Abstract: Systems and methods are disclosed that provide smart alerts to users, e.g., alerts to users about diabetic states that are only provided when it makes sense to do so, e.g., when the system can predict or estimate that the user is not already cognitively aware of their current condition, e.g., particularly where the current condition is a diabetic state warranting attention. In this way, the alert or alarm is personalized and made particularly effective for that user. Such systems and methods still alert the user when action is necessary, e.g., a bolus or temporary basal rate change, or provide a response to a missed bolus or a need for correction, but do not alert when action is unnecessary, e.g., if the user is already estimated or predicted to be cognitively aware of the diabetic state warranting attention, or if corrective action was already taken.

Abstract: The present invention provides compositions comprising a recombinant AAV and one or more pharmaceutically acceptable excipients. The compositions have improved stability and shelf life as compared to other AAV compositions.

Abstract: A 3D printer includes a gantry configured to move in a plane substantially parallel to a x-y build plane and a print head configured to extrude molten material to print a 3D part in a layer-by-layer process. The 3D printer includes a platen configured to support the part being printed in the layer by layer process and positionable with a primary Z positioner along a z-axis substantially normal to the x-y build plane. The 3D printer includes a local Z positioner moved by the gantry, the local Z positioner comprising a linear motor configured to move the print head in the z-direction and having an operable range of motion extending from a nominal build position at which a nozzle of the print head is positioned in the x-y build plane to a raised position above the x-y build plane.

Abstract: A valve assembly failsafe configured to be coupled to an actuator of a coolant control regulator assembly is provided. The valve assembly failsafe includes a wind arm, a spring that engages the wind arm under spring tension, a latch that engages the wind arm, a drive gear that engages the wind arm and the actuator, and a driver that engages the latch. The valve assembly failsafe is configured to be positioned in a set state where the latch engages and retains the wind arm under spring tension and the drive gear freely rotates during rotation of the actuator, and a tripped state where the driver rotates the latch to disengage the latch from the wind arm, causing the wind arm to rotate under the spring tension to engage the drive gear and cause the drive gear to drive the actuator to a default position.

Abstract: Disclosed herein are compositions that include antigen-encoding nucleic acid sequences and/or antigen peptides. Also disclosed are nucleotides, cells, and methods associated with the compositions including their use as vaccines, including vectors and methods for a heterologous prime/boost vaccination strategy.

Abstract: The various implementations described herein include methods and systems for providing input capabilities at various fidelity levels. In one aspect, a method includes receiving, from an application, a request identifying an input capability for making an input operation available within the application. The method further includes, in response to receiving the request: identifying techniques that the artificial-reality system can use to make the requested input capability available to the application using data from one or more devices; selecting a first technique for making the requested input capability available to the application; and using the first technique to provide to the application data to allow for performance of the requested input capability.

Abstract: A coolant control regulator assembly that comprises a plurality of modular housings, an actuator, and a plurality of ball valves. The actuator is operatively connected to at least one of the plurality of modular housings. Each of the modular housings comprises an internal cavity, at least one inlet port, and at least one outlet port. Further, each of the internal cavities includes one of the plurality of ball valves positioned therein. At least one of the plurality of ball valves comprises a plurality of apertures that are configured to align with the at least one inlet port and the at least one outlet port in certain rotational positions.

Abstract: In a general aspect, a quantum program is automatically synthesized. In some implementations, artificial intelligence systems are used to generate a quantum program to run on a quantum computer. In some aspects, quantum processor output data are generated by a quantum resource executing an initial version of a quantum program, and quantum state information is computed from the quantum processor output data. Neural network input data, which include the quantum state information and a representation of a problem to be solved by the quantum program, are provided to a neural network. Neural network output data are generated by the neural network processing the neural network input data. A quantum logic gate is selected based on the neural network output data. An updated version of the quantum program that includes the selected quantum logic gate is generated.

Abstract: A deaeration valve includes a housing and a ball in fluid communication with housing. The ball can include a body, a seat defining a bleed passage therein, and a deaeration pin slidably disposed within the bleed passage. Further, the deaeration pin may include a head, a retention feature, and a shaft positioned between the head and the retention feature.

Abstract: Methods and compositions for monitoring mutation burden, cancer status, vaccine efficacy using cell-free DNA sequencing are disclosed.

Abstract: Provided herein are target HLA-PEPTIDE antigens, e.g., HLA-PEPTIDE neoantigens and shared tumor HLA-PEPTIDE antigens, and antigen binding proteins (ABPs) that bind the target HLA-PEPTIDE antigens. Also disclosed are methods for identifying target HLA-PEPTIDE antigens as well as identifying one or more antigen binding proteins that bind a given HLA-PEPTIDE target antigen.

