Patents by Inventor Michael E. Jung

Michael E. Jung has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • INHIBITORS OF MTOR-DEPTOR INTERACTIONS AND METHODS OF USE THEREOF
    Publication number: 20190330142
    Abstract: Provided herein are substituted hydrazone compounds useful as inhibitors of DEPTOR. The invention further provides pharmaceutical compositions of the compounds of the invention. The invention also provides medical uses of substituted hydrazone compounds.
    Type: Application
    Filed: November 6, 2017
    Publication date: October 31, 2019
    Inventors: Alan Lichtenstein, Michael E. Jung, Joseph F. Gera, Jihye Lee, Yijiang Shi
  • Lipid compositions
    Patent number: 10456473
    Abstract: Disclosed herein are lipid compositions comprising a cationic lipid of formula (I), a neutral lipid, a sterol and a PEG or PEG-modified lipid, wherein formula (I) is Also disclosed are methods of producing the cationic lipid of formula (I).
    Type: Grant
    Filed: May 12, 2017
    Date of Patent: October 29, 2019
    Assignee: Arbutus Biopharma Corporation
    Inventors: Muthiah Manoharan, Kallanthottathil G. Rajeev, Muthusamy Jayaraman, David Butler, Michael E. Jung
  • COMPOUNDS AND METHODS FOR HEMATOPOIETIC REGENERATION
    Publication number: 20190292132
    Abstract: The invention relates to compounds that promote hematopoietic regeneration. The invention further relates to methods of promoting hematopoietic regeneration using the novel compounds of the invention.
    Type: Application
    Filed: May 26, 2017
    Publication date: September 26, 2019
    Inventors: John P. Chute, Michael E. Jung, Emelyne Diers
  • Estrogen receptor modulators
    Patent number: 10400006
    Abstract: Described herein, inter alia, are compositions and methods for treating or preventing hyperproliferative disorders, including cancer.
    Type: Grant
    Filed: November 20, 2015
    Date of Patent: September 3, 2019
    Assignee: The Regents of the University of California
    Inventors: Richard J. Pietras, Michael E. Jung, Diana C. Marquez-Garban, Gang Deng
  • Compositions and Methods for Treating Aging and Age-Related Diseases and Symptoms
    Publication number: 20190192470
    Abstract: Disclosed herein are methods for (a) inhibiting, reducing, slowing, or preventing, the aging of a subject, (b) for treating, inhibiting, reducing, or preventing an age-related disease in the subject, and/or (c) for increasing the lifespan of the subject which comprise administering to the subject one or more glutarate compounds, such as ?-ketoglutate, and/or one or more glutamate compounds, such as 2-hydroxypentanedioate, and compositions thereof.
    Type: Application
    Filed: March 9, 2019
    Publication date: June 27, 2019
    Inventors: Jing Huang, Randall M. Chin, Simon Diep, Melody Y. Pai, Brett Eugene Lomenick, Xudong Fu, Karen Reue, Laurent Vergnes, Michael E. Jung, Gang Deng, Heejun Hwang, Meisheng Jiang
  • ESTROGEN RECEPTOR LIGANDS, COMPOSITIONS AND METHODS RELATED THERETO
    Publication number: 20190192476
    Abstract: Provided are compounds and methods for treating neurodegenerative diseases and conditions, such as multiple sclerosis, using an estrogen receptor-? ligand (ER? ligand).
    Type: Application
    Filed: September 8, 2017
    Publication date: June 27, 2019
    Inventors: Michael E. Jung, Rhonda R. Voskuhl
  • ESTROGEN RECEPTOR MODULATOR COMBINATIONS
    Publication number: 20190175614
    Abstract: Described herein, inter alia, are compositions and methods for treating or preventing hyperproliferative disorders, including cancer.
    Type: Application
    Filed: May 25, 2017
    Publication date: June 13, 2019
    Inventors: Richard J. Pietras, Michael E. Jung
  • ANDROGEN RECEPTOR MODULATOR FOR THE TREATMENT OF PROSTATE CANCER AND ANDROGEN RECEPTOR-ASSOCIATED DISEASES
    Publication number: 20180318276
    Abstract: Described herein, inter alia, are compounds useful for the prevention or treatment of hyperproliferative diseases or disorders.
    Type: Application
    Filed: May 2, 2018
    Publication date: November 8, 2018
    Inventors: Michael E. Jung, Charles L. Sawyers, Samedy Ouk, Chris Tran, John Wongvipat
  • COMPOSITIONS AND METHODS FOR TREATING CANCER
    Publication number: 20180280346
    Abstract: Provided herein, inter alia, are compositions and methods useful for treating hyperproliferative diseases, including cancer and non-malignant hyperproliferative diseases.
    Type: Application
    Filed: September 29, 2016
    Publication date: October 4, 2018
    Inventors: Richard J. Pietras, Michael E. Jung, Diana C. Marquez-Garban, Gang Deng
  • POTENT ANTIVIRAL PYRAZOLOPYRIDINE COMPOUNDS
    Publication number: 20180273527
    Abstract: The present technology provides compounds according to Formulas (I), (II), or (III) useful in inhibiting an enterovirus, paramyxovirus, respiratory virus, flaviviridae virus, bunyaviridae virus, togaviridae virus, or rabies virus in a cell and/or treating subjects suffering from an enterovirus, paramyxovirus, respiratory virus, flaviviridae virus, bunyaviridae virus, togaviridae virus, or rabies virus.
