Patents by Inventor Mark R. Hellberg

Mark R. Hellberg has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • 6-aminoimidazo[1,2-b]pyridazine analogs as rho kinase inhibitors for the treatment of rho kinase-mediated diseases and conditions
    Patent number: 7820670
    Abstract: Methods for using 6-aminoimidazo[1,2-b]pyridazine analogs are disclosed herein to treat rho kinase-mediated diseases or rho kinase-mediated conditions, including controlling intraocular pressure and treating glaucoma, are disclosed. Ophthalmic pharmaceutical compositions useful in the treatment of eye diseases such as glaucoma, and additionally useful for controlling intraocular pressure, the compositions comprising an effective amount of 6-aminoimidazo[1,2-b]pyridazine analogs, are disclosed herein.
    Type: Grant
    Filed: December 19, 2007
    Date of Patent: October 26, 2010
    Assignee: Alcon Research, Ltd.
    Inventors: Hwang-Hsing Chen, Andrew Rusinko, Mark R. Hellberg, Bryon S. Severns, Alan J. Henderson, Cheng Guo, Mark Hadden
  • 5-substituted 2-aminopyridine analogs for treating allergic and inflammatory diseases
    Patent number: 7799778
    Abstract: Methods for treating an allergic or inflammatory disease or other Syk-mediated disease or Syk-mediated condition characterized by administering a composition which contains a therapeutically effective amount of a 5-substituted 2-aminopyridine compound.
    Type: Grant
    Filed: January 12, 2006
    Date of Patent: September 21, 2010
    Assignee: Alcon, Inc.
    Inventors: Mark R. Hellberg, Steven T. Miller, Andrew Rusinko
  • AMINOPYRAZINE ANALOGS FOR TREATING GLAUCOMA AND OTHER RHO KINASE-MEDIATED DISEASES AND CONDITIONS
    Publication number: 20100216777
    Abstract: Methods for using aminopyrazine analogs to treat rho kinase-mediated diseases or rho kinase-mediated conditions, including controlling intraocular pressure and treating glaucoma, are disclosed. Ophthalmic pharmaceutical compositions useful in the treatment of eye diseases such as glaucoma, and additionally useful for controlling intraocular pressure, the compositions comprising an effective amount of aminopyrazine analogs, are also disclosed.
    Type: Application
    Filed: May 5, 2010
    Publication date: August 26, 2010
    Applicant: ALCON, INC.
    Inventors: Mark R. Hellberg, Andrew Rusinko, Alan J. Henderson, Cheng Guo, Mark Hadden, Hélène Y. Decornez
  • SUPEROXIDE DISMUTASE MIMICS FOR THE TREATMENT OF OCULAR DISORDERS AND DISEASES
    Publication number: 20100204194
    Abstract: The use of SOD mimics particularly pentaazacycle Mn(II) complex SOD mimics, for the treatment of AMD, DR, and retinal edema is disclosed.
    Type: Application
    Filed: April 23, 2010
    Publication date: August 12, 2010
    Applicant: ALCON, INC.
    Inventors: Peter G. Klimko, Robert J. Collier, JR., Mark R. Hellberg
  • OPHTHALMIC COMPOSITION WITH NITRIC OXIDE DONOR COMPOUND AND METHOD OF FORMING AND USING SAME
    Publication number: 20100197702
    Abstract: The present invention is directed to the provision of ophthalmic compositions such as multi-dose, topical, ophthalmic compositions. The compositions include a nitric oxide (NO) donor compound.
    Type: Application
    Filed: January 27, 2010
    Publication date: August 5, 2010
    Inventors: Mark R. Hellberg, Peter G. Klimko, Jesse A. May, Suchismita Mohapatra
  • Compounds with 5-HTactivity useful for treating disorders of the outer retina
    Patent number: 7763619
    Abstract: Compositions and methods for treating disorders of the outer retina with compounds with 5-HT1A agonist activity are disclosed.
    Type: Grant
    Filed: July 22, 2005
    Date of Patent: July 27, 2010
    Assignee: Alcon, Inc.
    Inventors: Robert J. Collier, Jr., Michael A. Kapin, Mark R. Hellberg, Thomas R. Dean
  • Superoxide dismutase mimics for the treatment of ocular disorders and diseases
    Patent number: 7759333
    Abstract: The use of SOD mimics particularly pentaazacycle Mn(II) complex SOD mimics, for the treatment of AMD, DR, and retinal edema is disclosed.
    Type: Grant
    Filed: December 6, 2002
    Date of Patent: July 20, 2010
    Assignee: Alcon, Inc.
