Abstract: The present disclosure generally relates to compounds of Formula (I) and pharmaceutical compositions that may be used in methods of treating cancer.

Abstract: Provided herein are compounds, and pharmaceutically acceptable salts thereof, useful as KRAS G12D and/or KRAS G12C inhibitors, methods of making and using the same (singly or in combination with additional agents), and pharmaceutical compositions thereof.

Abstract: Methods for synthesizing chalcogenide perovskites and chalcogenide perovskites synthesized thereby. Such s method includes providing a precursor solution containing a metal precursor, depositing the precursor solution onto a substrate to form a precursor film, and heating the precursor film in the presence of a chalcogen source to form a chalcogenide perovskite. The precursor solution is oxygen-free, and the steps of depositing and heating are conducted in an inert atmosphere.

Abstract: Compounds and methods of using said compounds, singly or in combination with additional agents, and pharmaceutical compositions of said compounds for the treatment of viral infections are disclosed.

Abstract: Operating a gaseous fuel engine includes spark-igniting gaseous hydrogen fuel and air, and propagating combustion gases of the spark-ignited mixture outwardly from a spark gap. The propagating combustion gases are impinged upon a cone surface of a piston so as to limit a flame area of the propagating combustion gases. Additional gaseous hydrogen fuel and air is ignited in the combustion cylinder by way of the propagating combustion gases to urge a piston toward a bottom-dead-center position.

Abstract: Apparatuses of various forms and each having at least one LED string controlled by a current controller biased by voltage tap nodes in the LED string, and circuitry for implementing the same. In some implementations, circuitry made in accordance with the present disclosure includes a current controller and current-control circuitry. The current controller is biased by a voltage drop across one or more LEDs in an LED string and controls the current-control circuitry in a manner that controls the electrical current in the LED string. In some implementations, one or more additional LED strings and/or one or more other devices may be controlled directly or indirectly by operation of the current controller.

Abstract: A registration technique is provided that can combine one or more related registrations to enhance accuracy of a registration of image volumes. A registration relationship between a first source volume and a target volume and a registration relationship between the first source volume and a second source volume are concatenated to provide an estimate of a registration relationship between the second source volume and the target volume. The estimate is utilized to inform the direct registration of the second source volume to the target volume or utilized in place of the direct registration.

Abstract: Processing within a computing environment is facilitated by generating a hybrid security certificate using multiple cryptosystems. The generating includes obtaining data for inclusion in the hybrid security certificate, and generating a first digital signature associated with a first cryptosystem to cover the data, and a second digital signature associated with a second cryptosystem to cover the data. The generating further includes providing the hybrid security certificate, where the hybrid security certificate includes the data, the first digital signature associated with the first cryptosystem, and the second digital signature associated with the second cryptosystem, and where the first digital signature has no dependency on a key of the second cryptosystem or the second digital signature, and the second digital signature has no dependency on a key of the first cryptosystem or the first digital signature.

Abstract: A system including a bus, a processor coupled to the bus, a non-volatile memory coupled to the bus, circuitry for providing a detected condition, and a secure controller. The secure controller is coupled to the circuitry for providing a detected condition and to selectively enable communication of information between the non-volatile memory and the bus in response to the detected condition.

Abstract: A system for collaboratively generating and/or managing a media channel is provided. The system includes an identification component, a generation component and a permissions component. The identification component identifies a first set of media content associated with a first social group and a second set of media content associated with a second social group. The generation component generates a media channel based on the first and second sets of media content identified as being respectively associated with the first and second social groups. The permissions component grants access to the media channel based at least on permissions generated for the first and second sets of media content in connection with the respective first and second social groups.

Abstract: This application relates generally to certain substituted pyrrolizine compounds, and pharmaceutical compositions which inhibit HBV replication, and methods of making and using them.

Abstract: A material handling vehicle guidance system comprises a first conductive member, a second conductive member, and an electrical current source. The second conductive member is electrically coupled to the first conductive member and extends parallel to the first conductive member to define a loop. The first conductive member and second conductive member are coupled to a shielded cable connector. The electrical current source supplies current to the first conductive member in a first direction and supplies current to the second conductive member in a second direction opposite the first direction to produce a narrowcast radio frequency signal detectable between the first conductive member and the second member.

Abstract: Compounds and methods of using said compounds, alone or in combination with additional agents, and pharmaceutical compositions of said compounds for the treatment of viral infections are disclosed.

Abstract: Compounds and methods of using said compounds, singly or in combination with additional agents, and pharmaceutical compositions of said compounds for the treatment of viral infections are disclosed.

Abstract: An Internet of Things (IoT) device is deployed with embedded software. A debug client device stores an end-to-end encryption key that corresponds to an end-to-end encryption key stored on the IoT device. The debug client encrypts a debug instruction using the end-to-end encryption key and encrypts additional data using a point-to-point encryption key. The encrypted debug instruction and the encrypted additional data are sent to a debug server over a network. The debug server decrypts the additional data and identifies the IoT device from among multiple IoT devices. The debug server generates a message to the IoT device including the encrypted debug instruction, encrypts the message, and transmits the message to the IoT device. The IoT device decrypts the message using a first decryption key associated with the debug server, retrieves the encrypted message payload, and decrypts the message payload using the stored end-to-end encryption key.

Abstract: Various embodiments of the present disclosure provide a scan-based architecture for register-transfer-level (RTL) or gate-level designs that improves the security of scan chain-based design-for-testability (DFT) structures. In various embodiments, the scan-based architecture includes invisible scan chains that are hidden in such a way that an attacker cannot easily identify or locate the invisible scan chains for exploitation and revealing internal secure information of the design. The invisible scan chains are dynamically configurable into a scan chain with select flip-flops, such that scan paths of the invisible scan chains may be different between different designs, chips, or testing operations. Various embodiments further employ key-based obfuscation by combining a scan control finite state machine with existing state machines within a design, which improves design security against unauthorized use and increases confidentiality.

Abstract: Compounds of Formula (I), methods of using said compounds singly or in combination with additional agents and compositions of said compounds for the treatment of cancer are disclosed.

Abstract: The present invention relates to the field of perfumery. More particularly, it concerns malodor masking compositions and/or ingredients, as well as method for counteracting or masking malodors and perfuming compositions having odor masking properties.

Abstract: A system including a bus, a processor coupled to the bus, a non-volatile memory coupled to the bus, circuitry for providing a detected condition, and a secure controller. The secure controller is coupled to the circuitry for providing a detected condition and to selectively enable communication of information between the non-volatile memory and the bus in response to the detected condition.

Abstract: Described herein are methods and systems for providing therapeutic sound treatment to the human body. The present methods and systems may comprise a seating apparatus, a computing device, and a plurality of output devices. The computing device may provide a user interface allowing selection of one or more symptoms. The one or more symptoms may be associated with a sound frequency (or frequencies) and a duration(s) and/or pattern for output of the sound frequency (or frequencies). The computing device may cause the plurality of output devices to output the sound frequency (or frequencies) associated with the selected one or more symptoms, which may provide health benefits for the user, such as alleviating the selected one or more symptoms.