Abstract: Disclosed are various embodiments for accessing resources when a client device complies with distribution rules. A client device receives distribution rules associated with resources that are accessible at a distribution service. The client device determines whether the client device complies with the distribution rules. The client device transmits an indication of compliance for the distribution to the distribution service. The client device receives the resource from the distribution service.

Abstract: This disclosure describes manual release systems for electrified vehicle charge port locks. In some embodiments, a vehicle key may be used to manually override a position of the charge port lock. In other embodiments, a pull button and cable arrangement may be used to manually override the position of the charge port lock. The pull button may be packaged under a vehicle hood and, in some embodiments, may be mounted to either a cooling system component or a grille support structure.

Abstract: Provided herein are compounds and methods for the treatment of brain cancer in a mammal, wherein the method comprises the administration to the mammal a compound that stabilizes tubulin dimers or microtubules at G2-M interface during mitosis but is not a substrate for MDR protein. In particular, the present application relates to the use of an orally effective abeo-taxane, alone or in combination with temozolomide or bevacizumab, for the treatment of brain cancer.

Abstract: The invention relates to inhibitors of glucosylceramide synthase (GCS) useful for the treatment of metabolic diseases, such as lysosomal storage diseases, either alone or in combination with enzyme replacement therapy, and for the treatment of cancer.

Abstract: A method for removing ectoparasites, such as sea lice, from a fish in water, comprising: (i) administering a neonicotinoid to remove the ectoparasites from the fish; and (ii) exchanging the water comprising the removed ectoparasites with replacement water, thereby separating the removed ectoparasites and the fish. The neonicotinoid is not imidacloprid, and is not configured or formulated for in-feed administration. The fish may be a salmonid, char, or cleaner fish, and the neonicotinoid may be applied at a sublethal dose and/or for a sublethal time, at a lethal dose and/or for a lethal time, or at a dose that knocks down the ectoparasites. The method may further comprise the step of preventing release of the removed ectoparasites into the environment, for example by collecting the ectoparasites from a sample of water comprising the removed ectoparasites, for example by passing the sample through a filter, preferably a mesh filter. A neonicotinoid for use in the method is also provided.

Abstract: Disclosed are various embodiments for accessing resources when a client device complies with distribution rules. A client device receives selected resources and distribution rules associated with the resources. The client device determines whether the client device complies with the distribution rules. When the resources are modified, the changes are sent to a distribution service associated with the resources.

Abstract: Methods and systems are disclosed for managing shipped physical objects. The methods and systems comprise receiving data associated with a journey of the shipped object and determining, using a processor, alert conditions based on the received data. Alert conditions are representative of risk of damage, loss, or delay associated with the shipped object. In addition, the methods and systems comprise transmitting one or more alternative options for mitigating the alert condition to a user, receiving a selection of one of the alternative options, and modifying the journey based on the received selection.

Abstract: Described examples include an optical device having a first light source configured to provide a first light having a first characteristic. The optical device also has a second light source configured to provide a second light having a second characteristic. The optical device also has a combiner configured to combine the first light and the second light to provide a combined light. The optical device also has a spatial light modulator configured to modulate the combined light to provide modulated combined light. The optical device also has a divider configured to receive the modulated combined light and to direct a first portion of the modulated combined light having the first characteristic to a first target and to direct a second portion of the modulated combined light having the second characteristic to a second target.

Abstract: Disclosed are various embodiments for controlling a distribution of resources on a network. In one example, among others, a system is configured to transmit a request to access a plurality of resources at a distribution service and receive the plurality of resources and a plurality of location rules. The system is also configured to determine an authorized location and an authorized perimeter area based on the plurality of location rules. The authorized location and the authorized perimeter area are determined to have different access rights to the plurality of resources. The system is further configured to determine a location of the computing device and grant access to a resource based on the location of the computing device with respect to the authorization location or the authorized perimeter.

Abstract: Described examples include a device having a prism cube having a first side and a second side opposite the first side, the prism cube configured to: receive light comprising a first color light and a second color light, direct the first color light to the first side of the prism cube, and direct the second color light to the second side of the prism cube.

Abstract: The invention relates to inhibitors of glucosylceramide synthase (GCS), such as Compound of Formula I, shown below, as defined herein, useful for the treatment of metabolic diseases, such as lysosomal storage diseases, either alone or in combination with enzyme replacement therapy, cystic disease and for the treatment of cancer.

