Patents by Inventor Jia-He Li

Jia-He Li has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Substituted 4,9-dihydrocyclopent a [imn] phenanthridine-5-ones, derivatives thereof and their uses
    Publication number: 20020037904
    Abstract: This invention relates to compounds, pharmaceutical compositions, and methods of using the disclosed compounds for inhibiting PARP.
    Type: Application
    Filed: July 2, 2001
    Publication date: March 28, 2002
    Inventors: Jia-He Li, Jie Zhang, Vincent J. Kalish
  • OXO-SUBSTITUTED COMPOUNDS, PROCESS OF MAKING, AND COMPOSITIONS AND METHODS FOR INHIBITING PARP ACTIVITY
    Publication number: 20020022636
    Abstract: Compounds, compositions containing compounds, methods of using compounds, and processes of making compounds, of formula I containing at least one ring nitrogen: 1
    Type: Application
    Filed: September 1, 1998
    Publication date: February 21, 2002
    Inventors: JIA-HE LI, KEVIN LEONARD TAYS, JIE ZHANG
  • Methods, compounds and compositions for treating gout
    Patent number: 6348475
    Abstract: This invention relates to methods of preventing, treating or lessening the severity of gout by administration of PARP inhibitors.
    Type: Grant
    Filed: June 1, 2001
    Date of Patent: February 19, 2002
    Assignee: Guilford Pharmaceuticals Inc.
    Inventors: Jie Zhang, Jia-He Li
  • Methods, compounds and compositions for treating gout
    Publication number: 20020019417
    Abstract: This invention relates to methods of preventing, treating or lessening verity of gout by administration of PARP inhibitors.
    Type: Application
    Filed: June 1, 2001
    Publication date: February 14, 2002
    Inventors: Jie Zhang, Jia-He Li
  • Poly(ADP-ribose) polymerase inhibitors and method for treating neural or cardiovascular tissue damage using the same
    Patent number: 6346536
    Abstract: Poly(ADP-ribose) polymerase (“PARP”) inhibitors and methods for treating neurodegenerative diseases, neural tissue damage related to cerebral ischemia and reperfusion injury, and cardiovascular in an animal.
    Type: Grant
    Filed: September 3, 1997
    Date of Patent: February 12, 2002
    Assignee: Guilford Pharmaceuticals Inc.
    Inventors: Jia-He Li, Paul F. Jackson, Keith M. Maclin, Jie Zhang
  • Sulfonamide and carbamide derivatives of 6(5H)phenanthridinones and their uses
    Publication number: 20020006927
    Abstract: This invention relates to compounds, pharmaceutical compositions, and methods of using the disclosed compounds for inhibiting PARP.
    Type: Application
    Filed: May 15, 2001
    Publication date: January 17, 2002
    Inventors: Jia-He Li, Vincent J. Kalish, Jie Zhang, Larisa E. Serdyuk, Dana Victor Ferraris, Ge Xiao, Paul W. Kletzly
  • Heterocyclic ketone and thioester compounds and uses
    Publication number: 20010056103
    Abstract: This invention relates to neurotrophic, low molecular weight, small molecule heterocyclic ketone and thioester compounds, compositions containing the same, and the use of such compounds for treating neurological disorders, including physically damaged nerves and neurodegenerative diseases.
    Type: Application
    Filed: December 11, 2000
    Publication date: December 27, 2001
    Applicant: GPI NIL HOLDINGS, Inc.
    Inventors: Gregory S. Hamilton, Jia-He Li
  • Compounds, methods and pharmaceutical compositions for treating neural or cardiovascular tissue damage
    Patent number: 6306889
    Abstract: This invention relates to compounds, pharmaceutical compositions, and methods for the treatment or prevention of neural or cardiovascular tissue damage related to cerebral ischemia and reperfusion injury in an animal by administering Poly(ADP-ribose) polymerase (“PARP”) inhibitors.
    Type: Grant
    Filed: March 25, 1998
    Date of Patent: October 23, 2001
    Assignee: Guilford Pharmaceuticals Inc.
    Inventors: Jia-He Li, Jie Zhang, Paul F. Jackson, Keith M. Maclin
  • Compounds, methods and pharmaceutical compositions for treating cellular damage, such as neural or cardiovascular tissue damage
    Patent number: 6291425
    Abstract: This invention relates to compounds, pharmaceutical compositions, and methods of using the disclosed compounds for inhibiting PARP.
    Type: Grant
    Filed: September 1, 1999
    Date of Patent: September 18, 2001
    Assignee: Guilford Pharmaceuticals Inc.
    Inventors: Jia-He Li, Jie Zhang
  • Ortho-diphenol compounds, methods and pharmaceutical compositions for inhibiting parp
    Publication number: 20010020013
    Abstract: This invention relates to compounds, pharmaceutical compositions, and methods of using compounds of the formula; 1
    Type: Application
    Filed: December 26, 2000
    Publication date: September 6, 2001
    Applicant: GUILFORD PHARMACEUTICALS, INC.
    Inventors: Jie Zhang, Larisa E. Serdyuk, Jia-He Li
  • N-linked ureas and carbamates of heterocyclic thioesters
    Patent number: 6274607
    Abstract: This invention relates to neurotrophic low molecular weight, small molecule N-linked ureas and carbamates of heterocyclic thioesters having an affinity for FKBP-type immunophilins, and their use as inhibitors of the enzyme activity associated with immunophilin proteins, particularly peptidyl-prolyl isomerase, or rotamase, enzyme activity.
    Type: Grant
    Filed: September 10, 1999
    Date of Patent: August 14, 2001
    Assignee: GPI NIL Holdings, Inc.