    Inventors: Peter G. Klimko, Robert J. Collier, Jr., Mark R. Hellberg
  • SUPEROXIDE DISMUTASE MIMICS FOR THE TREATMENT OF OCULAR DISORDERS AND DISEASES
    Publication number: 20100179117
    Abstract: The use of SOD mimics, particularly Mn(III) salen SOD mimics, for the treatment of AMD, DR, and retinal edema is disclosed.
    Type: Application
    Filed: March 24, 2010
    Publication date: July 15, 2010
    Applicant: ALCON, INC.
    Inventors: Peter G. Klimko, Robert J. Collier, JR., Mark R. Hellberg
  • Superoxide dismutase mimics for the treatment of ocular disorders and diseases
    Patent number: 7754706
    Abstract: The use of SOD mimics, particularly Mn(III) salen SOD mimics, for the treatment of AMD, DR, and retinal edema is disclosed.
    Type: Grant
    Filed: December 5, 2003
    Date of Patent: July 13, 2010
    Assignee: Alcon, Inc.
    Inventors: Peter G. Klimko, Robert J. Collier, Jr., Mark R. Hellberg
  • COMPOUNDS WITH 5-HT1A ACTIVITY USEFUL FOR TREATING DISORDERS OF THE OUTER RETINA
    Publication number: 20100168121
    Abstract: Compositions and methods for treating disorders of the outer retina with compounds with 5-HT1A agonist activity are disclosed.
    Type: Application
    Filed: March 8, 2010
    Publication date: July 1, 2010
    Applicant: ALCON, INC.
    Inventors: Robert J. Collier, JR., Michael A. Kapin, Mark R. Hellberg, Thomas R. Dean
  • 3,6-SUBSTITUTED IMIDAZOL[1,2-B]PYRIDAZINE ANALOGS FOR TREATING ALLERGIC AND INFLAMMATORY DISEASES
    Publication number: 20100168116
    Abstract: Methods for treating an allergic or inflammatory disease or other Syk-mediated disease or Syk-mediated condition characterized by administering a composition which contains a therapeutically effective amount of a 3,6-substituted imidazol[1,2-b]pyridazine compound.
    Type: Application
    Filed: March 10, 2010
    Publication date: July 1, 2010
    Applicant: Alcon, Inc.
    Inventors: Mark R. Hellberg, Steven T. Miller, Andrew Rusinko
  • 3,6-substituted imidazol[1,2-b]pyridazine analogs for treating allergic and inflammatory diseases
    Patent number: 7713975
    Abstract: Methods for treating an allergic or inflammatory disease or other Syk-mediated disease or Syk-mediated condition characterized by administering a composition which contains a therapeutically effective amount of a 3,6-substituted imidazol[1,2-b]pyridazine compound.
    Type: Grant
    Filed: January 12, 2006
    Date of Patent: May 11, 2010
    Assignee: Alcon, Inc.
    Inventors: Mark R. Hellberg, Steven T. Miller, Andrew Rusinko
  • BICYCLIC HETEROARYL INHIBITORS OF PDE4
    Publication number: 20100081646
    Abstract: The present invention relates to compounds and methods which may be useful as inhibitors of phosphodiesterase 4 (PDE4) for the treatment or prevention of inflammatory diseases and other diseases involving elevated levels of cytokines and proinflammatory mediators.
    Type: Application
    Filed: August 19, 2009
    Publication date: April 1, 2010
    Applicant: KALYPSYS, INC.
    Inventors: Steven P. Govek, Clay Beauregard, Daniel A. Gamache, Mark R. Hellberg, Stewart A. Noble, Andrew K. Shiau, David J. Thomas, John M. Yanni
  • (Indazol-5-yl)-pyrazines and (1,3-dihydro-indol-2-one)-pyrazines for treating glaucoma and controlling intraocular pressure
    Patent number: 7655662
    Abstract: Methods for using (indazol-5-yl)-pyrazines and (1,3-dihydro-indol-2-one)-pyrazines are disclosed herein to treat rho kinase-mediated diseases or rho kinase-mediated conditions, including controlling intraocular pressure and treating glaucoma, are disclosed. Ophthalmic pharmaceutical compositions useful in the treatment of eye diseases such as glaucoma, and additionally useful for controlling intraocular pressure, the compositions comprising an effective amount of (indazol-5-yl)-pyrazines and (1,3-dihydro-indol-2-one)-pyrazines, are disclosed herein.
    Type: Grant
    Filed: December 19, 2006
    Date of Patent: February 2, 2010
    Assignee: Alcon Research, Ltd.
