Abstract: Disclosed are a control method and apparatus for safety boot of a chip, an electronic device and a storage medium. The method includes: determining, at a preset stage of a chip boot process, first mirror data to be checked at the preset stage and first check code corresponding to the first mirror data, from a decryption result obtained by a hardware security module; determining second check code based on the first mirror data; comparing the second check code with the first check code to obtain a comparison result; determining an integrity check result of the first mirror data based on the comparison result; and executing, based on the integrity check result, a safety boot program corresponding to the first mirror data at the preset stage.

Abstract: An engine includes an engine water jacket, a water pump and a thermostat assembly. The engine water jacket, the thermostat assembly and the water pump are connected to form a circulation passage. The thermostat assembly is connected between the engine water jacket and the water pump. The engine water jacket includes a cylinder head water jacket and a cylinder block water jacket. The thermostat assembly is configured to enable the coolant to enter the cylinder head water jacket of the cylinder head water jacket and the cylinder block water jacket upon cold start.

Abstract: A porous biochar for improving heavy pollution and a method for producing the same. Said porous biochar is prepared as follows: arrowhead, which has excellent enrichment of lead, is used to absorb heavy metal lead in polluted water or artificial wetlands, simultaneously absorb heavy metal cadmium, thereafter is dried and treated as a biomass, and then the biomass is calcined in stages with a passivating agent in a high temperature environment, so as to heavy metals such as lead and cadmium be stably coated or enriched in a biochar, which is mixed with Pseudomonas aeruginosa having high resistant, to obtain the porous biochar; the porous biochar has high specific surface area, high porosity and excellent mechanical properties, is very stable under different acid-base environments and oxidizing conditions.

Abstract: An integrated circuit includes an input circuit coupled to a first voltage supply, and configured to receive a first input signal, and to generate at least a second or a third input signal, and a level shifter circuit coupled to the input circuit and a second voltage supply, and configured to receive a first enable signal, the second or third input signal, and to generate a first signal responsive to the first enable signal, the second or third input signal. The input circuit includes a first set of transistors having a first threshold voltage. The first set of transistors includes a first set of active regions extending in a first direction. The level shifter circuit includes a second set of transistors having a second threshold voltage. The second set of transistors includes a second set of active regions extending in the first direction.

Abstract: An integrated circuit device includes a gate stack disposed over a substrate. A first L-shaped spacer is disposed along a first sidewall of the gate stack and a second L-shaped spacer is disposed along a second sidewall of the gate stack. The first L-shaped spacer and the second L-shaped spacer include silicon and carbon. A first source/drain epitaxy region and a second source/drain epitaxy region are disposed over the substrate. The gate stack is disposed between the first source/drain epitaxy region and the second source/drain epitaxy region. An interlevel dielectric (ILD) layer disposed over the substrate. The ILD layer is disposed between the first source/drain epitaxy region and a portion of the first L-shaped spacer disposed along the first sidewall of the gate stack and between the second source/drain epitaxy region and a portion of the second L-shaped spacer disposed along the second sidewall of the gate stack.

Abstract: Symmetrically and asymmetrically branched homopolymers are modified at the surface level with functional groups that enable forming aggregates with a taxane, such as, paclitaxel and derivatives thereof, which are water insoluble or poorly water soluble. The aggregates are formed by interaction of a taxane and a homopolymer. Such aggregates improve drug solubility, stability, delivery and efficacy.

Abstract: A current collector includes: a first polymer layer; a metal layer, the metal layer being disposed on a side of the first polymer layer; and a second polymer layer, the second polymer layer being disposed on a side of the metal layer far away from the first polymer layer; and in a direction from the first polymer layer to the second polymer layer, the current collector having a number of through-holes that penetrate the current collector.

Abstract: A touch control method is provided. The touch control method is applied in a touch device including a plurality of touch electrodes, the touch control method includes: step S1, sending a scanning signal to the plurality of touch electrodes, the scanning signal being a multi-frequency scanning signal; step S2, acquiring touch data according to the multi-frequency scanning signal; and step S3, calculating a current touch position according to the touch data.

Abstract: This disclosure is directed to a pharmaceutical composition comprising sodium bicarbonate and a polymer-drug nanoaggregate having a polymer and a taxane. The polymer is water soluble and comprises at least one first terminal group modified with a hydrophobic moiety and a second terminal group modified with a hydrophilic moiety and can be a modified symmetrically or asymmetrically branched polymers. The taxane can include paclitaxel, docetaxel, cabazitaxel, larotaxel, milataxel, ortataxel, tesetaxel, derivatives therefrom or a combination thereof, which are water insoluble or poorly water soluble. Such polymer-drug nanoaggregates can improve drug solubility, stability, in vivo availability and efficacy, and reduce side effects such as renal toxicity. This invention is also directed to a process for producing the pharmaceutical composition comprising the polymer-drug nanoaggregate.

