Abstract: The invention relates to methods of treating COVID-19 in a patient by administering therapeutically effective amounts of certain SARS-CoV-2 inhibitor compounds or pharmaceutical compositions containing them to a patient in need thereof.

Abstract: Method and system are provided for storage optimization for event streaming for multiple consumers. The method provides an entire event stream for storage in a first tier storage and dynamically determines advance portions of the event stream for at least some of the consumers based on a consumer's position index in the event stream. The advance portions are portions of the event stream that will be consumed next by the consumer and the method provides the advance portions of the event stream for storage in second tier storage that has a higher performance than the first tier storage.

Abstract: In one embodiment, a system includes an automatic speech recognition (ASR) module, a natural-language understanding (NLU) module, a dialog manager, one or more agents, an arbitrator, a delivery system, one or more processors, and a non-transitory memory coupled to the processors comprising instructions executable by the processors, the processors operable when executing the instructions to receive a user input, process the user input using the ASR module, the NLU module, the dialog manager, one or more of the agents, the arbitrator, and the delivery system, and provide a response to the user input.

Abstract: A system and methods are provided for a wing stabilizer charging system for recharging onboard batteries during operation of an electrically powered vehicle. The wing stabilizer charging system comprises a wing stabilizer configured to be coupled with a rear of the vehicle. One or more air inlets are disposed in the wing stabilizer and configured to receive an airstream during forward motion of the vehicle. Wind turbines are disposed within the wing stabilizer and configured to be turned by the airstream. A circuit box is configured to combine electricity received from the wind turbines into a useable electric current. A power cable extends from the circuit box and is configured to supply the useable electric current to any one or more electronic devices, such as any of an onboard battery for powering the vehicle, mobile phones or smart phones, portable music players, tablet computers, cameras, and the like.

Abstract: A membrane-spanning nanopore is provided that comprises: i. at least one scaffold polynucleotide strand; ii. a plurality of staple polynucleotide strands; and iii. at least one hydrophobically-modified polynucleotide strand, wherein the at least one hydrophobically-modified polynucleotide strand comprises a polynucleotide strand and a hydrophobic moiety; wherein each of the plurality of staple polynucleotide strands hybridises to the at least one scaffold polynucleotide strand to form the three-dimensional structure of the membrane-spanning nanopore, and wherein the at least one hydrophobically-modified polynucleotide strand hybridises to a portion of the at least one scaffold polynucleotide strand, the membrane-spanning nanopore defining a central channel with a minimum internal width of at least about 5 nm.

Abstract: An apparatus and a method are provided for an air box configured to cool an engine control unit (ECU) by way of an airstream being communicated to an air intake system of an internal combustion engine of a vehicle. The air box is comprised of a housing to support an air filter within an interior of the housing. An opening in the housing fixedly receives at least one surface of the ECU to transfer heat from the ECU to the airstream. A mount portion within the housing receives the air filter. A conduit to a clean side of the air filter is configured to be coupled with the air intake system. An inlet to the housing is configured to couple with an air inlet duct of the vehicle so as to direct the airstream into the interior of the housing.

Abstract: An apparatus and a method are provided for an oil filter-leak pressure-test station. The oil filter-leak pressure-test station comprises an air pump, a pressure gauge, a vent valve, an overflow reservoir, and a manifold configured to receive an oil filter. The oil filter-leak pressure-test station is configured to apply a desired internal air pressure to an oil filter for observing the oil filter assembly for any potential leaks, such as along a seal ring, rolled seam or a nut-end. The oil filter-leak pressure-test station is also configured to be mounted in a vise or similar mechanical attachment for observation to determine the extent or existence of any leak in the oil filter. The oil filter-leak pressure-test station may also be submerged in water using a submersion reservoir, so as to determine the existence and location of any leaks.

Abstract: Aspects of the present disclosure are directed to creating and administering artificial reality collaborative working environments and providing interaction modes for them. An XR work system can provide and control such artificial reality collaborative working environments to enable, for example, A) links between real-world surfaces and XR surfaces; B) links between multiple real-world areas to XR areas with dedicated functionality; C) maintaining access, while inside the artificial reality working environment, to real-world work tools such as the user's computer screen and keyboard; D) various hand and controller modes for different interaction and collaboration modalities; E) use-based, multi-desk collaborative room configurations; and F) context-based auto population of users and content items into the artificial reality working environment.

Abstract: An apparatus and method for a heat shield with an integrated air filter assembly is disclosed. Wherein the air filter assembly comprising a filter material circumferentially extending such that the filter material surrounds at least a portion of an interior cavity of the air filter, a distal end cap affixed to a distal end of the filter material, and a wire support extending along at least a portion of an exterior surface of the filter material; and wherein the heat shield is configured to direct cooler air into an air intake conduit extending from an intake portion of an automobile engine for combustion.

Abstract: An apparatus and methods are provided for a throttle body spacer that improves the performance of an internal combustion engine. The throttle body spacer comprises a body that includes an airflow opening for conducting airflow from a throttle body into an intake manifold. A spiral is disposed along a sidewall of the airflow opening and configured for swirling the airflow. The spiral comprises a helical shape disposed around a circumference of the sidewall and extends from an initial bore near a first contact surface of the body to a second contact surface. The helical shape includes a diameter that increases as the spiral extends toward the second contact surface, giving the body a sidewall taper angle that contributes to an increase in power output of the engine. A sawtooth cross-sectional shape of the spiral causes the airflow to swirl so as to improve atomization of an air-fuel mixture entering engine.

