Abstract: A novel synthetic functionalized backbone polymer is provided which is a polyanionic side-chain functionalized back-bone polymer comprising a hydrophilic backbone polymer functionalized with an activated alkene or epoxy group. The functionalized backbone polymer may be combined with a free or protected thiol-containing compound to form a crosslinked hydrogel having bio-medical application, and may additionally be combined with a hydrogel matrix to yield a hydrogel system useful for in vivo delivery of cells and other therapeutic agents.

Abstract: A system, method, and apparatus for fuel cell utilizing hydrogen from reforming propane fuel include a propane fuel reformer, controlling operating parameters of O2/C ratio, pressure, and catalyst temperature, and a high temperature proton exchange membrane fuel cell (HT-PEMFC) controlling operating parameters of pressure and temperature. For mobile application, the system includes a 3D printed reformer for generation of hydrogen rich gas.

Abstract: The present invention provides novel compounds of Formula (I) and Formula (II) and pharmaceutically acceptable salts, solvates, hydrates, tautomers, stereoisomers, isotopically labeled derivatives, and compositions thereof. Also provided are methods and kits involving the compounds or compositions for treating or preventing proliferative diseases (e.g., cancers (e.g., leukemia, melanoma, multiple myeloma), benign neoplasms, angiogenesis, inflammatory diseases, autoinflammatory diseases, and autoimmune diseases) in a subject. Treatment of a subject with a proliferative disease using a compound or composition of the invention may inhibit the aberrant activity of cyclin-dependent kinase 7 (CDK7), and therefore, induce cellular apoptosis and/or inhibit transcription in the subject.

Abstract: Exemplary embodiments include a hybrid cash recycler device that provides cash handling and extended capabilities for use within a financial institution. The hybrid cash recycler may be configured to support wireless communications with multiple distributed computing devices in a financial institution branch. The wireless connectivity may provide portable command and control capabilities for the hybrid cash recycler. The hybrid cash recycler may be configured to employ queuing mechanisms, in a manner that allows the device to systematically arrange and execute multiple command requests initiated from several computing devices. The hybrid cash recycler may require user authentication prior to completing cash handling services. Upon a successful authentication, requested cash handling services may be completed.

Abstract: The present invention provides novel compounds of Formula (I), and pharmaceutically acceptable salts, solvates, hydrates, tautomers, stereoisomers, isotopically labeled derivatives, and compositions thereof. Also provided are methods and kits involving the compounds or compositions for treating or preventing proliferative diseases (e.g., cancers (e.g., leukemia, melanoma, multiple myeloma), benign neoplasms, angiogenesis, inflammatory diseases, autoinflammatory diseases, and autoimmune diseases) in a subject. Treatment of a subject with a proliferative disease using a compound or composition of the invention may inhibit the aberrant activity of cyclin-dependent kinase 7 (CDK7), and therefore, induce cellular apoptosis and/or inhibit transcription in the subject.

Abstract: The present invention provides novel compounds of Formula (I), and pharmaceutically acceptable salts, solvates, hydrates, tautomers, stereoisomers, isotopically labeled derivatives, and compositions thereof. Also provided are methods and kits involving the compounds or compositions for treating or preventing proliferative diseases (e.g., cancers (e.g., leukemia, melanoma, multiple myeloma), benign neoplasms, angiogenesis, inflammatory diseases, autoinflammatory diseases, and autoimmune diseases) in a subject. Treatment of a subject with a proliferative disease using a compound or composition of the invention may inhibit the aberrant activity of a kinase, such as a cyclin-dependent kinase (CDK) (e.g., cyclin-dependent kinase 7 (CDK7)), and therefore, induce cellular apoptosis and/or inhibit transcription in the subject.

Abstract: A packaging machine hopper is provided for holding a stack of packaging articles with each article in a generally horizontal orientation. The hopper comprises a support for holding at least part of the stack at an angle to vertical.

Abstract: The Totem Pole Solar Capture Housing is an improved design for a photo voltaic module enclosure. It is cylindrical in shape to capture the maximum amount of solar radiation on the housing's surface transferred to the module for conversion to electricity, and eliminates positional orientation. The cylindrical glass outer shell exposes one half of its circumference to solar radiation on contact. Used singly or in multiples interconnected together, one atop the other and erected vertically on a foot print. The inner photo voltaic module support core diameter and height can be sized to fit modules of different electrical outputs. The hollow center of the support core acts as the wiring channel to the base. Assembly couplings form the top and bottom of the enclosure and are critical in joining multiple enclosures into one vertical electrical output-enhanced assembly.

Abstract: A bus seat for use in a bus comprises a base having a generally rectangular shape when viewed from a bottom. The bus seat further comprises a cushioning material arranged over a top and front portion of the base. The bus seat further comprises a cover material having a fastener with a first end and a second end attached thereto. The first end of the fastener is attached to the cover material while the second end of the fastener is connected to a predetermined portion of the base on a bottom surface thereof.

Abstract: The present invention provides novel compounds of Formula (I), and pharmaceutically acceptable salts, solvates, hydrates, polymorphs, co-crystals, tautomers, stereoisomers, isotopically labeled derivatives, prodrugs, and compositions thereof. Also provided are methods and kits involving the inventive compounds or compositions for treating or preventing proliferative diseases (e.g., cancers (e.g., leukemia, lymphoma, melanoma, multiple myeloma, breast cancer, Ewing's sarcoma, osteosarcoma, brain cancer, neuroblastoma, lung cancer), benign neoplasms, angiogenesis, inflammatory diseases, autoinflammatory diseases, and autoimmune diseases) in a subject. Treatment of a subject with a proliferative disease using a compound or composition of the invention may inhibit the aberrant activity of a kinase, such as a cyclin-dependent kinase (CDK) (e.g.

