Abstract: Systems and methods are provided for improving the operation of molten carbonate fuel cells that include cathode current collector structures that have reduced contact area with the cathode in order to create increased cathode open surface area. Molten carbonate fuel cells that have cathode collectors with reduced contact area with the cathode can have an increased tendency to suffer structural difficulties during operation, such as formation of gaps between electrolyte and one or both electrodes. Use of a sintered anode in such a fuel cell can reduce or minimize the impact of such structural difficulties. The sintered anode can provide higher pore volume and/or a more stable pore structure and/or increased structural stability in a fuel cell that includes a cathode collector that has a reduced contact area with the cathode. This can maintain a more stable interface between the cathode and electrolyte and/or between the anode and the electrolyte.

Abstract: The invention relates to an engineered immune cell comprising: (a) a first nucleic acid sequence encoding a chimeric antigen receptor or a chimeric antigen receptor encoded thereby, said chimeric antigen receptor comprises a first antigen binding region, a transmembrane domain, and an intracellular signaling domain; and (b) a second nucleic acid sequence encoding an Fc fusion polypeptide or an Fc fusion polypeptide encoded thereby, said Fc fusion polypeptide comprises a second antigen binding region and an Fc region, wherein the first antigen binding region and the second antigen binding region are not scFv at the same time. The invention also relates to compositions comprising the engineered immune cells of the invention, and the use of the engineered immune cells/compositions in the treatment of cancer.

Abstract: Provided is an NK inhibitory molecule, which includes one or more NK inhibitory ligands, a transmembrane domain and a co-stimulatory domain, wherein the NK inhibitory ligand specifically binds to NK inhibitory receptors to inhibit the killing of NK cells against the engineered immune cells expressing the NK inhibitory molecule. Also provided is an engineered immune cell expressing the NK inhibitory molecule of the present invention, wherein the expression of at least one MHC-related gene is suppressed or silenced. Further provided is the use of the engineered immune cell in the treatment of cancers, infections or autoimmune diseases. Compared to the traditional engineered immune cells, the engineered immune cell can significantly inhibit the killing effect of NK cells in a subject, thereby reducing the risk of HvGD.

Abstract: Systems and methods are provided for maintaining and/or improving operating lifetime for molten carbonate fuel cells that contain reforming catalyst in the anode when processing cathode input flows that contain sulfur oxides. The systems and methods can include a serial arrangement of molten carbonate fuel cells, where a first fuel cell includes a reduced or minimized amount of reforming catalyst in the anode. A second molten carbonate fuel cell can include reforming catalyst in the anode.

Abstract: A reforming element for a molten carbonate fuel cell stack and corresponding methods are provided that can reduce or minimize temperature differences within the fuel cell stack when operating the fuel cell stack with enhanced CO2 utilization. The reforming element can include at least one surface with a reforming catalyst deposited on the surface. A difference between the minimum and maximum reforming catalyst density and/or activity on a first portion of the at least one surface can be 20% to 75%, with the highest catalyst densities and/or activities being in proximity to the side of the fuel cell stack corresponding to at least one of the anode inlet and the cathode inlet.

Abstract: A module assembly is provided including a fuel cell stack assembly, a heat exchanger, and a housing enclosing the fuel cell stack assembly and the heat exchanger. The heat exchanger is configured to receive process gas from an external source and output said process gas to the fuel cell stack assembly, and configured to receive process gas from the fuel cell stack assembly and output said process gas. A fuel cell power plant is provided including a module assembly with a first end, a racking structure configured to hold the module assembly, balance of plant equipment, and ducting configured to provide fluid communication between the balance of plant equipment and the first end of the module assembly. The module assembly and the racking structure are configured such that the module assembly may be removed from the racking structure in a direction away from the first end of the module assembly.

Abstract: An engineered immune cell, which expresses (i) a cell surface molecule that specifically recognizes a ligand, (ii) an exogenous interleukin, and (iii) an exogenous Flt3L, XCL2, and/or XCL1; the engineered immune cell can be used for treating cancer, infection, or autoimmune diseases; and compared with a traditional engineered immune cell, the engineered immune cell has significantly improved tumor killing activity.

Abstract: A slip ring assembly includes a housing having a stator that rotatably supports a rotor. The rotor includes conductive disks that are electrically connected to respective conductors extending through a rotor shaft. The stator includes brushes that slidably and electrically engage the conductive disks. The one or more brushes are electrically connected to stator conductors extending at least partially through the stator. Electrical pathways are defined and extend from the stator conductors, the brushes, the conductive disks, and the respective conductors in the shaft. A smart board is connected to the stator and includes electronic components configured to monitor operation of the slip ring assembly and provide signals to an external source. The smart board is electrically connected to, and powered by, electrical power that is present and available on the stator conductors.

Abstract: A washout tooling for a composite layup is provided. The washout tooling comprises a casting mold having an exterior surface. The casting mold comprises a particulate material and a water-soluble binder. The casting mold is adapted to break down in the presence of an aqueous solution. The washout tooling further comprises a water-soluble coating layer overlying the exterior surface. The water-soluble coating layer is adapted to break down in the presence of an aqueous solution. The washout tooling further comprises a curable composite layer overlying the water-soluble coating layer. The water-soluble coating layer minimizes contact between the particulate material and the curable composite layer.

