Patents by Inventor Leonardo De Maria

Leonardo De Maria has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • GLUCOAMYLASE VARIANTS AND POLYNUCLEOTIDES ENCODING SAME
    Publication number: 20240084277
    Abstract: The present invention relates to glucoamylase variants having improved thermostability. The present invention also relates to polynucleotides encoding the variants; nucleic acid constructs, vectors, and host cells comprising the polynucleotides; and methods of using the variants.
    Type: Application
    Filed: October 25, 2023
    Publication date: March 14, 2024
    Applicant: Novozymes A/S
    Inventors: Esben Peter Friis, Leonardo De Maria, Jasper Vind, Thomas A. Poulsen, Allan Svendsen, Steffen Danielsen, Rolf T. Lenhard, Henrik Friis-Madsen, Lars K. Skov
  • Glucoamylase variants and polynucleotides encoding same
    Patent number: 11840713
    Abstract: The present invention relates to glucoamylase variants having improved thermostability. The present invention also relates to polynucleotides encoding the variants; nucleic acid constructs, vectors, and host cells comprising the polynucleotides; and methods of using the variants.
    Type: Grant
    Filed: November 10, 2020
    Date of Patent: December 12, 2023
    Assignee: NOVOZYMES A/S
    Inventors: Esben Peter Friis, Leonardo De Maria, Jesper Vind, Thomas A. Poulsen, Allan Svendsen, Steffen Danielsen, Rolf T. Lenhard, Henrik Friis-Madsen, Lars K. Skov
  • Subtilase variants and polynucleotides encoding same
    Patent number: 11591585
    Abstract: The present invention relates to subtilase variants suitable for use in, e.g., cleaning or detergent compositions, such as laundry detergent compositions and dish wash compositions, including automatic dish wash compositions. The present invention also relates to isolated DNA sequences encoding the variants, expression vectors, host cells, and methods for producing and using the variants of the invention.
    Type: Grant
    Filed: May 6, 2020
    Date of Patent: February 28, 2023
    Assignee: NOVOZYMES A/S
    Inventors: Miguel Duarte Guilherme Pereira Toscano, Leonardo De Maria
  • Oligomer extended insulin-Fc conjugates
    Patent number: 11471537
    Abstract: This invention is in the field of protein conjugates. More specifically the invention relates to oligomer extended insulins with covalently attached Fc monomer polypeptides, for use in the treatment of a metabolic disorder or condition, and to methods of producing such oligomer extended insulin-Fc conjugates. The invention also relates to novel Fc fragments, to intermediate products, and to the use of such intermediate products in processes for the synthesis of the oligomer extended insulin-Fc conjugates of the invention. Finally the invention provides pharmaceutical compositions comprising the oligomer extended insulin-Fc conjugates of the invention, and relates to the use of such compositions for the treatment or prevention of medical conditions relating to metabolic disorders or conditions.
    Type: Grant
    Filed: April 4, 2018
    Date of Patent: October 18, 2022
    Assignee: Novo Nordisk A/S
    Inventors: Tina Moeller Tagmose, Peter Madsen, Thomas Boerglum Kjeldsen, Lone Pridal, Leonardo De Maria, Zhaosheng Lin, Zhe Wan, Yuanyuan Zhang, Lennart Lykke, Martin Werner Borchsenius Muenzel, Janos Tibor Kodra
  • GLUCOAMYLASE VARIANTS AND POLYNUCLEOTIDES ENCODING SAME
    Publication number: 20210062172
    Abstract: The present invention relates to glucoamylase variants having improved thermostability. The present invention also relates to polynucleotides encoding the variants; nucleic acid constructs, vectors, and host cells comprising the polynucleotides; and methods of using the variants.
    Type: Application
    Filed: November 10, 2020
    Publication date: March 4, 2021
    Applicant: NOVOZYMES A/S
    Inventors: Esben Peter Friis, Leonardo De Maria, Jesper Vind, Thomas A. Poulsen, Allan Svendsen, Steffen Danielsen, Rolf T. Lenhard, Henrik Friis-Madsen, Lars K. Skov
  • Glucoamylase variants and polynucleotides encoding same
    Patent number: 10865399
    Abstract: The present invention relates to glucoamylase variants having improved thermostability. The present invention also relates to polynucleotides encoding the variants; nucleic acid constructs, vectors, and host cells comprising the polynucleotides; and methods of using the variants.
    Type: Grant
    Filed: September 19, 2018
    Date of Patent: December 15, 2020
    Assignee: NOVOZYMES A/S
    Inventors: Esben Peter Friis, Leonardo De Maria, Jesper Vind, Thomas A. Poulsen, Allan Svendsen, Steffen Danielsen, Rolf T. Lenhard, Henrik Friis-Madsen, Lars K. Skov
  • Oligomer Extended Insulin-FC Conjugates
    Publication number: 20200261595
    Abstract: This invention is in the field of protein conjugates. More specifically the invention relates to oligomer extended insulins with covalently attached Fc monomer polypeptides, for use in the treatment of a metabolic disorder or condition, and to methods of producing such oligomer extended insulin-Fc conjugates. The invention also relates to novel Fc fragments, to intermediate products, and to the use of such intermediate products in processes for the synthesis of the oligomer extended insulin-Fc conjugates of the invention. Finally the invention provides pharmaceutical compositions comprising the oligomer extended insulin-Fc conjugates of the invention, and relates to the use of such compositions for the treatment or prevention of medical conditions relating to metabolic disorders or conditions.
