Abstract: Provided herein are methods for treatment of cystic fibrosis (CF), including for patients with class I CFTR mutations. The methods may involve administration of a recombinant adeno-associated virus (rAAV) that includes an AV.TL65 capsid protein and a polynucleotide that includes an F5 enhancer and a tg83 promoter operably linked to a CFTR?R minigene, or a pharmaceutical composition thereof.

Abstract: Systems, apparatuses, and methods for cost evaluation and motion planning for robotic devices are disclosed herein. According to at least one non-limiting exemplary embodiment, a method for producing and evaluating a continuous and differentiable total cost as a function of all available motion commands is disclosed and may be utilized in conjunction with a gradient descent to determine a minimum cost motion command corresponding to an optimal motion for a robotic device to execute in accordance with a target trajectory and obstacle avoidance.

Abstract: The present invention relates to GH61 polypeptide variants. The present invention also relates to polynucleotides encoding the variants; nucleic acid constructs, vectors, and host cells comprising the polynucleotides; and methods of using the variants.

Abstract: User engagement is detected and used to control operation of a computing device. User engagement is detected by a sensor such as a camera that identifies if a user's face is oriented towards a display device. If the user is not facing the display device, the sensor determines that the user is unengaged. The computing device is thus able to perform a power-saving operation, such as dimming the display device, when the user is unengaged. The computing device includes an API that abstracts sensor data into a user engagement signal indicating that the user is either engaged or unengaged. The OS and applications running on the computing device act on the user engagement signal provided by the API without communicating directly with the sensor. The user engagement signal may be provided as an input to a state machine.

Abstract: A method for preparing a solid medium platform for cultivating algae, comprising obtaining an algae culture solution (“ACS”) at approximately room temperature of a specific volumetric quantity, denoted “x”; creating raw agarose solution (“AS”) by adding low melting point agarose powder (“AP”) to water of a volume equal to “x” in a container that is different from the one used for said ACS; heating and stirring AS; cooling or waiting for the AS to cool down to approximately 15-35% above the gelling temperature of the AS; adding micronutrients supportive of algae growth after AS has cooled to approximately 15-35% above the gelling temperature of the AS to create an agarose micronutrient solution (“AMS”); after the AMS has cooled, combining the AMS with ACS and pouring the mixture into an open container and stirring; apportioning the AMS/ACS mixture into cultivating container(s); and waiting for the mixture to congeal.

Abstract: A gripper assembly is disclosed. The gripper assembly includes a stage, a mounting platform, and a plurality of the flexible gripper elements. The flexible gripper element is configured to grip an object. The flexible gripper elements are supported by a first end piece, where the first end piece is attached to the mounting platform. The mounting platform is connected to the stage, where the stage is moveable. The flexible gripper element includes a hollow section that is selectively pressurizable. The hollow section includes one or more zones, where each zone includes chambers which are pressurizable by a fluid input. The selective pressurization of the hollow section allows the flexible gripper element to grip the object.

Abstract: Provided herein are combination therapies comprising a KRasG12C inhibitor (e.g. Compound 1) and an EGFR-inhibitor and methods of using such combination therapies.

Abstract: Provided herein are combination therapies (compositions) and methods and uses thereof for the treatment lung cancer, where the combination therapies comprise Compound 1 or a pharmaceutically acceptable salt thereof as described herein and a PD-L1 binding antagonist (e.g., atezolizumab).

Abstract: Provided herein are combination therapies comprising a KRasG12C inhibitor (e.g. Compound 1 or a pharmaceutically acceptable salt thereof) and a VEGF antagonist (e.g., bevacizumab) and methods of using such combination therapies.

Abstract: The invention provides a valve having an elongated main body and a substantially flat area defined within the valve between its first and second ends; wherein a stopping screw is received in said flat area so as to prevent extraction of the valve from a casing by applying a force against a portion of the valve once the valve is moved a predetermined number of turns. The invention also provides a method for inhibiting the turning of a valve having the steps of installing a threaded portion of a valve in a first threaded aperture through a casing, where the first threaded aperture receives the threads of the threaded portion of the valve; and threading a screw through a second threaded aperture in an exterior of the casing, where the screw, is disposed in a position to come into direct contact with the valve after a predetermined number of turns.

Abstract: Embodiments of the invention described herein include low cost infusion devices having basal and/or bolus fluid delivery options. Embodiments of the device include a housing, a reservoir to contain the fluid, a source of pressure to exert a force to expel the fluid contained in the reservoir, a bolus port adapted to receive an optional extra dose of fluid, and a cannula in fluid communication with the reservoir and the bolus port. The cannula is adapted for insertion into the user's skin for delivery of the fluid to the user's body. The device can provide a continuous delivery of the fluid along a first fluid flow path from the reservoir to the cannula and the optional extra dose of fluid along a second fluid flow path from the bolus port to the cannula.

