Abstract: A printing system for printing on a web of media traveling along a web transport path including a plurality of print stations located along the web transport path, each print station including a printing cylinder having a printing cylinder circumference for printing on the web of media at a corresponding print location. A plurality of web-transport rollers are used to guide the web of media along the web transport path, each having a roller circumference that is substantially equal to an integer fraction of the printing cylinder circumference.

Abstract: A printing system for printing on a web of media traveling along a web transport path including a plurality of print stations located along the web transport path, each print station including a printing cylinder having a printing cylinder circumference for printing on the web of media at a corresponding print location. A plurality of web-transport rollers are used to guide the web of media along the web transport path. The printing system includes one or more constrained driven rollers having an affixed driven gear, the driven gear being driven by a motor using a gear train including one or more drive gears which transfer torque from the motor to the driven gear, wherein the driven gear and the drive gears associated with the constrained driven rollers are constrained to have a rotate an integer number of times for every rotation of the printing cylinders.

Abstract: A printing system for printing on a web of media traveling along a web transport path, including a plurality of printheads for printing on the web of media, each of the printheads being configured to print at one or more corresponding print locations along the web transport path. A plurality of web transport rollers guide the web of media along the web transport path. Each of the plurality of web transport rollers has a roller circumference that is substantially equal to an integer fraction of a span of the web of media along the web transport path between two successive print locations.

Abstract: A printing system for printing on a web of media traveling along a web transport path, including a plurality of printheads for printing on the web of media, each of the printheads being configured to print at one or more corresponding print locations along the web transport path. A plurality of web transport rollers guide the web of media along the web transport path. A drive roller causes the web of media to move along the web transport path. The drive roller has an affixed driven gear driven by a motor using a gear train including one or more drive gears which transfer torque from the motor to the driven gear. The driven gear and the drive gears are constrained to rotate substantially an integer number of times as the web of media is advanced along the web transport path between two successive print locations.

Abstract: The present invention relates generally to branched macromolecules and their use as imaging or contrast agents. In particular, the invention relates to dendrimers, derived from lysine or lysine analogs, bearing a plurality of functional moieties and their application to imaging techniques in which a disease state may be imaged with a targeted contrast agent.

Abstract: This disclosure relates to temperature sensitive conjugates, compositions, and uses related thereto. In certain embodiments, the disclosure relates to conjugate polymers comprising a) a temperature sensitive polymer and b) an antibody. Typically the antibody has an epitope to a platelet receptor. The antibody may be a single-chain antibody wherein the platelet receptor is GPIIb/IIIa, such as an anti-GPIIb/IIIa antibody. In certain embodiments, the antibody binds specifically to the activated conformation of GPIIb/IIIa, i.e., an activation-specific GPIIb/IIIa antibody.

Abstract: The present invention provides an anticoagulant agent including a first element capable of inhibiting coagulation and a second element capable of targeting an activated platelet wherein upon administration of the agent to a subject the second element directs the first element to the activated platelet. Also provided is a probe for detecting a blood vessel abnormality including (a) a binding element capable of targeting an activated platelet and (b) a label. Applicant has shown that agents and probes directed to activated platelets are useful in the diagnosis and therapy of coagulation disorders.

Abstract: The CD40L/Mac-1 interaction is selectively targeted by small peptide inhibitors and/or antibodies and such peptides are used for the specific treatment of inflammation and atherogenesis. In particular, pharmaceutical compositions comprising a polypeptide having the amino acid sequence EQLKKSKTL and antibodies specifically binding to an epitope are disclosed.

Abstract: A method for automatically adapting a write cycle to a movement of a web-shaped medium in a digital printing machine, as a function of the thickness of the web-shaped medium guided around first and second transport or guide rollers, includes providing the first and second transport or guide rollers having a known diameters, the diameter of the second being different from the diameter of the first. A rotational speed ratio N(T) between the first and second transport or guide rollers (9, 11) is determined while the printing material (6) is guided around the transport or guide rollers (9, 11). The write cycle is determined at least with the use of the previously determined rotational speed ratio N(T).

Abstract: A device for controlling substrate web tension includes first and second driving units with respective driving rollers around which the substrate web is partially guided and tensioned. The first and second driving units have different rotational moments of inertia. A measuring unit measures the tension of the substrate web. A control unit has first and a second filtering units with different filtering characteristics for filtering the measured value. The control unit includes a first control device for controlling the first driving unit based on the measured value filtered by the first filtering device, and a second control device for controlling the second driving unit based on the measured value filtered by the second filtering device.

