Abstract: The disclosure provides systems, devices, and associated methods for mitigating traumatic brain injury, injury to an ocular structure, or injury to the inner ear of a subject by applying pressure to one or more neck veins before and during an injurious event.

Abstract: In alternative embodiments, the technology described herein is directed in part to combined magnetic tweezer-nanopore devices, in part to combined magnetic tweezer-nanopore sequencing of polymers, and in part to preparation of polymers for combined magnetic tweezer-nanopore sequencing.

Abstract: A closing element for restricting communication of a substance through an access passage of a body includes a first portion for being removably affixed to the body, the first portion having an inner wall, an outer wall surrounding the inner wall, and at least one bridge connecting the outer wall with the inner wall. The closing element has a second portion for being non-removably affixed to the body and a movable connecting element extending between the first portion and the second portion. The closing element has an unactuated configuration wherein a major portion of the length of the connecting element is located laterally between the inner wall and the outer wall to shield the major portion of the length of the connecting element.

Abstract: A valve (100) includes a base (110) defining a central axis (114). The valve (100) includes a post (118) connected to the base (110) and extending axially outwardly from the base (110), in the direction along the central axis (114). The valve (100) includes at least one flow aperture (122) in one or both of the base (110) and/or the post (118). The valve (100) further includes a flexible membrane (126) having an orifice (130) and having a non-dispensing configuration wherein the orifice (130) is located proximate to the post (118) to minimize communication through the valve (100). The flexible membrane (126) has a dispensing configuration wherein the orifice (130) is moved away from the post (118) for establishing communication through the valve (100).

Abstract: A closing element (28) for restricting communication of a substance through an access passage (34) of a body (24) includes a first portion (68) for being removably affixed to the body (24), the first portion (68) having an inner wall (80), an outer wall (96) surrounding the inner wall (80), and at least one bridge (100) connecting the outer wall (96) with the inner wall (80). The closing element (28) has a second portion (72) for being non-removably affixed to the body (24) and a movable connecting element (76) extending between the first portion (68) and the second portion (72). The closing element (28) has an unactuated configuration wherein a major portion (78) of the length of the connecting element (76) is located laterally between the inner wall (80) and the outer wall (96) to shield the major portion (78) of the length of the connecting element (76).

Abstract: A musical toy includes a wheel with a cylindrical face comprised of a magnetic sheet layer, a printed graphic and a top perforated layer such that when combined they form a radial array of rows of receiving recesses each preceded by a sequence indicator such as a number. These recesses are positioned to receive metal note balls by means of an upper housing containing lettered slots that correspond to the lettered columns of the musical analog in the songbook. The tubes of the upper housing are kept in alignment with the receiving recesses by a ratchet system that allows for controlled sequential advancement of the wheel. When the note balls are placed at predetermined locations corresponding with the locations of notes on the represented staff, they fall down a tube and are guided and into the corresponding lettered recess for that position on the wheel face. The note balls are retained by the magnetic attraction provided by the magnet sheet in the wheel assembly.

Abstract: A closing element (28) for restricting communication of a substance through an access passage (34) of a body (24) includes a first portion (68) for being removably affixed to the body (24), the first portion (68) having an inner wall (80), an outer wall (96) surrounding the inner wall (80), and at least one bridge (100) connecting the outer wall (96) with the inner wall (80). The closing element (28) has a second portion (72) for being non-removably affixed to the body (24) and a movable connecting element (76) extending between the first portion (68) and the second portion (72). The closing element (28) has an unactuated configuration wherein a major portion (78) of the length of the connecting element (76) is located laterally between the inner wall (80) and the outer wall (96) to shield the major portion (78) of the length of the connecting element (76).

