Abstract: A tumor neoantigen prediction platform and an application thereof in a neoantigen vaccine development system are provided. The present invention selects 55 HLA-A and HLA-B subtypes with a high proportion of Chinese population from a common database, then establishes a method for constructing cell lines expressing associated HLA subtypes, and subsequently analyzes the resulting HLA subtype cell line binding proteomes by protein mass spectrometry at an attomolar (10?18 molar) level; through very high-precision mass spectrometry of protein profiling presented on the surface of a single cell, the present invention builds a high-frequency HLA-binding polypeptide database for Chinese population; subsequently, a tumor neoantigen prediction algorithm is optimized by a prediction platform including the HLA-binding polypeptide database, thereby significantly improving the tumor neoantigen prediction accuracy.

Abstract: A method and a platform for detecting an immunogenicity of a tumor neoantigen are provided. Specifically, the detection method includes the following steps: culturing human peripheral blood monocytes ex vivo for 13 days, adding an antigenic peptide fragment of human influenza virus and stimulating and activating cytokines, antigenic peptides, and immunoadjuvants during the 13 days, and finally conducting enzyme-linked immunospot (ELISPOT) chromogenic reaction and instrument-based scanning, counting, and analysis to detect the immunogenicity of tumor neoantigen. An application of the detection method and platform in biomedicine is provided. Compared with the prior art, the detection method and platform have advantages and characteristics of a short detection period, high convenience, low consumption of experimental cells, and low detection cost. Therefore, the detection method and platform can be used for ex vivo high-throughput assay for the immunogenicity of the tumor neoantigen.

Abstract: Provided is a molybdenum sulfide that is ribbon-shaped and particularly suitable for a hydrogen generation catalyst. Disclosed are a ribbon-shaped molybdenum sulfide, in which 50 particles as measured by observation with a scanning electron microscope (SEM) have a shape of, on average, 500 to 10000 nm in length, 10 to 1000 nm in width, and 3 to 200 nm in thickness; a method for producing the ribbon-shaped molybdenum sulfide, including: (1) heating a molybdenum oxide at a temperature of 200 to 1000° C. in the presence of a sulfur source; or (2) heating a molybdenum oxide at a temperature of 100 to 800° C. in the absence of a sulfur source, and then heating the molybdenum oxide at a temperature of 200 to 1000° C. in the presence of a sulfur source; and a hydrogen generation catalyst including the ribbon-shaped molybdenum sulfide.

Abstract: A method may include establishing a Fifth Generation (5G) a network connection with a user equipment (UE) device and receiving, by a 5G wireless station, information associated with handling voice communication sessions for the UE device. The method may also include receiving information, from the UE device or directed to the UE device, associated with a first voice communication session, signaling a Fourth Generation (4G) wireless station to establish a connection to the UE device, in response to receiving the information associated with the first voice communication session and establishing, by the 4G wireless station, a connection to the UE device. The method may further include conducting the first voice communication session over a 4G network, determining whether the first voice communication session has terminated and determining whether to reconnect to the 5G network, in response to determining that the first voice communication session has terminated.

Abstract: A first device receives information indicating changed network conditions for a network supporting a call with a second device at a first audio bit rate, and provides, to the second device, a packet instructing use of a second audio bit rate. The first device starts a timer associated with receiving an indication that the second device is using the second audio bit rate, and receives, from the second device, a response packet at the first audio bit rate. The first device determines that the timer has expired, and provides, to the second device, additional packets instructing use of the second audio bit rate. The first device determines that a threshold quantity of additional packets have been provided to the second device, and re-negotiates the second audio bit rate with the second device. The first device continues the call with the second device at the second audio bit rate.

Abstract: A method includes obtaining, at a processor, first data associated with operation of a vehicle. The first data includes sensor data from sensor(s) onboard the vehicle and indicates one or more parameter values of a first parameter measured by the sensor(s) and one or more associated timestamps. The method includes determining, by the processor, a first amount of storage space associated with storing a first portion of the first data in accordance with a first storage scheme and a second amount of storage space associated with storing the first portion in accordance with a second storage scheme that is different than the first storage scheme. The method further includes storing the first portion of the first data in a memory in accordance with the first storage scheme based on the first amount of storage space satisfying a first threshold that is based on the second amount of storage space.

