Patents by Inventor Michael E. Jung

Michael E. Jung has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • DEOXYCYTIDINE KINASE INHIBITORS
    Publication number: 20170204090
    Abstract: Provided herein are compounds that bind to dCK and methods for treating cancer.
    Type: Application
    Filed: January 31, 2017
    Publication date: July 20, 2017
    Inventors: CAIUS G. RADU, ZHENG LI, RAYMOND M. GIPSON, JUE WANG, NAGICHETTIAR SATYAMURTHY, ARNON LAVIE, JENNIFER M. MURPHY, DAVID A. NATHANSON, MICHAEL E. JUNG
  • Lipid compositions
    Patent number: 9694077
    Abstract: Disclosed herein are lipid compositions comprising a cationic lipid of formula (I), a neutral lipid, a sterol and a PEG or PEG-modified lipid, wherein formula (I) is Also disclosed are methods of producing the cationic lipid of formula (I).
    Type: Grant
    Filed: October 7, 2014
    Date of Patent: July 4, 2017
    Assignee: ARBUTUS BIOPHARMA CORPORATION
    Inventors: Muthiah Manoharan, Kallanthottathil G. Rajeev, Muthusamy Jayaraman, David Butler, Michael E. Jung
  • Bone-selective osteogenic oxysterol-bone targeting agents
    Patent number: 9683009
    Abstract: Compounds and compositions for the treatment of bone disorders are presented.
    Type: Grant
    Filed: May 2, 2014
    Date of Patent: June 20, 2017
    Assignees: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA, UNIVERSITY OF LOUISVILLE RESEARCH FOUNDATION, INC.
    Inventors: Farhad Parhami, Frank Stappenbeck, Michael E. Jung, William M. Pierce, Jr., Kevyn Merten, K. Grant Taylor
  • Oxysterol compounds and the hedgehog pathway
    Patent number: 9670244
    Abstract: This invention relates, for example, to synthetic oxysterols. Also described are methods for using the compounds, including treating subjects in need thereof, and pharmaceutical compositions and kits for implementing methods of the invention.
    Type: Grant
    Filed: February 27, 2007
    Date of Patent: June 6, 2017
    Assignee: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventors: Farhad Parhami, Michael E. Jung, Jennifer R. Dwyer, Khanhlinh Nguyen
  • MONOMERS AND OLIGONUCLEOTIDES COMPRISING CYCLOADDITION ADDUCT(S)
    Publication number: 20170107513
    Abstract: The invention features compounds of formula V or XII: In one embodiment, the invention relates compounds and processes for conjugating ligand to oligonucleotide. The invention further relates to methods for treating various disorders and diseases such as viral infections, bacterial infections, parasitic infections, cancers, allergies, autoimmune diseases, immunodeficiencies and immunosuppression.
    Type: Application
    Filed: December 30, 2016
    Publication date: April 20, 2017
    Inventors: Muthiah MANOHARAN, Jayaprakash K. NAIR, Kallanthottahil G. RAJEEV, Michael E. JUNG
  • Premature-termination-codons readthrough compounds
    Patent number: 9598395
    Abstract: Premature termination codons readthrough compounds, composition thereof, and methods of making and using the same are provided.
    Type: Grant
    Filed: March 15, 2013
    Date of Patent: March 21, 2017
    Assignee: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventors: Richard A. Gatti, Liutao Du, Hailiang Hu, Robert Damoiseaux, Michael E. Jung, Jin-Mo Ku, Gladys Completo
  • Deoxycytidine kinase inhibitors
    Patent number: 9598404
    Abstract: Provided herein are compounds that bind to dCK and methods for treating cancer.
