Abstract: The present invention provides a method of treating or preventing an inflammatory neurological disease in a subject, the method comprising administering to the subject a protein comprising an extracellular domain of CD39. The present invention also relates to binding proteins comprising an extracellular domain of CD39.

Abstract: An electrophotographic printing system for printing with a set of toners including a white toner. A plurality of printing modules are configured to print respective toner patterns, each including a toner image printed onto a receiver medium being transported on a transparent transport web and a corresponding registration mark positioned outside a border of the receiver medium. A first registration mark sensing system is positioned to detect the registration marks printed with a first subset of the toners that doesn't include the white toner. A second registration mark sensing system is positioned to detect the registration marks printed with a second subset of the toners that includes the white toner. The registration mark sensing systems each include a reflector plate positioned behind the transport web. The reflector plate for the first registration mark sensing system is white, and the reflector plate for the second registration mark sensing system is black.

Abstract: A sensing apparatus for performing sensing in a blood vessel of a biological subject includes a guidewire including a circumferential window positioned proximate a distal end, the guidewire being configured to be positioned in the blood vessel of the biological subject, an optical fiber extending substantially from a proximal end of the guidewire to a position proximate the window and a substantially conical reflector positioned proximate the window and aligned with an axis of the optical fiber. The conical reflector is configured to reflect stimulating radiation emitted from the optical fiber so that the stimulating radiation passes substantially radially through the window to thereby expose the blood vessel to the stimulating radiation and reflect sample radiation emitted from within the blood vessel so that the sample radiation is transmitted to the optical fiber.

Abstract: An electrophotographic printing system for printing with a set of toners including a white toner. A plurality of printing modules are configured to print respective toner patterns, each including a toner image printed onto a receiver medium being transported on a transparent transport web and a corresponding registration mark positioned outside a border of the receiver medium. A first registration mark sensing system is positioned to detect the registration marks printed with a first subset of the toners that doesn't include the white toner. A second registration mark sensing system is positioned to detect the registration marks printed with a second subset of the toners that includes the white toner. The registration mark sensing systems each include a reflector plate positioned behind the transport web. The reflector plate for the first registration mark sensing system is white, and the reflector plate for the second registration mark sensing system is black.

Abstract: The present disclosure relates to a method of treating or preventing atherosclerosis in a subject by administering an inhibitor of FXII.

Abstract: The present disclosure relates to a method of treating or preventing atherosclerosis in a subject by administering an inhibitor of FXII.

Abstract: The present invention provides an isolated monoclonal antibody or an antigen-binding portion thereof which a) binds to Mac-1, b) specifically inhibits the interaction of CD40L with activated Mac-1 and c) does not induce integrin outside-in signaling.

Abstract: The CD40L/Mac-1 interaction is selectively targeted by small peptide inhibitors and/or antibodies and such peptides are used for the specific treatment of inflammation and atherogenesis. In particular, pharmaceutical compositions comprising a polypeptide having the amino acid sequence EQLKKSKTL and antibodies specifically binding to an epitope are disclosed.

Abstract: The present invention provides an isolated monoclonal antibody or an antigen-binding portion thereof which a) binds to Mac-1, b) specifically inhibits the interaction of CD40L with activated Mac-1 and c) does not induce integrin outside-in signaling.

Abstract: An apparatus is for use in detecting atherosclerotic plaques. The apparatus includes an electronic processing device that determines a level of fluorescence sensed by a sensing device at a second infrared wavelength in response to exposure of at least part of an artery to radiation at a first infrared wavelength and determines a fluorescence indicator using the level of fluorescence. The fluorescence indicator is indicative of the presence, absence or degree of an atherosclerotic plaque.

Abstract: An apparatus detects atherosclerotic plaques. The apparatus includes an electronic processing device that determines a level of fluorescence sensed by a sensor at a second infrared wavelength in response to exposure of at least part of an artery to radiation at a first infrared wavelength and determines a fluorescence indicator using the level of fluorescence. The fluorescence indicator is indicative of the presence, absence or degree of an atherosclerotic plaque.

Abstract: The CD40L/Mac-1 interaction is selectively targeted by small peptide inhibitors and/or antibodies and such peptides are used for the specific treatment of inflammation and atherogenesis. In particular, pharmaceutical compositions comprising a polypeptide having the amino acid sequence EQLKKSKTL and antibodies specifically binding to an epitope are disclosed.

Abstract: The present disclosure relates to a method of treating or preventing atherosclerosis in a subject by administering an inhibitor of FXII.

Abstract: The present invention provides an isolated monoclonal antibody or an antigen-binding portion thereof which a) binds to Mac-1, b) specifically inhibits the interaction of CD40L with activated Mac-1 and c) does not induce integrin outside-in signaling.

Abstract: The CD40L/Mac-1 interaction is selectively targeted by small peptide inhibitors and/or antibodies and such peptides are used for the specific treatment of inflammation and atherogenesis. In particular, pharmaceutical compositions comprising a polypeptide having the amino acid sequence EQLKKSKTL and antibodies specifically binding to an epitope are disclosed.

Abstract: The CD40L/Mac-1 interaction is selectively targeted by small peptide inhibitors and/or antibodies and such peptides are used for the specific treatment of inflammation and atherogenesis. In particular, pharmaceutical compositions comprising a polypeptide having the amino acid sequence EQLKKSKTL and antibodies specifically binding to an epitope are disclosed.

Abstract: The present invention provides an anticoagulant agent including a first element capable of inhibiting coagulation and a second element capable of targeting an activated platelet wherein upon administration of the agent to a subject the second element directs the first element to the activated platelet. Also provided is a probe for detecting a blood vessel abnormality including (a) a binding element capable of targeting an activated platelet and (b) a label. Applicant has shown that agents and probes directed to activated platelets are useful in the diagnosis and therapy of coagulation disorders.

Abstract: A printing system including a plurality of printheads for printing on a web of media traveling along a web transport path, at least one of the printheads being configured to print at first and second print lines. A plurality of web transport rollers guide the web of media along the web transport path. At least some of the plurality of web transport rollers are constrained to have a roller circumference that is substantially equal to an integer fraction of a span of the web of media along the web transport path between two successive print locations in successive print heads. A span extension member provides an increased span of the web of media between the first and second print lines in a particular printhead such that the increased span is an integer multiple of the roller circumferences of the constrained web transport rollers.

Abstract: A printing system for printing on a web of media traveling along a web transport path, including a plurality of printheads for printing on the web of media, each of the printheads being configured to print at one or more corresponding print locations along the web transport path. A plurality of web transport rollers guide the web of media along the web transport path. Each of the plurality of web transport rollers has a roller circumference that is substantially equal to an integer fraction of a span of the web of media along the web transport path between two successive print locations.

Abstract: A printing system including a plurality of printheads for printing on a web of media traveling along a web transport path, at least one of the printheads being configured to print at first and second print lines. A plurality of web transport rollers guide the web of media along the web transport path. At least some of the plurality of web transport rollers are constrained to have a roller circumference that is substantially equal to an integer fraction of a span of the web of media along the web transport path between two successive print locations in successive print heads. A span extension member provides an increased span of the web of media between the first and second print lines in a particular printhead such that the increased span is an integer multiple of the roller circumferences of the constrained web transport rollers.