Patent number: 6514983
Abstract: This invention relates to compounds, pharmaceutical compositions, and methods of using compounds of the formula:
or a pharmaceutically acceptable salt, hydrate, prodrug, or mixtures thereof, wherein
Y is alkylhalo, alkyl-CO—G, COG, a direct bond, C═O, O, NR11, or CR8;
G is NR11R16, OR9, SR9, or R10;
Z is O, S, or NR11;
X is NR16, O, S, CR12R13, C═O, a bond, —CR12═CR13—, —C(R12R13)C(R14R15)—, or;
Rhd 1, R2, R3, R4, R5, R6, R7, R8, R10, R12, R13, R14, or R15 are independently: hydrogen, halo, alkylhalo, hydroxy, C1-C9 straight or branched chain alkyl, C2-C9 straight or branched chain alkenyl group, C3-C8 cycloalkyl, C5-C7 cycloalkenyl, aryl, amino, alkylamino, nitro, nitroso, carboxy, or aralkyl;
R9 is hydrogen, hydroxy, C1-C9 straight or branched chain alkyl, C2-C9 straight or branched chain alkenyl group, C3-C8 cycloalkyl, C5-C7 cycloalkenyl, aryl, amino, alkylamino, carboxy, or aralkyl;
R11 or R16 are independently: hydrogen, halo, alkylha
Type:
Grant
Filed:
September 1, 1998
Date of Patent:
February 4, 2003
Assignee:
Guilford Pharmaceuticals Inc.
Inventors:
Jia-He Li, Jie Zhang, Paul F. Jackson, Keith M. Maclin