Abstract: A partition skirt device for a cleaning apparatus includes an inner ring and a skirt body. The skirt body includes: a root connected to the inner ring; an edge part arranged at an end of the skirt body away from the inner ring; and a plurality of collapsing parts arranged at intervals between the root and the edge part along a circumferential direction of the skirt body, and each extending along a radial direction of the skirt body. Along a thickness direction of the skirt body, the collapsing part protrudes relative to the skirt body on a first side surface of the skirt body and is recessed relative to the skirt body on a second side surface of the skirt body. On the first side surface of the skirt body, a size of a portion of the collapsing part protruding from the skirt body gradually decreases from the root to the edge part.

Abstract: A dust scraping device for a cleaning apparatus includes a dust cup and a removable cyclone separation unit arranged in the dust cup. The dust scraping device includes a dust scraping member. The dust scraping member has a connection portion extending in a removal direction of the cyclone separation unit, and a dust scraping portion extending to an interior of the dust cup in a direction perpendicular to the removal direction and slidably abutting against the cyclone separation unit. The dust scraping device is mounted at the dust cup, and the dust scraping portion scrapes off at least part of debris on an outer side of the cyclone separation unit when the cyclone separation unit is removed from the dust cup.

Abstract: Disclosed herein are in vitro methods of making splanchnic mesoderm cell types and subtypes thereof from pluripotent cells. These methods can be used to produced improved foregut- and hindgut-derived organoids containing enriched mesenchyme, which enhances organoid viability, growth, and maturation, both in in vitro culture and in vivo transplantation.

Abstract: Molten carbonate fuel cell configurations are provided that allow for introduction of an anode input gas flow on a side of the fuel cell that is adjacent to the entry side for the cathode input gas flow while allowing the anode and cathode to operate under co-current flow and/or counter-current flow conditions. It has been discovered that improved flow properties can be achieved within the anode or cathode during co-current flow or counter-current flow operation by diverting the input flow for the anode or cathode into an extended edge seal region (in an extended edge seal chamber) adjacent to the active area of the anode or cathode, and then using a baffle to provide sufficient pressure drop for even flow distribution of the anode input flow across the anode or cathode input flow across the cathode.

Abstract: A method of alarm of a screw-locking error includes retrieving a confidence interval of screw-locking parameter data of different screw specifications, setting locking parameter data of a screw-locking process according to a range of the confidence intervals, acquiring locking parameter data in real time, collating the acquired locking parameter data, analyzing the collated locking parameter data to obtain normal locking parameter data and abnormal locking parameter data, and analyzing the abnormal locking parameter data to obtain an error type of each abnormal locking parameter data. The abnormal locking parameter data and the corresponding error type of the abnormal locking parameter data are reported.

Abstract: The present invention provides use of Tadalafil as a protein arginine methyltransferase 5 (PRMT5) inhibitor. The present invention finds out that Tadalafil is a PRMT5 inhibitor by virtually screening active compounds targeting PRMT5 based on crystal structure and information about active sites of PRMT5. The present invention not only confirms that Tadalafil can inhibit an enzymatic activity of PRMT5, but also confirms that Tadalafil alone can inhibit tumor growth in breast cancer and improve sensitivity to chemotherapy for breast cancer.

Abstract: A washout tooling for a composite layup is provided. The washout tooling comprises a casting mold having an exterior surface. The casting mold comprises a particulate material and a water-soluble binder. The casting mold is adapted to break down in the presence of an aqueous solution. The washout tooling further comprises a water-soluble coating layer overlying the exterior surface. The water-soluble coating layer is adapted to break down in the presence of an aqueous solution. The washout tooling further comprises a curable composite layer overlying the water-soluble coating layer. The water-soluble coating layer minimizes contact between the particulate material and the curable composite layer.

Abstract: A call to action processor receives an entity datapoint containing data related to an entity, a campaign objective datapoint containing data associated with a campaign objective, at least one definite script element based on the campaign objective, and entity metadata containing data associated with the entity. The call to action further performs generating at least one variable script element based on the entity metadata, presenting to a device the at least one definite script element the at least one variable script element.

Abstract: A call to action processor receives an entity datapoint containing data related to an entity, a campaign objective datapoint containing data associated with a campaign objective, at least one definite script element based on the campaign objective, and entity metadata containing data associated with the entity. The call to action further performs generating at least one variable script element based on the entity metadata, presenting to a device the at least one definite script element the at least one variable script element.

Abstract: Systems and methods for audio advertising user interaction are disclosed. A voice interactive device causes an advertising audio file to be played for a user. The user can express interest in the advertising content of the advertising audio file by speaking one of a plurality of predetermined intents. Based on expressed user response, one or more results can be provided to the user and/or to a user device. The results relate to advertising content of the advertising audio file.

Abstract: A rotary union adapted for connection on a support segment for a shaft includes a sensor disposed within a sensor housing, the sensor housing connected to the housing of the rotary union, and a sound conduit having first and second ends, the first end of the sound conduit being connected to the sensor housing, and the second end of the sound conduit being adapted to be connected to a second support segment for the shaft opposite the first support segment along the shaft, wherein the sensor includes a sensing element in physical contact with the first end of the sound conduit, the sensing element configured to provide a signal in response to vibration present along the sound conduit.