Abstract: The present invention covers substituted. Pyrazolo-pyrrolo-pyrimidine-dione (PPPD) compounds of general formula (I): in which R1, R2 and R3 are as defined herein, methods of preparing said compounds, pharmaceutical compositions and combinations comprising said compounds and the use of said compounds for manufacturing pharmaceutical compositions for the treatment or prophylaxis of diseases, in particular of neurogenic diseases, as a sole agent or in combination with other active ingredients.

Abstract: A danger detector, for example a flame detector, includes an alarm housing with an alarm cover. The housing part of the alarm cover is permeable to heat radiation in the central infrared range. A non-contact, optical heat radiation sensor which is sensitive to the incoming heat radiation and optically oriented to the housing part is arranged in the alarm housing. A processing unit for further processing a sensor signal emitted by the heat radiation sensor is mounted downstream of the heat radiation sensor. The processing unit is designed to monitor the signal emitted by the sensor with respect to significant fluctuations or flicker frequencies for open flames and to determine, based on a direct component of the signal emitted by the sensor, a temperature value for the ambient temperature in the surroundings of the danger detector. The heat radiation sensor may be a thermopile or a bolometer.

Abstract: A damper device for a bicycle having a housing extending in the axial direction and disposed therein, a chamber which forms a chamber volume that is sealed outwardly. The chamber volume extends in the axial direction from a first end to a second end. In the axial direction, at least one adjustment member is rotatably disposed between the ends of the chamber volume. The adjustment member is configured as an annular member and is rotatably received at the housing and surrounds at least part of the housing. By way of movement of the adjustment member, at least one operational setting of the damper device is changeable by means of a mechanical transmitting device.

Abstract: A device for melt-spinning, drawing, and winding a thread group includes a spinning device having a row of spinning nozzles. The threads produced by the spinning nozzles are drawn by means of a godet device with multiple drivable godets. The device is paired with a winding device with multiple winding stations arranged in a row. The row of winding stations is arranged orthogonally to the row of spinning nozzles. The different thread spacings within the spinning device and the godet device are bridged by a thread deflecting device having a first group of thread guides and a second group of thread guides. The thread guides of the first group are arranged next to one another in a horizontal row with a spinning spacing. It is possible to obtain large deflections with a low height. The thread guides of the two groups are made of freely rotatable rollers.

Abstract: The present invention covers substituted. Pyrazolo-pyrrolo-pyrimidine-dione (PPPD) compounds of general formula (I): in which R1, R2 and R3 are as defined herein, methods of preparing said compounds, pharmaceutical compositions and combinations comprising said compounds and the use of said compounds for manufacturing pharmaceutical compositions for the treatment or prophylaxis of diseases, in particular of neurogenic diseases, as a sole agent or in combination with other active ingredients.

Abstract: The present invention relates to 1,3-thiazol-2-yl substituted benzamide compounds of general formula (I) as described and defined herein, to pharmaceutical compositions and combinations comprising said compounds and to the use of said compounds for manufacturing a pharmaceutical composition for the treatment or prophylaxis of a disease, in particular of neurogenic disorder, as a sole agent or in combination with other active ingredients.

Abstract: A composition is provided comprising: a) polyvinylchloride, b) inorganic solid particles, and c) a polymer having a polyether segment, wherein at least 60 mol-% of the end groups of the polymer are selected from the group consisting of carboxylic acid groups and hydroxyl groups, and wherein at least a part of the end groups of the polymer is a carboxylic acid group, wherein the carboxylic acid end groups are linked to the polyether segment via a linking segment comprising an ester group.

Abstract: A rotor, for a turbomachine, in particular a gas turbine, having a first flange and a second flange with recesses that are distributed in a direction of distribution, in particular in the peripheral direction, wherein the second flange is fastened to the first flange, in particular detachably, by at least one fastener, which engage in the first of these recesses of the first and second flanges, wherein second ones of these recesses of the first flange, which are free of a fastener, are covered by the second flange.

Abstract: The present invention relates to use 1,3-thiazol-2-yl substituted benzamide compounds of general formula (I) as described and defined herein, to pharmaceutical compositions and combinations comprising said compounds for the treatment or prophylaxis of diseases which are associated with nerve fiber sensitization, and/or other pathological conditions associated with autonomic imbalance caused by increased chemoreceptor sensitivity, in particular for the treatment of breathing disorders, Cheyne Stokes respiration, central and obstructive sleep apnea, cardiovascular disease, hypertension, resistant hypertension, and heart failure, which are related to increased activity of P2X3 receptors.

Abstract: The present invention relates to use 1,3-thiazol-2-yl substituted benzamide compounds of general formula (I) as described and defined herein, to pharmaceutical compositions and combinations comprising said compounds for the treatment or prophylaxis of diseases which are associated with nerve fibre sensitization, in particular for treatment and prophylaxis of Chronic Cough (CC), Idiopathic Pulmonary Fibrosis (IPF), Chronic Obstructive Pulmonary Disorder (COPD), and asthma.

