Abstract: A collection system including a storage tray and a swab positioned in the storage tray, wherein the swab is configured to collect a sample comprising one or more microorganisms. The system further includes a generally elongate storage device positioned in the tray. The storage device is configured to contain a culture medium therein and configured to receive therein at least part of the one or more microorganisms collected by the swab. The storage tray includes a first recess configured to receive the storage device in a longitudinal configuration, and a second recess configured to receive the storage device in an axial configuration oriented generally perpendicular to the longitudinal configuration.

Abstract: The present invention provides to compositions and methods useful in the treatment of neurological disorders including, but not limited to, Angelman syndrome, depression, traumatic brain injury, stroke, and Alzheimer's disease. CN2097, a rationally designed cyclic peptidomimetic drug that has been demonstrated to have effectiveness in preclinical models for the treatment of neurological disorders, is rapidly cleared and has a short half-life. The present invention provides a stable analog of CN2097.

Abstract: An improved bag spreader and methods of the using the same. The bag spreader includes a bag that holds particulate material, a base removably coupled to the bag and including an exit opening to permit the particulate material to fall therethrough, an impeller below the base and configured to receive the particulate material leaving the exit opening and spread the particulate material, and a fastener circumscribing the base and securing the bag to the base. The methods include removably securing a bag to a base using a single cable tie, filling the bag with particulate material, and turning a hand crank causing the impeller to spin and spread the particulate material.

Abstract: A monocone antenna with an impedance matching section that may allow a reduction in physical size of the cone while maintaining similar performance as a standard monocone antenna. Alternatively, the present disclosure may provide a monocone antenna with an impedance matching section that may allow operation at a lower frequency while maintaining the same physical size as a standard monocone antenna. Further, the present disclosure may provide a monocone antenna with an impedance matching section that may allow a reduction in physical size and operation at a lower frequency relative to a standard monocone antenna.

Abstract: This disclosure describes manual release systems for electrified vehicle charge port locks. In some embodiments, a vehicle key may be used to manually override a position of the charge port lock. In other embodiments, a pull button and cable arrangement may be used to manually override the position of the charge port lock. The pull button may be packaged under a vehicle hood and, in some embodiments, may be mounted to either a cooling system component or a grille support structure.

Abstract: Systems and methods described herein are optimized for cutting sealing elements on packages using optical radiation. Packages can pass through a cutting device that applies the optical radiation to damage, vaporize, or cut the sealing element (e.g., tape) on the package. The systems and methods control several aspects of the cutting process to adjust throughput, improve efficiency, and reduce line stoppages. Systems can include an in-feed conveyor that orients packages and rejects packages that are out of specification, which can lead to issues such as jamming or damage to the equipment. Systems can include a variable-speed cut conveyor controlled by a computing system to dynamically adjust the speed of packages based upon historical cut quality, environmental measurement data, and height data related to a vertical dimension of the package.

Abstract: A collection system including a storage tray and a swab positioned in the storage tray, wherein the swab is configured to collect a sample comprising one or more microorganisms. The system further includes a generally elongate storage device positioned in the tray. The storage device is configured to contain a culture medium therein and configured to receive therein at least part of the one or more microorganisms collected by the swab. The storage tray includes a first recess configured to receive the storage device in a longitudinal configuration, and a second recess configured to receive the storage device in an axial configuration oriented generally perpendicular to the longitudinal configuration.

Abstract: In described examples, a projector includes a light source to produce first light of a first color. The projector also includes a phosphor to selectively receive the first light and produce second light of a second color in response to the first light. The projector also includes a dichroic mirror to pass a portion of the second light to produce a third light of a third color. The dichroic mirror reflects a portion of the second light as fourth light of a fourth color.

Abstract: The present invention relates to a novel chemical compound for use in the treatment of cancer, to compositions containing said compound, methods of manufacture and combinations with other therapeutic agents.

Abstract: An electrified vehicle assembly includes, among other things, a traction battery, and at least one shield extending longitudinally and having a portion that is vertically beneath the traction battery. The shield is removably fastened directly to the traction battery.

Abstract: The invention relates to inhibitors of glucosylceramide synthase (GCS) useful for the treatment of metabolic diseases, such as lysosomal storage diseases, either alone or in combination with enzyme replacement therapy, cystic disease and for the treatment of cancer.