Abstract: A closure (40, 40A, 40B) for use with a container includes a body (54, 54A, 54B) defining a passage (72, 72A, 72B) and a first latch portion (92, 92B). The closure (40, 40A, 40B) has a lid (56, 56A, 56B) defining a deflectable press portion (96, 96A, 96B) that has a connection (100, 100A, 100B) to the closure body (54, 54A, 54B). The lid (56, 56A, 56B) has a cover portion (100, 100A, 100B) including a second latch portion (120, 120A, 120B) for engaging the first latch portion (92, 92B) to releasably hold the cover portion (100, 100A, 100B) in a latched closed position in which the cover portion (100, 100A, 100B) at least partially occludes the passage (72, 72A, 72B). The lid (56, 56A, 56B) has a biased hinge (104, 104A, 104B) connecting the cover portion (100, 100A, 100B) with the press portion (96, 96A, 96B) to accommodate movement of the cover portion (100, 100A, 100B) between the latched closed position and an unlatched open position.

Abstract: A liner (100) and closure (106) are provided for being initially assembled and subsequently installed on a container (104) of a product to create a package (107, 107A). The liner (100) is provided for being disposed between, and sealed to, the container (104) and the closure (106) mounted thereon. The liner (100) includes a metallic substrate layer (200) that is an aluminum alloy and that is located between first and second heat-sealable layers (212, 200), respectively. The liner (100) has a through hole (252), and the metallic substrate layer (200) has a laterally inward edge surface (210) that is exposed at the through hole (252).

Abstract: A liner (100) and closure (106) are provided for being initially assembled and subsequently installed on a container (104) of a product to create a package (107, 107A). The liner (100) is provided for being disposed between, and sealed to, the container (104) and the closure (106) mounted thereon. The liner (100) includes a metallic substrate layer (200) that is an aluminum alloy and that is located between first and second heat-sealable layers (212, 200), respectively. The liner (100) has a through hole (252), and the metallic substrate layer (200) has a laterally inward edge surface (210) that is exposed at the through hole (252).

Abstract: A closure (40, 40A, 40B) for use with a container includes a body (54, 54A, 54B) defining a passage (72, 72A, 72B) and a first latch portion (92, 92B). The closure (40, 40A, 40B) has a lid (56, 56A, 56B) defining a deflectable press portion (96, 96A, 96B) that has a connection (100, 100A, 100B) to the closure body (54, 54A, 54B). The lid (56, 56A, 56B) has a cover portion (100, 100A, 100B) including a second latch portion (120, 120A, 120B) for engaging the first latch portion (92, 92B) to releasably hold the cover portion (100, 100A, 100B) in a latched closed position in which the cover portion (100, 100A, 100B) at least partially occludes the passage (72, 72A, 72B). The lid (56, 56A, 56B) has a biased hinge (104, 104A, 104B) connecting the cover portion (100, 100A, 100B) with the press portion (96, 96A, 96B) to accommodate movement of the cover portion (100, 100A, 100B) between the latched closed position and an unlatched open position.

Abstract: A combination of a closing element (28) and a receiving structure (24) is provided wherein the closing element (28) and receiving structure (24) are in an initially assembled orientation which prevents, but which can be subsequently operated to permit, communication through the receiving structure (24). The receiving structure (24) includes at least one laterally projecting shear member (40) and a spout (30) defining (A) an access passage (32). The closing element (28) has an aperture (78) for receiving a shear member (40) of the receiving structure (24). At least one frangible bridge (78) extends across a portion of the aperture (74) for being severed by the shear member (40) during relative rotation between the closing element (28) and the receiving structure (24).

Abstract: A closure assembly (20) that includes a cap or overcap (28) and a fitment (24) for a container is provided wherein the fitment (24) has a laterally projecting shear member (40), and the overcap (28) has an aperture (74) for initially receiving the shear member (40) when the overcap (28) and fitment (24) are in an initially assembled orientation or condition. The aperture (74) and the shear member (40) cooperate in the initially assembled orientation such that when subjected to a flow of a sterilizing gas, turbulence is created in the sterilizing gas flow to enhance sterilization of the combination. The closure assembly (20) may, instead, or additionally, be provided wherein the overcap (28) has an elongate, hollow plug (58) for establishing a first seal between the fitment (24) and the overcap (28) in the initially assembled orientation, and the wherein overcap (28) has a skirt (50) for establishing a second seal between the fitment (24) and the overcap (28) in the initially assembled orientation.

