Abstract: Applications of different configurations of novel glucagon peptide 1 with fatty acid modification or nonmodification in the treatment of T2D or the pancreas protection are provided. The dimer of the present disclosure is formed by two identical cysteine-containing GLP-1 monomers through a disulfide bond. The H-like GLP-1 homodimer (disulfide bond is inside chains) showed remarkable increase in hypoglycemic duration without reducing specific activity. The GLP-1 dimer provided has an in-vivo effective duration of up to 19 days, which significantly prolonged compared with that of the positive control drug Liraglutide with 3 days of effective duration, or thereby greatly promoting the technical advancement in long-acting GLP-1 drugs and facilitating their clinical applications and business. Meanwhile the U-like homodimer (disulfide bond is at the C-terminus) does not affect blood glucose, but can obviously protect pancreatic exocrine cells such as acini and ducts, and improve pancreas function.

Abstract: A molecular sieve of MFI structure has a ratio of n(SiO2)/n(Al2O3) of more than 15 and less than 70. It has a content of phosphorus of 1-15 wt %, calculated as P2O5 and based on the dry weight of the molecular sieve and a content of the supported metal in the molecular sieve 1-10 wt % based on the oxide of the supported metal and the dry weight of the molecular sieve. The supported metal is one or two selected from lanthanum and cerium. The volume of mesopores in the molecular sieve represents 40-70% by volume of the total pore volume of the molecular sieve by volume, measured by a nitrogen adsorption BET specific surface area method, and the volume of mesopores means the pore volume of the pores having a diameter of more than 2 nm and less than 100 nm.

Abstract: A first planarization layer, an anode lap joint later, a pixel defining layer are between the first dam and the display area; the anode lap joint layer includes a main body portion and sharp angle portions; the sharp angle portion at least includes a first side edge close to the display area; the pixel defining layer wraps a border of the anode lap joint layer and has a first groove extending from one to the other sharp angle portion. An edge of the first groove adjacent to the first side edge of the sharp angle portion is a second side edge; and an orthographic projection of the second side edge on a base substrate is in an orthographic projection of the third groove on the base substrate.

Abstract: A method for detecting and compensating CNC tools being implemented in an electronic device, receives from a detector first parameters and second parameters in respect of a first tool. Such first parameters include at least one of service life, blade break information, and blade chipping information of the first tool, and such second parameters include at least one of length extension information, length wear information, radial wear information, and blade thickness wear information of the first tool. Based on the first parameters, instructions to process the workpiece are transmitted or not. Upon receiving the second parameters, instructions to adjust operation of the first tool are transmitted, to compensate for deterioration in normal use.

Abstract: Disclosed herein are, inter alia, inhibitors of protein arginine methyltransferase 9 and pharmaceutical compositions thereof, and methods comprising the use of protein arginine methyltransferase 9 inhibitors for the treatment of a protein arginine methyltransferase 9-modulated disease or disorder, such as a hematological cancer.

Abstract: A rare earth- and phosphorus-containing molecular sieve of MFI structure rich in mesopores has a ratio of n(SiO2)/n(Al2O3) of more than 15 and less than 70. The molecular sieve has a content of phosphorus of 1-15 wt %, calculated as P2O5 and based on the dry weight of the molecular sieve. The content of the supported metal in the molecular sieve is 1-10 wt % supported metal M1 and 0.1-5 wt % supported metal M2 based on the oxide of the supported metal and the dry weight of the molecular sieve. The supported metal M1 is one or two selected from lanthanum and cerium, and the supported metal M2 is one selected from iron, cobalt, nickel, copper, manganese, zinc, tin, bismuth and gallium; the volume of mesopores in the molecular sieve represents 40-70% by volume of the total pore volume of the molecular sieve by volume.

Abstract: A skin layer of a superconducting tape has a woven mesh structure and is disposed on a surface of a superconducting tape. The skin layer of a superconducting tape solves the problem where a vapor layer generated when a superconductor is in a normal resistive state greatly reduces the efficiency of a heat exchange between the superconductor and liquid nitrogen. Further provided are the superconducting tape and a superconducting coil.

Abstract: An auscultatory sphygmomanometer system includes a pressure sensing and working module and a cuff. The cuff has a tube connected with the pressure sensing and working module, a gasbag connected with the tube and inflated or deflated according to the working state of the pressure sensing and working module, an audio pickup probe disposed on the gasbag and using a lateral surface of the gasbag as an oscillation membrane, and a cuff body accommodating the gasbag. While the cuff body is wound around a testee's arm, the gasbag is positioned into a first surface neighboring the testee's arm and a second surface opposite thereto and far away from the testee's arm. The connection position where the tube is joined to the gasbag is on the second surface. The sounds picked up by the audio pickup probe are sued to determine the systolic pressure and the diastolic pressure.

Abstract: Techniques are described for linked blockchains that allow computing devices to access information from an acceptance blockchain about acceptance reports stored in an enterprise delivery blockchain that are also linked to a product blockchain that stores information of the products of the acceptance reports. An acceptance report is indicative of operability of a product in a service provided by a service provider. A processor is configured to access the block in the enterprise delivery blockchain, retrieve the acceptance report from the block in the enterprise delivery blockchain, determine an identifier, identified in the block in the enterprise delivery blockchain, to a block in an acceptance blockchain, access the block in the acceptance blockchain via the determined identifier, retrieve from the block in the acceptance blockchain contextual information of the acceptance report, and output the acceptance report and contextual information of the acceptance report.

Abstract: This invention discloses a method for extracting lithium from carbonate clay type lithium ore based on ion exchange, which belongs to the field of lithium extraction technologies. This method aims to, with iron salt as the extractant, extract lithium into the solution through exchange reaction with lithium ore, which mainly involves the following steps: have clay type lithium ores crushed and ground prior to high-temperature roasting activation, and then conduct iron exchange reaction by iron salt solution while heating, followed by solid-liquid separation by means of filtration. The filtrate obtained will be lithium-bearing solution, and the extraction rate of lithium can reach as high as over 90%.