Abstract: A network device may include a memory storing instructions and processor configured to execute the instructions to receive a file transfer request that includes at least a network location corresponding to a file to be transferred; determine whether the network location is internal or external to a network to which the network device belongs; modify the network location when it is determined that the network location included in the file transfer request is external to the network; and retrieve the file to be transferred using the modified network location.

Abstract: Certain aspects of the present disclosure generally relate to an integrated device including a low parasitic middle-of-line (MOL) structure. The integrated device generally includes a plurality of semiconductor devices; an MOL structure disposed above the plurality of semiconductor devices and comprising a dielectric layer; a first barrier-less conductor extending between a first terminal of a semiconductor device in the plurality of semiconductor devices and into the MOL structure; and a first air gap disposed between a lateral surface of an upper portion of the first barrier-less conductor and the dielectric layer of the MOL structure.

Abstract: [Object] An object of the present invention is to provide a high-aspect-ratio plate-like alumina particle having low aggregability and high dispersibility and a method for producing the particle. [Solving Means] The above problem is solved by providing a plate-like alumina particle including a step of firing an aluminum compound in the presence of a shape-controlling agent and a molybdenum compound serving as a fluxing agent. The above problem is solved also by providing a method for producing a plate-like alumina particle, the method including a step in which the aluminum compound and the molybdenum compound react with each other to form aluminum molybdate and a step in which the aluminum molybdate is decomposed to obtain the plate-like alumina particle.

Abstract: The invention provides a conjugate comprising a biomolecule linked to a fatty acid via a linker wherein the fatty acid has the following Formulae A1, A2 or A3: wherein R1, R2, R3, R4, Ak, n, m and p are defined herein. The invention also relates to a method for manufacturing the conjugate of the invention such as GDF15 conjugate, and its therapeutic uses such as treatment or prevention of metabolic disorders or diseases, type 2 diabetes mellitus, obesity, pancreatitis, dyslipidemia, alcoholic and nonalcoholic fatty liver disease/steatohepatitis and other progressive liver diseases, insulin resistance, hyperinsulinemia, glucose intolerance, hyperglycemia, metabolic syndrome, hypertension, cardiovascular disease, atherosclerosis, peripheral arterial disease, stroke, heart failure, coronary heart disease, diabetic complications (including but not limited to chronic kidney disease), neuropathy, gastroparesis and other metabolic disorders.

Abstract: A system described herein may provide a technique for allowing User Equipment (“UE”) to connect to base stations of a wireless network based on base station support for packet switched (“PS”) one or more voice service types that are implemented by the UE. The UE may indicate one or more PS voice types implemented by the UE when registering with the base station. Additionally, or alternatively, the base station may broadcast an indicator of the type(s) of PS voice supported by the base station, based on which the UE may determine whether to register with the base station.

Abstract: A network device determines radio frequency (RF) conditions at a first endpoint and a second endpoint of a call or session. The network device determines optimum first codec parameters for the determined RF conditions at the first endpoint of the call or session, and determines optimum second codec parameters for the determined RF conditions at the second endpoint of the call or session. The network device sends the first codec parameters to the first endpoint for altering operation of a first codec at a first device at the first endpoint. The network device sends the second codec parameters to the second endpoint for altering operation of a second codec at a second device at the second endpoint.

Abstract: A network device may include a memory storing instructions and processor configured to execute the instructions to receive a file transfer request that includes at least a network location corresponding to a file to be transferred; determine whether the network location is internal or external to a network to which the network device belongs; modify the network location when it is determined that the network location included in the file transfer request is external to the network; and retrieve the file to be transferred using the modified network location.