Abstract: Aspects of the present disclosure are directed to creating and administering artificial reality collaborative working environments and providing interaction modes for them. An XR work system can provide and control such artificial reality collaborative working environments to enable, for example, A) links between real-world surfaces and XR surfaces; B) links between multiple real-world areas to XR areas with dedicated functionality; C) maintaining access, while inside the artificial reality working environment, to real-world work tools such as the user's computer screen and keyboard; D) various hand and controller modes for different interaction and collaboration modalities; E) use-based, multi-desk collaborative room configurations; and F) context-based auto population of users and content items into the artificial reality working environment.

Abstract: A system and methods are provided for a wing stabilizer charging system for recharging onboard batteries during operation of an electrically powered vehicle. The wing stabilizer charging system comprises a wing stabilizer configured to be coupled with a rear of the vehicle. One or more air inlets are disposed in the wing stabilizer and configured to receive an airstream during forward motion of the vehicle. Wind turbines are disposed within the wing stabilizer and configured to be turned by the airstream. A circuit box is configured to combine electricity received from the wind turbines into a useable electric current. A power cable extends from the circuit box and is configured to supply the useable electric current to any one or more electronic devices, such as any of an onboard battery for powering the vehicle, mobile phones or smart phones, portable music players, tablet computers, cameras, and the like.

Abstract: A turbo-boost controlled intake system is disclosed that provides a driver of a vehicle with greater control over vehicle performance. The turbo-boost controlled intake system includes a control module that is coupled with an aircharger air intake. The control module instructs an electronic control unit of the vehicle to increase manifold pressure to a higher level before releasing the pressure through a waste gate so as to provide a greater power output of the engine. The turbo-boost controlled intake system further includes a wiring harness and a signal adjuster. The wiring harness couples the control module with a turbo inlet pressure sensor, a manifold absolute pressure sensor, and an electronic control unit of the vehicle. The signal adjuster includes a rheostat that enables manual adjustment of the power output of the engine.

Abstract: A lighting control device is provided which includes a microcontroller, at least one wireless transceiver, at least one dimmer, one or more lighting terminals powered by the at least one dimmer, at least one environmental sensor, and at least one input device. In operation, the microcontroller obtains environmental data from the at least one environmental sensor, obtains input data from the at least one input device, transmits the environmental data and the input data to an external server, obtains a lighting operating schedule based on the environmental data and the input data from the external server, and executes the lighting operating schedule from the external server by controlling one or more smart bulbs via the at least one wireless transceiver and controlling the electrical current output to lighting terminals.

Abstract: An organ perfusion system comprises: a perfusion fluid circuit (16) arranged to circulate perfusion fluid through the organ; a surrogate organ (126) arranged to be connected into the circuit in place of the organ so that the circuit can circulate fluid through the surrogate organ; and organ sensing means arranged to distinguish between the presence of the organ in the circuit and the presence of the surrogate organ in the circuit. The sensing means may comprise one or more pressure sensors (136, 137, 138), or a flow meter (125). Further aspects relate to adjusting the content of at least one component, such as oxygen or a nutrient, in the perfusion fluid. Bubble detection means (113), and means (74) to measure the amount of fluid secreted by or leaked from the organ, may also be provided.

Abstract: A cylinder head in a cylinder head assembly includes an upper deck, a fire deck, gas exchange conduits, and a coolant cavity extending peripherally around the gas exchange conduits. The cylinder head also includes an igniter socket having an igniter post, and a radially outward sleeve step continuously circumferential of an igniter bore center axis. A cooling moat is formed between the igniter post and the sleeve step. The coolant cavity includes a valve bridge through-channel and a valve bridge part-way channel each fluidly connected to the igniter socket to provide coolant flow into and out of the cooling moat passively.

Abstract: Exemplary systems and methods are disclosed for detecting embedded data in a digital image. The system includes a processing device that extracts one or more features from a digital image and analyzes the one or more extracted features in a plurality of steganography analyzers, each steganography analyzer configured to execute a different steganography algorithm. The processing device generates an output data value at each steganography analyzer, the output data value indicating a probability that the digital image includes steganography according to the steganography algorithm of the steganography analyzer.

Abstract: A prechamber sparkplug assembly includes a sparkplug, and a sparkplug housing having a prechamber tip. The sparkplug housing includes a plug bore centered on a longitudinal axis of the sparkplug housing and receiving the sparkplug, an inside radial wall extending around the plug bore, and an outside radial wall. A cooling cavity is formed between the inside radial wall and the outside radial wall. Coolant ports extend through the outside radial wall and fluidly connect to the cooling cavity to place the cooling cavity in fluid communication with a water jacket in a cylinder head.

Abstract: An apparatus and a method are provided for an air box configured to cool an engine control unit (ECU) by way of an airstream being communicated to an air intake system of an internal combustion engine of a vehicle. The air box is comprised of a housing to support an air filter within an interior of the housing. An opening in the housing fixedly receives at least one surface of the ECU to transfer heat from the ECU to the airstream. A mount portion within the housing receives the air filter. A conduit to a clean side of the air filter is configured to be coupled with the air intake system. An inlet to the housing is configured to couple with an air inlet duct of the vehicle so as to direct the airstream into the interior of the housing.

Abstract: Data characterizing a set of models trained on a dataset using a set of resourcing levels can be received. The set of resourcing levels can specify a condition on outputs of models in the set of models. Performance of the set of models can be assessed using the set of resourcing levels. A feasible performance region can be determined using the assessment. The feasible performance region can associate each constraint in the set of resourcing levels with a model in the set of models. The feasible performance region can be displayed. Related apparatus, systems, articles, and techniques are also described.