Patent number: 6600042
Abstract: Preparation of pyrimido[5,4-g]pteridine of formula I
wherein A1, A2, A3 and A4 are each independently of the others —NR1R2, wherein R1 and R2 are hydrogen, C1-C8alkyl, —CO—C1-C8alkyl, —CO—C6-C14aryl, —COO—C1-C8alkyl, —COO—C6-C14aryl, —CONH—C1-C8alkyl or —CONH—C6-C14aryl, or —OH, —SH, hydrogen, C1-C8alkyl, C1-C8alkoxy, or C6-C14aryl or —O—C6-C14aryl each unsubstituted or mono- or poly-substituted by halogen, nitro, cyano, —OR10, —SR10, —NR10R11, —CONR10R11, —COOR10, —SO2R10, —SO2NR10R11, —SO3R10, —NR11COR10 or by —NR11COOR10, wherein R10 and R11 are each independently of the other hydrogen, C1-C8alkyl, C5-C12cycloalkyl or C2-C8alkenyl, by a) reacting the pyrimidine of formula II
with the pyrimidine of formula III
in the presence of an acid and, if desired, of a solvent, the molar ratio of
Type:
Grant
Filed:
October 13, 2000
Date of Patent:
July 29, 2003
Assignee:
Ciba Specialty Chemicals Corporation
Inventors:
Thomas Eichenberger, Max Hügin, Karl-Heinz Müller