Abstract: In a general aspect, an optimization problem is solved using a hybrid computing system. A classical processor unit receives a first data structure that represents the optimization problem. The classical processor unit executes a branch-and-bound process on the first data structure to generate values for a first subset of elements of a solution to the optimization problem. A second data structure is generated based on the first data structure and the first subset of elements. The second data structure represents a reduced version of the optimization problem. A quantum processor unit and a classical processor unit are used to execute a quantum approximate optimization algorithm (QAOA) on the second data structure to generate values for a second subset of the elements of the solution to the optimization problem. The first subset and second subset are combined to obtain the solution to the optimization problem.

Abstract: In a general aspect, a quantum logic circuit is executed on multiple processing nodes in a computing system that includes quantum computing resources. In some aspects, methods of operating the computing system may include obtaining a computer program that includes a quantum logic circuit. The methods may include obtaining hardware resource metadata specifying properties of processing nodes in the computing system. The processing nodes include at least a subset of the quantum computing resources, and the hardware resource metadata includes error rate information and availability information for the respective processing nodes. The methods may include generating execution tasks configured to execute the quantum logic circuit on the processing nodes based on the hardware resource metadata; dispatching the execution tasks to the processing nodes; receiving output data generated by the processing nodes; and producing an output of the computer program based on the output data.

Abstract: Disclosed herein are compositions that include antigen-encoding nucleic acid sequences and/or antigen peptides. Also disclosed are nucleotides, cells, and methods associated with the compositions including their use as vaccines, including vectors and methods for a heterologous prime/boost vaccincation strategy.

Abstract: A coolant control ball valve assembly comprises a housing that includes a housing chamber. The coolant control ball valve assembly further comprises a channel and a plurality of ports that extend from the housing chamber, and a valve element positioned in line with the channel and the plurality of ports. Additionally, the coolant control ball valve assembly comprises an actuator assembly in communication with the valve element. The actuator assembly includes an expansion element, and linear translation of the actuator assembly results in rotational translation of the valve element. Further, the coolant control ball valve comprises a flow diverter positioned adjacent the valve element. The flow diverter allows for coolant to reach a minimum velocity around the expansion element.

Abstract: A valve assembly failsafe configured to be coupled to an actuator of a coolant control regulator assembly is provided. The valve assembly failsafe includes a wind arm, a spring that engages the wind arm under spring tension, a latch that engages the wind arm, a drive gear that engages the wind arm and the actuator, and a driver that engages the latch. The valve assembly failsafe is configured to be positioned in a set state where the latch engages and retains the wind arm under spring tension and the drive gear freely rotates during rotation of the actuator, and a tripped state where the driver rotates the latch to disengage the latch from the wind arm, causing the wind arm to rotate under the spring tension to engage the drive gear and cause the drive gear to drive the actuator to a default position.

Abstract: Methods are provided to separately isolate antigen-binding T cells and antigen-activated T cells derived from a starting population of peripheral blood mononuclear cells, and to identify overlapping T cell receptor clonotypes. Antigens include personal and shared neoantigens as well as cancer-testis antigens. The T cell receptor clonotypes can be further used to develop cancer treatment therapies.

Abstract: A method for identifying T-cells that are antigen-specific for at least one neoantigen that is likely to be presented by class II MHC alleles on surfaces of tumor cells of a subject. Peptide sequences of tumor neoantigens are obtained by sequencing the tumor cells of the subject. The peptide sequences are input into a machine-learned presentation model to generate presentation likelihoods for the tumor neoantigens, each presentation likelihood representing the likelihood that a neoantigen is presented by the class II MHC alleles on the surfaces of the tumor cells of the subject. A subset of the neoantigens is selected based on the presentation likelihoods. T-cells that are antigen-specific for at least one of the neoantigens in the subset are identified. These T-cells can be expanded for use in T-cell therapy. TCRs of these identified T-cells can also be sequenced and cloned into new T-cells for use in T-cell therapy.

Abstract: An apparatus for determining the position of artificial reality wearables may include a wearable dimensioned to be donned by a user of an artificial reality system. The apparatus may also include a sensor incorporated into the wearable. The sensor may detect physical interactions between the wearable and at least one specific body part of the user. The apparatus may further include a processing device communicatively coupled to the sensor. The processing device may determine, based at least in part on one or more physical interactions between the wearable and the specific body part of the user, a change in a position of the wearable relative to the specific body part of the user. Various other apparatuses, systems, and methods are also disclosed.

Abstract: Using a set of anomalies indicative of a malicious pattern of behavior collected from data to determine new alerts for anomalies included in subsequently collected data. A set of anomalies found in data collected from data sources is accessed. The set of anomalies is determined by a prior analysis to be indicative of a malicious pattern of behavior by entities associated with the set of anomalies. Data that is subsequently collected from the data sources is searched to determine if any of the data includes the set of anomalies. Alerts are generated for any of the subsequently collected data that includes the set of anomalies.