    Inventors: Mark R. Hellberg, Najam A. Sharif, Jesse A. May, Andrew Rusinko, Hwang-Hsing Chen
  • INHIBITORS OF GLYCOGEN SYNTHASE KINASE-3 (GSK-3) FOR TREATING GLAUCOMA
    Publication number: 20090312390
    Abstract: The use of inhibitors of GSK-3 useful for treating glaucoma is disclosed.
    Type: Application
    Filed: August 21, 2009
    Publication date: December 17, 2009
    Applicant: ALCON, INC.
    Inventors: Mark R. Hellberg, Abbot F. Clark, Iok-Hou Pang, Peggy Elizabeth Hellberg, Loretta Graves McNatt, Wan-Heng Wang
  • Inhibitors of glycogen synthase kinase-3 (GSK-3) for treating glaucoma
    Patent number: 7598288
    Abstract: The use of inhibitors of GSK-3 useful for treating glaucoma is disclosed.
    Type: Grant
    Filed: September 23, 2002
    Date of Patent: October 6, 2009
    Assignee: Alcon, Inc.
    Inventors: Mark R. Hellberg, Abbot F. Clark, Iok-Hou Pang, Peggy Elizabeth Hellberg, Loretta Graves McNatt, Wan-Heng Wang
  • PAI-1 EXPRESSION AND ACTIVITY INHIBITORS FOR THE TREATMENT OF OCULAR DISORDERS
    Publication number: 20090202524
    Abstract: The invention concerns in one embodiment a method for treating glaucoma or elevated IOP in a patient comprising administering to the patient an effective amount of a composition comprising an agent that inhibits PAI-1 expression or PAI-1 activity. Another embodiment of the present invention is a method of treating a PAI-1-associated ocular disorder in a subject in need, comprising administering to the patient an effective amount of a composition comprising an agent that inhibits PAI-1 activity or expression.
    Type: Application
    Filed: April 9, 2009
    Publication date: August 13, 2009
    Applicant: ALCON RESEARCH, LTD.
    Inventors: Debra L. Fleenor, Allan R. Shepard, Iok-Hou Pang, Mark R. Hellberg, Abbot F. Cark
  • Benzopyran analogs and their use for the treatment of glaucoma
    Patent number: 7396856
    Abstract: Novel benzopyran analogs are disclosed. Also disclosed are methods for the lowering and controlling of normal or elevated intraocular pressure as well as a method for the treatment of glaucoma using compositions containing one or more of the compounds of the present invention.
    Type: Grant
    Filed: May 6, 2005
    Date of Patent: July 8, 2008
    Assignee: Alcon, Inc.
    Inventors: Mark R. Hellberg, Abdelmoula Namil
  • 6-AMINOIMIDAZO[1,2-b]PYRIDAZINE ANALOGS AS RHO KINASE INHIBITORS FOR THE TREATMENT OF RHO KINASE-MEDIATED DISEASES AND CONDITIONS
    Publication number: 20080153813
    Abstract: Methods for using 6-aminoimidazo[1,2-b]pyridazine analogs are disclosed herein to treat rho kinase-mediated diseases or rho kinase-mediated conditions, including controlling intraocular pressure and treating glaucoma, are disclosed. Ophthalmic pharmaceutical compositions useful in the treatment of eye diseases such as glaucoma, and additionally useful for controlling intraocular pressure, the compositions comprising an effective amount of 6-aminoimidazo[1,2-b]pyridazine analogs, are disclosed herein.
    Type: Application
    Filed: December 19, 2007
    Publication date: June 26, 2008
    Applicant: ALCON MANUFACTURING, LTD.
    Inventors: Hwang-Hsing CHEN, Andrew RUSINKO, Mark R. HELLBERG, Bryon S. SEVERNS, Alan J. HENDERSON, Cheng GUO, Mark HADDEN
  • USE OF MDCK CELL LINE TO PREDICT CORNEAL PENETRATION OF DRUGS
    Publication number: 20080138849
    Abstract: A new method of evaluating the ability of drug molecules to penetrate the cornea is described. The permeation rate of the drug molecules in MDCK cells is utilized to predict the ability of the molecules to penetrate the cornea. The method is useful for in vitro screening of potential new ophthalmic drugs, as well as in the design of new drug molecules for topical ocular administration.
    Type: Application
    Filed: October 12, 2007
    Publication date: June 12, 2008
    Applicant: ALCON, INC.
    Inventors: Andrew RUSINKO, Mark R. HELLBERG, Jesse Albert May, Geoffrey Robert Owen