Abstract: A combination of a closing element (28) and a receiving structure (24) is provided wherein the closing element (28) and receiving structure (24) are in an initially assembled orientation which prevents, but which can be subsequently operated to permit, communication through the receiving structure (24). The receiving structure (24) includes at least one laterally projecting shear member (40) and a spout (30) defining (A) an access passage (32). The closing element (28) has an aperture (78) for receiving a shear member (40) of the receiving structure (24). At least one frangible bridge (78) extends across a portion of the aperture (74) for being severed by the shear member (40) during relative rotation between the closing element (28) and the receiving structure (24).

Abstract: A combination of a closing element (28) and a receiving structure (24) is provided wherein the closing element (28) and receiving structure (24) are in an initially assembled orientation which prevents, but which can he subsequently operated to permit, communication through the receiving structure (24). The receiving structure (24) includes at least one laterally projecting shear member (40) and a spout (30) defining (A) an access passage (32). The closing element (28) has an aperture (78) for receiving a shear member (40) of the receiving structure (24). At least one frangible bridge (78) extends across a portion of the aperture (74) for being severed by the shear member (40) during relative rotation between the closing element (28) and the receiving structure (24).

Abstract: A closure (20) is provided to selectively permit or restrict communication between the exterior and the interior of a system that has an opening between the exterior and interior. The closure (20) includes a closure body (24) that defines an access passage (30) and a membrane (60) that initially occludes the access passage (30). The connection of the membrane (60) to the body (24) is defined by a tearable portion (68) of material that defines a tear path along which the material can be torn. The tear path has; (A) a first separation path (80) where separation of the membrane (60) from the body (24) initially originates; and (B) a second separation path (90) where separation of the membrane (60) from the body (24) terminates. The second separation path (90) has a generally tapered configuration.

Abstract: In one aspect, the invention relates to substituted N-([1,1?-biphenyl]-3-yl)-[1,1?-biphenyl]-3-carboxamide analogues, derivatives thereof, and related compound; synthetic methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of treating disorders, e.g., various tumors and cancers, associated with ?-Catenin/BCL9 protein-protein interaction dysfunction using the compounds and compositions. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.

Abstract: A closure assembly (20) that includes a cap or overcap (28) and a fitment (24) for a container is provided wherein the fitment (24) has a laterally projecting shear member (40), and the overcap (28) has an aperture (74) for initially receiving the shear member (40) when the overcap (28) and fitment (24) are in an initially assembled orientation or condition. The aperture (74) and the shear member (40) cooperate in the initially assembled orientation such that when subjected to a flow of a sterilizing gas, turbulence is created in the sterilizing gas flow to enhance sterilization of the combination. The closure assembly (20) may, instead, or additionally, be provided wherein the overcap (28) has an elongate, hollow plug (58) for establishing a first seal between the fitment (24) and the overcap (28) in the initially assembled orientation, and the wherein overcap (28) has a skirt (50) for establishing a second seal between the fitment (24) and the overcap (28) in the initially assembled orientation.

Abstract: A closure assembly (20) that includes a cap or overcap (28) and a fitment (24) for a container is provided wherein the fitment (24) has a laterally projecting shear member (40), and the overcap (28) has an aperture (74) for initially receiving the shear member (40) when the overcap (28) and fitment (24) are in an initially assembled orientation or condition. The aperture (74) and the shear member (40) cooperate in the initially assembled orientation such that when subjected to a flow of a sterilizing gas, turbulence is created in the sterilizing gas flow to enhance sterilization of the combination. The closure assembly (20) may, instead, or additionally, be provided wherein the overcap (28) has an elongate, hollow plug (58) for establishing a first seal between the fitment (24) and the overcap (28) in the initially assembled orientation, and the wherein overcap (28) has a skirt (50) for establishing a second seal between the fitment (24) and the overcap (28) in the initially assembled orientation.