Patents by Inventor Michael E. Jung

Michael E. Jung has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • COMPOSITIONS AND METHODS FOR TREATING EPIGENETIC DISEASE
    Publication number: 20210309634
    Abstract: The present disclosure provides compounds and compositions capable of treating cancer or an autoimmune disease, such as Crohn's disease, and methods of use thereof.
    Type: Application
    Filed: July 22, 2019
    Publication date: October 7, 2021
    Inventors: Dimitrios Iliopoulos, Michael E. Jung, Jonghoon Kim, Jill M. Hoffman, Iordanes Karagiannides
  • INHIBITORS OF IRES-MEDIATED PROTEIN SYNTHESIS
    Publication number: 20210220331
    Abstract: This disclosure relates to inhibitors of IRES-mediated protein synthesis, compositions comprising therapeutically effective amounts of these compounds, and methods of using those compounds and compositions in treating hyperproliferative disorders, e.g., cancers. This disclosure also relates to compositions comprising inhibitors of IRES-mediated protein synthesis and mTOR inhibitors, and to methods of treating cancer by conjoint administration of inhibitors of IRES-mediated protein synthesis and mTOR inhibitors.
    Type: Application
    Filed: May 3, 2017
    Publication date: July 22, 2021
    Inventors: Joseph F. Gera, Alan Lichtenstein, Michael E. Jung, Jihye Lee, Brent Holmes, Angelica Benavides-Serrato
  • Potent antiviral pyrazolopyridine compounds
    Patent number: 11059817
    Abstract: The present technology provides compounds according to Formulas (I), (II), or (III) useful in inhibiting an enterovirus, paramyxovirus, respiratory virus, flaviviridae virus, bunyaviridae virus, togaviridae virus, or rabies virus in a cell and/or treating subjects suffering from an enterovirus, paramyxovirus, respiratory virus, flaviviridae virus, bunyaviridae virus, togaviridae virus, or rabies virus.
    Type: Grant
    Filed: September 22, 2016
    Date of Patent: July 13, 2021
    Assignee: The Regents of the University of California
    Inventors: Paul Krogstad, Michael E. Jung, Jun Zuo, Yanpeng Xing
  • ESTROGEN RECEPTOR LIGANDS, COMPOSITIONS AND METHODS RELATED THERETO
    Publication number: 20210196667
    Abstract: Provided are compounds and methods for treating neurodegenerative diseases and conditions, such as multiple sclerosis, using an estrogen receptor-? ligand (ER? ligand).
    Type: Application
    Filed: March 16, 2021
    Publication date: July 1, 2021
    Inventors: Michael E. Jung, Rhonda R. Voskuhl
  • COMPOUNDS AND METHODS FOR HEMATOPOIETIC REGENERATION
    Publication number: 20210188763
    Abstract: The invention relates to compounds that promote hematopoietic regeneration. The invention further relates to methods of promoting hematopoietic regeneration using the novel compounds of the invention.
    Type: Application
    Filed: November 29, 2018
    Publication date: June 24, 2021
    Inventors: John P. Chute, Michael E. Jung, Emelyne Diers, Hyo Jin Gim, Martina Roos
  • ANDROGEN RECEPTOR MODULATOR FOR THE TREATMENT OF PROSTATE CANCER AND ANDROGEN RECEPTOR-ASSOCIATED DISEASES
    Publication number: 20210121450
    Abstract: Described herein, inter alia, are compounds useful for the prevention or treatment of hyperproliferative diseases or disorders.
    Type: Application
    Filed: November 9, 2020
    Publication date: April 29, 2021
    Inventors: Michael E. Jung, Charles L. Sawyers, Samedy Ouk, Chris Tran, John Wongvipat
  • Estrogen receptor ligands, compositions and methods related thereto
    Patent number: 10980767
    Abstract: Provided are compounds and methods for treating neurodegenerative diseases and conditions, such as multiple sclerosis, using an estrogen receptor-? ligand (ER? ligand).