Abstract: A method and apparatus for a connection interface between a reservoir or syringe, infusion set tubing, and an infusion pump is provided. The reservoir, a base and a cap are connected to form an integrated unit that is capable of being inserted and secured in an infusion pump housing. The cap and the infusion pump are each provided with at least one sensor or at least one detectable feature, arranged to interact with at least one corresponding detectable feature or sensor on the other of the cap and infusion pump device, to detect one or more of the presence, position or other characteristic of the cap when the cap is aligned or coupled with the infusion pump housing. The detectable feature and sensor may be magnetic, RF, mechanical, optical or any combination.

Abstract: A method and apparatus for a connection interface between a reservoir or syringe, infusion set tubing, and an infusion pump is provided. The reservoir, a base and a cap are connected to form an integrated unit that is capable of being inserted and secured in an infusion pump housing. The cap and the infusion pump are each provided with at least one sensor or at least one detectable feature, arranged to interact with at least one corresponding detectable feature or sensor on the other of the cap and infusion pump device, to detect one or more of the presence, position or other characteristic of the cap when the cap is aligned or coupled with the infusion pump housing. The detectable feature and sensor may be magnetic, RF, mechanical, optical or any combination.

Abstract: The present invention relates to a convertible child cycle, which includes a cycle frame extending in a horizontal longitudinal direction and curved upwardly. The cycle frame is formed with a slot facing downward. The cycle frame is further formed with a first installation connector adjacent to the front end, a second installation connector adjacent to the rear end, and a third installation connector disposed between the first and second installation connectors. The child cycle further includes a headset assembly and a rear fork assembly releasably engaged the first and the second installation connectors, respectively. With the growth of a preschool child rider, the invention may be readily converted into a tricycle, a balance bicycle or a bicycle by combining the cycle frame with various accessory parts, thereby satisfying the recreation needs of the preschool child at different developmental stages.

Abstract: A gripper assembly is disclosed. The gripper assembly includes a stage, a mounting platform, and a plurality of the flexible gripper elements. The flexible gripper element is configured to grip an object. The flexible gripper elements are supported by a first end piece, where the first end piece is attached to the mounting platform. The mounting platform is connected to the stage, where the stage is moveable. The flexible gripper element includes a hollow section that is selectively pressurizable. The hollow section includes one or more zones, where each zone includes chambers which are pressurizable by a fluid input. The selective pressurization of the hollow section allows the flexible gripper element to grip the object.

Abstract: Aspects of the disclosure are directed to a digital design with bundled data asynchronous logic and body-biasing tuning. In one aspect, implementation includes establishing a control path between a first controller and a second controller using a handshaking protocol; establishing a data path between a first latch and a second latch using a bundled data technique; executing a first dynamic body biasing tuning by applying a first body bias signal to the control path; executing a second dynamic body biasing tuning by applying a second body bias signal to the data path. The digital design includes a first controller with a control path to connect to a second controller, wherein a first body bias tuning signal tunes body bias in the control path, a first latch with a data path to connect to a second latch, wherein a second body bias tuning signal tunes body bias in the data path.

Abstract: The invention provides a valve having an elongated main body and a substantially flat area defined within the valve between its first and second ends; wherein a stopping screw is received in said flat area so as to prevent extraction of the valve from a casing by applying a force against a portion of the valve once the valve is moved a predetermined number of turns. The invention also provides a method for inhibiting the turning of a valve having the steps of installing a threaded portion of a valve in a first threaded aperture through a casing, where the first threaded aperture receives the threads of the threaded portion of the valve; and threading a screw through a second threaded aperture in an exterior of the casing, where the screw, is disposed in a position to come into direct contact with the valve after a predetermined number of turns.

Abstract: A method and apparatus for a connection interface between a reservoir or syringe, infusion set tubing, and an infusion pump is provided. The reservoir, a base and a cap are connected to form an integrated unit that is capable of being inserted and secured in an infusion pump housing. The cap and the infusion pump are each provided with at least one sensor or at least one detectable feature, arranged to interact with at least one corresponding detectable feature or sensor on the other of the cap and infusion pump device, to detect one or more of the presence, position or other characteristic of the cap when the cap is aligned or coupled with the infusion pump housing. The detectable feature and sensor may be magnetic, RF, mechanical, optical or any combination.

Abstract: A valve having an elongated main body and a substantially flat area defined within the valve between its first and second ends; wherein a stopping screw is received in said flat area so as to prevent extraction of the valve from a casing by applying a force against a portion of the valve once the valve is moved a predetermined number of turns. A method for inhibiting the turning of a valve having the steps of installing a threaded portion of a valve in a first threaded aperture through a casing, where the first threaded aperture receives the threads of the threaded portion of the valve; and threading a screw through a second threaded aperture in an exterior of the casing, where the screw, is disposed in a position to come into direct contact with the valve after a predetermined number of turns.