Abstract: Methods and systems for metering computing resources in cloud computing environments are disclosed. A method includes: executing, by a computing device, computing tasks on computing resources; determining, by the computing device, an amount of time and an amount of power used in the executing the computing tasks on the computing resources; determining, by the computing device, a number of standard units consumed by the computing tasks based on the determined amount of time and the determined amount of power; and metering, by the computing device, the computing resources based on the determined number of standard units consumed by the computing tasks.

Abstract: The present disclosure discloses a method for synthesizing quinolones intermediates by a continuous flow reaction. Specifically, according to the method, a microchannel reactor is used, which improves the selectivity and conversion rate of the reaction, and the conversion rate of compound ii is increased to more than 95% and the yield is increased to more than 85%; avoids the use of a solvent such as methanol, and methyl tert-butyl ether, etc., in the intermittent reaction process, which simplifies the post-processing method, shortens the overall operation time from about 24 hours to a few minutes, greatly improving the production efficiency, and realizing the continuity and automation of the whole process; and thus makes the product have high purity and high yield, which is suitable for industrial production.

Abstract: A dynamic loose vehicle formation method based on real-time online navigation map, which belongs to the field of vehicle formation technologies. The method includes a driver inputs travel information of a destination and waypoints in a GIS app; the GIS app uploads the travel information to a GIS server; the driver chooses to join a recommended formation or create a formation in the GIS app; when the driver chooses the formation and joins the formation, the formation information is displayed on the GIS app interface and sent to other vehicles within the formation for information interaction; when the driver chooses to leave the formation and leaves the formation, the formation is adjusted and the GIS server updates the formation information.

Abstract: The embodiments of the disclosure disclose methods, a system, apparatuses, and an electronic device for information referencing. A specific embodiment of the method includes: in response to creating a target formula, determining parameters of the target formula; generating an identification token of the target formula with a first target information, wherein the first target information includes a user identification of a target user, an identification of the referencing document, the identification of the referenced document and the identification of the referenced region, and the target user is a user creating the target formula; receiving a first verification result returned based on a second target information, wherein the second target information comprises the identification token and the first target information; and performing information presentation in the referencing document based on the first verification result.

Abstract: A whole-vehicle-based method for evaluating extreme pressure and antiwear properties of grease includes injecting the grease onto a key bearing pin and causing the engineering machine to operate without load is disclosed. The method includes causing the engineering machine to operate under a load of 10% to 150% rated load at least once, viewing and analyzing a wear condition of a surface of the bearing pin, and issuing a whole-vehicle-based evaluation report of extreme pressure and antiwear properties of grease. The engineering machine is caused to operate once under a load of 10% to 150% rated load for 0.5 min to 100 h.

Abstract: A cell selection method includes receiving, by an access stratum (AS) of a terminal device, first information from a non-access stratum (NAS) of the terminal device. The first information includes identity information of a first public land mobile network (PLMN) to be accessed by the terminal device. The cell selection method also includes determining, by the AS based on the first information, whether to camp on a first candidate cell. The first candidate cell supports the first PLMN. The first candidate cell satisfies a first camping condition. The first camping condition comprises a cell selection criterion and a service requirement. The service requirement is a preset threshold of a parameter reflecting signal quality of a cell.

Abstract: The disclosure provides a border touch module, including a cover plate, a shielding layer, a first adhesive layer, a sensing electrode layer, a second adhesive layer, an opaque adhesive, and a backlight layer. The shielding layer is disposed below the cover plate. The first adhesive layer is disposed below the shielding layer. The sensing electrode layer is disposed below the first adhesive layer. The second adhesive layer is disposed below the sensing electrode layer. The opaque adhesive is disposed below the sensing electrode layer. The backlight layer is disposed below the opaque adhesive and is in the same plane as the second adhesive layer. The shielding layer has a backlight pattern, and the opaque adhesive has a light source hole. When the backlight layer is in the state of driving backlight, the light illuminates the backlight pattern of the shielding layer through the light source hole.

Abstract: The disclosure in some aspects relates to recombinant adeno-associated viruses having distinct tissue targeting capabilities. In some aspects, the disclosure relates to gene transfer methods using the recombinant adeno-associated viruses. In some aspects, the disclosure relates to isolated AAV capsid proteins and isolated nucleic acids encoding the same.

Abstract: An insulin aspart derivative and a preparation method therefor are provided. The derivative has a fusion protein of a green fluorescent protein folding unit and an insulin aspart precursor or an active fragment thereof. The expression level of the fusion protein is significantly increased, and the insulin aspart precursor protein in the fusion protein is folded correctly and has a biological activity. In addition, the green fluorescent protein folding unit in the fusion protein can be digested into small fragments by a protease, which has a large molecular weight difference compared to the target protein and is thus easy to separate. Further provided is a method for preparing the insulin aspart and an intermediate by means of using the fusion protein.

Abstract: A method for reducing blasting vibration of tunneling includes the steps of: dividing the cutting holes into several groups according to different cutting methods; conducting layout and test blasting on one group of cutting holes; testing blasting parameters for the layout and test blasting; calculating an interval t; conducting layout and test blasting on at least two groups of cutting holes again; testing blasting parameters for the layout and test blasting of each group for the second time; taking the minimum interval t of each group as the interval for formal blasting of the remaining groups of cutting holes. The use of the characteristics of the wave in the invention can superpose the peaks and troughs of the vibration wave, and further cancel out mutually; reduce the peaks of the blasting vibration and fill the troughs of the blasting vibration.