    Inventors: Gregory S. Hamilton, Jia-He Li, Wei Huang
  • Method of using neurotrophic sulfonamide compounds
    Patent number: 6245783
    Abstract: This invention relates to a method of using neurotrophic low molecular weight, small molecule sulfonamide compounds having an affinity for FKBP-type immunophilins, as inhibitors of the enzyme activity associated with immunophilin proteins, particularly peptidyl-prolyl isomerase, or rotamase, enzyme activity.
    Type: Grant
    Filed: October 18, 1999
    Date of Patent: June 12, 2001
    Assignee: GPI NIL Holdings, Inc.
    Inventors: Gregory S. Hamilton, Jia-He Li, Joseph P. Steiner
  • Carbamate and urea compositions and neurotrophic uses
    Patent number: 6242468
    Abstract: This invention relates to pharmaceutical compositions and methods for effecting a neuronal activity using low molecular weight, small molecule carbamates and ureas having an affinity for FKBP-type immunophilins.
    Type: Grant
    Filed: August 25, 1998
    Date of Patent: June 5, 2001
    Inventors: Jia-He Li, Joseph P. Steiner, Gregory S. Hamilton
  • Oxo-substituted compounds, process of making, and compositions and methods for inhibiting parp activity
    Patent number: 6235748
    Abstract: A compound of formula I containing at least one ring nitrogen: or a pharmaceutically acceptable base or acid addition salt, prodrug, metabolite, optical isomer or stereoisomer thereof.
    Type: Grant
    Filed: March 14, 2000
    Date of Patent: May 22, 2001
    Assignee: Guilford Pharmaceuticals Inc.
    Inventors: Jia-He Li, Jie Zhang
  • Heterocyclic esters and amides
    Patent number: 6218544
    Abstract: This invention relates to neurotrophic low molecular weight, small molecule heterocyclic esters and amides having an affinity for FKBP-type immunophilins, and their use as inhibitors of the enzyme activity associated with immunophilin proteins, particularly peptidyl-prolyl isomerase, or rotamase, enzyme activity.
    Type: Grant
    Filed: November 18, 1999
    Date of Patent: April 17, 2001
    Assignee: Gpi Nil Holdings, Inc.
    Inventors: Jia-He Li, Gregory S. Hamilton
  • Heterocyclic ketone and thioester compounds and uses
    Patent number: 6218424
    Abstract: This invention relates to neurotrophic, low molecular weight, small molecule heterocyclic ketone and thioester compounds, compositions containing the same, and the use of such compounds for treating neurological disorders, including physically damaged nerves and neurodegenerative diseases.
    Type: Grant
    Filed: November 22, 1999
    Date of Patent: April 17, 2001
    Assignee: GPI NIL Holdings, Inc.
    Inventors: Gregory S. Hamilton, Jia-He Li
  • Ortho-diphenol compounds, methods and pharmaceutical compositions for inhibiting parp
    Patent number: 6201020
    Abstract: This invention relates to compounds, pharmaceutical compositions, and methods of using compounds of the formula: A is O or S; R is C1-C10 straight or branched chain alkyl, C2-C10 straight or branched chain alkenyl, C2-C10 straight or branched chain alkynyl, aryl, heteroaryl, carbocycle, or heterocycle; D is a bond, or a C1-C3 straight or branched chain alkyl, C2-C3 straight or branched chain alkenyl, C2-C3 straight or branched chain alkynyl, wherein any of the carbon atoms of said alkyl, alkenyl, or alkynyl of D are optionally replaced with oxygen, nitrogen, or sulfur; and X is aryl, heteroaryl, carbocycle, or heterocycle.
    Type: Grant
    Filed: December 31, 1998
    Date of Patent: March 13, 2001
    Assignee: Guilford Pharmaceuticals, Inc.
    Inventors: Jie Zhang, Larisa E. Serdyuk, Jia-He Li
  • Heterocyclic esters and amides
    Patent number: 6200972
    Abstract: This invention relates to neurotrophic low molecular weight, small molecule heterocyclic esters and amides having an affinity for FKBP-type immunophilins, and their use as inhibitors of the enzyme activity associated with immunophilin proteins, particularly peptidyl-prolyl isomerase, or rotamase, enzyme activity.
    Type: Grant
    Filed: February 23, 1998
    Date of Patent: March 13, 2001
    Assignee: GPI NIL Holdings, Inc.
    Inventors: Jia-He Li, Gregory S. Hamilton
  • N-linked ureas and carbamates of heterocyclic thioesters
    Patent number: 6184243
    Abstract: This invention relates to neurotrophic low molecular weight, small molecule N-linked ureas and carbamates of heterocyclic thioesters having an affinity for FKBP-type immunophilins, and their use as inhibitors of the enzyme activity associated with immunophilin proteins, particularly peptidyl-prolyl isomerase, or rotamase, enzyme activity.
    Type: Grant
    Filed: October 2, 1998
    Date of Patent: February 6, 2001
    Assignee: GPI NIL Holdings, Inc.
    Inventors: Gregory S. Hamilton, Jia-He Li, Wei Huang
  • Heterocyclic thioesters and ketones
    Patent number: 5990131
    Abstract: This invention relates to neurotrophic low molecular weight, small molecule heterocyclic thioesters and ketones having an affinity for FKBP-type immunophilins, and their use as inhibitors of the enzyme activity associated with immunophilin proteins, particularly peptidyl-prolyl isomerase, or rotamase, enzyme activity.
    Type: Grant
    Filed: August 1, 1997
    Date of Patent: November 23, 1999
    Assignee: Gpi Nil Holdings Inc.
    Inventors: Gregory S. Hamilton, Jia-He Li