Abstract: A respiratory interface system for use in delivering a flow of a positive pressure breathing gas to an airway of a patient that includes a patient interface device with a tubing assembly structured to be disposed on the head of the patient, a mask having a sealing element structured to sealingly engage about the airway of the patient, and an adaptor. The adapter includes a flange portion that extends generally radially outward from a central aperture and a hollow male connector extending from the flange portion and coupled with a correspondingly-shaped female connector of the tubing assembly or the mask. The mask is coupled to the tubing assembly via the adaptor, and the tubing assembly, the mask, and the adapter define a pathway structured to conduct the flow of the positive pressure breathing gas to the airway of the patient.

Abstract: Extracellular protein degraders and compositions are provided that have a potent asialoglycoprotein receptor (ASGPR) Binding Ligand bound to an Extracellular Protein Targeting Ligand for the selective degradation of the Target Extracellular Protein, for example immunoglobulin in vivo to treat disorders mediated by the extracellular protein.

Abstract: A wheelchair assembly is provided for easy assembly, disassembly, and transport. The wheelchair assembly includes a plurality of subassemblies, including a first subassembly having a first frame and a second subassembly having a second frame. The wheelchair assembly includes at least one motor and a plurality of wheels. The plurality of subassemblies are configured to be selectively attached with each other to form the wheelchair assembly, and the wheelchair assembly is configured to be easily assembled and disassembled. The subassemblies are configured to be disassembled from each other so that each of the plurality of subassemblies can be separately carried by a single person. The wheelchair assembly is an all-terrain wheelchair assembly.

Abstract: Compounds and compositions that have an asialoglycoprotein receptor (ASGPR) binding ligand bound to an extracellular protein binding ligand for the selective degradation of the target extracellular protein in vivo to treat disorders mediated by the extracellular protein are described.

Abstract: A GPS-tracked wireless-networked wheelchair system includes a wheelchair framework for carrying a passenger, and having a set of wheels adapted to rotate. A device-level machine-readable code is displayed on a surface associated with the wheelchair system. A brake assembly is arranged with the set of wheels and has a locked position, and an unlocked position. A wireless control module is operably connected to a wireless communication network. When a web-enabled mobile phone is used to (i) scan the device-level machine-readable code displayed on the wheelchair system, (ii) complete a wheelchair rental transaction over the wireless communication network, and (iii) obtain access control over the rented wheelchair system, then the wireless wheel locking control module unlocks the brake assembly, and the wheelchair framework is allowed to move relative to the ground surface.

Abstract: A wireless-networked stroller access control system includes a plurality of wireless-networked strollers, each having stroller framework for carrying a passenger, and having a set of wheels mounted on an axle. A device-level machine-readable code is displayed on a surface associated with the stroller system. A wheel brake assembly is arranged with the set of wheels and has a locked position, and an unlocked position. A manually-actuated control bar assembly is mounted on the stroller framework, arranged with respect to the wheel brake assembly, and has a locked state of operation and an unlocked state of operation. A wireless wheel-axle locking control module is arranged in wireless communication with a wireless communication infrastructure, and configured with the manually-actuated control bar assembly to control the state of operation of the manually-actuated control bar assembly and also the wheel brake assembly.

Abstract: A GPS-tracked wireless-networked electric convenience vehicle (ECV) includes a body portion adapted for supporting the body of passenger; a GPS system for providing GPS-location services to the GPS-tracked wireless-networked ECV; a transport system with wheels and a drive mechanism, for supporting and transporting the body portion; and a wireless electronic control module being integrated with the transport system, and in wireless communication with a wireless communication infrastructure, for controlling said wheels and/or the drive mechanism. When a web-enabled mobile phone is used to (i) scan a device-level machine-readable code displayed on the GPS-tracked wireless-networked ECV, (ii) complete an ECV rental transaction over the wireless communication infrastructure, and (iii) obtain access control over the rented GPS-tracked wireless-networked ECV, then the wireless electronic control module enables the GPS-tracked wireless-networked ECV to be operated on a ground surface.

Abstract: A single-sided ride storage locker system deployed at any site within a facility, and providing guest visitors with access control enabled by scanning multi-level machine-readable codes using mobile scanning computing systems, such as web-enabled smartphones with digital cameras and mobile application support. The storage locker system supports automated modes of discovering and finding where a guest's rented locker is located within the facility and its sites at any moment in time, simply by using the guest' smart phone to scan a device-level code, a site-level code, a facility-level code or a discovery-level code, posted anywhere within the facility or any site, without need for using a physical locker lookup kiosk or other conventional systems and methods.

Abstract: A wireless network, mobile systems and methods for controlling access to lockers, strollers, wheel chairs and electronic convenience vehicles and other networked devices provided with machine-readable codes that are scanned by mobile phones and computing devices.

Abstract: The instant launder cover is readily fabricated by pultrusion, vacuum bag, or other non-sprayed methods and may advantageously be used with various sizes of tanks and/or launder troughs. The cover system effectively controls odor using, for example, optional gaskets while not requiring stiffening flanges or interfering with wiper mechanisms or other components of the tank or system.