    Type: Grant
    Filed: September 8, 2017
    Date of Patent: April 20, 2021
    Assignee: The Regents of the University of California
    Inventors: Michael E. Jung, Rhonda R. Voskuhl
  • Lipid compositions
    Patent number: 10953095
    Abstract: Disclosed herein are lipid compositions comprising a cationic lipid of formula (I), a neutral lipid, a sterol and a PEG or PEG-modified lipid, wherein formula (I) is Also disclosed are methods of producing the cationic lipid of formula (I).
    Type: Grant
    Filed: October 4, 2019
    Date of Patent: March 23, 2021
    Assignee: ARBUTUS BIOPHARMA CORPORATION
    Inventors: Muthiah Manoharan, Kallanthottathil G. Rajeev, Muthusamy Jayaraman, David Butler, Michael E. Jung
  • Estrogen receptor modulator combinations
    Patent number: 10918648
    Abstract: Described herein, inter alia, are compositions and methods for treating or preventing hyperproliferative disorders, including cancer.
    Type: Grant
    Filed: May 25, 2017
    Date of Patent: February 16, 2021
    Assignee: The Regents of the University of California
    Inventors: Richard J. Pietras, Michael E. Jung
  • Tricyclic Gyrase inhibitors
    Patent number: 10865216
    Abstract: Disclosed herein are compounds having the structure of Formula I and pharmaceutically suitable salts, esters, and prodrugs thereof that are useful as antibacterially effective tricyclic gyrase inhibitors. In addition, species of tricyclic gyrase inhibitors compounds are also disclosed herein. Related pharmaceutical compositions, uses and methods of making the compounds are also contemplated.
    Type: Grant
    Filed: September 11, 2013
    Date of Patent: December 15, 2020
    Assignees: MERCK SHARP & DOHME CORP., LAWRENCE LIVERMORE NATIONAL SECURITY, LLC
    Inventors: Daniel Bensen, Allen Borchardt, Zhiyong Chen, John M. Finn, Thanh To Lam, Suk Joong Lee, Xiaoming Li, Leslie William Tari, Min Teng, Michael Trzoss, Junhu Zhang, Michael E. Jung, Felice C. Lightstone, Sergio E. Wong, Toan B. Nguyen
  • Substituted diazaspiroalkanes as androgen receptor modulators
    Patent number: 10857139
    Abstract: Provided herein are compounds and pharmaceutical compositions including the compound having a formula: These compounds are androgen receptor modulators useful for the treatment of androgen receptor-associated conditions.
    Type: Grant
    Filed: May 2, 2018
    Date of Patent: December 8, 2020
    Assignee: The Regents of the University of California
    Inventors: Michael E. Jung, Charles L. Sawyers, Samedy Ouk, Chris Tran, John Wongvipat
  • Compounds and methods for hematopoietic regeneration
    Patent number: 10822299
    Abstract: The invention relates to compounds that promote hematopoietic regeneration. The invention further relates to methods of promoting hematopoietic regeneration using the novel compounds of the invention.
    Type: Grant
    Filed: May 26, 2017
    Date of Patent: November 3, 2020
    Assignee: The Regents of the University of California
    Inventors: John P. Chute, Michael E. Jung, Emelyne Diers
  • PRODRUGS OF ALPHA-KETOGLUTARATE, ALPHA-KETOBUTYRATE, ALPHA-KETOISOVALERATE, AND ALPHA-KETOISOHEXANOATE, AND USES THEREOF
    Publication number: 20200325113
    Abstract: The present disclosure provides compounds and compositions capable of extending lifespan, and methods of use thereof.
    Type: Application
    Filed: June 30, 2020
    Publication date: October 15, 2020
    Inventors: Michael E. Jung, Jing Huang, Yanpeng Xing, Brett E. Lomenick, Min Chai, Xudong Fu
  • COMPOSITIONS AND METHODS FOR TREATING CANCER
    Publication number: 20200290978
    Abstract: The present disclosure relates to compounds that are capable penetrating to the blood brain barrier to modulate the activity of EGFR tyrosine kinase. The disclosure further relates to methods of treating glioblastoma and other EGFR mediated cancers. The disclosure further relates to methods of treating glioblastoma and other EGFR mediated cancers that have been determined to have altered glucose metabolism in the presence of inhibitors. The present disclosure also provides methods of administering to a subject a glucose metabolism inhibitor and a cytoplasmic p53 stabilizer.
