Abstract: In one implementation, a mobility-based ion separation system includes a first ion channel extending between a first end and a second end, and configured to receive an ion packet. The separation system includes a controller configured to apply a first voltage signal and a second voltage signal to a first plurality of electrodes adjacent to the first ion channel. The first plurality of electrodes are configured to generate, based on receipt of the first voltage signal, a first traveling drive potential that travels at a first speed along a first direction, the first direction extending from the first end to the second end. The first plurality of electrodes are configured to generate, based on receipt of the second voltage signal, a second DC potential decreasing along a second direction, the second direction extending from the second end to the first end.

Abstract: The present disclosure relates to crystalline forms of 2-[(2S)-1-azabicyclo[2.2.2]oct-2-yl]-6-(3-methyl-1H-pyrazol-4-yl)thieno[3,2-d]pyrimidin-4(3H)-one hemihydrate (Compound 1) and/or tautomers thereof, wherein Compound 1 has the structure: (I).0.5H2O; processes for preparing crystalline forms of Compound 1 and/or tautomers thereof; pharmaceutical compositions comprising the crystalline forms; methods of inhibiting a cell division cycle 7 in a mammal comprising administering the crystalline forms; and methods of treating a cell division cycle 7 mediated cancer in a mammal comprising administering the crystalline forms or a pharmaceutical composition comprising the crystalline forms.

Abstract: An electric vacuum jet engine is a more ecofriendly alternative to gas-fueled jet engines that generates the same or higher thrust than traditional gas-fueled jet engines. The jet engine includes a tubular housing, at least one first propeller assembly, and at least one second propeller assembly. The tubular housing accommodates an alternating of series of propeller assemblies formed by the at least one first propeller assembly and the at least one second propeller assembly. Together, the at least one first propeller assembly and the at least one second propeller assembly generate several vacuums along the tubular housing that increase the velocity of air flow through the tubular housing to generate the thrust necessary to propel the desired aircraft. The tubular housing also includes a housing inlet and a housing outlet corresponding to the open ends of the tubular housing through which air flow enters and exits the tubular housing, respectively.

Abstract: Described herein are dehydrated, laminated tissue grafts composed of two or more membrane layers of an amnion membrane, a chorion membrane, a Wharton's jelly, or an intermediate tissue layer, where a layer of micronized placental tissue is interposed between two of the layers. Also described herein are methods for making and using the laminated tissue grafts.

Abstract: Described herein are tissue grafts derived from the placenta with improved physical and biological properties. In one aspect, the tissue graft includes a first membrane comprising Wharton's jelly laminated with amnion, chorion, or a combination thereof. The presence of Wharton's jelly in the grafts enhances the performance of allograft amniotic-derived, caderivic allograft, xenograft, or alloplast soft tissue substitutes.

Abstract: The present invention relates to methods and compositions for identifying, selecting and/or producing a Disease resistant soybean plant or germplasm using markers, genes and chromosomal intervals derived from Glycine tomentella PI441001, PI441008, PI446958, PI509501, PI583970, PI499939 or PI483224. A soybean plant or germplasm that has been identified, selected and/or produced by any of the methods of the present invention is also provided. Disease resistant soybean seeds, plants and germplasms are also provided.

Abstract: Low-pH compositions are provided for dissolvable solid unit dose formulations that can be used with a wand apparatus to clean a toilet surface. The formulations include surfactants, an organic acid and an organic acid buffering agent, and virgin soap pellets and/or a cellulose filler. Formulations having antibacterial efficacy include an anionic surfactant present at about 15% to about 30% by weight of the composition, an organic acid-buffer system in an amount sufficient to provide toilet water with a pH which is less than 4.6 when the composition is dissolved in toilet water, and virgin soap pellets.

Abstract: Aspects of the present disclosure relate generally to methods, compositions, and kits for in situ whole cell barcoding. Aspects of the present disclosure also include a computer readable-medium and a processor to carry out the steps of the method described herein. In some embodiments, the disclosure relates to whole cell barcoding performed in situ.

Abstract: A dissolvable toilet cleaning solid tablet includes an anionic surfactant; virgin soap pellets; and borax, and desirably, a carbonate or bicarbonate salt; and an acid. The borax comprises about 0.5% to about 10% by weight of the composition, and the virgin soap pellets comprise about 12% to about 25% by weight of the composition.

Abstract: The present disclosure is directed to an ion funnel and associated systems, where the ion funnel includes a plurality of electrodes each define an opening having an associated inner dimension and receive a RF voltage. The associated inner dimensions progressively reduce in size from approximately a first inner dimension to approximately a second inner dimension. The electrodes define a slope parameter with respect to adjacent electrodes, which is less than 0.04 for at least a majority of the electrodes. Additional systems and methods are provided for transferring ions from an ion funnel to an ion mobility device having a pressure greater than that of the ion funnel, for selectively transferring ions from the ion funnel to the ion mobility device, and for stripping ions of certain molecules adducted thereto during transfer.

