Abstract: Antibodies that bind SARS-CoV spike protein, SARS-CoV-2 spike protein, and methods of using same for treating or preventing conditions associated with SARS or COVID-19 and for detecting SARS-CoV or SARS-CoV-2.

Abstract: A folding bicycle trailer that converts between a bicycle trailer mode, a stroller mode, and a folded mode. The trailer has a frame having a first and second side frame assemblies, and a floor assembly. Each side frame assembly has a front wheel and a rear wheel. The front wheels are removed from the frame in the bicycle trailer mode, and are connected to the frame in the stroller and folded modes. A connection arm removably connects to a bicycle in bicycle trailer mode. The connection arm is removable in the stroller and folded modes, but can be connected to the trailer in a second position in those modes. The trailer has a removable push bar for stroller mode. The first and second side frame assemblies remain vertical but move closer to one another in the folded mode.

Abstract: Systems, devices, media, and methods are presented for releasing an application feature in incremental stages while monitoring the application for anomalies. The feature includes a package of code and an action setting. The methods in some implementations include identifying active devices on which the application has been installed, monitoring the application according to a set of metrics, activating the feature by changing its action setting for a first segment of the active devices, pausing the feature if an anomaly is detected among the set of metrics, and generating a repair ticket. As long as no anomaly is detected, the activating step proceeds for subsequent segments of the active devices, iteratively, until the release is completed. A feature rank may be used to process and release a plurality of features in order of priority.

Abstract: A pulmonary function test filter and filter assembly for use with a breathing tube of a spirometer. The filter assembly includes a first portion having an exhaust end configured to removably engage an exhaust end of a flow tube of a spirometer, preferably without an adapter, a second portion configured to cooperatively engage the first portion and including a mouthpiece, and filter media. The filter media is removably securable between the first and second portions.

Abstract: The disclosure provides methods for predicting surface-presenting peptides using binding and surface-presentation characteristics. The method can include accessing a trained machine-learning model that is configured to generate an output that indicates an extent to which the one or more expression levels and the one or more peptide-presentation metrics are related in accordance with a population-level relationship between expression and presentation. For each peptide of the set of peptides for a tissue sample, a score can be determined using the machine-learning model and genomic and transcriptomic data corresponding to the peptide. The score is predictive of whether a corresponding peptide is a surface-presenting peptide that binds to an MHC molecule and is presented on a cell surface.

Abstract: Methods for generating a composite biomarker that identifies a predicted level of responsiveness of a subject to a particular type of an immunotherapy treatment is provided. The method can include generating genomic metrics that represent one or more characteristics corresponding to one or more DNA sequences. The method can also include generating transcriptomic metrics represent one or more characteristics corresponding to a set of peptides that are translated from a corresponding RNA sequence of the one or more RNA sequences. The method can also include generating a composite biomarker score derived from the set of genomic metrics and the set of transcriptomic metrics. The method can also include determining, based on the composite biomarker score, a predicted level of responsiveness of the subject to a particular type of an immunotherapy treatment.

Abstract: Breathing tubes for use with a spirometer. The breathing tubes include a body having an oval interior cross-sectional shape and are configured to engage interior surfaces of the spirometer, so as to ensure the proper orientation of the body within the spirometer.

Abstract: A retractable load carrier system for a vehicle comprising a rail assembly comprising a first rail and a second rail, wherein each rail is configured to be mounted to a vehicle roof. The system can further include a rack assembly comprising a first support member and a second support member generally parallel to each other, wherein the first support member and second support member can be coupled together with at least one cross members, wherein the rack assembly has a first end and a second end, wherein both the first and second end can include a handle portion. A locking means can be coupled to the handle portion of the rack assembly, wherein the locking means comprises a plurality of engagement members configured to latch to engage the grooved portion of the rail assembly or the pins are configured to engage the pinion portion of the rail assembly.

Abstract: A multi-functional coupler for one or more vehicle components includes a shank, a head connected to the shank, a connector carried by the shank, and a tool. The tool is carried by the head or shank spaced from the connector, and the tool has a fastener engaging portion by which a fastener may be moved to install or remove the fastener from a component. The coupler may be used to both coupled together two or more components, and to remove fasteners or other connections via the tool of the coupler. Conveniently, as the coupler is normally installed on the vehicle to couple together two or more vehicle components, the coupler is readily available to a user wanting to remove fasteners compatible/drivable with the tool of the coupler.

