Abstract: The present invention relates to a novel chemical compound for use in the treatment of cancer, to compositions containing said compound, methods of manufacture and combinations with other therapeutic agents.

Abstract: Disclosed are various embodiments for controlling access to data on a network. Upon receiving a request comprising a device identifier and at least one user credential to access a remote resource, the request may be authenticated according to at least one compliance policy. If the request is authenticated, a resource credential associated with the remote resource may be provided.

Abstract: The present invention provides a peptide that selectively binds ?v?6 integrin, the peptide having an amino acid sequence comprising the motif X1BnRGDLX2X3X4ZmX5, wherein X1 is any D-amino acid, Bn is a sequence of any n amino acids, which may be natural or unnatural, D- or L-, and may be the same or different, wherein n is a number between 1 and 10, X2 and X3 are independently selected from any amino acid, X4 is Leu or Ile, Zm is a sequence of any m amino acids, which may be natural or unnatural, D- or L-, and may be the same or different, wherein m is a number between 1 and 10, X5 is any L- or D-amino acid. Also provided are conjugates comprising said peptide, pharmaceutical compositions comprising said peptide or said conjugates, and uses of said peptide, conjugate or composition, for example, in the treatment, imaging and/or diagnosis of an ?v?6-expressing tumour in a mammalian subject.

Abstract: Time-based functionality restrictions may be provided. Periodic scans may be performed to identify requests to perform functions on user devices, to determine whether the functions are compliant with compliance rules associated with the user devices that specify time periods during which the user devices are authorized to perform the functions, and to perform remedial actions if the functions are not compliant with the compliance rules.

Abstract: The present invention relates to a novel chemical compound for use in the treatment of cancer, to compositions containing said compound, methods of manufacture and combinations with other therapeutic agents.

Abstract: The present disclosure generally relates to methods and formulations for treating central nervous system (CNS) disorders. The present disclosure involves intranasal delivery of at least one antioxidant compound, allowing for effective treatment of a central nervous system disorder such as traumatic brain injury or stroke.

Abstract: Described examples include an optical device having a first light source configured to provide a first light having a first characteristic. The optical device also has a second light source configured to provide a second light having a second characteristic. The optical device also has a combiner configured to combine the first light and the second light to provide a combined light. The optical device also has a spatial light modulator configured to modulate the combined light to provide modulated combined light. The optical device also has a divider configured to receive the modulated combined light and to direct a first portion of the modulated combined light having the first characteristic to a first target and to direct a second portion of the modulated combined light having the second characteristic to a second target.

Abstract: Disclosed are methods and systems for removing submicron particles from a gas stream, in particular from urea prilling off-gas, wherein a Venturi ejector is used. A method comprises contacting a gas stream containing submicron particles in a Venturi ejector with an injected high velocity scrubbing liquid to provide a pumping action, wherein the scrubbing liquid has an initial velocity of at least 25 m/s and wherein the ratio of scrubbing liquid and gas flow is between 0.0005 and 0.0015 (m3/h)/(m3/h).

Abstract: Disclosed are methods and systems for removing submicron particles from a gas stream, in particular from urea prilling off-gas, wherein a Venturi ejector is used. A method comprises contacting a gas stream containing submicron particles in a Venturi ejector with an injected high velocity scrubbing liquid to provide a pumping action, wherein the scrubbing liquid has an initial velocity of at least 25 m/s and wherein the ratio of scrubbing liquid and gas flow is between 0.0005 and 0.0015 (m3/h)/(m3/h).

Abstract: Systems and methods for managing spreading of particulate material over a surface by a spreader. One step of the method includes receiving a selection of a type of the spreader. An additional step includes receiving a selection of a type of the particulate material to be spread by the spreader. An additional step includes obtaining data indicative of a travel speed of the spreader, with the data being received from a sensor associated with the spreader. An additional step includes determining an operational attribute of the spreader. The determination is based on (i) the type of the spreader, (ii) the type of the particulate material, and (ii) the travel speed of the spreader. A further step includes presenting the operational attribute.

Abstract: A dual-impeller spreader capable of independently a flowrate of particulate material about two halves of the spreader's coverage area. The spreader includes a frame, a hopper, and wheels rotatably connected to the frame via an axle. A first impeller is fixed to a first impeller shaft rotatably coupled to the axle via a first gear train, and a second impeller is fixed to a second impeller shaft rotatably coupled to the axle via a second gear train. A first shut-off control selectively opens and closes a first set of hopper exit openings located above the first impeller, while a second shut-off control selectively opens and closes a second set of hopper exit openings located above the second impeller. The first shut-off control and the second shut-off control selectively open and close the respective openings independent of each other.