Abstract: A multi-spot ophthalmic laser device that produces spatially distributed laser spots with the spatial distribution of the laser spots defined by a spot diameter to space ratio in the range 1:2 to 1:20. The multi-spot ophthalmic laser device comprises: a laser module producing a laser pulse or sequence of laser pulses each having: a pulse duration in the range of 10 ps to 20 ?s; a wavelength in the range 500 nm to 900 nm; and a pulse energy in the range 10 ?J to 10 mJ per pulse; and an optical beam profiling module that modifies an output beam profile of each pulse of the laser module to deliver multiple spatially distributed laser spots of defined size and energy. The multi-spot ophthalmic laser device is used in a method of improving the function of the retina of a human eye by irradiation through the cornea of the eye to the retinal pigmented epithelium by a treatment laser having a beam profile with spatially distributed energy peaks.

Abstract: Methods and systems are disclosed for managing shipped physical objects. The methods and systems comprise receiving data associated with a journey of the shipped object and determining, using a processor, alert conditions based on the received data. Alert conditions are representative of risk of damage, loss, or delay associated with the shipped object. In addition, the methods and systems comprise transmitting one or more alternative options for mitigating the alert condition to a user, receiving a selection of one of the alternative options, and modifying the journey based on the received selection.

Abstract: The present invention provides to compositions and methods useful in the treatment of neurological disorders including, but not limited to, Angelman syndrome, depression, traumatic brain injury, stroke, and Alzheimer's disease. CN2097, a rationally designed cyclic peptidomimetic drug that has been demonstrated to have effectiveness in preclinical models for the treatment of neurological disorders, is rapidly cleared and has a short half-life. The present invention provides a stable analog of CN2097.

Abstract: Devices and approaches for activating cross-linking within corneal tissue to stabilize and strengthen the corneal tissue following an eye therapy treatment. A feedback system is provided to acquire measurements and pass feedback information to a controller. The feedback system may include an interferometer system, a corneal polarimetry system, or other configurations for monitoring cross-linking activity within the cornea. The controller is adapted to analyze the feedback information and adjust treatment to the eye based on the information. Aspects of the feedback system may also be used to monitor and diagnose features of the eye. Methods of activating cross-linking according to information provided by a feedback system in order to improve accuracy and safety of a cross-linking therapy are also provided.

Abstract: Disclosed are various embodiments for controlling a distribution of resources on a network. In one embodiment, among others, a processor is configured to transmit a request to access resources at a distribution service and receives location rules associated with the resources. The location rules specify an authorized location and an authorized perimeter area. The authorized location and the authorized perimeter area specify different access rights to the resources. The processor can determine a location of a computing device and determine that the computing device is compliant with at least one of the location rules based on the location of the computing device. The processor is configured to transmit a compliance indication to the distribution service for the location rules and receive access to at least some of the resources from the distribution service.

Abstract: Described examples include a projection system having projection optics with a projection optics axis tilted from an axis perpendicular to an image target, the projection optics configured to project an image. The projection system also having an image source, the image source configured to provide the image, the image source having an offset from the projection optics axis, a plane of the image source having an angle from perpendicular to the projection optics axis such that a projected image from the image source projected by the projection optics is focused onto the image target along an extent of the projected image.

Abstract: A cable slack controller may include a deflector coupled to a movable carriage device; at least one end of a cable coupled to the carriage device; and an engagement tab formed with the cable wherein the engagement tab engages a notch defined in a portion of a channel on which the movable carriage device translates across.

Abstract: This disclosure details exemplary insulating flexible membranes for use with vehicle high voltage modules. The high voltage modules may include any module that is adapted for supporting electric propulsion within the vehicle. The insulating flexible membranes may be attached to an exterior of a housing, to an interior of the housing, or may be disposed about a high voltage component housed inside the module. The insulating flexible membranes of this disclosure are configured to distort to prevent access to damaged high voltage components of the high voltage modules.

Abstract: Time-based functionality restrictions may be provided. Periodic scans may be performed to identify requests to perform functions on user devices, to determine whether the functions are compliant with compliance rules associated with the user devices that specify time periods during which the user devices are authorized to perform the functions, and to perform remedial actions if the functions are not compliant with the compliance rules.