Patents by Inventor Mark R. Hellberg

Mark R. Hellberg has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • ARYL AND HETEROARYL TETRAHYDROBENZAZEPINE DERIVATIVES AND THEIR USE FOR TREATING GLAUCOMA
    Publication number: 20070293475
    Abstract: Aryl tetrahydrobenzazepine derivatives with minimal 5-HT2B activity relative to 5-HT2A and 5-HT2C activity that are useful for treating glaucoma are disclosed.
    Type: Application
    Filed: June 12, 2007
    Publication date: December 20, 2007
    Applicant: ALCON MANUFACTURING LTD.
    Inventors: Suchismita Mohapatra, Mark R. Hellberg, Zixia Feng
  • Use of MDCK cell line to predict corneal penetration of drugs
    Patent number: 7297505
    Abstract: A new method of evaluating the ability of drug molecules to penetrate the cornea is described. The permeation rate of the drug molecules in MDCK cells is utilized to predict the ability of the molecules to penetrate the cornea. The method is useful for in vitro screening of potential new ophthalmic drugs, as well as in the design of new drug molecules for topical ocular administration.
    Type: Grant
    Filed: April 25, 2005
    Date of Patent: November 20, 2007
    Assignee: Alcon, Inc.
    Inventors: Andrew Rusinko, Mark R. Hellberg, Jesse Albert May, Geoffrey Robert Owen
  • Methods of treating dry eye disorders
    Patent number: 7235556
    Abstract: Fused pyridazine derivatives are useful for treating dry eye disorders and other disorders requiring the wetting of the eye.
    Type: Grant
    Filed: April 14, 2004
    Date of Patent: June 26, 2007
    Assignee: Alcon, Inc.
    Inventors: Najam A. Sharif, Mark R. Hellberg
  • Benzodifuranimidazoline and benzofuranimidazoline derivatives and their use for the treatment of glaucoma
    Patent number: 7208512
    Abstract: The present invention provides benzodifuran imidazoline derivatives and benzofuran imidazoline derivatives for lowering intraocular pressure and providing ocular neuroprotection.
    Type: Grant
    Filed: December 9, 2002
    Date of Patent: April 24, 2007
    Assignee: Alcon, Inc.
    Inventors: Zixia Feng, Mark R. Hellberg
  • Use of proteasome inhibitors to treat dry eye disorders
    Patent number: 7112588
    Abstract: Proteasome inhibitors are useful for treating dry eye disorders and other disorders requiring the wetting of the eye.
    Type: Grant
    Filed: March 24, 2004
    Date of Patent: September 26, 2006
    Assignee: Alcon, Inc.
    Inventors: Peter G. Klimko, Mark R. Hellberg
  • Arylaminopropane analogues and their use for the treatment of glaucoma
    Patent number: 7071225
    Abstract: Arylaminopropane analogues are disclosed. Also disclosed are methods for the lowering and controlling of normal or elevated intraocular pressure as well as a method for the treatment of glaucoma using compositions containing one or more of the compounds of the present invention.
    Type: Grant
    Filed: November 26, 2003
    Date of Patent: July 4, 2006
    Assignee: Alcon, Inc.
    Inventors: Mark R. Hellberg, Abdelmoula Namil
  • Methods of treating dry eye disorders
    Publication number: 20040209888
    Abstract: Fused pyridazine derivatives are useful for treating dry eye disorders and other disorders requiring the wetting of the eye.
    Type: Application
    Filed: April 14, 2004
    Publication date: October 21, 2004
    Applicant: Alcon, Inc.
    Inventors: Najam A. Sharif, Mark R. Hellberg
  • Hydroxyeicosatetraenoic acid analogs and methods of their use in treating dry eye disorders
    Patent number: 6803385
    Abstract: Hydroxyeicosatetraenoic acid esters and methods of their use in treating dry eye disorders are disclosed.
    Type: Grant
    Filed: April 4, 2003
    Date of Patent: October 12, 2004
    Assignee: Alcon, Inc.
    Inventors: Peter G. Klimko, Mark R. Hellberg, John R. Falck, Raymond E. Conrow
  • Inhibitors of glycogen synthase kinase-3 (gsk-3) for treating glaucoma
    Publication number: 20040186159
    Abstract: The use of inhibitors of GSK-3 useful for treating glaucoma is disclosed.
    Type: Application
    Filed: March 2, 2004
    Publication date: September 23, 2004
    Inventors: Mark R. Hellberg, Abbott F. Clark, Iok-Hou Pang, Peggy Elizabeth Hellberg, Loretta Graves McNatt, Wan-Heng Wang
  • Use of proteasome inhibitors to treat dry eye disorders
    Publication number: 20040180859
    Abstract: Proteasome inhibitors are useful for treating dry eye disorders and other disorders requiring the wetting of the eye.
