Abstract: The invention provides a conjugate comprising a biomolecule linked to a fatty acid via a linker wherein the fatty acid has the following Formulae A1, A2 or A3: wherein R1, R2, R3, R4, Ak, n, m and p are defined herein. The invention also relates to a method for manufacturing the conjugate of the invention such as GDF15 conjugate, and its therapeutic uses such as treatment or prevention of metabolic disorders or diseases, type 2 diabetes mellitus, obesity, pancreatitis, dyslipidemia, alcoholic and nonalcoholic fatty liver disease/steatohepatitis and other progressive liver diseases, insulin resistance, hyperinsulinemia, glucose intolerance, hyperglycemia, metabolic syndrome, hypertension, cardiovascular disease, atherosclerosis, peripheral arterial disease, stroke, heart failure, coronary heart disease, diabetic complications (including but not limited to chronic kidney disease), neuropathy, gastroparesis and other metabolic disorders.

Abstract: A network device determines radio frequency (RF) conditions at a first endpoint and a second endpoint of a call or session. The network device determines optimum first codec parameters for the determined RF conditions at the first endpoint of the call or session, and determines optimum second codec parameters for the determined RF conditions at the second endpoint of the call or session. The network device sends the first codec parameters to the first endpoint for altering operation of a first codec at a first device at the first endpoint. The network device sends the second codec parameters to the second endpoint for altering operation of a second codec at a second device at the second endpoint.

Abstract: An aircraft landing weight determination system and method are configured to determine an accurate gross weight of an aircraft. The aircraft landing weight determination system and method include a gross weight determination control unit that is configured to determine an accurate gross weight of an aircraft based on a first source of gross weight data of the aircraft and a second source of gross weight data of the aircraft.

Abstract: Provided are integrated locks, aircraft galley systems using such locks, and aircraft including such galley systems. An integrated lock has a low profile and provides secure locking and visual indication of the lock status to meet various FAA regulations. The visual indication may be provided mechanically (e.g., by moving a two-color indicator between two positions) or electronically (e.g., by triggering a switch connected to a light or an electro-chromic device). Furthermore, a main indicator may be connected to multiple different locks to provide a combined visual indication of the status of all locks. A visual indicator may be disposed on a galley system frame. Each integrated lock may include a handle portion and a locking portion connected to the handle portion and configured to engage the galley system frame when the handle portion is in the locked position and the door is closed.

Abstract: A network device may include a memory storing instructions and processor configured to execute the instructions to receive, from a first service provider, a file transfer request that includes at least a network location corresponding to a file to be transferred; determine whether the network location is internal or external to a second service provider network to which the network device belongs; modify the network location when it is determined that the network location included in the file transfer request is external to the second service provider network; retrieve the file to be transferred using the modified network location; and forward the retrieved file to a terminating user equipment (UE) device.

Abstract: A sampling device includes a switch capacitor circuit. First ends of two switches are respectively connected to an input signal. Second end of the first switch is connected to an upper plate of a first capacitor. Second end of the second switch is connected to a lower plate of a second capacitor. A connection node connecting a lower plate of the first capacitor to an upper plate of the second capacitor is connected to a power source. The first ends of a third switch and a fourth switch are respectively connected to an input common-mode voltage. A second end of the third switch is connected to the upper plate of the first capacitor. A second end of the fourth switch is connected to the lower plate of the second capacitor. The connection node is connected to the power source. Thus, an output common-mode voltage of the sampling device is adjustable.

Abstract: A four valve disc frictionless ball valve includes a spherical valve core assembly, wherein the spherical valve core assembly includes a wedge-shaped valve core. A closed-position valve disc is respectively installed on a pair of closed-position wedge-shaped sides. A closed-position guide key is respectively arranged at the middle positions of the pair of closed-position wedge-shaped sides along an axial direction. A closed-position guide groove is arranged on each closed-position valve disc along the axial direction. An open-position valve disc is respectively installed on a pair of open-position wedge-shaped sides. An open-position guide key is respectively arranged at the middle positions of the pair of open-position wedge-shaped sides along the axial direction. An open-position guide groove is arranged on each open-position valve disc along the axial direction.

Abstract: A user equipment transmits user equipment information, associated with a communication of the user equipment, to permit a base station to select a first bandwidth part, a second bandwidth part, or a third bandwidth part. The user equipment is configured to communicate by the first bandwidth part, the second bandwidth part, and the third bandwidth part. The user equipment receives, from the base station, an instruction to monitor the first bandwidth part, the second bandwidth part, or the third bandwidth part. The instruction is selected based on the user equipment information. The user equipment monitors, based on the instruction, the first bandwidth part, the second bandwidth part, or the third bandwidth part.

Abstract: A method and system are provided having an uplink control structure and a pilot signal having minimal signal overhead for providing channel estimation and data demodulation in a wireless communication network. The uplink control structures enable mobile terminals to communicate with corresponding base stations to perform various functions including obtaining initial system access, submitting a bandwidth request, triggering a continuation of negotiated service, or providing a proposed allocation re-configuration header. A dedicated random access channel is provided to communicatively couple the base station and the mobile terminal so that the mobile terminal can select a random access signaling identification. A resource request is received at the base station to uplink resource information from the mobile terminal and an initial access information request is received from the mobile terminal to configure the base station connection.

Abstract: A method includes obtaining data associated with operation of an aircraft and determining a first operational phase of the aircraft based on the data. The method includes identifying a candidate operational phase transition from the first operational phase to a candidate operational phase based on a first portion of the data satisfying a first condition associated with the candidate operational phase, the first portion of the data corresponding to a first time. The method includes evaluating a second portion of the data based on a second condition associated with the candidate operational phase, the second portion of the data corresponding to a second time that is subsequent to the first time. The method further includes, based on the second condition being satisfied, generating an operational phase transition indication that indicates an occurrence of an operational phase transition to the candidate operational phase at the first time.