    Type: Application
    Filed: April 4, 2018
    Publication date: August 20, 2020
    Applicant: Novo Nordisk A/S
    Inventors: Tina Moeller Tagmose, Peter Madsen, Thomas Boerglum Kjeldsen, Lone Pridal, Leonardo De Maria, Zhaosheng Lin, Zhe Wan, Yuanyuan Zhang, Lennart Lykke, Martin Werner Borchsenius Muenzel, Janos Tibor Kodra
  • SUBTILASE VARIANTS AND POLYNUCLEOTIDES ENCODING SAME
    Publication number: 20200263157
    Abstract: The present invention relates to subtilase variants suitable for use in, e.g., cleaning or detergent compositions, such as laundry detergent compositions and dish wash compositions, including automatic dish wash compositions. The present invention also relates to isolated DNA sequences encoding the variants, expression vectors, host cells, and methods for producing and using the variants of the invention.
    Type: Application
    Filed: May 6, 2020
    Publication date: August 20, 2020
    Applicant: NOVOZYMES A/S
    Inventors: Miguel Duarte Guilherme Pereira Toscano, Leonardo De Maria
  • Dough with a lipolytic enzyme and/or xylanase and a monooxygenase
    Patent number: 10743551
    Abstract: A method for preparing a dough or a baked product prepared from the dough which method comprises incorporating into the dough a lipolytic enzyme and/or a xylanase and an X143 polypeptide, wherein the X143 polypeptide is a monooxygenase.
    Type: Grant
    Filed: July 6, 2015
    Date of Patent: August 18, 2020
    Assignee: Novozymes A/S
    Inventors: Henrik Lundkvist, Morten Tovborg, Leonardo De Maria, Chee-Leong Soong
  • Subtilase variants and polynucleotides encoding same
    Patent number: 10683491
    Abstract: The present invention relates to subtilase variants suitable for use in, e.g., cleaning or detergent compositions, such as laundry detergent compositions and dish wash compositions, including automatic dish wash compositions. The present invention also relates to isolated DNA sequences encoding the variants, expression vectors, host cells, and methods for producing and using the variants of the invention.
    Type: Grant
    Filed: December 3, 2015
    Date of Patent: June 16, 2020
    Assignee: NOVOZYMES A/S
    Inventors: Miguel Duarte Guilherme Pereira Toscano, Leonardo De Maria
  • Improved Processes For Production Of Ethanol From Xylose-Containing Cellulosic Substrates Using Engineered Yeast Strains
    Publication number: 20190345522
    Abstract: Provided herein are recombinant host cells having a heterologous polynucleotide encoding a hexose transporter and a heterologous polynucleotide encoding a xylose isomerase, wherein the cells are capable of fermenting xylose in the presence of glucose and under oxygen limited growth. Also described are processes of fermenting saccharified material using the recombinant cells to produce ethanol at higher yields.
    Type: Application
    Filed: December 6, 2017
    Publication date: November 14, 2019
    Applicant: Novozymes A/S
    Inventors: Jean-Marie Mouillon, Nicholas Jochumsen, José Arnau, Leonardo De Maria, Monica Tassone
  • GLUCOAMYLASE VARIANTS AND POLYNUCLEOTIDES ENCODING SAME
    Publication number: 20190002856
    Abstract: The present invention relates to glucoamylase variants having improved thermostability. The present invention also relates to polynucleotides encoding the variants; nucleic acid constructs, vectors, and host cells comprising the polynucleotides; and methods of using the variants.
    Type: Application
    Filed: September 19, 2018
    Publication date: January 3, 2019
    Applicant: NOVOZYMES A/S
    Inventors: Esben Peter Friis, Leonardo De Maria, Jesper Vind, Thomas A. Poulsen, Allan Svendsen, Steffen Danielsen, Rolf T. Lenhard, Henrik Friis-Madsen, Lars K. Skov
  • Polypeptides Having Organophosphorous Hydrolase Activity
    Publication number: 20180346892
    Abstract: The present invention relates to isolated polypeptides having organophosphorous hydrolase activity, and polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides.
    Type: Application
    Filed: August 7, 2018
    Publication date: December 6, 2018
    Applicant: Novozymes A/S
    Inventors: Bjarne Gram Hansen, Steffen Danielsen, Lars Kobberosee Skov, Leonardo De Maria, Julie Bille Rannes
  • Glucoamylase variants and polynucleotides encoding same
    Patent number: 10113158
    Abstract: The present invention relates to glucoamylase variants having improved thermostability. The present invention also relates to polynucleotides encoding the variants; nucleic acid constructs, vectors, and host cells comprising the polynucleotides; and methods of using the variants.
