Abstract: A connector assembly for multiple components includes a dog having an engagement feature configured to engage a first component while the dog is in a locked position. The connector assembly also includes a lock ring disposed about the dog along a circumferential axis of the connector assembly. One of the dog or the lock ring includes a cam surface, the other of the dog or the lock ring includes a driver, and the driver is configured to move along the cam surface in response to rotation of the lock ring and/or the dog along the circumferential axis to drive the dog to the locked position.

Abstract: The present disclosure provides methods and systems for detecting multiple different nucleotides in a sample. In particular, the disclosure provides for detection of multiple different nucleotides in a sample utilizing fewer detection moieties than the number of nucleotides being detected and/or fewer imaging events than the number of nucleotides being detected.

Abstract: A method for aligning a tree within a resource extraction system includes disposing a riser system on a wellhead of the resource extraction system without utilizing a mechanical alignment system to circumferentially align the riser system with the wellhead. The method also includes disposing a tubing hanger at a landed position within the wellhead. In addition, the method includes disposing an orientation mechanism on the wellhead. The orientation mechanism includes an alignment feature configured to engage a corresponding alignment feature of the tree. Furthermore, the method includes moving the tree toward the wellhead such that the alignment feature of the tree engages the alignment feature of the orientation mechanism to approximately establish a target circumferential orientation of the tree relative to the tubing hanger.

Abstract: Disclosed are compounds, compositions, and methods useful for treating neuronal and mitochondrial diseases.

Abstract: A patient interface can have a frame supporting a sealing member. Various features of the sealing member can improve comfort and sealing performance in the context of forming seals with the nares of a user, as well as contact with other facial surfaces. The sealing member can include convex portions, concave portions and thickness variations for providing various sealing, comfort, and deformability effects.

Abstract: This disclosure relates to a composition useful for making edible food carriers and food carriers made therefrom. In an aspect, the composition is gluten-free. In an aspect, the composition is higher in protein and lower in carbohydrate than traditional food carriers. In an aspect, the composition contains egg whites. In an aspect, the composition may also contain one or more plant protein ingredients.

Abstract: A monitoring system includes one or more units that are adapted monitor the radio frequency conditions of a facility or portion of the facility. The units include a packet sniffer and/or an RF spectrum analyzer. Sniffed packets and spectrum data are recorded and made available for analysis and display, either locally on the units or at one or more remote locations. The locations of the units are also gathered, thereby enabling correlation of the sniffed packets and/or RF spectrum data with locations within the facility. Real time RF conditions can thereby be gathered and used to improve the wireless communications within the facility and/or to ensure the wireless communication infrastructure of the facility is operating satisfactorily. The units may be person support apparatuses, such as beds, chairs, stretchers, cots, or the like.

Abstract: A person support apparatus, such as a bed, cot, stretcher, chair, or the like, includes a frame, a support surface supported by the frame, a plurality of load cells that detect weight supported on the support surface, at least one A/D converter, and a controller. The load cells output analog signals that are converted to digital by the A/D converters. The controller switches a sampling rate of the A/D converters between at least first and second rates. The outputs from the load cells are forwarded to a plurality of signal acquisition nodes that include the A/D converters. The nodes are positioned at locations that minimize the length of travel of the analog signals, thereby reducing noise interference. Shivering, occupant absence/presence, vital signs, occupant movement, and/or other parameters are detected by the load cells.

Abstract: A surgical tracker assembly for use with a navigation system. The tracker assembly includes a tracker body defining a chamber configured to receive a printed circuit board (PCB) including a plurality of markers that are actively energizable through the PCB. A plurality of openings formed in the tracker body and at least one channel formed in the tracker body extending between the chamber and one of the defined by the tracker body. Each of the markers are visible through one of the plurality of openings of the tracker body. The tracker body is configured to be sterilizable, with the PCB being located within the chamber of the tracker body, and the at least one channel is configured to enable sterilization fluid to enter into and drain from the chamber of the tracker body during sterilization. The PCB may also include a sterilization resistant protective coating.