    Type: Grant
    Filed: January 11, 2016
    Date of Patent: March 21, 2017
    Assignees: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA, THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS
    Inventors: Caius G. Radu, Zheng Li, Raymond M. Gipson, Jue Wang, Nagichettiar Satyamurthy, Arnon Lavie, Jennifer M. Murphy, David A. Nathanson, Michael E. Jung
  • Positron emission tomography probe to monitor selected sugar metabolism in vivo
    Patent number: 9592309
    Abstract: The invention disclosed herein discloses selected ribose isomers that are useful as PET probes (e.g. [18F]-2-fluoro-2-deoxy-arabinose). These PET probes are useful, for example, in methods designed to monitor physiological processes including ribose metabolism and/or to selectively observe certain tissue/organs in vivo. The invention disclosed herein further provides methods for making and using such probes.
    Type: Grant
    Filed: May 9, 2013
    Date of Patent: March 14, 2017
    Assignee: The Regents of the University of California
    Inventors: Owen Witte, Peter M. Clark, Blanca Graciela Flores Castillo, Michael E. Jung, Nikolai M. Evdokimov
  • Monomers and oligonucleotides comprising cycloaddition adduct(s)
    Patent number: 9566340
    Abstract: The invention features compounds of formula V or XII: In one embodiment, the invention relates compounds and processes for conjugating ligand to oligonucleotide. The invention further relates to methods for treating various disorders and diseases such as viral infections, bacterial infections, parasitic infections, cancers, allergies, autoimmune diseases, immunodeficiencies and immunosuppression.
    Type: Grant
    Filed: October 20, 2015
    Date of Patent: February 14, 2017
    Assignee: Alnylam Pharmaceuticals, Inc.
    Inventors: Muthiah Manoharan, Jayaprakash K. Nair, Kallanthottahil G. Rajeev, Michael E. Jung
  • ANDROGEN RECEPTOR MODULATOR FOR THE TREATMENT OF PROSTATE CANCER AND ANDROGEN RECEPTOR-ASSOCIATED DISEASES
    Publication number: 20170014399
    Abstract: Described herein, inter alia, are compounds useful for the prevention or treatment of hyperproliferative diseases or disorders.
    Type: Application
    Filed: June 13, 2016
    Publication date: January 19, 2017
    Inventors: Michael E. Jung, Charles L. Sawyers, Samedy Ouk, Chris Tran, John Wongvipat
  • Oxysterols for activation of hedgehog signaling, osteoinduction, antiadipogenesis, and Wnt signaling
    Patent number: 9526737
    Abstract: Synthetic oxysterols can be made and can be used for the treatment of bone disorders, obesity, cardiovascular disorders, and neurological disorders.
    Type: Grant
    Filed: December 3, 2008
    Date of Patent: December 27, 2016
    Assignee: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventors: Farhad Parhami, Michael E. Jung, Khanhlinh Nguyen, Dongwon Yoo, Woo-Kyun Kim
  • Compositions and Methods for Treating Aging and Age-Related Diseases and Symptoms
    Publication number: 20160354334
    Abstract: Disclosed herein are methods for (a) inhibiting, reducing, slowing, or preventing, the aging of a subject, (b) for treating, inhibiting, reducing, or preventing an age-related disease in the subject, and/or (c) for increasing the lifespan of the subject which comprise administering to the subject one or more glutamate compounds, such as ?-ketoglutate, and/or one or more glutamate compounds, such as 2-hydroxypentanedioate, and compositions thereof.
    Type: Application
    Filed: February 11, 2015
    Publication date: December 8, 2016
    Inventors: Jing Huang, Randall Chin, Simon Diep, Melody Y. Pai, Brett E. Lomenick, Xudong Fu, Karen Reue, Laurent Vergnes, Michael E. Jung, Gang Deng, Heejun Hwang, Meisheng Jiang
  • Compositions and methods for treating cancer
    Patent number: 9512138
    Abstract: Provided herein, inter alia, are compositions and methods useful for treating hyperproliferative diseases, including cancer and non-malignant hyperproliferative diseases.
