Abstract: The present invention is directed to furan derivatives, pharmaceutical compositions comprising the compounds and the use of the compounds or the compositions in the treatment of various diseases

Abstract: Systems and methods are disclosed for, without access to the original set of data elements from which the online filter was originally constructed, converting online filters to other types of filters. To convert a particular type of online filter to either an offline filter or a different type of online filter, the system, in various embodiments, first determines the types/formats of each of the relevant filters. Then, in various embodiments, the system extracts the appropriate data representations from the original online filter. In various embodiments, the system converts the extracted data representations into the data representation format of the new filter. The system, in various embodiments, then constructs the new filter from the converted data representations.

Abstract: Methods, systems, and devices for language mapping are described. Some machine learning models may be trained to support multiple languages. However, word embedding alignments may be too general to accurately capture the meaning of certain words when mapping different languages into a single reference vector space. To improve the accuracy of vector mapping, a system may implement a supervised learning layer to refine the cross-lingual alignment of particular vectors corresponding to a vocabulary of interest (e.g., toxic language). This supervised learning layer may be trained using a dictionary of toxic words or phrases across the different supported languages in order to learn how to weight an initial vector alignment to more accurately map the meanings behind insults, threats, or other toxic words or phrases between languages. The vector output from this weighted mapping can be sent to supervised models, trained on the reference vector space, to determine toxicity scores.

Abstract: Systems, devices, and methods for performing photoacoustic measurements using ultrasound-based guidance are provided. In one embodiment, an imaging system includes: an ultrasound imaging probe comprising an ultrasound transducer array, a processor circuit in communication with the ultrasound imaging probe, and a light source configured to emit light. The processor circuit receives first ultrasound data representative of an anatomical feature within a field of view, identifies a location of the anatomical feature within the field of view, and performs a photoacoustic measurement using the identified location of the anatomical feature. Performing the photoacoustic measurement includes: controlling the light source to emit light into the field of view and processing second ultrasound data representative of photoacoustic energy generated in the anatomical feature by the light source. The processor circuit then outputs a graphical representation of the photoacoustic measurement to a display.

Abstract: A medical imaging element support unit is for use in fixing a medical imaging element (26) releasably against a region of skin of a subject. The support unit includes a support body (14), having a base for engaging with skin of a subject in use and having a coupling means (22) for releasably coupling the medical imaging element (26) to the support body in use. A pneumatic positioning mechanism facilitates adjustment of a position of the medical imaging element relative to the support body, this being fluidly supplied by an air pump mechanism. The same air pump mechanism facilitates releasable fixation of the support body (14) to the skin, through creation of a configurable suction force at the skin engagement surface.

Abstract: Techniques are disclosed herein for generating microbiome fingerprints, dietary fingerprints, and microbiome ancestry. Microbiome data associated with an individual is analyzed to generate a microbiome fingerprint, and a dietary fingerprint for a user. A “microbiome fingerprint” uniquely identifies the microbiome of a user at a particular point in time and is based on a combination of different profiles generated from the microbiome data. The dietary fingerprint identifies how the microbiome of a user is associated with one or more different indexes, such as a dietary index and/or a particular characteristic (e.g., a Mediterranean diet index, a vegetarian diet index, a fast food index, an internal fat index, a fat-digesting index, a carbohydrate-digesting index, a health index, a fasting index, a ketogenic index, . . . ). The microbiome data may also be utilized to determine microbiome ancestry for the user that indicates other users to which the user is related to.

Abstract: An ultrasound imaging system is for determining stroke volume and/or cardiac output. The imaging system may include a transducer unit for acquiring ultrasound data of a heart of a subject (or an input for receiving the acquired ultrasound data), and a controller. The controller is adapted to implement a two-step procedure, the first step being an initial assessment step, and the second being an imaging step having two possible modes depending upon the outcome of the assessment. In the initial assessment procedure, it is determined whether regurgitant ventricular flow is present. This is performed using Doppler processing techniques applied to an initial ultrasound data set. If regurgitant flow does not exist, stroke volume is determined using segmentation of 3D ultrasound image data to identify and measure the volume of the left or right ventricle at each of end systole and end-diastole, the difference between them giving a measure of stroke volume.