    Type: Grant
    Filed: August 15, 2017
    Date of Patent: October 30, 2018
    Assignee: NOVOZYMES A/S
    Inventors: Esben Peter Friis, Leonardo De Maria, Jesper Vind, Thomas A. Poulsen, Allan Svendsen, Steffen Danielsen, Rolf T. Lenhard, Henrik Friis-Madsen, Lars K. Skov
  • Polypeptides having organophosphorous hydrolase activity
    Patent number: 10066220
    Abstract: The present invention relates to isolated polypeptides having organophosphorous hydrolase activity, and polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides.
    Type: Grant
    Filed: November 3, 2016
    Date of Patent: September 4, 2018
    Assignee: NOVOZYMES A/S
    Inventors: Bjarne Gram Hansen, Steffen Danielsen, Lars Kobberoee Skov, Leonardo De Maria, Julie Bille Rannes
  • Phytase variants
    Patent number: 10041052
    Abstract: The present invention relates to a phytase which has at least 74% identity to a phytase derived from Citrobacter braakii and comprises at least one alteration as compared to this phytase. These phytase variants have amended, preferably improved, properties, such as thermostability, temperature profile, pH profile, specific activity, performance in animal feed, reduced protease sensibility, and/or an amended glycosylation pattern. The invention also relates to DNA encoding these phytases, methods of their production, as well as the use thereof, e.g., in animal feed and animal feed additives.
    Type: Grant
    Filed: August 29, 2016
    Date of Patent: August 7, 2018
    Assignee: Novozymes A/S
    Inventors: Leonardo De Maria, Carsten Andersen, Lars Kobberoee Skov, Mikael Blom Soerensen
  • Cutinase variants and polynucleotides encoding same
    Patent number: 9951299
    Abstract: The present invention relates to variants with cutinase activity of a parent cutinase, comprising an alteration at one or more (e.g. several) positions corresponding to positions: 36, 37, 40, 78, 90, 114, 150, 196, 216, or 217 of SEQ ID NO: 2, wherein the alteration is a substitution for positions 40, 78, 90, 114, 150, 196 and 216, and a deletion for positions 36, 37 and 217, and wherein the variant has at least 75% but less than 100% sequence identity to the mature polypeptide of SEQ ID NO: 2. The present invention also relates to polynucleotides encoding the variants; nucleic acid constructs, vectors, and host cells comprising the polynucleotides; and method for obtaining and methods of producing the variants. It also relates to compositions comprising the variant, and to methods for using the variant.
    Type: Grant
    Filed: December 10, 2014
    Date of Patent: April 24, 2018
    Assignee: Novozymes A/S
    Inventors: Leonardo De Maria, Rakhi Saikia, Santhosh Vasu Mepadam, Ting Sun
  • GLUCOAMYLASE VARIANTS AND POLYNUCLEOTIDES ENCODING SAME
    Publication number: 20170342393
    Abstract: The present invention relates to glucoamylase variants having improved thermostability. The present invention also relates to polynucleotides encoding the variants; nucleic acid constructs, vectors, and host cells comprising the polynucleotides; and methods of using the variants.
    Type: Application
    Filed: August 15, 2017
    Publication date: November 30, 2017
    Applicant: NOVOZYMES A/S
    Inventors: Esben Peter Friis, Leonardo De Maria, Jesper Vind, Thomas A. Poulsen, Allan Svendsen, Steffen Danielsen, Rolf T. Lenhard, Henrik Friis-Madsen, Lars K. Skov
  • SUBTILASE VARIANTS AND POLYNUCLEOTIDES ENCODING SAME
    Publication number: 20170335307
    Abstract: The present invention relates to subtilase variants suitable for use in, e.g., cleaning or detergent compositions, such as laundry detergent compositions and dish wash compositions, including automatic dish wash compositions. The present invention also relates to isolated DNA sequences encoding the variants, expression vectors, host cells, and methods for producing and using the variants of the invention.
    Type: Application
    Filed: December 3, 2015
    Publication date: November 23, 2017
    Applicant: NOVOZYMES A/S
    Inventors: Miguel Duarte Guilherme Pereira Toscano, Leonardo De Maria
  • Organophosphorous hydrolase variants
    Patent number: 9771566
    Abstract: The present invention relates to organophosphorous hydrolase variants. The present invention also relates to polynucleotides encoding the variants; nucleic acid constructs, vectors, and host cells comprising the polynucleotides; and methods of using the variants.
    Type: Grant
    Filed: November 28, 2014
    Date of Patent: September 26, 2017
    Assignee: Novozymes A/S
    Inventors: Bjarne G. Hansen, Lars Kobberoe Skov, Leonardo De Maria, Julie Bille Rannes