Abstract: Disclosed herein, in certain embodiments, are methods of detecting the presence of a skin cancer based on molecular risk factors. In some instances, the skin cancer is cutaneous T cell lymphoma (CTCL). In some cases, the skin cancer is mycosis fungoides (MF) or Sézary syndrome (SS).

Abstract: A cutting element has a cutting face at an opposite axial end from a base, a side surface extending from the base to the cutting face, an edge formed at the intersection between the cutting face and the side surface, and an elongated protrusion formed at the cutting face and extending between opposite sides of the edge, wherein the elongated protrusion has a geometry including a border extending around a concave surface and sloped surfaces extending between the border and the edge, and wherein the concave surface has a major axis dimension measured between opposite sides of the border and a minor axis dimension measured perpendicularly to the major axis dimension and ranging from 50 percent to 99 percent of the major axis dimension.

Abstract: Uncultured amniotic cell and protein fraction products derived from amniotic fluid and methods of preparing and using those compositions are provided. According to the methods of the present invention, uncultured amniotic cell and protein products may be derived from a large sample of amniotic fluid to provide a higher concentration of tissue regeneration components. Described are methods for separating uncultured amniotic cells or protein fractions from other components of amniotic fluid and the resulting uncultured amniotic cell and protein products. Furthermore, the present invention includes methods for delivering the uncultured amniotic cell and protein products to the skin and eye, including before, during, or after a treatment procedure.

Abstract: Systems and methods are provided for adjusting point of sale (POS) interfaces. In some embodiments, a POS device includes a display. The display is configured to present a user interface, the user interface having a first interface and a second interface. The first interface has a first set of functionalities that is prevented from being accessible in the second interface.

Abstract: The present disclosure is directed to an ion funnel and associated systems, where the ion funnel includes a plurality of electrodes each define an opening having an associated inner dimension and receive a RF voltage. The associated inner dimensions progressively reduce in size from approximately a first inner dimension to approximately a second inner dimension. The electrodes define an internal chamber having an outer dimension that reduces at a convergence angle of approximately 30 degrees for at least a majority of a length of the internal chamber from the first inner dimension to the second inner dimension. Additional systems and methods are provided for transferring ions from an ion funnel to an ion mobility device having a pressure greater than that of the ion funnel, for selectively transferring ions from the ion funnel to the ion mobility device, and for stripping ions of certain molecules adducted thereto during transfer.

Abstract: In one implementation, a mobility-based ion separation system includes a first ion channel extending between a first end and a second end, and configured to receive an ion packet. The separation system includes a controller configured to apply a first voltage signal and a second voltage signal to a first plurality of electrodes adjacent to the first ion channel. The first plurality of electrodes are configured to generate, based on receipt of the first voltage signal, a first traveling drive potential that travels at a first speed along a first direction, the first direction extending from the first end to the second end. The first plurality of electrodes are configured to generate, based on receipt of the second voltage signal, a second DC potential decreasing along a second direction, the second direction extending from the second end to the first end.

Abstract: The present invention provides processes and synthetic intermediates for the synthesis of 2-[(2S)-1-azabicyclo[2.2.2]oct-2-yl]-6-(3-methyl-1H-pyrazol-4-yl)thieno[3,2-d]pyrimidin-4 {3H)-one or a salt, hydrate, or tautomer thereof, or any combination thereof, which are Cdc7 kinase inhibitors, and are useful for the treatment of disorders of cell proliferation, particularly cancer, and other disorders associated with Cdc7 activity.

Abstract: The subject matter described herein provides non-invasive patch stripping methods for the collection of a skin sample. The patch stripping method includes applying and removing at least one adhesive patch, provided that a skin sample is adhered to the adhesive patch after removal. The at least one adhesive patch is supplied in an adhesive skin sample collection kit. Optionally, the adhesive skin sample collection kit further comprises a sample collector and/or instructions for use.

Abstract: A wireless power transfer system that employs a form of conductively coupled power transfer to transfer energy to deeply implanted devices.

Abstract: In providing USB communication functionality over a non-USB-compliant extension medium, increased latency and processing delays may be introduced, including during configuration of endpoints. In some embodiments of the present disclosure, an upstream facing port device (UFP device) and a downstream facing port device (DFP device) are used to extend USB communication across an extension medium. In some embodiments, the UFP device extracts information from packets sent between a host device and a USB device during configuration of an endpoint. In some embodiments, the UFP device sends a synthetic NRDY packet to the host device in response to a STATUS Transaction Packet to provide the UFP device and DFP device additional time to complete configuration for servicing the endpoint.