Abstract: Example user identification systems and methods are described. In one implementation, a method determines a first step pulse associated with a user carrying a key fob and detects a user device proximate the key fob. The method further identifies a second step pulse measured by the user device and determines whether the first and second step pulses match. If the step pulses match, the user carrying the key fob is identified as the owner of the user device.

Abstract: A carburetor drain apparatus includes a carburetor bowl, a fuel supply pipe, a fuel drain pipe, and a bail interface. The carburetor bowl is configured to store fuel and provide the fuel to an air passage. The fuel supply pipe is connected a fuel tank and the carburetor bowl. The fuel drain pipe is connected to the carburetor bowl. The bail interface is configured to operate in response to actuation of a bail to open the fuel drain pipe.

Abstract: The invention provides an ultrasound processing unit. A controller (18) of the unit is adapted to receive ultrasound data of an anatomical region, for example of the heart. The controller processes the ultrasound data over a period of time to monitor and detect whether alignment of a particular anatomical feature (34) represented in the data relative to a field of view (36) of the transducer unit is changing over time. In the event that the alignment is changing, the controller generates an output signal for communicating this to a user, allowing a user to be alerted at an early stage to likelihood of misalignment and loss of imaging or measurement capability.

Abstract: A carburetor drain apparatus includes a carburetor bowl, a fuel supply pipe, a fuel drain pipe, and a bail interface. The carburetor bowl is configured to store fuel and provide the fuel to an air passage. The fuel supply pipe is connected a fuel tank and the carburetor bowl. The fuel drain pipe is connected to the carburetor bowl. The bail interface is configured to operate in response to actuation of a bail to open the fuel drain pipe.

Abstract: A supercharger having twisted meshing rotors sealingly contained within a housing having an inlet port to admit air into the meshing rotors and an outlet port to expel air from the meshing rotors, the rotors having mesh points where the rotors contact one another and spaces between their mesh points to accept air from the inlet port and propel it to the outlet port as the rotors are rotated and the mesh points travel axially, the housing, inlet and rotors defining an angle known as the seal transfer angle which is greater than or equal to zero degrees when the inlet port is closed and the volume of air between rotors is sealed and has no leakage path. In the described supercharger the housing, rotors and inlet port are configured to have a negative seal transfer angle of, e.g., ?10 to ?40 degrees or more, up to the maximum available, and to provide a leakage path for an angular portion of the rotors' rotation, improving high end performance without degrading low end performance.

Abstract: The present invention is directed to pyrazole derivatives, pharmaceutical compositions comprising the compounds and the use of the compounds or the compositions in the treatment of various diseases.

Abstract: A method for routing a vehicle includes determining, based on roadway section information for two or more potential driving routes for a vehicle, a first route along which a driver assistance feature or an automated driving feature will not be available and a second route along which the driver assistance feature or the automated driving feature will be available. The method further includes providing navigation instructions for the second route to a driver or control system.

Abstract: Techniques are disclosed herein for generating personalized food guidance using predicted food responses. Using the technologies described herein, instead of providing food guidance that is generalized for a group of individuals, personalized food guidance is provided that takes into account an individual's personalized responses to foods, such as the individual's glucose and fat responses, the individual's micro biome, the individual's overall health, potential health risks for the individual, and/or other data associated with the individual. Providing an individual with personalized food guidance can make choosing food easier and healthier.

Abstract: Curable compositions containing a compound comprising a conjugated diene group and a 1,1-di-activated vinyl compound are described. The curable compositions can cure by pericyclic reaction mechanisms.

Abstract: The present invention relates to compounds of formula (I) and salts thereof, pharmaceutical compositions containing such compounds and to their use in therapy.

Abstract: The present invention relates to compounds of formula (I) and salts thereof, pharmaceutical compositions containing such compounds and to their use in therapy

Abstract: The present invention relates to novel compounds, pharmaceutical compositions containing such compounds and to their use in therapy.

Abstract: Methods, devices and apparatuses pertaining to routing with U-turn inhibition. A method may include receiving, by a computing device, geographic information of a destination and geographic information of a current location of a vehicle and evaluating feasibility of a U-turn along a path between the current location and the destination using the geographic information. The computing device may further calculate a U-turn cost parameter associated with the U-turn representative of the feasibility, and determine a feasible route between the current location and the destination based on the U-turn cost parameter using a routing algorithm.