Abstract: The disclosure provides antibody constructs that can reversibly bind to biological or chemical target analytes. Upon target analyte binding, the antibody construct can change its conformational state to produce a detectable readout. An antibody construct can be a single-antibody construct or a dual-antibody construct.

Abstract: Symmetrically and asymmetrically branched homopolymers are modified at the surface level with functional groups that enable forming aggregates with a taxane, such as, paclitaxel and derivatives thereof, which are water insoluble or poorly water soluble. The aggregates are formed by interaction of a taxane and a homopolymer. Such aggregates improve drug solubility, stability, delivery and efficacy.

Abstract: The present disclosure provides compositions and methods of eliciting an anti-tumor immune response and treating cancer comprising at least one peptide of KRAS.

Abstract: The present invention provides an effective and less invasive approach for direct delivery of therapeutic agents to the central nervous system (CNS). In some embodiments, the present invention provides methods including a step of administering intrathecally to a subject suffering from or susceptible to a lysosomal storage disease associated with reduced level or activity of a lysosomal enzyme, a composition comprising a replacement enzyme for the lysosomal enzyme.

Abstract: The present disclosure provides materials and methods for the continuous measurement of biomolecules in vivo and in real-time. The present disclosure relates more specifically to using capture agents and detection agents within a microfluidic device to detect and quantify biochemical features of biomarkers, enabling real-time detection and concentration measurements.

Abstract: The present invention provides, among other things, compositions and methods for CNS delivery of lysosomal enzymes for effective treatment of lysosomal storage diseases. In some embodiments, the present invention includes a stable formulation for direct CNS intrathecal administration comprising an iduronate-2-sulfatase (I2S) protein, salt, and a polysorbate surfactant for the treatment of Hunters Syndrome.

Abstract: A medical device includes a display area that has a thin panel having a substantially flat front surface portion, a translucent layer on a back surface of the thin panel, a layer of text or graphics on a back surface of the translucent layer, and arranged so that the text or graphics is not visible to a user on the front side when light is not provided from inside the device housing, a switch to allow a user to select a first mode or a second mode for the device, and circuitry arranged to energize one or more light sources to provide light from behind the thin panel when the device is in the first mode, and to thereby make visible the text or graphics when the device is in the first mode.

Abstract: The present disclosure describes a system, method, and computer program for predicting sentiment labels for audio speech utterances using an audio speech sentiment classifier pretrained with pseudo sentiment labels. A speech sentiment classifier for audio speech (“a speech sentiment classifier”) is pretrained in an unsupervised manner by leveraging a pseudo labeler previously trained to predict sentiments for text. Specifically, a text-trained pseudo labeler is used to autogenerate pseudo sentiment labels for the audio speech utterances using transcriptions of the utterances, and the speech sentiment classifier is trained to predict the pseudo sentiment labels given corresponding embeddings of the audio speech utterances. The speech sentiment classifier is then subsequently fine tuned using a sentiment-annotated dataset of audio speech utterances, which may be significantly smaller than the unannotated dataset used in the unsupervised pretraining phase.

Abstract: For any application that processes speech, improving the quality of the feature vectors may improve the quality of the speech application. The quality of feature vectors may be improved by modifying a neural network architecture for computing feature vectors to allocate computational resources where they are more effective for learning and computing the feature vectors. Contextual feature vectors may be computed from feature vectors by using a parameterized downsampling operation that decreases a vector sequence rate, processing the downsampled vectors with a neural network, and using a parameterized upsampling operation that increases a vector sequence rate. For example, parameterized downsampling may decrease a vector sequence rate by a factor of two, a neural may require fewer computational resources since it operates with a lower vector sequence rate, and parameterized upsampling may then increase the vector sequence rate by a factor of two.

Abstract: Methods and systems for team cooperation with real-time recording of one or more moment-associating elements. For example, a method includes: delivering, in response to an instruction, an invitation to each member of one or more members associated with a workspace; granting, in response to acceptance of the invitation by one or more subscribers of the one or more members, subscription permission to the one or more subscribers; receiving the one or more moment-associating elements; transforming the one or more moment-associating elements into one or more pieces of moment-associating information; and transmitting at least one piece of the one or more pieces of moment-associating information to the one or more subscribers.

Abstract: The present invention provides an effective and less invasive approach for direct delivery of therapeutic agents to the central nervous system (CNS). In some embodiments, the present invention provides methods including a step of administering intrathecally to a subject suffering from or susceptible to a lysosomal storage disease associated with reduced level or activity of a lysosomal enzyme, a composition comprising a replacement enzyme for the lysosomal enzyme.