Abstract: Disclosed are various embodiments for controlling access to data on a network. Upon receiving a request comprising a device identifier and at least one user credential to access a remote resource, the request may be authenticated according to at least one compliance policy. If the request is authenticated, a resource credential associated with the remote resource may be provided.

Abstract: Embodiments disclosed herein relate to systems including at least one ophthalmic device and methods of using the system. The ophthalmic device includes at least one switchable lens therein that includes at least one electro-optical material. The ophthalmic device also includes at least one charging electrical circuitry. The charging electrical circuitry is electrically coupled to the switchable lens and is configured to receive electrical energy from or provide electrical energy to the switchable lens. The ophthalmic device can also include at least one transfer electrical circuitry that can be coupled to and configured to transfer electrical energy between the charging electrical circuitry and the switchable lens. The ophthalmic device can also include at least one controller operably coupled to at least the charging electrical circuitry and the transfer electrical circuitry.

Abstract: A method for removing ectoparasites from a fish in water may comprise administering to the fish a neonicotinoid to remove the ectoparasites from the fish and exchanging the water comprising the neonicotinoid and the removed ectoparasites with replacement water, thereby separating the removed ectoparasites and the fish. The method may comprise the further step of preventing release of the removed ectoparasites into the environment, for example by passing sample of the water comprising the removed ectoparasite through a mesh filter. A neonicotinoid may be used in treating an ectoparasite infestation in a fish, and a composition for use in treating an ectoparasite infestation in a fish may comprise one or more ectoparasiticides, wherein one of the one or more ectoparasiticides is the neonicotinoid, is provided. The neonicotinoid may be imidacloprid. In use, the dosage regime may be sublethal and/or lethal.

Abstract: A wireless charging station includes a movable charger having a primary coil and a controller having memory with a plurality of desired values for tire pressure sensor signal strength. The controller is programmed to position the primary coil relative to a secondary coil of a vehicle based on tire pressure signal strength values from the vehicle and the desired values.

Abstract: The invention relates to inhibitors of glucosylceramide synthase (GCS) useful for the treatment of metabolic diseases, such as lysosomal storage diseases, either alone or in combination with enzyme replacement therapy, and for the treatment of cancer.

Abstract: Systems and methods described herein are optimized for cutting sealing elements on packages using optical radiation. Packages can pass through a cutting device that applies the optical radiation to damage, vaporize, or cut the sealing element (e.g., tape) on the package. The systems and methods control several aspects of the cutting process to adjust throughput, improve efficiency, and reduce line stoppages. Systems can include an in-feed conveyor that orients packages and rejects packages that are out of specification, which can lead to issues such as jamming or damage to the equipment. Systems can include a variable-speed cut conveyor controlled by a computing system to dynamically adjust the speed of packages based upon historical cut quality, environmental measurement data, and height data related to a vertical dimension of the package.

Abstract: Systems and methods described herein are optimized for cutting sealing elements on packages using optical radiation. Packages can pass through a cutting device that applies the optical radiation to damage, vaporize, or cut the sealing element (e.g., tape) on the package. The systems and methods control several aspects of the cutting process to adjust throughput, improve efficiency, and reduce line stoppages. Systems can include an in-feed conveyor that orients packages and rejects packages that are out of specification, which can lead to issues such as jamming or damage to the equipment. Systems can include a variable-speed cut conveyor controlled by a computing system to dynamically adjust the speed of packages based upon historical cut quality, environmental measurement data, and height data related to a vertical dimension of the package.

Abstract: Disclosed are various embodiments for controlling a distribution of resources on a network. In one embodiment, among others, a processor is configured to transmit a request to access resources at a distribution service and receives location rules associated with the resources. The location rules specify an authorized location and an authorized perimeter area. The authorized location and the authorized perimeter area specify different access rights to the resources. The processor can determine a location of a computing device and determine that the computing device is compliant with at least one of the location rules based on the location of the computing device. The processor is configured to transmit a compliance indication to the distribution service for the location rules and receive access to at least some of the resources from the distribution service.

Abstract: A cable slack controller may include a deflector coupled to a movable carriage device; at least one end of a cable coupled to the carriage device; and an engagement tab formed with the cable wherein the engagement tab engages a notch defined in a portion of a channel on which the movable carriage device translates across.