Abstract: A retractable load carrier system for a vehicle comprising a rail assembly comprising a first rail and a second rail, wherein each rail is configured to be mounted to a vehicle roof. The system can further include a rack assembly comprising a first support member and a second support member generally parallel to each other, wherein the first support member and second support member can be coupled together with at least one cross members, wherein the rack assembly has a first end and a second end, wherein both the first and second end can include a handle portion. A locking means can be coupled to the handle portion of the rack assembly, wherein the locking means comprises a plurality of engagement members configured to latch to engage the grooved portion of the rail assembly or the pins are configured to engage the pinion portion of the rail assembly.

Abstract: A multi-functional coupler for one or more vehicle components includes a shank, a head connected to the shank, a connector carried by the shank, and a tool. The tool is carried by the head or shank spaced from the connector, and the tool has a fastener engaging portion by which a fastener may be moved to install or remove the fastener from a component. The coupler may be used to both coupled together two or more components, and to remove fasteners or other connections via the tool of the coupler. Conveniently, as the coupler is normally installed on the vehicle to couple together two or more vehicle components, the coupler is readily available to a user wanting to remove fasteners compatible/drivable with the tool of the coupler.

Abstract: Compositions and methods for repelling arthropods. The compositions include a carrier and an arthropod repelling compound, which can be a compound discovered by a novel and complex cheminformatic process to demonstrate repellency behavior across a broad spectrum of arthropods. The compound can be a thiane compound, a pyrrolidone compound, a cyclohexadiene compound, a cyclohexenone compound, a cyclohexene compound, a furanone compound, a pyran compound, a tetrahydropyran compound, a thiazolidine compound, a thiazoline compound, a dihydrothiophene compound, a dithiolane compound, a dithiane compound, an epoxide compound, an oxathiane compound, a cyclopentene compound, a cyclohexane compound, a quinoline compound, an oxazoline compound, a tetrahydropyridine compound, and an imidazolidinone compound, or a combination thereof.

Abstract: A putter-type golf club head has a main body and a face component including a first element formed of a resilient material. The putter-type golf club head also has a second element forward of the first element and including a rigid material. The second element is secured directly to the first element. The first element has a thickness that gradually increases toward a sole portion of the club head.

Abstract: A retractable load carrier system for a vehicle comprising a rail assembly comprising a first rail and a second rail, wherein each rail is configured to be mounted to a vehicle roof. The system can further include a rack assembly comprising a first support member and a second support member generally parallel to each other, wherein the first support member and second support member can be coupled together with at least one cross members, wherein the rack assembly has a first end and a second end, wherein both the first and second end can include a handle portion. A locking means can be coupled to the handle portion of the rack assembly, wherein the locking means comprises a plurality of engagement members configured to latch to engage the grooved portion of the rail assembly or the pins are configured to engage the pinion portion of the rail assembly.

Abstract: The invention provides improved natural sweetener compositions comprising certain isolated compounds and their derivatives. The present invention also includes ingestible compositions comprising the present compounds and methods of sweetening the sweet taste of consumable materials.

Abstract: Provided herein are screening methods for identifying compounds for use as an arthropod repellent based on the masking or inhibition of the detection of the skin odor by a cpA neuron. Provided herein are also screening methods for identifying compounds for use as an arthropod attractant based on activation of the cpA neuron. Further provided are one or more compounds identified using the screening methods described herein, and compositions containing such compounds.

Abstract: The disclosure provides compounds useful as insect repellents, compositions comprising such repellents, and methods of repelling an arthropod using such compounds and compositions. The disclosure further provides insect traps and method for identifying ligands and cognates for biological molecules.

Abstract: A method is described for manipulating a view displayed on one or more follower participants' devices to track a view displayed on a lead participant's device. A request to manipulate the view displayed on the one or more follower participant devices is received. The lead participant is identified. The follower participants are identified. A lead view of the lead participant is determined. The lead view is communicated to the follower participants computing devices for display. A computing device and a non-transitory computer readable medium having instructions configured to implement the method are also described.