Abstract: Provided is a manufacturing method for high-toughness and plasticity hypereutectoid rail, including: a. hot rolling the steel billet into rail; b. blowing a cooling medium to the top surface of railhead, wherein, the two sides of railhead and the lower jaws on the two sides of railhead after the center of top surface of rail is air-cooled to 800-850° C., and cooling the rail until the center temperature of the top surface is 520-550° C.; c. stop blowing the cooling medium to the lower jaws on the two sides of railhead, continue blowing the cooling medium to the top surface of railhead and the two sides of railhead, and air cool the rail to room temperature after the surface temperature of railhead is cooled to 430-480° C. The resulting hypereutectoid rail has higher toughness and plasticity than existing products, which is suitable for heavy-haul railway, especially for small radius curve sections.

Abstract: Offsetting or modulating the location of a gate between two transistors may achieve a lower power circuit and a higher speed circuit depending on the new location of the gate. In one example, a gate between a PFET transistor and an NFET transistor may be offset towards the PFET transistor to achieve a higher speed circuit than a conventional circuit with the gate located equal distance between the transistors. In another example, a gate between a PFET transistor and an NFET transistor may be offset towards the NFET transistor to achieve a lower power circuit than a conventional circuit with the gate located equal distance between the transistors.

Abstract: An object of the present invention is to provide a high-aspect-ratio plate-like alumina particle having low aggregability and high dispersibility and a method for producing the particle. The above problem is solved by providing a plate-like alumina particle including a step of firing an aluminum compound in the presence of a shape-controlling agent and a molybdenum compound serving as a fluxing agent. The above problem is solved also by providing a method for producing a plate-like alumina particle, the method including a step in which the aluminum compound and the molybdenum compound react with each other to form aluminum molybdate and a step in which the aluminum molybdate is decomposed to obtain the plate-like alumina particle.

Abstract: A method and system are provided having an uplink control structure and a pilot signal having minimal signal overhead for providing channel estimation and data demodulation in a wireless communication network. The uplink control structures enable mobile terminals to communicate with corresponding base stations to perform various functions including obtaining initial system access, submitting a bandwidth request, triggering a continuation of negotiated service, or providing a proposed allocation re-configuration header. A dedicated random access channel is provided to communicatively couple the base station and the mobile terminal so that the mobile terminal can select a random access signaling identification. A resource request is received at the base station to uplink resource information from the mobile terminal and an initial access information request is received from the mobile terminal to configure the base station connection.

Abstract: Alumina is generally used as an inorganic filler, while spinel, which is known to be lower in thermal conductivity than alumina, is used in applications such as gems, fluorescence emitters, catalyst carriers, adsorbents, photocatalysts and heat-resistant insulating materials, but not expected to be used as a thermally conductive inorganic filler. Thus, an object of the invention is to provide spinel particles having excellent thermal conductive properties. The invention relates to a spinel particle including magnesium, aluminum and oxygen atoms and molybdenum and having a [111] plane crystallite diameter of 220 nm or more.

Abstract: The invention provides a conjugate comprising a biomolecule linked to a fatty acid via a linker wherein the fatty acid has the following Formulae A1, A2 or A3: wherein R1, R2, R3, R4, Ak, n, m and p are defined herein. The invention also relates to a method for manufacturing the conjugate of the invention such as GDF15 conjugate, and its therapeutic uses such as treatment or prevention of metabolic disorders or diseases, type 2 diabetes mellitus, obesity, pancreatitis, dyslipidemia, alcoholic and nonalcoholic fatty liver disease/steatohepatitis and other progressive liver diseases, insulin resistance, hyperinsulinemia, glucose intolerance, hyperglycemia, metabolic syndrome, hypertension, cardiovascular disease, atherosclerosis, peripheral arterial disease, stroke, heart failure, coronary heart disease, diabetic complications (including but not limited to chronic kidney disease), neuropathy, gastroparesis and other metabolic disorders.

Abstract: A network device determines radio frequency (RF) conditions at a first endpoint and a second endpoint of a call or session. The network device determines optimum first codec parameters for the determined RF conditions at the first endpoint of the call or session, and determines optimum second codec parameters for the determined RF conditions at the second endpoint of the call or session. The network device sends the first codec parameters to the first endpoint for altering operation of a first codec at a first device at the first endpoint. The network device sends the second codec parameters to the second endpoint for altering operation of a second codec at a second device at the second endpoint.