Abstract: The disclosure relates to nucleic acids that contain modifications at the 5?-end, 3?-end or 5?-end and 3?-ends, and compounds that can be used to make the modified nucleic acids are disclosed. The modified nucleic acids have improved expression, lower immunogenicity and improved stability compared to unmodified nucleic acids.

Abstract: Methods described herein are for wireless communication systems. One aspect of the invention is directed to a method for a HARQ process, in which the HARQ process includes a first transmission of an encoder packet and at least one retransmission. The method involves allocating a transmission resource for each respective transmission. The method involves transmitting control information from a base station to a mobile station for each respective transmission. The control information includes information to uniquely identify the HARQ process and an identification of one of a time resource, a frequency resource and a time and frequency resource that is allocated for the transmission. In some embodiments of the invention, specific control information is signalled from a base station to a mobile station to enable RAS-HARQ operation. In some embodiments of the invention, retransmission signaling in included as part of regular unicast signaling used for both first transmission and retransmissions.

Abstract: Provided is a metal oxide production apparatus that implements a flux evaporation method. The production apparatus includes a firing furnace configured to subject a metal compound to firing in the presence of flux, a cooling pipe connected to the firing furnace and configured to convert vaporized flux resulting from the firing into powder, and a recovery means configured to recover powdered flux converted in the cooling pipe. Furthermore, provided is a metal oxide production method comprising a step (1) of subjecting a metal compound to firing in the presence of flux and obtaining a metal oxide and vaporized flux, a step (2) of converting the vaporized flux into powder by cooling the vaporized flux, and a step (3) of recovering powdered flux resulting from the converting.

Abstract: The disclosure relates to nucleic acids that contain modifications at the 5?-end, 3?-end or 5?-end and 3?-ends, and compounds that can be used to make the modified nucleic acids are disclosed. The modified nucleic acids have improved expression, lower immunogenicity and improved stability compared to unmodified nucleic acids.

Abstract: The present invention discloses a cellular structure of a silicon carbide UMOSFET device having surge voltage self-suppression and self-overvoltage protection capabilities. A p-well region of the cellular structure is divided into three layers; the top layer is on the left and right sides of a U-shaped trench and in contact with the U-shaped trench; the middle layer and the bottom layer are respectively constituted by two parts on the left and right sides of the cellular structure, and the left and right parts of the two are not in contact; the distances between the left and right parts of the middle layer and the vertical axis of the cellular structure are greater than the distances between the left and right parts of the bottom layer and the vertical axis of the cellular structure; that is, a JFET structure is introduced to a drain current path of the cellular structure.

Abstract: Methods described herein are for wireless communication systems. One aspect of the invention is directed to a method for a HARQ process, in which the HARQ process includes a first transmission of an encoder packet and at least one retransmission. The method involves allocating a transmission resource for each respective transmission. The method involves transmitting control information from a base station to a mobile station for each respective transmission. The control information includes information to uniquely identify the HARQ process and an identification of one of a time resource, a frequency resource and a time and frequency resource that is allocated for the transmission. In some embodiments of the invention, specific control information is signalled from a base station to a mobile station to enable RAS-HARQ operation. In some embodiments of the invention, retransmission signaling in included as part of regular unicast signaling used for both first transmission and retransmissions.

Abstract: An example method includes receiving, from a high bitrate communication device, a first request to communicate via a high bitrate communication protocol; responding to the first request from the high bitrate communication device by establishing a high bitrate communication session; sending, after the high bitrate communication session is established, a second request to the high bitrate communication device to communicate via a low bitrate communication protocol; receiving, from the high bitrate communication device, a response associated with the second request; and establishing a low bitrate communication session using the low bitrate communication protocol.

Abstract: The invention provides a conjugate comprising a biomolecule linked to a fatty acid via a linker wherein the fatty acid has the following Formulae A1, A2 or A3: wherein R1, R2, R3, R4, Ak, n, m and p are defined herein. The invention also relates to a method for manufacturing the conjugate of the invention such as GDF15 conjugate, and its therapeutic uses such as treatment or prevention of metabolic disorders or diseases, type 2 diabetes mellitus, obesity, pancreatitis, dyslipidemia, alcoholic and nonalcoholic fatty liver disease/steatohepatitis and other progressive liver diseases, insulin resistance, hyperinsulinemia, glucose intolerance, hyperglycemia, metabolic syndrome, hypertension, cardiovascular disease, atherosclerosis, peripheral arterial disease, stroke, heart failure, coronary heart disease, diabetic complications (including but not limited to chronic kidney disease), neuropathy, gastroparesis and other metabolic disorders.

Abstract: A spinel compound oxide particle includes metallic atoms, aluminum atoms, oxygen atoms, and molybdenum atoms, wherein the metallic atoms are selected from the group consisting of zinc atoms, cobalt atoms, and strontium atoms, and a crystallite size in a [111] plane is 100 nm or more. Included are a step (1) of firing a first mixture including a molybdenum compound and a metallic-atom-containing compound or a first mixture including a molybdenum compound, a metallic-atom-containing compound, and an aluminum compound to prepare an intermediate; and a step (2) of firing, at a temperature higher than a temperature selected in the step (1), a second mixture including the intermediate or a second mixture including the intermediate and an aluminum compound.

Abstract: A novel PVC board and method of manufacture. The board provides shock absorption, temperature-insulation for energy saving, and noise-reduction advantages. The method of manufacture simplifies the production process, and improves production time and efficiency.