Abstract: A system and method dynamically generates structured graphical user interfaces based on the type of device accessing a user interface. The system and method dynamically trigger the pre-population of content within a native application or internet-based application on user agent information and user-entered information and initiates SMS communications between users of disparate device types.

Abstract: An automatic packaging machine is provided and comprises a plurality of in-feed conveyors for separately conveying contents. The conveyors are at different heights. The machine includes means for placing the contents into a packaging article, or placing the packaging article around the contents, with the contents in a vertically stacked configuration.

Abstract: The present invention provides novel compounds of Formula (I) and Formula (II) and pharmaceutically acceptable salts, solvates, hydrates, tautomers, stereoisomers, isotopically labeled derivatives, and compositions thereof. Also provided are methods and kits involving the compounds or compositions for treating or preventing proliferative diseases (e.g., cancers (e.g., leukemia, melanoma, multiple myeloma), benign neoplasms, angiogenesis, inflammatory diseases, autoinflammatory diseases, and autoimmune diseases) in a subject. Treatment of a subject with a proliferative disease using a compound or composition of the invention may inhibit the aberrant activity of cyclin-dependent kinase 7 (CDK7), and therefore, induce cellular apoptosis and/or inhibit transcription in the subject.

Abstract: The present invention provides novel compounds of Formula (I) and Formula (II) and pharmaceutically acceptable salts, solvates, hydrates, tautomers, stereoisomers, isotopically labeled derivatives, and compositions thereof. Also provided are methods and kits involving the compounds or compositions for treating or preventing proliferative diseases (e.g., cancers (e.g., leukemia, melanoma, multiple myeloma), benign neoplasms, angiogenesis, inflammatory diseases, autoinflammatory diseases, and autoimmune diseases) in a subject. Treatment of a subject with a proliferative disease using a compound or composition of the invention may inhibit the aberrant activity of cyclin-dependent kinase 7 (CDK7), and therefore, induce cellular apoptosis and/or inhibit transcription in the subject.

Abstract: Systems, apparatuses, and method for preparing dough-based products are disclosed. One disclosed system for preparing dough-based products comprises a fryer comprising a bottom and at least one sidewall, a proofer comprising a proofing chamber with a top, bottom, and at least one sidewall, and a conveying mechanism configured to transport the dough-based products from the proofing chamber to the fryer, wherein the top of the proofing chamber is located below the bottom of the fryer.

Abstract: The present invention provides novel compounds of Formula (I) and Formula (II) and pharmaceutically acceptable salts, solvates, hydrates, tautomers, stereoisomers, isotopically labeled derivatives, and compositions thereof. Also provided are methods and kits involving the compounds or compositions for treating or preventing proliferative diseases (e.g., cancers (e.g., leukemia, melanoma, multiple myeloma), benign neoplasms, angiogenesis, inflammatory diseases, autoinflammatory diseases, and autoimmune diseases) in a subject. Treatment of a subject with a proliferative disease using a compound or composition of the invention may inhibit the aberrant activity of cyclin-dependent kinase 7 (CDK7), and therefore, induce cellular apoptosis and/or inhibit transcription in the subject.

Abstract: The present invention provides novel compounds of Formula (I), and pharmaceutically acceptable salts, solvates, hydrates, polymorphs, co-crystals, tautomers, stereoisomers, isotopically labeled derivatives, prodrugs, and compositions thereof. Also provided are methods and kits involving the inventive compounds or compositions for treating or preventing proliferative diseases (e.g., cancers (e.g., leukemia, lymphoma, melanoma, multiple myeloma, breast cancer, Ewing's sarcoma, osteosarcoma, brain cancer, neuroblastoma, lung cancer), benign neoplasms, angiogenesis, inflammatory diseases, autoinflammatory diseases, and autoimmune diseases) in a subject. Treatment of a subject with a proliferative disease using a compound or composition of the invention may inhibit the aberrant activity of a kinase, such as a cyclin-dependent kinase (CDK) (e.g.

Abstract: The present invention is directed to a guitar pick or plectrum for use with a stringed musical instrument and which is constructed with generally two or three veneers which are adhered to each other such that each veneer is cross grain to each adjacently adhered veneer. In other embodiments, the tip portion of the plectrum has a gauge less than the grip portion of the plectrum.

Abstract: The present invention provides novel compounds of Formula (I) and Formula (II) and pharmaceutically acceptable salts, solvates, hydrates, tautomers, stereoisomers, isotopically labeled derivatives, and compositions thereof. Also provided are methods and kits involving the compounds or compositions for treating or preventing proliferative diseases (e.g., cancers (e.g., leukemia, melanoma, multiple myeloma), benign neoplasms, angiogenesis, inflammatory diseases, autoinflammatory diseases, and autoimmune diseases) in a subject. Treatment of a subject with a proliferative disease using a compound or composition of the invention may inhibit the aberrant activity of cyclin-dependent kinase 7 (CDK7), and therefore, induce cellular apoptosis and/or inhibit transcription in the subject.

Abstract: The present invention is directed to a guitar pick or plectrum for use with a stringed musical instrument and which is constructed with generally two or three veneers which are adhered to each other such that each veneer is cross grain to each adjacently adhered veneer. In other embodiments, the tip portion of the plectrum has a gauge less than the grip portion of the plectrum.