    Type: Grant
    Filed: January 7, 2016
    Date of Patent: December 6, 2016
    Assignee: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventors: Richard J. Pietras, Michael E. Jung, Diana C. Márquez-Garbán, Gang Deng
  • DEOXYCYTIDINE KINASE INHIBITORS
    Publication number: 20160237076
    Abstract: Provided herein are compounds that bind to dCK and methods for treating cancer.
    Type: Application
    Filed: January 11, 2016
    Publication date: August 18, 2016
    Inventors: Caius G. Radu, Zheng Li, Raymond M. Gipson, Jue Wang, Nagichettiar Satyamurthy, Arnon Lavie, Jennifer M. Murphy, David A. Nathanson, Michael E. Jung
  • BROAD SPECTRUM ANTIVIRAL AND ANTIPARASITIC AGENTS
    Publication number: 20160207908
    Abstract: The invention provides compounds represented by the formulae: (I) and (II) where the compounds are useful in treating, for example, viral and/or parasitic infections. Also provided are pharmaceutical compositions comprising the compounds and methods of treatment using the compounds.
    Type: Application
    Filed: September 16, 2015
    Publication date: July 21, 2016
    Inventors: Benhur Lee, Michael E. Jung, Jihye Lee, Frederic Vigant, Peter J. Bradley, Michael C. Wolf, Bettina E. Hajagos
  • Substituted diazaspiroalkanes as androgen receptor modulators
    Patent number: 9388159
    Abstract: This invention provides for compounds of the Formula II: wherein A, B, Het, R1, R2 and R3 are as described herein. These compounds are androgen receptor modulators useful for the treatment of androgen receptor-associated conditions.
    Type: Grant
    Filed: June 27, 2014
    Date of Patent: July 12, 2016
    Assignee: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventors: Michael E. Jung, Charles L. Sawyers, Samedy Ouk, Chris Tran, John Wongvipat
  • COMPOSITIONS AND METHODS FOR TREATING CANCER
    Publication number: 20160137662
    Abstract: Provided herein, inter alia, are compositions and methods useful for treating hyperproliferative diseases, including cancer and non-malignant hyperproliferative diseases.
    Type: Application
    Filed: January 7, 2016
    Publication date: May 19, 2016
    Inventors: Richard J. Pietras, Michael E. Jung, Diana C. Márquez-Garbán, Gang Deng
  • MONOMERS AND OLIGONUCLEOTIDES COMPRISING CYCLOADDITION ADDUCT(S)
    Publication number: 20160101189
    Abstract: The invention features compounds of formula V or XII: In one embodiment, the invention relates compounds and processes for conjugating ligand to oligonucleotide. The invention further relates to methods for treating various disorders and diseases such as viral infections, bacterial infections, parasitic infections, cancers, allergies, autoimmune diseases, immunodeficiencies and immunosuppression.
    Type: Application
    Filed: October 20, 2015
    Publication date: April 14, 2016
    Inventors: Muthiah MANOHARAN, Jayaprakash N. NAIR, Kallanthottahil G. RAJEEV, Michael E. JUNG
  • Compositions and methods for treating cancer
    Patent number: 9266901
    Abstract: Provided herein, inter alia, are compositions and methods useful for treating hyperproliferative diseases, including cancer and non-malignant hyperproliferative diseases.
    Type: Grant
    Filed: October 2, 2014
    Date of Patent: February 23, 2016
    Assignee: The Regents of The University of Califronia
    Inventors: Richard J. Pietras, Michael E. Jung, Diana C. Marquez-Garban, Gang Deng
  • PROTECTIVE MOLECULES AGAINST ANTHRAX TOXIN
    Publication number: 20160016930
    Abstract: Disclosed herein inter alia are compositions and methods useful in the treatment of infectious diseases and exposure to toxins.
    Type: Application
    Filed: July 16, 2015
    Publication date: January 21, 2016
    Inventors: Eugene Gillespie, Robert Damoiseaux, Chi-Lee Charlie Ho, Brian T. Chamberlain, Michael E. Jung, Kenneth A. Bradley