Abstract: Resource watermarking and management actions on electronic resources are described. In one example, a process for resource watermarking and management actions includes receiving, from a client device, a request to perform an action on an electronic resource and a device profile for the client device. The device profile can include at least one attribute of the client device. The process also includes identifying a watermark template for the electronic resource, determining descriptive data of the watermark template based on the request to perform the action and whether the device profile complies with a compliance rule, overlaying the watermark template and the descriptive data onto the electronic resource, and determining that the client device is authorized to perform the action on the electronic resource in response to the electronic resource being united with the watermark template.

Abstract: Techniques are presented for scheduling the charging of electric vehicles (EVs) that protect the resources of local low voltage distribution networks. From utilities, data on local low voltage distribution networks, such as the rating of a distribution transformer through which a group of EVs are supplied, is provided to a load manager application. Telematics information on vehicle usage is provided from the EVs, such as by way of the original equipment manufacturer. From these data, the load manager application determines schedules for charging the group of EVs through a shared low voltage distribution network so that the capabilities of the local low voltage distribution network are not exceeded while meeting the needs of the EV user. Charging schedules are then transmitted to the on-board control systems of the EVs for implementation.

Abstract: The present invention relates to a novel chemical compound for use in the treatment of cancer, to compositions containing said compound, methods of manufacture and combinations with other therapeutic agents.

Abstract: Provided herein are compounds and methods for the treatment of brain cancer in a mammal, wherein the method comprises the administration to the mammal a compound that stabilizes tubulin dimers or microtubles at G2-M interface during mitosis but is not a substrate for MDR protein. In particular, the present application relates to the use of an orally effective abeo-taxane, alone or in combination with temozolomide or bevacizumab, for the treatment of brain cancer.

Abstract: The hemitartrate salt of a compound represented by the following structural formula: (Formula 1 Hemitartrate), which may be used in pharmaceutical applications, are disclosed. Particular single crystalline forms of the Formula (I) Hemitartrate are characterized by a variety of properties and physical measurements. As well, methods of producing crystalline Formula (I) Hemitartrate, and using it to inhibit glucosylceramide synthase or lowering glycosphingolipid concentrations in subjects to treat a number of diseases, are also discussed. Pharmaceutical compositions are also described.

Abstract: Location-based configuration profile toggling may be provided. Configuration profiles associated with user devices may be identified, determinations of whether the user devices are authorized to enable the configuration profiles on the user devices may be made based at least in part on location constraints, and the configuration profiles may be enabled an the user devices if the location constraints are satisfied.

Abstract: The hemitartrate salt of a compound represented by the following structural formula: (Formula I Hemitartrate), which may be used in pharmaceutical applications, are disclosed. Particular single crystalline forms of the Formula (I) Hemitartrate are characterized by a variety of properties and physical measurements. As well, methods of producing crystalline Formula (I) Hemitartrate, and using it to inhibit glucosylceramide synthase or lowering glycosphingolipid concentrations in subjects to treat a number of diseases, are also discussed. Pharmaceutical compositions are also described.

Abstract: Handheld spreaders and methods of operating the same. The spreader can include a cup to hold particulate material and having an open upper end, a scoop assembly provided proximate the open upper end of the cup and including a scoop for directing particulate material being dispersed from the cup, and a sifter assembly removably coupled to the scoop assembly for metering an amount of the particulate material being dispersed from the cup. When the sifter assembly is removed from the scoop assembly, the scoop remains attached to the cup to direct particulate material being provided into the cup via the open upper end. The method can include opening the cup by removing the sifter assembly from the scoop assembly, placing particulate material into an open interior of the cup, closing the cup by replacing the sifter assembly, and dispersing the particulate material through the sifter assembly.

Abstract: The present disclosure relates generally to treatment and diagnosis of diseases, disorders or conditions characterized by vascular leakage. More particularly, the present disclosure relates to methods for treating a vascular leakage-associated disease or disorder in a subject; for reducing vascular leakage in a subject; for reducing reactive oxygen species production in a subject; for inducing apoptosis of neutrophils in a subject; and for increasing survival of a subject having a vascular leakage-associated disease or disorder. The methods comprise administering a G9a and/or G9a-like protein (GLP) methyltransferase inhibitor to the subject. The present disclosure further relates to methods for developing a treatment plan for a subject with a vascular leakage-associated disease, disorder or condition, and for identifying a subject as a candidate for treatment of a vascular leakage-associated disease or disorder.