Abstract: The present invention is directed to an antibody or derivative thereof of human origin for inhibiting platelet aggregation, characterized in that it is effective by substantially exclusive binding to the activated state of platelet integrin receptor GPIIb/IIIa.

Abstract: This disclosure relates to temperature sensitive conjugates, compositions, and uses related thereto. In certain embodiments, the disclosure relates to conjugate polymers comprising a) a temperature sensitive polymer and b) an antibody. Typically the antibody has an epitope to a platelet receptor. The antibody may be a single-chain antibody wherein the platelet receptor is GPIIb/IIIa, such as an anti-GPIIb/IIIa antibody. In certain embodiments, the antibody binds specifically to the activated conformation of GPIIb/IIIa, i.e., an activation-specific GPIIb/IIIa antibody.

Abstract: A device for controlling substrate web tension includes first and second driving units with respective driving rollers around which the substrate web is partially guided and tensioned. The first and second driving units have different rotational moments of inertia. A measuring unit measures the tension of the substrate web. A control unit has first and a second filtering units with different filtering characteristics for filtering the measured value. The control unit includes a first control device for controlling the first driving unit based on the measured value filtered by the first filtering device, and a second control device for controlling the second driving unit based on the measured value filtered by the second filtering device.

Abstract: The present invention relates to a method for the printing of substrates, wherein the substrates are printed at a printing speed and the thusly produced printed image is subsequently fused at a speed that is lower than the printing speed.

Abstract: The invention relates to a method and a device for controlling the circumferential register in a digital multi-color printing machine for printing sheets during a printing process, whereby, for each sheet, at least one register mark per color printing unit of the multi-color printing machine is produced, assigned to said sheet and defined with respect to its position, and whereby, based on the determination of the position of the register marks of a sheet, the circumferential register of at least one sheet, which follows the sheet associated with said determined register marks downstream of the printing process, is controlled. In duplex printing a sheet by recto and verso printing with the invention, register marks are applied for each side and, in order to control recto and verso printing of at least one subsequent sheet, said register marks are analyzed.

Abstract: A method for feeding a plurality of sheets from a stack of sheets into a sheet processing machine includes picking up a first sheet from the stack of sheets using a first feeding device. The sheet is conveyed to a first transfer point of the processing machine. A second sheet is picked up from the stack of sheets using a second feeding device and conveyed to a second transfer point. The first and second transfer points are spatially separated. The sheets alternately move into a sheet conveyor device of the sheet processing machine. A single transfer point can also be used.

Abstract: A method for automatically adapting a write cycle to a movement of a web-shaped medium in a digital printing machine, as a function of the thickness of the web-shaped medium guided around first and second transport or guide rollers, includes providing the first and second transport or guide rollers having a known diameters, the diameter of the second being different from the diameter of the first. A rotational speed ratio N(T) between the first and second transport or guide rollers (9, 11) is determined while the printing material (6) is guided around the transport or guide rollers (9, 11). The write cycle is determined at least with the use of the previously determined rotational speed ratio N(T).

Abstract: The invention relates to a method of ensuring a correct lateral registration setting, in a digital multi-color electrographic sheet-printing machine, which the sheets adhere to a support, preferably a transport belt, are transported past printing units.

Abstract: A method for printing a multi-color image on a web that is moved in a transport direction along a plurality of printing units for respectively printing one color separation of the multi-color image. A line clock is determined for the printing unit being the first one in transport direction, as a function of the transport speed of the web, and a plurality of synchronization marks is printed with the web, said synchronization marks located in a region of the web that is outside the region of the multi-color image, and printed at a prespecified clock that is formed of a partial set of the line clock. The synchronization marks are detected at a position between the first and the second printing units, and a line clock for the second printing unit in the direction of movement is determined based on the detection of the synchronization marks.

Abstract: A method of printing an image onto a sheet in a printer having at least one print module and a transport arrangement defining a transport path for transporting sheets through the at least one print module is shown. In accordance with the method, a series of constant frame clock signals is generated and a sheet is approximately feed into a frame along the sheet transport path in accordance with the frame clock signal, wherein the frame defines a virtual desired sheet position, which moves with a predetermined speed along the sheet transport path. The sheet is transported along the sheet transport path, an in-track position of the sheet in the sheet transport path is detected and it is determined whether the in-track sheet position matches the frame within predetermined limits.