    Type: Application
    Filed: March 24, 2004
    Publication date: September 16, 2004
    Inventors: Peter G. Klimko, Mark R. Hellberg
  • Use of compounds for treating conditions resulting from injury to the corneal nerve after LASIK and other ocular surgeries or trauma
    Publication number: 20040162315
    Abstract: The present invention provides methods for the treatment of conditions resulting from injury to the corneal nerve after LASIK and other ocular surgeries or trauma.
    Type: Application
    Filed: February 10, 2004
    Publication date: August 19, 2004
    Inventors: Mark R. Hellberg, Iok-Hou Pang, John M. Yanni
  • Superoxide dismutase mimics for the treatment of ocular disorders and diseases
    Publication number: 20040116402
    Abstract: The use of SOD mimics, particularly Mn(III) salen SOD mimics, for the treatment of AMD, DR, and retinal edema is disclosed.
    Type: Application
    Filed: December 5, 2003
    Publication date: June 17, 2004
    Inventors: Peter G. Klimko, Robert J. Collier, Mark R. Hellberg
  • Superoxide dismutase mimics for the treatment of ocular disorders and diseases
    Publication number: 20040116403
    Abstract: The use of SOD mimics, particularly Mn(III) porphyrin complexes, for the treatment of AMD, DR, and retinal edema is disclosed.
    Type: Application
    Filed: December 5, 2003
    Publication date: June 17, 2004
    Inventors: Peter G. Klimko, Robert J. Collier, Mark R. Hellberg
  • Use of propentofylline to control intraocular pressure
    Publication number: 20040110776
    Abstract: Methods for controlling intraocular pressure with propentofylline are disclosed.
    Type: Application
    Filed: June 30, 2003
    Publication date: June 10, 2004
    Inventors: Iok-hou Pang, Mark R Hellberg, Abbott F Clark, Peggy E Hellberg, Debra L Fleenor
  • Novel arylaminopropane analogues and their use for the treatment of glaucoma
    Publication number: 20040110791
    Abstract: Arylaminopropane analogues are disclosed. Also disclosed are methods for the lowering and controlling of normal or elevated intraocular pressure as well as a method for the treatment of glaucoma using compositions containing one or more of the compounds of the present invention.
    Type: Application
    Filed: November 26, 2003
    Publication date: June 10, 2004
    Inventors: Mark R. Hellberg, Abdelmoula Namil
  • Use of proteasome inhibitors to treat dry eye disorders
    Patent number: 6740674
    Abstract: Proteasome inhibitors are useful for treating dry eye disorders and other disorders requiring the wetting of the eye.
    Type: Grant
    Filed: May 17, 2002
    Date of Patent: May 25, 2004
    Assignee: Alcon, Inc.
    Inventors: Peter G. Klimko, Mark R. Hellberg
  • 15-fluoro prostaglandins as ocular hypotensives
    Patent number: 6680339
    Abstract: 15-fluoro substituted analogs of PGF2&agr; and methods of their use in treating glaucoma and ocular hypertension are disclosed.
    Type: Grant
    Filed: March 18, 2002
    Date of Patent: January 20, 2004
    Assignee: Alcon Manufacturing, Ltd.
    Inventors: Peter G. Klimko, Mark R. Hellberg, Paul W. Zinke
  • Hydroxyeicosatetraenoic acid analogs and methods of their use in treating dry eye disorders
    Publication number: 20030236305
    Abstract: Hydroxyeicosatetraenoic acid esters and methods of their use in treating dry eye disorders are disclosed.
    Type: Application
    Filed: April 4, 2003
    Publication date: December 25, 2003
    Inventors: Peter G. Klimko, Mark R. Hellberg, John R. Falck, Raymond E. Conrow
  • Serotonergic 5ht2 agonists for treating glaucoma
    Patent number: 6664286
    Abstract: Compounds with 5HT2 receptor agonist activity useful for treating glaucoma, including lowering intraocular pressure. Compositions and methods for their use are also disclosed.
    Type: Grant
    Filed: March 15, 2001
    Date of Patent: December 16, 2003
    Assignee: Alcon Manufacturing, Ltd.
    Inventors: Jesse A. May, Thomas R. Dean, Najam A. Sharif, Mark R. Hellberg
  • 2-acylaminobenzimidazole derivatives for treating glaucoma
    Patent number: 6660870
    Abstract: 2-Acylaminobenzimidazole deviates useful for treating glaucoma are disclosed.
    Type: Grant
    Filed: September 10, 2002
    Date of Patent: December 9, 2003
    Assignee: Alcon, Inc.
    Inventors: Andrew Ruskinko, Mark R. Hellberg, Namil Abdelmoula