Abstract: A cryptographically enforced data exchange is disclosed that enables an exchange of customer travel records between a plurality of travel providers while preserving customer privacy. The disclosed system receives customer travel data from publishers, and communicates a portion of the customer travel data to one or more subscribers in response to determining a customer match, without disclosing any protected data elements between the publisher and the subscriber.

Abstract: Systems and methods are disclosed for identifying one or more RF transponders from a group of RF transponders in an environment based on motions and associated change in radio signal strength. An example method includes causing a target object to move, in accordance with a target path, relative to remaining objects, and obtaining signal strength information of signals emitted from the transponders for a period of time during which the target object is moved and identifying the transponder associated with the target object based, at least in part, on analyzing the signal strength information in accordance with one or more criteria predetermined for the target path.

Abstract: Provided herein are compositions and methods of integrating one or more exogenous donor nucleic acids into one or more exogenous landing pads engineered into a host cell's genome. In certain embodiments, the exogenous landing pads and exogenous donor nucleic acids comprise standardized, compatible homology regions so that exogenous donor nucleic acids can integrate into any of the landing pads, independent of the genomic sequences surrounding the landing pads. In certain embodiments, the methods comprise contacting the host cell comprising landing pads with one or more exogenous donor nucleic acids, and a nuclease capable of causing a double-strand break within the landing pads, and recovering a host cell comprising one or more exogenous donor nucleic acids integrated in any of the landing pads.

Abstract: The present disclosure generally relates to a robotic gripping system and method that utilizes vacuum suction and finger grasping, wherein the suction and grasping are actuated based on a dynamic collision model. In an exemplary embodiment, the present disclosure is directed to generating collision scenes of a surrounding environment which is used to determine possible collisions in a motion path, and which is used to selectively actuate the vacuum suction and/or finger grasping.

Abstract: The present disclosure generally relates to a robotic gripping system and method that utilizes vacuum suction and finger grasping, wherein the suction and grasping are actuated based on a dynamic collision model. In an exemplary embodiment, the present disclosure is directed to generating collision scenes of a surrounding environment which is used to determine possible collisions in a motion path, and which is used to selectively actuate the vacuum suction and/or finger grasping.

Abstract: Provided herein are compositions and methods of integrating one or more exogenous donor nucleic acids into one or more exogenous landing pads engineered into a host cell's genome. In certain embodiments, the exogenous landing pads and exogenous donor nucleic acids comprise standardized, compatible homology regions so that exogenous donor nucleic acids can integrate into any of the landing pads, independent of the genomic sequences surrounding the landing pads. In certain embodiments, the methods comprise contacting the host cell comprising landing pads with one or more exogenous donor nucleic acids, and a nuclease capable of causing a double-strand break within the landing pads, and recovering a host cell comprising one or more exogenous donor nucleic acids integrated in any of the landing pads.

Abstract: A double-sided ride storage locker system deployed at a park facility with ride sites, including a system integrated with a facility ride management system, for automated management and control over the operation of locker-rental state indication lights displayed as rented on the egress side of the double-sided ride storage locker system. The double-sided ride storage locker system provides guest visitors with access control enabled by scanning multi-level machine-readable codes using mobile scanning computing systems, such as web-enabled smartphones with digital cameras and mobile application support.

Abstract: A wireless network, mobile systems and methods for controlling access to lockers, strollers, wheel chairs and electronic convenience vehicles and other networked devices provided with machine-readable codes that are scanned by mobile phones and computing devices.

Abstract: A wireless-networked stroller access control system includes a plurality of wireless-networked strollers, each having stroller framework for carrying a passenger, and having a set of wheels mounted on an axle. A device-level machine-readable code is displayed on a surface associated with the stroller system. A wheel brake assembly is arranged with the set of wheels and has a locked position, and an unlocked position. A manually-actuated control bar assembly is mounted on the stroller framework, arranged with respect to the wheel brake assembly, and has a locked state of operation and an unlocked state of operation. A wireless wheel-axle locking control module is arranged in wireless communication with a wireless communication infrastructure, and configured with the manually-actuated control bar assembly to control the state of operation of the manually-actuated control bar assembly and also the wheel brake assembly.

Abstract: A GPS-tracked wireless-networked wheelchair system includes a wheelchair framework for carrying a passenger, and having a set of wheels adapted to rotate. A device-level machine-readable code is displayed on a surface associated with the wheelchair system. A brake assembly is arranged with the set of wheels and has a locked position, and an unlocked position. A wireless control module is operably connected to a wireless communication network. When a web-enabled mobile phone is used to (i) scan the device-level machine-readable code displayed on the wheelchair system, (ii) complete a wheelchair rental transaction over the wireless communication network, and (iii) obtain access control over the rented wheelchair system, then the wireless wheel locking control module unlocks the brake assembly, and the wheelchair framework is allowed to move relative to the ground surface.