Abstract: The present invention provides an effective and less invasive approach for direct delivery of therapeutic agents to the central nervous system (CNS). In some embodiments, the present invention provides methods including a step of administering intrathecally to a subject suffering from or susceptible to a lysosomal storage disease associated with reduced level or activity of a lysosomal enzyme, a composition comprising a replacement enzyme for the lysosomal enzyme.

Abstract: Methods and systems for team cooperation with real-time recording of one or more moment-associating elements. For example, a method includes: delivering, in response to an instruction, an invitation to each member of one or more members associated with a workspace; granting, in response to acceptance of the invitation by one or more subscribers of the one or more members, subscription permission to the one or more subscribers; receiving the one or more moment-associating elements; transforming the one or more moment-associating elements into one or more pieces of moment-associating information; and transmitting at least one piece of the one or more pieces of moment-associating information to the one or more subscribers.

Abstract: A vehicle includes at least one hose extending from the vehicle and configured to extend below ground through a manhole, and a light system. The light system includes a storage member, such as a retractable reel, coupled to the vehicle, a flexible line wrapped at least partially around the storage member, and a light source coupled to the flexible line. The storage member is adapted to selectively extend and retract the light source together with the hose below ground, and the light source is storable on the vehicle adjacent the storage member. The light source has a self-contained power source. In some systems, the flexible line and/or the light source are removable from the vehicle so they can be moved to a remote location from the vehicle.

Abstract: Among other things, the present invention provides methods and compositions of treating Sanfilippo syndrome type B (Sanfilippo B) by, e.g., intrathecal (IT) administration of a Naglu protein. A suitable Naglu protein can be a recombinant, gene-activated or natural protein. In some embodiments, a suitable Naglu protein is a recombinant Naglu protein. In some embodiments, a recombinant Naglu protein is a fusion protein containing a Naglu domain and a lysosomal targeting moiety. In some embodiments, the lysosomal targeting domain is an IGF-II moiety.

Abstract: The present invention provides, among other things, compositions and methods for CNS delivery of lysosomal enzymes for effective treatment of lysosomal storage diseases. In some embodiments, the present invention includes a stable formulation for direct CNS intrathecal administration comprising a heparan N-sulfatase (HNS) protein, salt, and a polysorbate surfactant for the treatment of Sanfilippo Syndrome Type A.

Abstract: Provided are a speed planning method and apparatus, an electronic device, and a storage medium. The method includes determining a planned path on which a target object reaches a target position from a current position; in the planned path, performing cubic B-spline curve fitting on a path between the current position and a position with a set distance from the current position to obtain a fitted curve; calculating a radius of curvature of the fitted curve, and calculating a corresponding angular speed based on the radius of curvature and a preset forward speed; based on current obstacle information in a map where the target object is located, judging whether a risk of collision with an obstacle during a process of the target object traveling along the fitted curve at the angular speed exists.

Abstract: A medical device includes a display area that has a thin panel having a substantially flat front surface portion, a translucent layer on a back surface of the thin panel, a layer of text or graphics on a back surface of the translucent layer, and arranged so that the text or graphics is not visible to a user on the front side when light is not provided from inside the device housing, a switch to allow a user to select a first mode or a second mode for the device, and circuitry arranged to energize one or more light sources to provide light from behind the thin panel when the device is in the first mode, and to thereby make visible the text or graphics when the device is in the first mode.

Abstract: The present invention provides, among other things, compositions and methods for CNS delivery of lysosomal enzymes for effective treatment of lysosomal storage diseases. In some embodiments, the present invention includes a stable formulation for direct CNS intrathecal administration comprising an iduronate-2-sulfatase (I2S) protein, salt, and a polysorbate surfactant for the treatment of Hunters Syndrome.

Abstract: Disclosed are compositions and methods for targeted treatment of TLR9-expressing cancers. In particular, disclosed herein are molecules or conjugates containing a TLR9 targeting ligand, such as a CpG oligodeoxynucleotide, and a cytotoxic nanoparticle that targets TLR9-expressing malignant cells. Also disclosed is a pharmaceutical composition comprising a molecule disclosed herein in a pharmaceutically acceptable carrier. Also disclosed is a method for treating a TLR9-positive cancer in a subject that involves administering to the subject a therapeutically effective amount of a disclosed pharmaceutical composition.

Abstract: A system for assisting a rescuer in performing cardio-pulmonary resuscitation (CPR) on a patient includes: a proximity sensor configured to be positioned at a location corresponding to a location of a rescuer's hand when delivering compressions to a patient's chest, the proximity sensor configured to produce a signal indicative of the rescuer's hands being released from the patient's chest; a medical device operatively coupled with the proximity sensor and configured to provide resuscitative treatment to the patient; and a controller communicatively coupled with the medical device and the proximity sensor. The controller is configured to: determine, based upon the signal from the proximity sensor, if the rescuer's hands have been released from the patient's chest, and trigger an action by the medical device in response to a determination that the rescuer's hands have been released from the patient's chest.