    Type: Application
    Filed: September 22, 2016
    Publication date: September 27, 2018
    Inventors: Paul Krogstad, Michael E. Jung, Jun Zuo, Yanpeng Xing
  • METHODS AND COMPOSITIONS FOR DELIVERY OF ACTIVE AGENTS
    Publication number: 20180221510
    Abstract: A lipid particle can include a cationic lipid. The cationic lipid can include one or more hydrophobic tails, which can include one or more sites of unsaturation. The sites of unsaturation can include cycloalkyl groups, e.g., cyclopropyl, cyclobutyl, cyclopentyl, or cyclohexyl groups. The lipid particle is suitable for delivering an active agent.
    Type: Application
    Filed: October 19, 2017
    Publication date: August 9, 2018
    Applicant: Arbutus Biopharma Corporation
    Inventors: Muthiah Manoharan, Kallanthottathil G. Rajeev, Muthusamy Jayaraman, Michael E. Jung
  • Substituted diazaspiroalkanes as androgen receptor modulators
    Patent number: 9987261
    Abstract: Described herein, inter alia, are compounds useful for the prevention or treatment of hyperproliferative diseases or disorders.
    Type: Grant
    Filed: June 13, 2016
    Date of Patent: June 5, 2018
    Assignee: The Regents of the University of California
    Inventors: Michael E. Jung, Charles L. Sawyers, Samedy Ouk, Chris Tran, John Wongvipat
  • Deoxycytidine kinase inhibitors
    Patent number: 9981961
    Abstract: Provided herein are compounds that bind to dCK and methods for treating cancer.
    Type: Grant
    Filed: January 31, 2017
    Date of Patent: May 29, 2018
    Assignees: The Regents of the University of California, The Board of Trustees of the University of Illinois
    Inventors: Caius G. Radu, Zheng Li, Raymond M. Gipson, Jue Wang, Nagichettiar Satyamurthy, Arnon Lavie, Jennifer M. Murphy, David A. Nathanson, Michael E. Jung
  • LIPID COMPOSITIONS
    Publication number: 20180104342
    Abstract: Disclosed herein are lipid compositions comprising a cationic lipid of formula (I), a neutral lipid, a sterol and a PEG or PEG-modified lipid, wherein formula (I) is Also disclosed are methods of producing the cationic lipid of formula (I).
    Type: Application
    Filed: May 12, 2017
    Publication date: April 19, 2018
    Applicant: Arbutus Biopharma Corporation
    Inventors: Muthiah Manoharan, Kallanthottathil G. Rajeev, Muthusamy Jayaraman, David Butler, Michael E. Jung
  • ESTROGEN RECEPTOR MODULATORS
    Publication number: 20180086787
    Abstract: Described herein, inter alia, are compositions and methods for treating or preventing hyperproliferative disorders, including cancer.
    Type: Application
    Filed: November 20, 2015
    Publication date: March 29, 2018
    Inventors: Richard J. PIETRAS, Michael E. JUNG, Diana C. MARQUEZ-GARBAN, Gang DENG
  • Diarylhydantoin compounds
    Patent number: 9896437
    Abstract: The present invention relates to diarylhydantoin compounds and methods for synthesizing them and using them in the treatment of hormone refractory prostate cancer.
    Type: Grant
    Filed: March 24, 2014
    Date of Patent: February 20, 2018
    Assignee: The Regents of the University of California
    Inventors: Michael E. Jung, Dongwon Yoo
  • Compounds and methods of treating cancer
    Patent number: 9862693
    Abstract: Presented herein inter alia are novel compounds and methods of using the same for the treatment of cancers.
    Type: Grant
    Filed: December 10, 2014
    Date of Patent: January 9, 2018
    Assignee: The Regents of the University of California
    Inventors: Richard J. Pietras, Michael E. Jung, Diana C. Marquez-Garban, Gang Deng
  • APOE4-TARGETED THERAPUTICS THAT INCREASE SIRT1
    Publication number: 20170226059
    Abstract: A link between ApoE4 allele and sirtuins expression level is identified that is believed to be associated with elevated risk for the promotion of processing of amyloid precursor protein (APP) by the non-amyloidogenic pathway in a mammal leading to elevated risk for Alzheimer's disease. Compounds are identified that upregulate sirtuins (e.g., SirT1) expression levels and appear to be useful in the treatment and/or prophylaxis of MCI and/or Alzheimer's disease.
    Type: Application
    Filed: August 19, 2015
    Publication date: August 10, 2017
    Inventors: Barbara Jagodzinska, Jesus Campagna, Johnny Pham, Michael E. Jung, Varghese John, Rammohan Rao, Dale E. Bredesen, Veena P. Theendakara
  • Oxysterol analogue OXY133 induces osteogenesis and hedgehog signaling and inhibits adipogenesis
    Patent number: 9717742
    Abstract: This invention relates, e.g., to a synthetic compound, Oxy133, having the structure [Formula I] or a bioactive or pharmaceutical composition comprising Oxy133 and a pharmaceutically acceptable carrier. Methods are also disclosed for using the compound or bioactive or pharmaceutical composition to treat a variety of disorders, including e.g. bone disorders, obesity, cardiovascular disorders, and neurological disorders.
    Type: Grant
    Filed: March 15, 2013
    Date of Patent: August 1, 2017
    Assignee: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventors: Farhad Parhami, Michael E. Jung, Frank Stappenbeck
  • DEOXYCYTIDINE KINASE INHIBITORS
    Publication number: 20170204090
    Abstract: Provided herein are compounds that bind to dCK and methods for treating cancer.
    Type: Application
    Filed: January 31, 2017
    Publication date: July 20, 2017
    Inventors: CAIUS G. RADU, ZHENG LI, RAYMOND M. GIPSON, JUE WANG, NAGICHETTIAR SATYAMURTHY, ARNON LAVIE, JENNIFER M. MURPHY, DAVID A. NATHANSON, MICHAEL E. JUNG