse or abuse of esketamine, instructions for use of the esketamine product, and methods for selling a drug product containing esketamine.

Abstract: Apparatuses and techniques are described for reducing an injection type of program disturb in a memory device. A voltage on a selected word line is increased in a first step from an initial level such as 0 V to an intermediate, pass level such as Vpass, and in a second step from Vpass to a peak program level of Vpgm. A voltage on an adjacent unselected word line can be increased from the initial level to Vpass and then temporarily increased to an elevated level of Vpass_el during the second step increase on the selected word line. This helps reduce the magnitude of a channel gradient between the selected word line and the adjacent word line. The increase to Vpass_el may be implemented for program loops in the later part of a program operation, when Vpgm and the risk of program disturb is relatively high.

Abstract: Apparatuses and techniques are described for reducing an injection type of program disturb in a memory device. A voltage on a selected word line is increased in a first step from an initial level such as 0 V to an intermediate, pass level such as Vpass, and in a second step from Vpass to a peak program level of Vpgm. A voltage on an adjacent unselected word line can be increased from the initial level to Vpass and then temporarily increased to an elevated level of Vpass_el during the second step increase on the selected word line. This helps reduce the magnitude of a channel gradient between the selected word line and the adjacent word line. The increase to Vpass_el may be implemented for program loops in the later part of a program operation, when Vpgm and the risk of program disturb is relatively high.

Abstract: A circuit module includes a power amplifier, a switch, and a bypass capacitor. The power amplifier has a signal input node coupled to an input signal, a signal output node to generate an output signal, and a power input node coupled to a supply output signal of a supply modulator. The switch is coupled between the power input node of the power amplifier and the bypass capacitor. The bypass capacitor is an equivalently removable bypass capacitor coupled between the switch and a ground level.

Abstract: Methods, systems, and articles of manufacture are described that facilitate computation of a model of an interface between two molecules and analyzing characteristics of the interface. The complex of the two molecules can be modeled, and location of the atoms on the surface can be determined. One of the two molecules can be similarly modeled, and the location of the atoms on the surface can be determined. An interface model utilizing atoms that are located in the same place on the complex and the molecule can be calculated. Properties of the interface can be utilized to analyze the interaction between the two molecules.

Abstract: A package or a chip including a linear amplifier and a power amplifier is provided, wherein the linear amplifier is configured to receive an envelope tracking signal to generate an amplified envelope tracking signal, the power amplifier is supplied by an envelope tracking supply voltage comprising a DC supply voltage and the amplified envelope tracking signal, and the power amplifier is configured to receive an input signal to generate an output signal.

Abstract: A micro water pump capable of controlling flow precisely includes an upper cover, a valve seat, a water capsule seat, a base casing, a water capsule, a crank lever, a drive shaft, an eccentric wheel, a motor, a photoelectric switch, and an output circuit board. The output circuit board is electrically connected with an external motor controller. Through the photoelectric switch to detect the revolution of the motor and to cooperate with the external motor controller, the revolution of the motor control can be controlled precisely so as to get a stable water flow under different volumes and back pressures.

Abstract: In one embodiment, a method includes managing delivery of messages to non-stationary mobile clients. A computing system receives a request from a first user to send a message to a second user. The computing system then accesses the location information of the second user which includes the velocity of the mobile client of the second user. The computing system further accesses the activity information of the second user which indicates if the second user is currently active on a social-networking application. If the velocity indicates that the second user is non-stationary, the computing system then determines an activity-level of the second user. If the activity-level is below a threshold activity-level, the computing system confirms with the first user whether the message to the second user should be sent. If the activity-level is above a threshold activity-level, the computing system sends the message to the receiver.

Abstract: Techniques for reducing program disturb of memory cells which are formed in a two-tier stack, when a selected word line is in the upper tier. In one approach, at the start of the program phase of a program loop, voltages of word lines adjacent to the interface are increased to a pass voltage before voltages of remaining word lines are increased to a pass voltage. This delay provides time for residue electrons in the lower tier to move toward the drain end of a NAND string to reduce the likelihood of program disturb. In another approach, the voltages of the word lines adjacent to the interface are maintained at 0 V or other turn-off voltage during the program phase to block the passage of residue electrons from the lower tier to the upper tier.

Abstract: The present invention relates to hydroxamate compounds which are inhibitors of histone deacetylase. More particularly, the present invention relates to benzimidazole containing compounds and methods for their preparation. These compounds may be useful as medicaments for the treatment of proliferative disorders as well as other diseases involving, relating to or associated with dysregulation of histone deacetylase (HDAC).

Abstract: Facilitation of monitoring and analysis of user motion is performed to facilitate detecting when a user has fallen. A device can comprise a housing configured to attach to a body part of a human, a sensor module configured to capture motion data corresponding to motion of an object to which the device is attached, and a communication module configured to communicatively couple the sensor module to another device and transmit the motion data to the other device, wherein the motion data is configured to be analyzed by the other device to determine a type of the motion of the object, and in response to a determination that the type of motion is a falling motion, the other device is configured to activate a notification mechanism to notify an entity that the human has fallen.

Abstract: A base assembly integrated into an appliance including a lower frame and an upper operating component. A plurality of inter-assembleable and planar shaped members include each of a bottom and upwardly supported and interconnected front, back and sides, these collectively defining an enclosure having an upper surface adapted to support the operating component and a lower surface adapted to secure upon the lower frame. Mounting hardware including at least a plurality of threaded fasteners secures the bottom to locations along the front and back. Pluralities of vertically spaced tabs and opposing vertically spaced slots are configured along each of opposite edges of the sides and along each of first and second pairs of opposite edge extending brackets secured to each of the front and back and which overlap the side edges. The planar shaped members and mounting hardware are adapted to being shipped in a first flat-packed arrangement and subsequently assembled on site in a second use arrangement.

Abstract: In one embodiment, a method includes managing delivery of messages to non-stationary mobile clients. A computing system receives a request from a first user to send a message to a second user. The computing system then accesses the location information of the second user which includes the velocity of the mobile client of the second user. The computing system further accesses the activity information of the second user which indicates if the second user is currently active on a social-networking application. If the velocity indicates that the second user is non-stationary, the computing system then determines an activity-level of the second user. If the activity-level is below a threshold activity-level, the computing system confirms with the first user whether the message to the second user should be sent. If the activity-level is above a threshold activity-level, the computing system sends the message to the receiver.

Abstract: An aptamer platform capable of efficiently delivering and silencing one, two or more genes in vivo or in vitro is provided. Methods of using the aptamer compositions for selectively targeting cells to down-regulate the expression of multiple genes are also provided.