Abstract: The present invention is directed to an antibody or derivative thereof of human origin for inhibiting platelet aggregation, characterized in that it is effective by substantially exclusive binding to the activated state of platelet integrin receptor GPIIb/IIIa.

Abstract: The present invention relates generally to branched macromolecules and their use as imaging or contrast agents. In particular, the invention relates to dendrimers, derived from lysine or lysine analogues, bearing a plurality of functional moieties and their application to imaging techniques in which a disease state may be imaged with a targeted contrast agent.

Abstract: The present invention is directed to an antibody or derivative thereof of human origin for inhibiting platelet aggregation, characterized in that it is effective by substantially exclusive binding to the activated state of platelet integrin receptor GPIIb/IIIa.

Abstract: The present invention provides an anticoagulant agent including a first element capable of inhibiting coagulation and a second element capable of targeting an activated platelet wherein upon administration of the agent to a subject the second element directs the first element to the activated platelet. Also provided is a probe for detecting a blood vessel abnormality including (a) a binding element capable of targeting an activated platelet and (b) a label. Applicant has shown that agents and probes directed to activated platelets are useful in the diagnosis and therapy of coagulation disorders.

Abstract: Disclosed herein are compositions, methods, and kits for diagnosing or predicting a disease in a subject, for detecting activated platelets in a subject, and for treating a disease in a subject, wherein the diseases are mediated by platelet activation.

Abstract: The present invention provides molecules capable of specifically binding the activated form of the beta-integrin Mac-1. The molecules may be provided in the form of peptides, polypeptides and single chained antibodies. The molecules may be used therapeutically for the treatment of disease mediated by Mac-1 (such as inflammation), or used diagnostically to locate sites of Mac-1 activity in the body.

Abstract: A device and a method using a printing device and system for printing sheets whereby, for each sheet, at least one register mark per color printing unit of the multi-color printing machine is produced, assigned to said sheet and defined with respect to its position, so that in duplex printing register marks are applied to each side. The position of each mark is determined by analyzing the position of the mark assigned to the appropriate previous recto or verso sheet.

Abstract: The invention relates to a method of ensuring a correct lateral registration setting, in a digital multi-color electrographic sheet-printing machine, which the sheets adhere to a support, preferably a transport belt, are transported past printing units.

Abstract: Disclosed herein are compositions, methods, and kits for diagnosing or predicting a disease in a subject, for detecting activated platelets in a subject, and for treating a disease in a subject, wherein the diseases are mediated by platelet activation.

Abstract: The present invention provides an anticoagulant agent including a first element capable of inhibiting coagulation and a second element capable of targeting an activated platelet wherein upon administration of element directs the first element to the activated platelet. Also provided is a probe for detecting a blood vessel abnormality including (a) a binding element capable of targeting an activated platelet and (b) a label. Applicant has shown that agents and probes directed to activated platelets are useful in the diagnosis and therapy of coagulation disorders.

Abstract: A device and a method for improving the quality of prints using a printing device and system for printing sheets whereby, for each sheet, at least one register mark per color printing unit of the multi-color printing machine is produced, assigned to said sheet and defined with respect to its position, including in duplex printing.

Abstract: A method and control device for determining a register error, whereby at least one register mark is printed and at least one sensor records the register mark, whereby the sheet edge of the sheet is recorded by the sensor, and the register error is determined from the sensor data and the target data.

Abstract: Positioning a printing head of a printing press in which marks are applied on a support that is detected by sensors and as a consequence, the printing head is adjusted, the marks being applied on two opposite sides of the support that are detected by two correspondingly arranged sensors, and the printing head is oriented in response to the results of the two sensors.

Abstract: A method and device for detecting the position of a transparent conveyor belt including directing light beams (2) onto the region of an edge (3) of the conveyor belt, detecting a jump in intensity of the light beam (2, 2′) as a consequence of the partial insertion of the conveyor belt into the beam path (2) and evaluating the detected jump in intensity in order to determine the position of the conveyor belt, wherein the light beams (2) are linear polarized light and the beam path (2) is directed at an angle or irradiation (&agr;) between 40° and 80° of the light (2) onto the bounding surface (7) in such a way that a high degree of reflection is achieved and reflected light and non-reflected light is detected.

Abstract: The invention relates to a process for alignment of sheet material (1) which is processed in a machine which processes sheet material (1). To do this the sheet material (1) is aligned into one conveyor plane (9) laterally and with respect to its twisting (6) with reference to its conveyor direction (22). The position of the sheet material (1) in the conveyor plane (9) is always acquired at a point (35) on one side edge (24) of the sheet material with a position which is defined to the reference edge (23) of the sheet material (1).

Abstract: Transfer cylinder with an electromotive drive unit includes a common bearing for a rotor of the electromotive drive unit and for the transfer cylinder, the bearing being disposed in a unit of a printing press supporting the drive unit and the transfer cylinder.