    Type: Application
    Filed: September 26, 2018
    Publication date: September 17, 2020
    Applicant: The Regents of the University of California
    Inventors: David A. Nathanson, Wilson X. Mai, Michael E. Jung, Peter M. Clark, Timothy F. Cloughesy, Gyudong Kim, Jonathan Tsang, Lorenz Urner
  • Protective molecules against anthrax toxin
    Patent number: 10730848
    Abstract: Disclosed herein inter alia are compositions and methods useful in the treatment of infectious diseases and exposure to toxins.
    Type: Grant
    Filed: July 16, 2015
    Date of Patent: August 4, 2020
    Assignee: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventors: Eugene Gillespie, Robert Damoiseaux, Chi-Lee Charlie Ho, Brian T. Chamberlain, Michael E. Jung, Kenneth A. Bradley
  • POTENT ANTIVIRAL PYRIDINE-CONTAINING COMPOUNDS
    Publication number: 20200223842
    Abstract: The present technology provides compounds according to Formula I expected to be useful in inhibiting an enterovirus, paramyxovirus, respiratory virus, flaviviridae virus, bunyaviridae virus, togaviridae virus, or rabies virus in a cell and/or treating subjects suffering from an enterovirus, paramyxovirus, respiratory virus, flaviviridae virus, bunyaviridae virus, togaviridae virus, or rabies virus.
    Type: Application
    Filed: September 26, 2018
    Publication date: July 16, 2020
    Applicant: The Regents of the University of California
    Inventors: Paul Krogstad, Michael E. Jung, Jun Zuo, Yanpeng Xing
  • COMPOSITIONS AND METHODS FOR MODULATING HAIR GROWTH
    Publication number: 20200157093
    Abstract: The present disclosure relates to compounds that are capable of inhibiting the mitochondrial pyruvate carrier and promoting hair growth. The disclosure further relates to methods of promoting hair growth or treating conditions or disorders affecting hair growth, such as baldness or alopecia.
    Type: Application
    Filed: June 29, 2018
    Publication date: May 21, 2020
    Inventors: William E. Lowry, Michael E. Jung, Heather R. Christofk, Xiaoguang Liu
  • LIPID COMPOSITIONS
    Publication number: 20200138955
    Abstract: Disclosed herein are lipid compositions comprising a cationic lipid of formula (I), a neutral lipid, a sterol and a PEG or PEG-modified lipid, wherein formula (I) is Also disclosed are methods of producing the cationic lipid of formula (I).
    Type: Application
    Filed: October 4, 2019
    Publication date: May 7, 2020
    Applicant: Arbutus Biopharma Corporation
    Inventors: Muthiah Manoharan, Kallanthottathil G. Rajeev, Muthusamy Jayaraman, David Butler, Michael E. Jung
  • Monomers and oligonucleotides comprising cycloaddition adduct(s)
    Patent number: 10550386
    Abstract: The invention features compounds of formula V or XII: In one embodiment, the invention relates compounds and processes for conjugating ligand to oligonucleotide. The invention further relates to methods for treating various disorders and diseases such as viral infections, bacterial infections, parasitic infections, cancers, allergies, autoimmune diseases, immunodeficiencies and immunosuppression.
    Type: Grant
    Filed: December 30, 2016
    Date of Patent: February 4, 2020
    Assignee: Alnylam Pharmaceuticals, Inc.
    Inventors: Muthiah Manoharan, Jayaprakash K. Nair, Kallanthottahil G. Rajeev, Michael E. Jung
  • Compositions and methods for treating cancer
    Patent number: 10512630
    Abstract: Provided herein, inter alia, are compositions and methods useful for treating hyperproliferative diseases, including cancer and non-malignant hyperproliferative diseases.
    Type: Grant
    Filed: September 29, 2016
    Date of Patent: December 24, 2019
    Assignee: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventors: Richard J. Pietras, Michael E. Jung, Diana C. Marquez-Garban, Gang Deng