Abstract: Disclosed are compounds, compositions, and methods useful for treating neuronal and mitochondrial diseases.

Abstract: An apparatus may receive, through a user interface, an indication for one or more filters that provide at least one of user-specific search results or organization-specific search results in response to a search query. The one or more filters may be applied to an initial set of data associated with execution of the search query. The apparatus may receive, through the user interface, user input for the execution of the search query and for generation of the initial set of data. The apparatus may filter the initial set of data using the one or more filters indicated via the user interface and output, in response to the execution of the search query, the at least one of the user-specific search results or the organization-specific search results filtered based on the one or more filters.

Abstract: Disclosed are compounds, compositions, and methods useful for treating neuronal and mitochondrial diseases.

Abstract: An apparatus may receive, through a user interface, an input indicative of a document corpus from which to indicate trends of a document set. The document corpus may be one of a plurality of document corpuses included in the document set. The apparatus may filter the document corpus based on user-specific criteria to provide a filtered document corpus. The filtered document corpus includes a subset of documents from the document corpus. The apparatus may output an indication of the trends of the document set based on trending text of the filtered document corpus, where the trends of the document set correspond to the trending text of the filtered document corpus.

Abstract: Disclosed are compounds, compositions, and methods useful for treating neuronal and mitochondrial diseases.

Abstract: An apparatus may map one or more fields from a plurality of tables having a first table type to one or more mapped fields of a single table having a second table type and index the one or more mapped fields to correspond to a single index for the single table having the second table type. The apparatus may execute a first query using the single index corresponding to the one or more mapped fields to output a result for the first query. The apparatus may execute a second query for search activity that has occurred on the database since a last update to the single index and combine the result for the first query with the search activity that has occurred on the database since the last update to the single index to output a combined result based on the second query.

Abstract: One or more embodiments relates to compositions, method of using and methods of producing a gas mixture. The method includes supplying a composition LaxSryCozMwO3, where x ranges from 0.5 to 1, y ranges 0.0 to 1-x, z ranges from 0.1 to 1.0, and M is a dopant or dopants where w ranges from 0.0 to 1-z; and energizing the composition directly using electromagnetic energy to heat the composition to a temperature above 700° C. The method further includes contacting the composition with a reactant gas mixture comprising methane and an oxidant forming a product gaseous mixture.

Abstract: An apparatus may map one or more fields from a plurality of tables having a first table type to one or more mapped fields of a single table having a second table type and index the one or more mapped fields to correspond to a single index for the single table having the second table type. The apparatus may execute a first query using the single index corresponding to the one or more mapped fields to output a result for the first query. The apparatus may execute a second query for search activity that has occurred on the database since a last update to the single index and combine the result for the first query with the search activity that has occurred on the database since the last update to the single index to output a combined result based on the second query.

Abstract: Provided herein are compositions, systems, and methods for causing weight loss and treating and/or preventing a disease or condition, such as obesity, diabetes, and cancer, with an agent or procedure that inhibits the TMA/FMO3/TMAO pathway in a subject.

Abstract: The present disclosure provides methods and systems for detecting multiple different nucleotides in a sample. In particular, the disclosure provides for detection of multiple different nucleotides in a sample utilizing fewer detection moieties than the number of nucleotides being detected and/or fewer imaging events than the number of nucleotides being detected.

Abstract: A system is provided for monitoring, managing, and maintaining a distributed network of information handling systems. The system includes a first information handling system and a second information handling system. The first information handling system creates a software bundle. The second information handling system receives the bundle from the first information handling system, and executes an executable included in the bundle. The executable changes a configuration of the second information handling system from a first operating state to a second operating state.

Abstract: The present invention generally relates to golf bags having a lightweight and durable top frame assembly. The lightweight top frame assembly can have handle and leg sub-assemblies. Three-dimensional printing methods can be used to form the top frame assembly or any portion thereof. The golf bags may include a cord assembly extending across the top frame to form one or more club dividers for organizing golf clubs.

Abstract: The present invention relates to compounds of formula I that function as inhibitors of RET (rearranged during transfection) kinase enzyme activity: wherein HET, bonds a, b, c and d, X1, X2, X3, X4, R2, and R3 are each as defined herein. The present invention also relates to processes for the preparation of these compounds, to pharmaceutical compositions comprising them, and to their use in the treatment of proliferative disorders, such as cancer, as well as other diseases or conditions in which RET kinase activity is implicated.

Abstract: There is disclosed system for oxygenating a patient in relation to anaesthesia using high flow gas delivery. The system has a flow source, and a controller for determining oxygenation requirements of the patient before or during anaesthesia. A method of oxygenating a patient in relation to anaesthesia using high flow gas delivery is also disclosed. The method determines oxygenation requirements of the patient before or during anaesthesia.

Abstract: The disclosure relates to methods, compositions, and kits for improving seeding efficiency of flow cells with polynucleotides, and applications thereof, including for sequencing.

Abstract: The present invention relates to compounds of formula I that function as inhibitors of RET (rearranged during transfection) kinase enzyme activity: wherein HET, X1, X2, X3, X4, integer a and R3 are each as defined herein. The present invention also relates to processes for the preparation of these compounds, to pharmaceutical compositions comprising them, and to their use in the treatment of proliferative disorders, such as cancer, as well as other diseases or conditions in which RET kinase activity is implicated.

Abstract: Bias circuits and methods for silicon-based amplifier architectures that are tolerant of supply and bias voltage variations, bias current variations, and transistor stack height, and compensate for poor output resistance characteristics. Embodiments include power amplifiers and low-noise amplifiers that utilize a cascode reference circuit to bias the final stages of a cascode amplifier under the control of a closed loop bias control circuit. The closed loop bias control circuit ensures that the current in the cascode reference circuit is approximately equal to a selected multiple of a known current value by adjusting the gate bias voltage to the final stage of the cascode amplifier. The final current through the cascode amplifier is a multiple of the current in the cascode reference circuit, based on a device scaling factor representing the relative sizes of the transistor devices in the cascode amplifier and in the cascode reference circuit.

Abstract: The present invention relates to methods of imaging template hybridisation for estimating cluster numbers prior to solid phase amplification and sequencing. More particularly, an initial round of imaging is carried out at the single molecule template hybridisation stage which allows a general estimation of cluster numbers prior to clusters being formed. Amplification of the signal allows single molecule imaging to be carried out using standard sequencing imaging apparatus.

Abstract: An audio filtering and power extraction apparatus for filtering out audio signal and extracting power from a combined signal and direct-current power line, with an input configured to couple to a combined signal and direct-current power line, a filtering extractor system functionally coupled to the input, a DC sensing switch circuit, and a second order low-pass filter functionally coupled to the DC sensing switch circuit, the second order low-pass filter including, an inductor, a capacitor and resistor in series with each other, and an output functionally coupled to an output of the filtering extractor system and through which output extracted power is provided.