Abstract: An approach for distributed tracing is provided. The approach for distributed tracing comprises receiving a user request for a transaction by one or more processing units, and extracting feature data from the received user request by one or more processing units. Further, if the extracted feature data matches at least one policy generated based on at least one error response received from at least one service is determined by one or more processing units and the at least one service is instructed to collect tracing data for the transaction in a head-based fashion responsive to the extracted feature data matching at least one policy by one or more processing units.

Abstract: Symmetrically and asymmetrically branched homopolymers are modified at the surface level with functional groups that enable forming aggregates with a taxane, such as, paclitaxel and derivatives thereof, which are water insoluble or poorly water soluble. The aggregates are formed by interaction of a taxane and a homopolymer. Such aggregates improve drug solubility, stability, delivery and efficacy.

Abstract: The present disclosure provides a method, computer system and computer program product for generating a conversation content. According to the method, a rule corresponding to a first component of a user interface can be obtained, wherein the first component represents one or more resources provided to a user, an operation for the first component can be determined based on the rule and a feature of the first component, a virtual component tree can be constructed according to the operation, wherein the virtual component tree depicts components to be included in the user interface and relationship between the components; and the user interface can be rendered based on the virtual component tree.

Abstract: A system for assisting a rescuer in performing cardio-pulmonary resuscitation (CPR) on a patient includes: a proximity sensor configured to be positioned at a location corresponding to a location of a rescuer's hand when delivering compressions to a patient's chest, the proximity sensor configured to produce a signal indicative of the rescuer's hands being released from the patient's chest; a medical device operatively coupled with the proximity sensor and configured to provide resuscitative treatment to the patient; and a controller communicatively coupled with the medical device and the proximity sensor. The controller is configured to: determine, based upon the signal from the proximity sensor, if the rescuer's hands have been released from the patient's chest, and trigger an action by the medical device in response to a determination that the rescuer's hands have been released from the patient's chest.

Abstract: Among other things, the present invention provides methods and compositions of treating Sanfilippo syndrome type B (Sanfilippo B) by, e.g., intrathecal (IT) administration of a Naglu protein. A suitable Naglu protein can be a recombinant, gene-activated or natural protein. In some embodiments, a suitable Naglu protein is a recombinant Naglu protein. In some embodiments, a recombinant Naglu protein is a fusion protein containing a Naglu domain and a lysosomal targeting moiety. In some embodiments, the lysosomal targeting domain is an IGF-II moiety.

Abstract: The present invention provides, among other things, compositions and methods for CNS delivery of lysosomal enzymes for effective treatment of lysosomal storage diseases. In some embodiments, the present invention includes a stable formulation for direct CNS intrathecal administration comprising a heparan N-sulfatase (HNS) protein, salt, and a polysorbate surfactant for the treatment of Sanfilippo Syndrome Type A.

Abstract: The present disclosure provides compositions and methods of eliciting an anti-tumor immune response and treating cancer comprising at least one peptide of KRAS.

Abstract: Technology for predicting online user shopping behavior, such as whether a user will purchase a product, is described. An example method includes receiving current session data describing a current session for a current user, extracting a current clickstream from the current session data classifying the current clickstream as a purchase clickstream or a non-purchase clickstream by processing the current clickstream using one or more sets of Hidden Markov Model parameters produced by one or more Hidden Markov Models, and computing, using the one or more computing devices, a purchase probability that the current user will purchase a product during the current session based on the classifying.

Abstract: Embodiments of the present disclosure relate to reuse ongoing reusable Ajax requests. According to the method, one or more processors receive a first Ajax request in a web application. The method further includes detecting at least one ongoing Ajax request comprising a second ongoing reusable Ajax request. The second ongoing Ajax request may be substantially similar to the first Ajax request. The method further includes receiving the second ongoing reusable Ajax request from a server of the web application. The method further includes executing a call-back function of the second ongoing reusable Ajax request.

Abstract: A vehicle includes at least one hose extending from the vehicle and configured to extend below ground through a manhole, and a light system. The light system includes a storage member, such as a retractable reel, coupled to the vehicle, a flexible line wrapped at least partially around the storage member, and a light source coupled to the flexible line. The storage member is adapted to selectively extend and retract the light source together with the hose below ground, and the light source is storable on the vehicle adjacent the storage member. The light source has a self-contained power source. In some systems, the flexible line and/or the light source are removable from the vehicle so they can be moved to a remote location from the vehicle.