Abstract: The present invention relates to compounds of Formula I that function as inhibitors of RET (rearranged during transfection) kinase enzyme activity: wherein HET, bonds a, b, c and d, X1, X2, X3, X4, R2, and R3 are each as defined herein. The present invention also relates to processes for the preparation of these compounds, to pharmaceutical compositions comprising them, and to their use in the treatment of proliferative disorders, such as cancer, as well as other diseases or conditions in which RET kinase activity is implicated.

Abstract: The present disclosure relates to the field of molecular biology and more specifically to microarrays and methods.

Abstract: A subsea tree assembly with a flow monitoring and measuring apparatus includes a production wing valve block coupled to a production wing branch, the production wing valve block including a wing block connector, and a fluid processing module including a frame, a module connector including an inlet and an outlet, and a fluid flow loop coupled between the inlet and the outlet, wherein the module connector is fluidicly coupled to the wing block connector. A production fluid flow goes from the production wing valve block and returns to the same block via the wing block connector, the module connector, and the fluid flow loop. A flow monitoring and measuring apparatus for a subsea tree assembly includes a module frame, a module connector connectable to a production wing valve block, the module connector including an inlet and an outlet, and a fluid flow conduit forming a loop from the outlet of the module connector back to the inlet of the module connector.

Abstract: A method of characterizing candidate agents including steps of (a) providing a library of candidate agents attached to nucleic acid tags; (b) contacting the library with a solid support to attach the candidate agents to the solid support, whereby an array of candidate agents is formed; (c) contacting the array with a screening agent, wherein one or more candidate agents in the array react with the screening agent; (d) detecting the array to determine that at least one candidate agent in the array reacts with the screening agent; (e) sequencing the nucleic acid tag to determine the tag sequences attached to candidate agents in the array; and (f) identifying the at least one candidate agent in the array that reacts with the screening agent based on the tag sequence that is attached to the at least one candidate agent.

Abstract: Provided herein are compositions, systems, and methods for causing weight loss and treating and/or preventing a disease or condition, such as obesity, diabetes, and cancer, with an agent or procedure that inhibits the TMA/FMO3/TMAO pathway in a subject.

Abstract: This invention relates to a breath indicator that is receivable by a part of a breathing assistance apparatus that supplies gas to a patient. The indicator comprises an elongate body having a gas sampling end and an attachment end. The attachment end is adapted to attach to a part of a breathing assistance apparatus and for locating the gas sampling end. The gas sampling end is to be located in a region where gas from the patient is to be exhaled. The gas sampling end being in communication with a sensor comprising a detector material changeable between a first visual indicator state relating to an inhalation phase of the patient, and a second visual indicator state relating to an exhalation phase of the patient. The detector material is capable of changing between the visual indicator states at a sufficient rate to substantially correspond with the inhalation and exhalation phases of the patient.

Abstract: The present disclosure is concerned with compositions and methods for reducing the steps used in the generation of monoclonal clusters by combining the enzymes used for linearization and removal of unused surface primers.

Abstract: A lint brush includes a housing and a lint tool having a lint-removing material. The lint tool is movable along a longitudinal axis of the housing between a stowed position where the lint tool is housed in the housing and a deployed position where the lint tool is extended from the housing. The lint tool is rotatable relative to the longitudinal axis from the deployed position to a first rotated position. An actuator is mounted to one of the housing and the lint tool. The actuator is configured to move the lint tool from the first rotated position back to the deployed position.

Abstract: Techniques and architectures for data ingestion in an environment having a distributed data storage system. A request to import data into the environment. The data to be imported from an external source through an application programming interface (API). The request is analyzed to determine if the request corresponds to a request to import a large data load. The data is staged if the request is for the large data load. Data management jobs are created to cause the data to be stored in one or more nodes of the distributed data storage system. The data management jobs are transmitted to corresponding nodes in the distributed data storage system. The jobs are executed asynchronously to cause the data to be stored in the nodes.

Abstract: An example of a flow cell includes a substrate having depressions separated by interstitial regions. First and second primers are immobilized within the depressions. First transposome complexes are immobilized within the depressions, and the first transposome complexes include a first amplification domain. Second transposome complexes are also immobilized within the depressions, and the second transposome complexes include a second amplification domain. Some of the first transposome complexes, or some of the second transposome complexes, or some of both of the first and second transposome complexes include a modification to reduce tagmentation efficiency.