Abstract: A thermal plant treatment (TPT) machine is configured to apply heated air to crops to induce commercially beneficial effects in the target plants. The TPT machine includes a thermal assembly with interchangeable vents for applying the heat treatment. The thermal assembly includes a heater duct, blowers mounted on the heater duct, a heater supported by the blowers, and a vent assembly mounted to the heater duct. The blower is configured to generate and provide an airstream to the heater duct. The heater is configured to increase a temperature of the heater duct at a location downstream of the blower to generate a heated airstream. The vent assembly is configured to receive the heated airstream from the heater duct and eject the heated airstream onto a target. The vent assembly includes interchangeable vents configured to alter the flow of the airstream exiting the vent assembly.

Abstract: The invention relates to a method of impacting the fruit production of a plant or crop by applying short-duration thermal shock streams of hot air to the plant periodically to impact the flavonoid biosynthetic pathway mechanisms in a plant thereby improving its fruit. The method includes the steps of (1) passing by the plant in a row at a speed of 1-5 mph in an improved Thermal Plant Treatment (TPT) machine, (2) ejecting from the TPT machine at least one hot stream of air in the direction of the unit plant area for no more than 15 seconds per unit plant area per pass, (3) optionally measuring the thermal shock profile that the plant is subjected with thermal sensors, and (4) repeating the thermal shock profile treatment steps (1) and (2) at pre-determined regular intervals over at least a fraction of the crop year.

Abstract: A power supply is configured to perform an at least partial compensation of a voltage variation caused by a load change using a voltage variation compensation mechanism which is triggered in response to an expected load change. An Automated test equipment for testing a device under test comprises a power supply, which is configured to supply the device under test. The automated test equipment comprises a pattern generator configured to provide one or more stimulus signals for the device under test. The power supply is configured to perform an at least partial compensation of a voltage variation caused by a load change using a voltage variation compensation mechanism which is activated in synchronism with one or more of the stimulus signals and/or in response to one or more response data signals from the device under test. Corresponding methods and a computer program are also described.

Abstract: A device for melt-spinning, drawing, and winding a thread group includes a spinning device having a row of spinning nozzles. The threads produced by the spinning nozzles are drawn by means of a godet device with multiple drivable godets. The device is paired with a winding device with multiple winding stations arranged in a row. The row of winding stations is arranged orthogonally to the row of spinning nozzles. The different thread spacings within the spinning device and the godet device are bridged by a thread deflecting device having a first group of thread guides and a second group of thread guides. The thread guides of the first group are arranged next to one another in a horizontal row with a spinning spacing. It is possible to obtain large deflections with a low height. The thread guides of the two groups are made of freely rotatable rollers.

Abstract: The invention relates to a method of impacting the fruit production of a plant or crop by applying short-duration thermal shock streams of hot air to the plant periodically to impact the flavonoid biosynthetic pathway mechanisms in a plant thereby improving its fruit. The method includes the steps of (1) passing by the plant in a row at a speed in an improved Thermal Plant Treatment (TPT) machine, (2) ejecting from the TPT machine at least one hot stream of air in the direction of the unit plant area, (3) optionally measuring the thermal shock profile that the plant is subjected with thermal sensors, and (4) repeating the thermal shock profile treatment steps (1) and (2) at pre-determined regular intervals over at least a fraction of the crop year.

Abstract: The present invention relates to 1,3-thiazol-2-yl substituted benzamide compounds of general formula (I) as described and defined herein, to pharmaceutical compositions and combinations comprising said compounds and to the use of said compounds for manufacturing a pharmaceutical composition for the treatment or prophylaxis of a disease, in particular of neurogenic disorder, as a sole agent or in combination with other active ingredients.

Abstract: Systems and methods for generating scheduling options in consideration of space and resource constraints in accordance with embodiments of the invention are disclosed. One embodiment of the invention includes a scheduling application that configures the processor to generate a project schedule from a TODO list comprising a plurality of construction operations, where the construction operations comprise at least one specific space requirements within a construction site, resource requirements, and a duration time.

Abstract: A damper device for a bicycle having a housing extending in the axial direction and disposed therein, a chamber which forms a chamber volume that is sealed outwardly. The chamber volume extends in the axial direction from a first end to a second end. In the axial direction, at least one adjustment member is rotatably disposed between the ends of the chamber volume. The adjustment member is configured as an annular member and is rotatably received at the housing and surrounds at least part of the housing. By way of movement of the adjustment member, at least one operational setting of the damper device is changeable by means of a mechanical transmitting device.

Abstract: The present invention relates to 1,3-thiazol-2-yl substituted benzamide compounds of general formula (I) as described and defined herein, to pharmaceutical compositions and combinations comprising said compounds and to the use of said compounds for manufacturing a pharmaceutical composition for the treatment or prophylaxis of a disease, in particular of neurogenic disorder, as a sole agent or in combination with other active ingredients.

Abstract: Various embodiments may include fire detector comprising: a fire sensor generating a signal corresponding to a characteristic fire parameter; a control unit; and a photodiode for detecting ambient light in a spectrally delimited range of 400 nm to 1150 nm. The control unit analyzes the signal and generates a fire alarm if the signal corresponds to a predetermined threshold for a fire. The control unit analyzes a photo-signal received from the photodiode and if the flicker frequencies characteristic of open fire are detected, the control unit increases a sampling rate for acquiring the sensor signal from the fire sensor by reducing a filter time of an evaluation filter for the fire analysis and/or by lowering an alerting threshold.